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Citations to this article

Albumin-associated free fatty acids induce macropinocytosis in podocytes
Jun-Jae Chung, … , Jeffrey H. Miner, Andrey S. Shaw
Jun-Jae Chung, … , Jeffrey H. Miner, Andrey S. Shaw
Published April 27, 2015
Citation Information: J Clin Invest. 2015;125(6):2307-2316. https://doi.org/10.1172/JCI79641.
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Research Article Nephrology Article has an altmetric score of 1

Albumin-associated free fatty acids induce macropinocytosis in podocytes

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Abstract

Podocytes are specialized epithelial cells in the kidney glomerulus that play important structural and functional roles in maintaining the filtration barrier. Nephrotic syndrome results from a breakdown of the kidney filtration barrier and is associated with proteinuria, hyperlipidemia, and edema. Additionally, podocytes undergo changes in morphology and internalize plasma proteins in response to this disorder. Here, we used fluid-phase tracers in murine models and determined that podocytes actively internalize fluid from the plasma and that the rate of internalization is increased when the filtration barrier is disrupted. In cultured podocytes, the presence of free fatty acids (FFAs) associated with serum albumin stimulated macropinocytosis through a pathway that involves FFA receptors, the Gβ/Gγ complex, and RAC1. Moreover, mice with elevated levels of plasma FFAs as the result of a high-fat diet were more susceptible to Adriamycin-induced proteinuria than were animals on standard chow. Together, these results support a model in which podocytes sense the disruption of the filtration barrier via FFAs bound to albumin and respond by enhancing fluid-phase uptake. The response to FFAs may function in the development of nephrotic syndrome by amplifying the effects of proteinuria.

Authors

Jun-Jae Chung, Tobias B. Huber, Markus Gödel, George Jarad, Björn Hartleben, Christopher Kwoh, Alexander Keil, Aleksey Karpitskiy, Jiancheng Hu, Christine J. Huh, Marina Cella, Richard W. Gross, Jeffrey H. Miner, Andrey S. Shaw

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2009 Total
Citations: 2 4 4 6 10 7 2 4 7 7 3 1 57
Citation information
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Citations to this article in year 2020 (7)

Title and authors Publication Year
Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis
Y Chen, Q Yan, M Lv, K Song, Y Dai, Y Huang, L Zhang, C Zhang, H Gao
Cell Death and Disease 2020
Plasminogenuria is associated with podocyte injury, edema, and kidney dysfunction in incident glomerular disease
MA Egerman, JS Wong, T Runxia, G Mosoyan, K Chauhan, J ReyesBahamonde, N Anandakrishnan, NJ Wong, E Bagiella, F Salem, K Meliambro, H Li, EU Azeloglu, SG Coca, KN Campbell, L Raij
The FASEB Journal 2020
Correlation between plasma proprotein convertase subtilisin/kexin type 9 and blood lipids in patients with newly diagnosed primary nephrotic syndrome
H Shen, S Feng, Y Lu, L Jiang, T Yang, Z Wang
Renal Failure 2020
Comprehensive Lipidome Profiling of the Kidney in Early-Stage Diabetic Nephropathy
B Hou, P He, P Ma, X Yang, C Xu, SM Lam, G Shui, X Yang, L Zhang, G Qiang, G Du
Frontiers in Endocrinology 2020
Macropinocytosis in Different Cell Types: Similarities and Differences
XP Lin, JD Mintern, PA Gleeson
Membranes 2020
Nanoparticles exhibit greater accumulation in kidney glomeruli during experimental glomerular kidney disease
GW Liu, JW Pippin, DG Eng, S Lv, SJ Shankland, SH Pun
Physiological Reports 2020
Association between Neck Circumference and the Risk of Decreased Estimated Glomerular Filtration Rate in the General Population of China: A Cross-Sectional Study
J Xue, B Li, J Wang, S Yu, A Wang, P An, Y Mu, KT Tan
BioMed Research International 2020

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