Nerves enable cancer progression, as cancers have been shown to extend along nerves through the process of perineural invasion, which carries a poor prognosis. Furthermore, the innervation of some cancers promotes growth and metastases. It remains unclear, however, how nerves mechanistically contribute to cancer progression. Here, we demonstrated that Schwann cells promote cancer invasion through direct cancer cell contact. Histological evaluation of murine and human cancer specimens with perineural invasion uncovered a subpopulation of Schwann cells that associates with cancer cells. Coculture of cancer cells with dorsal root ganglion extracts revealed that Schwann cells direct cancer cells to migrate toward nerves and promote invasion in a contact-dependent manner. Upon contact, Schwann cells induced the formation of cancer cell protrusions in their direction and intercalated between the cancer cells, leading to cancer cell dispersion. The formation of these processes was dependent on Schwann cell expression of neural cell adhesion molecule 1 (NCAM1) and ultimately promoted perineural invasion. Moreover, NCAM1-deficient mice showed decreased neural invasion and less paralysis. Such Schwann cell behavior reflects normal Schwann cell programs that are typically activated in nerve repair but are instead exploited by cancer cells to promote perineural invasion and cancer progression.
Sylvie Deborde, Tatiana Omelchenko, Anna Lyubchik, Yi Zhou, Shizhi He, William F. McNamara, Natalya Chernichenko, Sei-Young Lee, Fernando Barajas, Chun-Hao Chen, Richard L. Bakst, Efsevia Vakiani, Shuangba He, Alan Hall, Richard J. Wong
Title and authors | Publication | Year |
---|---|---|
Extracellular vesicles from pancreatic cancer and its tumour microenvironment promote increased Schwann cell migration
Fang Cheng Wong, Sebastian R. Merker, Lisa Bauer, Yi Han, Hung Van Mahn Le, Carina Wenzel, Lukas Böthig, Max Heiduk, Pascal Drobisch, Venkatesh Rao, Christian Sperling, Heike Polster, Mathieu Pecqueux, Bo Kong, Daniela Aust, Gustavo Baretton, Lena Seifert, Adrian Seifert, Jürgen Weitz, Ihsan Demir, Christoph Kahlert |
British journal of cancer | 2025 |
Complement activation at the interface between adipocytes and cancer cells drives tumor progression
Andres Valdivia, Ana Isac, Horacio Cardenas, Guangyuan Zhao, Yaqi Zhang, Hao Huang, Jian-Jun Wei, Mauricio Cuello-Fredes, Sumie Kato, Fernán Gómez-Valenzuela, Francoise A. Gourronc, Aloysius J. Klingelhutz, Daniela Matei |
JCI Insight | 2025 |
Understanding the role of nerves in head and neck cancers - a review
Rutkowski K, Gola M, Godlewski J, Starzyńska A, Marvaso G, Mastroleo F, Giulia Vincini M, Porazzi A, Zaffaroni M, Jereczek-Fossa BA |
Oncology Reviews | 2025 |
Schwann cells in regeneration and cancer
Zhang L, Xie J, Dai W, Lu B, Yi S |
Frontiers in Pharmacology | 2025 |
Multiomics analysis provides insights into musk secretion in muskrat and musk deer
Wang T, Yang M, Shi X, Tian S, Li Y, Xie W, Zou Z, Leng D, Zhang M, Zheng C, Feng C, Zeng B, Fan X, Qiu H, Li J, Zhao G, Yuan Z, Li D, Jie H |
GigaScience | 2025 |
Visualization of protrusion-localized STAT3 mRNA using a self-powered lipidic nanoflare for predicting hepatocellular carcinoma metastasis
Zhang Y, Zeng R, Xia Y, Han W, Luan Y, Zhang Y, Wu S, Wang S, Wang J, Chen Y, Chen D |
Mikrochimica Acta | 2025 |
Single-cell analysis reveals that GFAP+ dedifferentiated Schwann cells promote tumor progress in PNI-positive distal cholangiocarcinoma via lactate/HMGB1 axis
Zu Z, Zhang C, Shi J, Chen K, Tang H, Hu K, Liu E, Ji C, Feng R, Shi X, Zhai W |
Cell Death & Disease | 2025 |
Cancer neuroscience in head and neck: interactions, modulation, and therapeutic strategies
Wang H, Song X, Shen H, Liu W, Wang Y, Zhang M, Yang T, Mou Y, Ren C, Song X |
Molecular Cancer | 2025 |
Pancreatic cancer extracellular vesicles stimulate Schwann cell activation and perineural invasion in vitro via IL-8/CCL2
Gregory E, Powers I, Jamshidi-Parsian A, Griffin RJ, Song Y |
In Vitro Models | 2025 |
Single-cell transcriptomic analysis reveals prognosis-related stromal signatures that potentiate stratification of patients with extrahepatic cholangiocarcinoma
Ni C, Hua R, Yang Y, Liang J, Liu W, Wang L, Yao X, Li A, Yu L, Feng R, Lv D, Qin Z, Zhai W |
BMC Gastroenterology | 2025 |
Sympathetic axonogenesis promotes adenoid cystic carcinoma progression
Chen CH, Reva B, Katabi N, Wizel A, Xu H, Ho AL, Morris LG, Bakst RL, Parikh AS, Drier Y, Deborde S, Wong RJ |
The Journal of Experimental Medicine | 2025 |
The Role of the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma: Recent Advancements and Emerging Therapeutic Strategies
Glapiński F, Zając W, Fudalej M, Deptała A, Czerw A, Sygit K, Kozłowski R, Badowska-Kozakiewicz A |
Cancers | 2025 |
Significance and mechanisms of perineural invasion in malignant tumors
Wang M, Pu N, Bo X, Chen F, Zhou Y, Cheng Q |
Frontiers in Oncology | 2025 |
Nerves at Play: The Peripheral Nervous System in Extracranial Malignancies
Vermeer PD, Restaino AC, Barr JL, Yaniv D, Amit M |
Cancer discovery | 2025 |
Schwann Cells and Their Exosomes: Research Progress and Prospect in Spinal Cord Injury
Wang X, Yan W, Zhu L, Wei L, Cao H, Yang F, Zhang Y |
Neural Plasticity | 2025 |
Tumor Neurobiology in the Pathogenesis and Therapy of Head and Neck Cancer.
Liang S, Hess J |
Cells | 2024 |
Cholangiocarcinoma Malignant Traits Are Promoted by Schwann Cells through TGFβ Signaling in a Model of Perineural Invasion
de Franchis V, Petrungaro S, Pizzichini E, Camerini S, Casella M, Somma F, Mandolini E, Carpino G, Overi D, Cardinale V, Facchiano A, Filippini A, Gaudio E, Fabrizi C, Giampietri C |
Cells | 2024 |
Unraveling the Connection: Pancreatic Cancer Cells and Schwann Cells
Garajová I, Trentini F, Leonardi F, Giovannetti E |
Journal of Clinical Medicine | 2024 |
Schwann cells in the normal and pathological lung microenvironment
Shurin MR, Wheeler SE, Shurin GV, Zhong H, Zhou Y |
Frontiers in Molecular Biosciences | 2024 |
Neuron-derived neurotensin promotes pancreatic cancer invasiveness and gemcitabine resistance via the NTSR1/Akt pathway
Hung YH, Wang HC, Hsu SH, Wang LY, Tsai YL, Su YY, Hung WC, Chen LT |
American journal of cancer research | 2024 |
Promotion of perineural invasion of cholangiocarcinoma by Schwann cells via nerve growth factor
Qian X, Liu E, Zhang C, Feng R, Tran N, Zhai W, Wang F, Qin Z |
Journal of Gastrointestinal Oncology | 2024 |
Neuroimmune cell interactions and chronic infections in oral cancers
D\u2019Silva NJ, Pandiyan P |
Frontiers in Medicine | 2024 |
Perineural Invasion in Cervical Cancer: A Hidden Trail for Metastasis.
Chen G, Sun H, Chen Y, Wang L, Song O, Zhang J, Li D, Liu X, Feng L |
Diagnostics (Basel, Switzerland) | 2024 |
The Role of the Neurotrophin Network in Skin Squamous Cell Cancer and the Novel Use of the Zebrafish System.
Quadri M, Palazzo E |
JID innovations : skin science from molecules to population health | 2024 |
GDNF-induced phosphorylation of MUC21 promotes pancreatic cancer perineural invasion and metastasis by activating RAC2 GTPase.
Chen Y, Zhang W, Zeng Y, Yang P, Li Y, Liang X, Liu K, Lin H, Dai Y, Zhou J, Hou B, Ma Z, Lin Y, Pang W, Zeng L |
Oncogene | 2024 |
Combining single-cell spatial transcriptomics and molecular simulation to develop in vivo probes targeting the perineural invasion region of adenoid cystic carcinoma
Yuan X, Dong Z, Zhang B, Li Q, Jiang W |
Heliyon | 2024 |
Cervical cancer-produced neuromedin-B reprograms Schwann cells to initiate perineural invasion
Gao X, Wang Q, Huang T, Xu C, Yang X, Zhang L, Wang J, Yang L, Zheng X, Fan Q, Cao D, Li L, Ni T, Sun X, Hou J, Wang Y |
Cell Death & Disease | 2024 |
Neuroscience of cancer: Research progress and emerging of the field
AbuQeis I, Zou Y, Ba Y, Teeti AA |
Ibrain | 2024 |
Remarks on Selected Morphological Aspects of Cancer Neuroscience: A Microscopic Photo Review.
Iżycka-Świeszewska E, Gulczyński J, Sejda A, Kitlińska J, Galli S, Rogowski W, Sigorski D |
Biomedicines | 2024 |
Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk.
Fan HY, Liang XH, Tang YL |
MedComm | 2024 |
Reconceiving Perineural Invasion in Cutaneous Squamous Cell Carcinoma: From Biological to Histopathological Assessment
Nozzoli F, Nassini R, De Logu F, Catalano M, Roviello G, Massi D |
Pathobiology | 2024 |
NGF-mediated crosstalk: unraveling the influence of metabolic deregulation on the interplay between neural and pancreatic cancer cells and its impact on patient outcomes
Trentini F, Agnetti V, Manini M, Giovannetti E, Garajová I |
Frontiers in Pharmacology | 2024 |
The Emerging Role of Schwann Cells in the Tumor Immune Microenvironment and Its Potential Clinical Application
Zhang S, Chen J, Cheng F, Zheng F |
International Journal of Molecular Sciences | 2024 |
Targeting Perineural Invasion in Pancreatic Cancer
Garajová I, Giovannetti E |
Cancers | 2024 |
How the bone microenvironment shapes the pre-metastatic niche and metastasis.
Jackett KN, Browne AT, Aber ER, Clements M, Kaplan RN |
Nature cancer | 2024 |
Phenotype screens of murine pancreatic cancer identify a Tgfa-Ccl2-paxillin axis driving human-like neural invasion
Xiaobo Wang, Rouzanna Istvanffy, Steffen Teller, Melanie Laschinger, Kalliope Diakopoulos, Kıvanç Görgülü, Linhan Ye, Qiaolin Li, Lei Ren, Carsten Jäger, Katja Steiger, Alexander Muckenhuber, Baiba Vilne, Maximilian Reichert, Roland Schmid, Stefanie Bärthel, Rupert Ollinger, Achim Krüger, Roland Rad, Dieter Saur, Hana Algül, Helmut Friess, Marina Lesina, Güralp Onur Ceyhan, Ihsan Demir |
Journal of Clinical Investigation | 2023 |
Translational Research for Identifying Potential Early-stage Prostate Cancer Biomarkers
NAKAMURA N, ROGERS P, EGGERSON R, POST SR, DAVIS R |
Cancer genomics & proteomics | 2023 |
Survival outcomes of stage I colorectal cancer: development and validation of the ACEPLY model using two prospective cohorts.
Wu Q, Chen P, Shu C, Chen L, Jin Z, Huang J, Wang X, Li X, Wei M, Yang T, Deng X, Wu A, He Y, Wang Z |
BMC Medicine | 2023 |
Tumor-associated nonmyelinating Schwann cell–expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion
Sun C, Ye Y, Tan Z, Liu Y, Li Y, Hu W, Liang K, Egranov SD, Huang LA, Zhang Z, Zhang Y, Yao J, Nguyen TK, Zhao Z, Wu A, Marks JR, Caudle AS, Sahin AA, Gao J, Gammon ST, Piwnica-Worms D, Hu J, Chiao PJ, Yu D, Hung MC, Curran MA, Calin GA, Ying H, Han L, Lin C, Yang L |
Science Advances | 2023 |
Important Cells and Factors from Tumor Microenvironment Participated in Perineural Invasion
Chen Z, Fang Y, Jiang W |
Cancers | 2023 |
Perineural Invasion in Papillary Thyroid Cancer: A Rare Indicator of Aggressive Disease.
Limberg J, Lee-Saxton YJ, Egan CE, AlAnazi A, Easthausen I, Stefanova D, Stamatiou A, Beninato T, Zarnegar R, Scognamiglio T, Fahey TJ 3rd, Finnerty BM |
Annals of Surgical Oncology | 2023 |
Melanoma-associated repair-like Schwann cells suppress anti-tumor T-cells via 12/15-LOX/COX2-associated eicosanoid production
Kruglov O, Vats K, Soman V, Tyurin VA, Tyurina YY, Wang J, Williams L, Zhang J, Donahue Carey C, Jaklitsch E, Chandran UR, Bayir H, Kagan VE, Bunimovich YL |
OncoImmunology | 2023 |
The neural addiction of cancer.
Magnon C, Hondermarck H |
Nature reviews. Cancer | 2023 |
Pancreatic Ductal Adenocarcinoma Induces Neural Injury that Promotes a Transcriptomic and Functional Repair Signature by Peripheral Neuroglia.
Weitz J, Garg B, Tiriac H, Martsinkovskiy A, Patel S, Lowy A |
Research square | 2023 |
Rapid cancer cell perineural invasion utilizes amoeboid migration.
Marcadis AR, Kao E, Wang Q, Chen CH, Gusain L, Powers A, Bakst RL, Deborde S, Wong RJ |
Proceedings of the National Academy of Sciences | 2023 |
Pancreatic ductal adenocarcinoma induces neural injury that promotes a transcriptomic and functional repair signature by peripheral neuroglia.
Weitz J, Garg B, Martsinkovskiy A, Patel S, Tiriac H, Lowy AM |
Oncogene | 2023 |
Combining perineural invasion with staging improve the prognostic accuracy in colorectal cancer: a retrospective cohort study
Zhang B, Lin Y, Wang C, Chen Z, Huang T, Chen H, Wang G, Lan P, He X, He X |
BMC Cancer | 2023 |
Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment.
Xue M, Zhu Y, Jiang Y, Han L, Shi M, Su R, Wang L, Xiong C, Wang C, Wang T, Deng S, Wu D, Cao Y, Dong L, Bai F, Zhao S, Deng X, Peng C, Li H, Chen J, Shen B, Jiang L, Chen H |
Nature Communications | 2023 |
Perineural invasion in colorectal cancer: mechanisms of action and clinical relevance.
Wang H, Huo R, He K, Cheng L, Zhang S, Yu M, Zhao W, Li H, Xue J |
Cellular oncology (Dordrecht) | 2023 |
Ion channels in cancer-induced bone pain: from molecular mechanisms to clinical applications
Lu HJ, Wu XB, Wei QQ |
Frontiers in molecular neuroscience | 2023 |
Cell-free therapy based on extracellular vesicles: a promising therapeutic strategy for peripheral nerve injury
Namini MS, Daneshimehr F, Beheshtizadeh N, Mansouri V, Ai J, Jahromi HK, Ebrahimi-Barough S |
Stem Cell Research & Therapy | 2023 |
Hearing loss and vestibular schwannoma: new insights into Schwann cells implication
Mohamed T, Melfi V, Colciago A, Magnaghi V |
Cell Death and Disease | 2023 |
Transcriptome analyses reveal new insights on key determinants of perineural invasion in high-grade serous ovarian cancer
Zheng Z, Li X, Chen G, Chen J, Zhu X, Teng Y |
Frontiers in Cell and Developmental Biology | 2023 |
Dedifferentiated Schwann cells promote perineural invasion mediated by the PACAP paracrine signalling in cervical cancer
Chen G, Zheng Z, Sun H, You J, Chu J, Gao J, Qiu L, Liu X |
Journal of Cellular and Molecular Medicine | 2023 |
Tumour-associated macrophages and Schwann cells promote perineural invasion via paracrine loop in pancreatic ductal adenocarcinoma.
Zhang B, Guo X, Huang L, Zhang Y, Li Z, Su D, Lin L, Zhou P, Ye H, Lu Y, Zhou Q |
British Journal of Cancer | 2023 |
Spatial and transcriptomic analysis of perineural invasion in oral cancer
Ligia B. Schmitd, Cindy Perez-Pacheco, Emily Bellile, Weisheng Wu, Keith Casper, Michelle Mierzwa, Rozek Laura, Gregory Wolf, Jeremy Taylor, Nisha D'Silva |
Clinical cancer research | 2022 |
Autophagic Schwann cells promote perineural invasion mediated by the NGF/ATG7 paracrine pathway in pancreatic cancer
W Zhang, R He, W Yang, Y Zhang, Q Yuan, J Wang, Y Liu, S Chen, S Zhang, W Zhang, Z Zhu, J Zhang, Z Wang, J Li |
Journal of Experimental & Clinical Cancer Research | 2022 |
Schwann Cells in the Tumor Microenvironment: Need More Attention
L Sun, S Chen, M Chen, F Frauscher |
Journal of Oncology | 2022 |
High‑glucose microenvironment promotes perineural invasion of pancreatic cancer via activation of hypoxia inducible factor 1α
L Zhang, W Zhang, X Zhang, Y Min, Y Zhao, B Wang, W Li, S Mao, W Min |
Oncology reports | 2022 |
Schwann Cells in Digestive System Disorders
K Goluba, L Kunrade, U Riekstina, V Parfejevs |
Cells | 2022 |
Tumor Innervation: History, Methodologies, and Significance
J Baraldi, G Martyn, G Shurin, M Shurin |
Cancers | 2022 |
The Role of Extracellular Vesicles in Cancer–Nerve Crosstalk of the Peripheral Nervous System
Y Guo, Z Gil |
Cells | 2022 |
Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk
I Gu, E Gregory, C Atwood, S Lee, Y Song |
Nutrients | 2022 |
Plasma circRNA microarray profiling identifies novel circRNA biomarkers for the diagnosis of ovarian cancer
L Ge, Y Sun, Y Shi, G Liu, F Teng, Z Geng, X Chen, H Xu, J Xu, X Jia |
Journal of Ovarian Research | 2022 |
Prognostic Significance of Perineural Invasion in Patients with Stage II/III Gastric Cancer Undergoing Radical Surgery
Chen YF, Wang SY, Le PH, Chen TH, Kuo CJ, Lin CJ, Chou WC, Yeh TS, Hsu JT |
Journal of Personalized Medicine | 2022 |
Paracrine Interaction of Cholangiocellular Carcinoma with Cancer-Associated Fibroblasts and Schwann Cells Impact Cell Migration
Gundlach JP, Kerber J, Hendricks A, Bernsmeier A, Halske C, Röder C, Becker T, Röcken C, Braun F, Sebens S, Heits N |
Journal of Clinical Medicine | 2022 |
Peak density of immature nerve cells occurs with high-grade dysplasia in intraductal papillary mucinous neoplasms of the pancreas.
Trinh VQ, Roland JT, Wong J, Revetta F, Patel K, Shi C, DelGiorno KE, Carter BD, Tan MCB |
The Journal of Pathology | 2022 |
Ubiquitous Neural Cell Adhesion Molecule (NCAM): Potential Mechanism and Valorisation in Cancer Pathophysiology, Drug Targeting and Molecular Transductions.
Sowparani S, Mahalakshmi P, Sweety JP, Francis AP, Dhanalekshmi UM, Selvasudha N |
Molecular Neurobiology | 2022 |
Insights and opportunities at the crossroads of cancer and neuroscience.
Pan C, Winkler F |
Nature Cell Biology | 2022 |
The Role of Schwann Cells in Cancer.
Deborde S, Wong RJ |
2022 | |
Schwann Cells Induce Phenotypic Changes in Oral Cancer Cells.
Santi MD, Zhang M, Salvo E, Asam K, Viet CT, Xie T, Amit M, Aouizerat B, Ye Y |
2022 | |
REPROGRAMMED SCHWANN CELLS ORGANIZE INTO DYNAMIC TRACKS THAT PROMOTE PANCREATIC CANCER INVASION
Deborde S, Gusain L, Powers A, Marcadis A, Yu Y, Chen CH, Frants A, Kao E, Tang LH, Vakiani E, Amisaki M, Balachandran VP, Calo A, Omelchenko T, Jessen KR, Reva B, Wong RJ |
Cancer Discovery | 2022 |
Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression.
Rocha BGS, Picoli CC, Gonçalves BOP, Silva WN, Costa AC, Moraes MM, Costa PAC, Santos GSP, Almeida MR, Silva LM, Singh Y, Falchetti M, Guardia GDA, Guimarães PPG, Russo RC, Resende RR, Pinto MCX, Amorim JH, Azevedo VAC, Kanashiro A, Nakaya HI, Rocha EL, Galante PAF, Mintz A, Frenette PS, Birbrair A |
Angiogenesis | 2022 |
Role of nerves in neurofibromatosis type 1-related nervous system tumors.
Ge LL, Xing MY, Zhang HB, Li QF, Wang ZC |
Cellular oncology (Dordrecht) | 2022 |
Tumor-Induced T Cell Polarization by Schwann Cells
Shurin GV, Vats K, Kruglov O, Bunimovich YL, Shurin MR |
Cells | 2022 |
A Novel Therapeutic Target for Small-Cell Lung Cancer: Tumor-Associated Repair-like Schwann Cells
Cao S, Wang Y, Zhou Y, Zhang Y, Ling X, Zhang L, Li J, Yang Y, Wang W, Shurin MR, Zhong H |
Cancers | 2022 |
Beyond Wrapping: Canonical and Noncanonical Functions of Schwann Cells
Taveggia C, Feltri ML |
Annual Review of Neuroscience | 2022 |
Peripheral Nerve Decellularization for In Vitro Extracellular Matrix Hydrogel Use: A Comparative Study.
Gregory E, Baek IH, Ala-Kokko N, Dugan R, Pinzon-Herrera L, Almodóvar J, Song YH |
ACS Biomaterials Science & Engineering | 2022 |
Trick or treat? Does cancer fool Schwann cells by mimicking axons to promote metastasis into nerves?
Arthur-Farraj P |
Neural Regeneration Research | 2022 |
Diffuse pattern, orbital invasion, perineural invasion and Ki-67 are associated with nodal metastasis in patients with eyelid sebaceous carcinoma
Gu X, Xie M, Luo Y, Song X, Xu S, Fan X |
The British journal of ophthalmology | 2022 |
The Boring Schwann Cells: Tumor Me-TAST-asis along Nerves
Amit M, Maitra A |
Cancer discovery | 2022 |
Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2
N Vaes, SL Schonkeren, G Rademakers, AM Holland, A Koch, MJ Gijbels, TG Keulers, M de Wit, L Moonen, JR der Meer, E van den Boezem, TG Wolfs, DW Threadgill, J Demmers, RJ Fijneman, CR Jimenez, PV Berghe, KM Smits, KM Rouschop, W Boesmans, RM Hofstra, V Melotte |
EMBO reports | 2021 |
Disorders of the enteric nervous system — a holistic view
B Niesler, S Kuerten, IE Demir, KH Schäfer |
Nature Reviews Gastroenterology & Hepatology | 2021 |
Many Voices in a Choir: Tumor-Induced Neurogenesis and Neuronal Driven Alternative Splicing Sound Like Suspects in Tumor Growth and Dissemination
Z Dlamini, K Mathabe, L Padayachy, R Marima, G Evangelou, KN Syrigos, A Bianchi, G Lolas, R Hull |
Cancers | 2021 |
Roles of the nervous system in pancreatic cancer
T Wakiya, K Ishido, T Yoshizawa, T Kanda, K Hakamada |
Annals of Gastroenterological Surgery | 2021 |
The Diagnosis of Perineural Invasion: A Crucial Factor in Novel Algorithm of Coexistence of Conventional and Nerve-Sparing Radical Hysterectomy
A Skręt, JE Skręt-Magierło, M Książek, B Gawlik, J Bielatowicz, E Barnaś |
Diagnostics | 2021 |
TNFα promotes oral cancer growth, pain, and Schwann cell activation
E Salvo, NH Tu, NN Scheff, ZA Dubeykovskaya, SA Chavan, BE Aouizerat, Y Ye |
Scientific Reports | 2021 |
Nerve density in cancer: Less is better
LB Schmitd, C PerezPacheco, NJ D'Silva |
FASEB bioAdvances | 2021 |
Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma
TJ Eviston, E Minaei, SA Mueller, N Ahmadi, B Ashford, JR Clark, N West, P Zhang, R Gupta, M Ranson |
Scientific Reports | 2021 |
Perineural Invasion and Associated Pain Transmission in Pancreatic Cancer
J Wang, Y Chen, X Li, X Zou |
Cancers | 2021 |
Hyperbolic geometry of gene expression
Y Zhou, TO Sharpee |
iScience | 2021 |
Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma
J Li, R Kang, D Tang |
2021 | |
Neuroimmune Regulation of Surgery-Associated Metastases
MR Shurin, JH Baraldi, GV Shurin |
Cells | 2021 |
Glia and Orofacial Pain: Progress and Future Directions
Y Ye, E Salvo, M Romero-Reyes, S Akerman, E Shimizu, Y Kobayashi, B Michot, J Gibbs |
International journal of molecular sciences | 2021 |
Asparagine Synthetase-Mediated l-Asparagine Metabolism Disorder Promotes the Perineural Invasion of Oral Squamous Cell Carcinoma
Y Fu, L Ding, X Yang, Z Ding, X Huang, L Zhang, S Chen, Q Hu, Y Ni |
Frontiers in Oncology | 2021 |
Discovery of bladder cancer biomarkers in paired pre- and postoperative urine samples
X Li, C Huang, X Zhang, T Yang, S Zuo, C Fu, Y Zhang, C Yang, L Chen |
Translational andrology and urology | 2021 |
Construction of differential expression plasmids of NGF to detect its influence on PC12 cell neuronal differentiation
Y Liu, L Zou, P Wang, J Zhou, C Yuan, J Wang |
Experimental and therapeutic medicine | 2021 |
Molecular and Cellular Mechanisms of Perineural Invasion in Oral Squamous Cell Carcinoma: Potential Targets for Therapeutic Intervention
CI Misztal, C Green, C Mei, R Bhatia, JM Torres, B Kamrava, S Moon, E Nicolli, D Weed, Z Sargi, CT Dinh |
Cancers | 2021 |
Perineural Invasion in Vulvar Squamous-Cell Carcinoma Is an Independent Risk Factor for Cancer-Specific Survival, but Not for Locoregional Recurrence: Results from a Single Tertiary Referral Center
L Micheletti, F Borella, M Preti, V Frau, S Cosma, S Privitera, L Bertero, C Benedetto |
Cancers | 2021 |
Squamous Cell Carcinoma with Clinical Perineural Invasion: Challenges and Review in Single Case Study
V Chalfant, D Semerad, J Gossen, A Gurney, C Nguyen |
Journal of Radiology Case Reports | 2021 |
The Key Genes for Perineural Invasion in Pancreatic Ductal Adenocarcinoma Identified With Monte-Carlo Feature Selection Method
JH Zhu, QL Yan, JW Wang, Y Chen, QH Ye, ZJ Wang, T Huang |
Frontiers in Genetics | 2020 |
Tumor Microenvironments in Organs: From the Brain to the Skin – Part B
A Birbrair |
2020 | |
Nerves in the Tumor Microenvironment: Origin and Effects
W Wang, L Li, N Chen, C Niu, Z Li, J Hu, J Cui |
Frontiers in Cell and Developmental Biology | 2020 |
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies
RD Cervantes-Villagrana, D Albores-García, AR Cervantes-Villagrana, SJ García-Acevez |
Signal Transduction and Targeted Therapy | 2020 |
Peripheral nerve injury and sensitization underlie pain associated with oral cancer perineural invasion
E Salvo, WM Campana, NN Scheff, TH Nguyen, S Jeong, I Wall, AK Wu, S Zhang, H Kim, A Bhattacharya, MN Janal, C Liu, DG Albertson, BL Schmidt, JC Dolan, RE Schmidt, MD Boada, Y Ye |
PAIN | 2020 |
Novel Glial Cell Functions: Extensive Potency, Stem Cell-Like Properties, and Participation in Regeneration and Transdifferentiation
V Milichko, V Dyachuk |
Frontiers in Cell and Developmental Biology | 2020 |
Targeting Tumor Associated Macrophages to Overcome Conventional Treatment Resistance in Glioblastoma
H Grégoire, L Roncali, A Rousseau, M Chérel, Y Delneste, P Jeannin, F Hindré, E Garcion |
Frontiers in pharmacology | 2020 |
Schwann Cell Stimulation of Pancreatic Cancer Cells: A Proteomic Analysis
A Ferdoushi, X Li, N Griffin, S Faulkner, MF Jamaluddin, F Gao, CC Jiang, DF van Helden, PS Tanwar, P Jobling, H Hondermarck |
Frontiers in Oncology | 2020 |
Schwann Cell-Derived CCL2 Promotes the Perineural Invasion of Cervical Cancer
T Huang, Q Fan, Y Wang, Y Cui, Z Wang, L Yang, X Sun, Y Wang |
Frontiers in Oncology | 2020 |
Future directions in preclinical and translational cancer neuroscience research
IE Demir, CM Reyes, W Alrawashdeh, GO Ceyhan, S Deborde, H Friess, K Görgülü, R Istvanffy, D Jungwirth, R Kuner, M Maryanovich, S Naara, S Renders, JL Saloman, NN Scheff, H Steenfadt, P Stupakov, V Thiel, D Verma, BS Yilmaz, RA White, TC Wang, RJ Wong, PS Frenette, Z Gil, BM Davis |
2020 | |
Cdc42 Mediates Cancer Cell Chemotaxis in Perineural Invasion
N Chernichenko, T Omelchenko, S Deborde, RL Bakst, S He, CH Chen, L Gusain, E Vakiani, N Katabi, A Hall, RJ Wong |
Molecular cancer research : MCR | 2020 |
Integrating the Tumor Microenvironment into Cancer Therapy
S Sanegre, F Lucantoni, R Burgos-Panadero, L de La Cruz-Merino, R Noguera, TÁ Naranjo |
Cancers | 2020 |
Establishment of a Convenient System for the Culture and Study of Perineurium Barrier In Vitro
X Yin, X Liu, Y Zhang, J Zeng, X Liang, X Yang, J Hou |
Cellular and Molecular Neurobiology | 2020 |
Perineural Invasion in Adenoid Cystic Carcinoma of the Salivary Glands: Where We Are and Where We Need to Go
X Liu, X Yang, C Zhan, Y Zhang, J Hou, X Yin |
Frontiers in Oncology | 2020 |
Tumor-neuroglia interaction promotes pancreatic cancer metastasis
D Su, X Guo, L Huang, H Ye, Z Li, L Lin, R Chen, Q Zhou |
Theranostics | 2020 |
Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications
P Jézéquel, O Kerdraon, H Hondermarck, C Guérin-Charbonnel, H Lasla, W Gouraud, JL Canon, A Gombos, F Dalenc, S Delaloge, J Lemonnier, D Loussouarn, V Verrièle, M Campone |
Breast Cancer Research | 2019 |
Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures
RM Marton, Y Miura, SA Sloan, Q Li, O Revah, RJ Levy, JR Huguenard, SP Pașca |
Nature Neuroscience | 2019 |
Reciprocal interactions between cancer and Schwann cells contribute to oral cancer progression and pain
E Salvo, P Saraithong, JG Curtin, MN Janal, Y Ye |
Heliyon | 2019 |
Melanoma-induced reprogramming of Schwann cell signaling aids tumor growth
GV Shurin, O Kruglov, F Ding, Y Lin, X Hao, AA Keskinov, Z You, AE Lokshin, WA LaFramboise, LD Falo, MR Shurin, YL Bunimovich |
Cancer research | 2019 |
Perineural invasion in cervical cancer: pay attention to the indications of nerve-sparing radical hysterectomy
Y Zhu, GN Zhang, Y Shi, L Cui, XF Leng, JM Huang |
Annals of translational medicine | 2019 |
Nerves and Pancreatic Cancer: New Insights into a Dangerous Relationship
Gasparini, Pellegatta, Crippa, Lena, Belfiori, Doglioni, Taveggia, Falconi |
Cancers | 2019 |
Immunomodulation by Schwann cells in disease
SH Zhang, GV Shurin, H Khosravi, R Kazi, O Kruglov, MR Shurin, YL Bunimovich |
Cancer Immunology, Immunotherapy | 2019 |
Schwann cell reprogramming and lung cancer progression: a meta-analysis of transcriptome data
VM Silva, JA Gomes, LP Tenório, GC de Omena Neta, K da Costa Paixão, AK Duarte, GC da Silva, RJ Ferreira, BD Koike, C de Sales Marques, RD da Silva Miguel, AC de Queiroz, LX Pereira, CA de Carvalho Fraga |
Oncotarget | 2019 |
Schwann cells support oncogenic potential of pancreatic cancer cells through TGFβ signaling
E Roger, S Martel, A Bertrand-Chapel, A Depollier, N Chuvin, RM Pommier, K Yacoub, C Caligaris, V Cardot-Ruffino, V Chauvet, S Aires, K Mohkam, JY Mabrut, M Adham, T Fenouil, V Hervieu, L Broutier, M Castets, C Neuzillet, PA Cassier, R Tomasini, S Sentis, L Bartholin |
Cell Death and Disease | 2019 |
Schwann cells shape the neuro-immune environs and control cancer progression
GV Martyn, GV Shurin, AA Keskinov, YL Bunimovich, MR Shurin |
Cancer Immunology, Immunotherapy | 2019 |
Antibodies against cell adhesion molecules and neural structures in paraneoplastic neuropathies
AM Siles, E Martínez-Hernández, J Araque, J Diaz-Manera, R Rojas-Garcia, E Gallardo, I Illa, F Graus, L Querol |
Annals of Clinical and Translational Neurology | 2018 |
Perineural Invasion in Head and Neck Cancer
LB Schmitd, CS Scanlon, NJ DSilva |
Journal of dental research | 2018 |
Redefining Perineural Invasion: Integration of Biology With Clinical Outcome
LB Schmitd, LJ Beesley, N Russo, EL Bellile, RC Inglehart, M Liu, G Romanowicz, GT Wolf, JM Taylor, NJ D'Silva |
Neoplasia (New York, N.Y.) | 2018 |
L1CAM induces perineural invasion of pancreas cancer cells by upregulation of metalloproteinase expression
S Naara, M Amit, Z Gil |
Oncogene | 2018 |
An In Vivo Murine Sciatic Nerve Model of Perineural Invasion
S Deborde, Y Yu, A Marcadis, CH Chen, N Fan, RL Bakst, RJ Wong |
Journal of visualized experiments : JoVE | 2018 |
Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
RL Bakst, H Xiong, CH Chen, S Deborde, A Lyubchik, Y Zhou, S He, W McNamara, SY Lee, OC Olson, IM Leiner, AR Marcadis, JW Keith, HA Al-Ahmadie, N Katabi, Z Gil, E Vakiani, JA Joyce, E Pamer, RJ Wong |
Cancer research | 2017 |
How Schwann cells facilitate cancer progression in nerves
S Deborde, RJ Wong |
Cellular and Molecular Life Sciences | 2017 |
Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System
E Duchalais, C Guilluy, S Nedellec, M Touvron, A Bessard, Y Touchefeu, C Bossard, H Boudin, G Louarn, M Neunlist, LV Landeghem |
Cellular and Molecular Gastroenterology and Hepatology | 2017 |
Cancer’s got nerve: Schwann cells drive perineural invasion
Chad Pecot, Salma Azam |
Journal of Clinical Investigation | 2016 |
The Cohesive Metastasis Phenotype in Human Prostate Cancer
WL Harryman, JP Hinton, CP Rubenstein, P Singh, RB Nagle, SJ Parker, BS Knudsen, AE Cress |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2016 |
Can Stopping Nerves, Stop Cancer?
JL Saloman, KM Albers, AD Rhim, BM Davis |
Trends in Neurosciences | 2016 |
Schwann cells: a new player in the tumor microenvironment
YL Bunimovich, AA Keskinov, GV Shurin, MR Shurin |
Cancer Immunology, Immunotherapy | 2016 |
Mechanisms of Perineural Invasion
Bakst RL, Wong RJ |
Journal of Neurological Surgery Part B Skull Base | 2016 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |