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Citations to this article

Disruption of the myocardial extracellular matrix leads to cardiac dysfunction
Henry E. Kim, … , Myron L. Weisfeldt, Jeanine D’Armiento
Henry E. Kim, … , Myron L. Weisfeldt, Jeanine D’Armiento
Published October 1, 2000
Citation Information: J Clin Invest. 2000;106(7):857-866. https://doi.org/10.1172/JCI8040.
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Article

Disruption of the myocardial extracellular matrix leads to cardiac dysfunction

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Abstract

MMP activity with disruption of structural collagen has been implicated in the pathophysiology of dilated cardiomyopathy. To examine the role of this enzyme in cardiac function, a transgenic mouse was created that constitutively expressed human collagenase (MMP-1) in the heart. At 6 months of age, these animals demonstrated compensatory myocyte hypertrophy with an increase in the cardiac collagen concentration due to elevated transcription of type III collagen. Chronic myocardial expression of MMP-1 produced loss of cardiac interstitial collagen coincident with a marked deterioration of systolic and diastolic function at 12 months of age. This is the first animal model demonstrating that direct disruption of the extracellular matrix in the heart reproduces the changes observed in the progression of human heart failure.

Authors

Henry E. Kim, Seema S. Dalal, Erik Young, Marianne J. Legato, Myron L. Weisfeldt, Jeanine D’Armiento

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 Total
Citations: 4 2 4 2 1 6 5 7 4 3 3 3 2 4 4 8 2 1 1 4 2 6 1 1 3 1 84
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2012 (4)

Title and authors Publication Year
Diastolic dysfunction and heart failure with a preserved ejection fraction: Relevance in critical illness and anaesthesia
R Maharaj
Journal of the Saudi Heart Association 2012
Changes in Plasma Profiles of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of MMPs in Stress-Induced Cardiomyopathy
EM Essa, MR Zile, RE Stroud, A Rice, RJ Gumina, CV Leier, FG Spinale
Journal of Cardiac Failure 2012
MT1-MMP-dependent remodeling of cardiac extracellular matrix structure and function following myocardial infarction
GC Koenig, RG Rowe, SM Day, F Sabeh, JJ Atkinson, KR Cooke, SJ Weiss
The American Journal of Pathology 2012
α -Enolase, a Multifunctional Protein: Its Role on Pathophysiological Situations
À Díaz-Ramos, A Roig-Borrellas, A García-Melero, R López-Alemany
Journal of Biomedicine and Biotechnology 2012

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