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Citations to this article

Lifespan of mice and primates correlates with immunoproteasome expression
Andrew M. Pickering, … , Marcus Lehr, Richard A. Miller
Andrew M. Pickering, … , Marcus Lehr, Richard A. Miller
Published April 13, 2015
Citation Information: J Clin Invest. 2015;125(5):2059-2068. https://doi.org/10.1172/JCI80514.
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Research Article Aging Article has an altmetric score of 12

Lifespan of mice and primates correlates with immunoproteasome expression

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Abstract

There is large variation in lifespan among different species, and there is evidence that modulation of proteasome function may contribute to longevity determination. Comparative biology provides a powerful tool for identifying genes and pathways that control the rate of aging. Here, we evaluated skin-derived fibroblasts and demonstrate that among primate species, longevity correlated with an elevation in proteasomal activity as well as immunoproteasome expression at both the mRNA and protein levels. Immunoproteasome enhancement occurred with a concurrent increase in other elements involved in MHC class I antigen presentation, including β-2 microglobulin, (TAP1), and TAP2. Fibroblasts from long-lived primates also appeared more responsive to IFN-γ than cells from short-lived primate species, and this increase in IFN-γ responsiveness correlated with elevated expression of the IFN-γ receptor protein IFNGR2. Elevation of immunoproteasome and proteasome activity was also observed in the livers of long-lived Snell dwarf mice and in mice exposed to drugs that have been shown to extend lifespan, including rapamycin, 17-α-estradiol, and nordihydroguaiaretic acid. This work suggests that augmented immunoproteasome function may contribute to lifespan differences in mice and among primate species.

Authors

Andrew M. Pickering, Marcus Lehr, Richard A. Miller

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 Total
Citations: 1 1 3 1 3 2 4 4 6 7 4 36
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2019 (4)

Title and authors Publication Year
RNA-seq analysis provides insight into molecular adaptations of Andrias davidianus
X Geng, L Zhang, X Zang, J Guo, C Xu
Development Genes and Evolution 2019
Cap-independent mRNA translation is upregulated in long-lived endocrine mutant mice
U Ozkurede, R Kala, C Johnson, Z Shen, RA Miller, GG Garcia
Journal of Molecular Endocrinology 2019
Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing
LC Pomatto, PY Sun, K Yu, S Gullapalli, CP Bwiza, C Sisliyan, S Wong, H Zhang, HJ Forman, PL Oliver, KE Davies, KJ Davies
Redox Biology 2019
Improved mitochondrial stress response in long‐lived Snell dwarf mice
U Ozkurede, RA Miller
Aging Cell 2019

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