Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis
Franck Oury, Mathieu Ferron, Wang Huizhen, Cyrille Confavreux, Lin Xu, Julie Lacombe, Prashanth Srinivas, Alexandre Chamouni, Francesca Lugani, Herve Lejeune, T. Rajendra Kumar, Ingrid Plotton, Gerard Karsenty
Franck Oury, Mathieu Ferron, Wang Huizhen, Cyrille Confavreux, Lin Xu, Julie Lacombe, Prashanth Srinivas, Alexandre Chamouni, Francesca Lugani, Herve Lejeune, T. Rajendra Kumar, Ingrid Plotton, Gerard Karsenty
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Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis

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Franck Oury, Mathieu Ferron, Wang Huizhen, Cyrille Confavreux, Lin Xu, Julie Lacombe, Prashanth Srinivas, Alexandre Chamouni, Francesca Lugani, Herve Lejeune, T. Rajendra Kumar, Ingrid Plotton, Gerard Karsenty

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Figure 5

Insulin signaling in osteoblasts favors testosterone production.

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Insulin signaling in osteoblasts favors testosterone production. (A) Tes...
(A) Testis size, and (B) testis, (C) epididymal, and (D) seminal vesicle weights normalized to BW (mg/g of BW); (E) sperm count; (F) circulating testosterone levels in InsRosb–/– versus InsRfl/fl (Cre–) male mice. (G) qPCR analysis of the expression of StAR, Cyp11a, Cyp17, 3β-HSD, Cyp19, and HSD-17 genes in testes of InsRosb–/– (n = 10) and InsRfl/fl (n = 12) mice. All analyses presented were performed on nonbreeder mix background (129/Sv: 87.5%; 129/Sv: 12.5%) mice. *P < 0.05; **P < 0.01.