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Citations to this article

Abdominal obesity: a marker of ectopic fat accumulation
Ulf Smith
Ulf Smith
Published May 1, 2015
Citation Information: J Clin Invest. 2015;125(5):1790-1792. https://doi.org/10.1172/JCI81507.
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Abdominal obesity: a marker of ectopic fat accumulation

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Abstract

In the early 1980s, we analyzed the metabolic profile of 930 men and women and concluded that an abdominal distribution of fat for a given BMI is associated with increased insulin resistance and risk of developing type 2 diabetes and cardiovascular disease. The correlation between abdominal fat and metabolic dysfunction has since been validated in many studies, and waist circumference is now a criterion for the diagnosis of metabolic syndrome. Several mechanisms for this relationship have been postulated; however, we now know that visceral fat is only one of many ectopic fat depots used when the subcutaneous adipose tissue cannot accommodate excess fat because of its limited expandability.

Authors

Ulf Smith

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 Total
Citations: 8 21 18 32 15 13 11 13 8 8 3 150
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Impact of physical activity and sedentary time on glycated hemoglobin levels and body composition: Cross‐sectional study using outpatient clinical data of Japanese patients with type 2 diabetes
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Journal of Diabetes Investigation 2019
Auricular Acupuncture Associated with Reduced Waist Circumference in Overweight Women-A Randomized Controlled Trial
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Evidence-Based Complementary and Alternative Medicine 2019
Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation
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Journal of lipid research 2018
Visceral Adipose Tissue Accumulation and Residual Cardiovascular Risk
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Current Hypertension Reports 2018
Early postnatal soluble FGFR3 therapy prevents the atypical development of obesity in achondroplasia
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PloS one 2018
Mesenteric visceral lipectomy using tissue liquefaction technology reverses insulin resistance and causes weight loss in baboons
MS Andrew, DM Huffman, E Rodriguez-Ayala, NN Williams, RM Peterson, RA Bastarrachea
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2018
Genetic risk scores for body fat distribution attenuate weight loss in women during dietary intervention
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International Journal of Obesity 2018
Concentrations of Plasma Free Palmitoleic and Dihomo-Gamma Linoleic Fatty Acids Are Higher in Children with Abdominal Obesity
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Nutrients 2018
Adipose tissue depot volume relationships with spinal trabecular bone mineral density in African Americans with diabetes
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PloS one 2018
Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans
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Cancer Science 2018
Endoplasmic reticulum stress epigenetics is related to adiposity, dyslipidemia, and insulin resistance
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Adipocyte 2018
Quantitative assessment of mesorectal fat: new prognostic biomarker in patients with mid-to-lower rectal cancer
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European Radiology 2018
Association between abdominal obesity and increased risk for the development of hypertension regardless of physical activity: A nationwide population-based study
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Journal of clinical hypertension (Greenwich, Conn.) 2018
The relationship between the effect of matured hop extract and physical activity on reducing body fat: re-analysis of data from a randomized, double-blind, placebo-controlled parallel group study
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Nutrition Journal 2018
In-vivo metabolic studies of regional adipose tissue:
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Cardiovascular endocrinology & metabolism 2018
Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases
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Cell Metabolism 2017
Chromatin-modifying agents convert fibroblasts to OCT4+ and VEGFR-2+ capillary tube-forming cells
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PloS one 2017
The Angiogenesis Inhibitor ALS-L1023 from Lemon-Balm Leaves Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease through Regulating the Visceral Adipose-Tissue Function
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International journal of molecular sciences 2017
The Need for Standardized Assessment of Muscle Quality in Skeletal Muscle Function Deficit and Other Aging-Related Muscle Dysfunctions: A Symposium Report
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Frontiers in physiology 2017
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BMC Public Health 2017
Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance
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Scientific Reports 2017
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Nature Genetics 2016
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Prostaglandin E2 receptor EP3 regulates both adipogenesis and lipolysis in mouse white adipose tissue
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Calcium Sensing Receptor as a Novel Mediator of Adipose Tissue Dysfunction: Mechanisms and Potential Clinical Implications
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Frontiers in physiology 2016
Vaspin regulates the osteogenic differentiation of MC3T3-E1 through the PI3K-Akt/miR-34c loop
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Scientific Reports 2016
Metabolic aspects of adult patients with nonalcoholic fatty liver disease
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World journal of gastroenterology : WJG 2016
Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity
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Open Heart 2016
Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice
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AJP Gastrointestinal and Liver Physiology 2016
Adipose tissue and metabolic syndrome: too much, too little or neither
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European Journal of Clinical Investigation 2015
Immunological contributions to adipose tissue homeostasis
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Seminars in Immunology 2015
Gene expression of different adipose tissues of severely obese women with or without a dysmetabolic profile
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Journal of Physiology and Biochemistry 2015

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