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Citations to this article

Disruption of the myocardial extracellular matrix leads to cardiac dysfunction
Henry E. Kim, … , Myron L. Weisfeldt, Jeanine D’Armiento
Henry E. Kim, … , Myron L. Weisfeldt, Jeanine D’Armiento
Published October 1, 2000
Citation Information: J Clin Invest. 2000;106(7):857-866. https://doi.org/10.1172/JCI8040.
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Article

Disruption of the myocardial extracellular matrix leads to cardiac dysfunction

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Abstract

MMP activity with disruption of structural collagen has been implicated in the pathophysiology of dilated cardiomyopathy. To examine the role of this enzyme in cardiac function, a transgenic mouse was created that constitutively expressed human collagenase (MMP-1) in the heart. At 6 months of age, these animals demonstrated compensatory myocyte hypertrophy with an increase in the cardiac collagen concentration due to elevated transcription of type III collagen. Chronic myocardial expression of MMP-1 produced loss of cardiac interstitial collagen coincident with a marked deterioration of systolic and diastolic function at 12 months of age. This is the first animal model demonstrating that direct disruption of the extracellular matrix in the heart reproduces the changes observed in the progression of human heart failure.

Authors

Henry E. Kim, Seema S. Dalal, Erik Young, Marianne J. Legato, Myron L. Weisfeldt, Jeanine D’Armiento

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 Total
Citations: 4 2 4 2 1 6 5 7 4 3 3 3 2 4 4 8 2 1 1 4 2 6 1 1 3 1 84
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2011 (4)

Title and authors Publication Year
Type I Collagen Cleavage Is Essential for Effective Fibrotic Repair after Myocardial Infarction
Z Nong, C O'Neil, M Lei, R Gros, A Watson, A Rizkalla, K Mequanint, S Li, MJ Frontini, Q Feng, JG Pickering
The American Journal of Pathology 2011
Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart
CL Miller, Y Cai, M Oikawa, T Thomas, WR Dostmann, M Zaccolo, K Fujiwara, C Yan
Basic Research in Cardiology 2011
Transforming growth factor-β inhibits myocardial PPARγ expression in pressure overload-induced cardiac fibrosis and remodeling in mice
K Gong, YF Chen, P Li, JA Lucas, FG Hage, Q Yang, SE Nozell, S Oparil, D Xing
Journal of Hypertension 2011
Matrix metalloproteinas-9 functional promoter polymorphism 1562C>T increased risk of early-onset coronary artery disease
M Saedi, A Vaisi-Raygani, S Khaghani, A Shariftabrizi, M Rezaie, P Pasalar, Z Rahimi, T Pourmotabbed
Molecular Biology Reports 2011

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