Citations to this article

Unraveling the relationship between microbial translocation and systemic immune activation in HIV infection
Liang Shan, Robert F. Siliciano
Liang Shan, Robert F. Siliciano
Published May 16, 2014
Citation Information: J Clin Invest. 2014;124(6):2368-2371. https://doi.org/10.1172/JCI75799.
View: Text | PDF
Commentary Article has an altmetric score of 18

Unraveling the relationship between microbial translocation and systemic immune activation in HIV infection

Abstract

Chronic immune activation is a key factor in HIV-1 disease progression. The translocation of microbial products from the intestinal lumen into the systemic circulation occurs during HIV-1 infection and is associated closely with immune activation; however, it has not been determined conclusively whether microbial translocation drives immune activation or occurs as a consequence of HIV-1 infection. In an important study in this issue of the JCI, Kristoff and colleagues describe the role of microbial translocation in producing immune activation in an animal model of HIV-1 infection, SIV infection of pigtailed macaques. Blocking translocation of intestinal bacterial LPS into the circulation dramatically reduced T cell activation and proliferation, production of proinflammatory cytokines, and plasma SIV RNA levels. This study directly demonstrates that microbial translocation promotes the systemic immune activation associated with HIV-1/SIV infection.

Authors

Liang Shan, Robert F. Siliciano

×

Total citations by year

Year: 2023 2022 2021 2020 2019 2018 2017 2016 2015 Total
Citations: 1 1 1 2 1 1 1 5 5 18
Citation information

Citations to this article (18)

Title and authors Publication Year
The Many Faces of Immune Activation in HIV-1 Infection: A Multifactorial Interconnection
Mazzuti L, Turriziani O, Mezzaroma I 		Biomedicines 2023
Markers of Immune Activation and Inflammation Are Associated with Higher Levels of Genetically-Intact HIV in HIV-HBV Co-Infected Individuals
Wang XQ, Zerbato JM, Avihingsanon A, Fisher K, Schlub T, Rhodes A, Audsley J, Singh KP, Zhao W, Lewin SR, Palmer S 		Journal of virology 2022
Low Dietary Fiber Intake Links Development of Obesity and Lupus Pathogenesis
AL Schäfer, A Eichhorst, C Hentze, AN Kraemer, A Amend, DT Sprenger, C Fluhr, S Finzel, C Daniel, U Salzer, M Rizzi, RE Voll, N Chevalier 		Frontiers in immunology 2021
Alterations in Circulating Fatty Acid Are Associated With Gut Microbiota Dysbiosis and Inflammation in Multiple Sclerosis
M Saresella, I Marventano, M Barone, FL Rosa, F Piancone, L Mendozzi, A d'Arma, V Rossi, L Pugnetti, G Roda, E Casagni, MD Cas, R Paroni, P Brigidi, S Turroni, M Clerici 		Frontiers in immunology 2020
A theoretic approach to the mode of gut microbiome translocation in SIV-infected Asian macaques
W Li, ZS Ma 		FEMS Microbiology Ecology 2020
Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?
G Morris, M Maes, M Berk, BK Puri 		Metabolic Brain Disease 2019
Multiple Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways Explain the Frequent Presence of Depression in Multiple Sclerosis
G Morris, EM Reiche, A Murru, AF Carvalho, M Maes, M Berk, BK Puri 		Molecular Neurobiology 2018
HIV as a Cause of Immune Activation and Immunosenescence
T Sokoya, HC Steel, M Nieuwoudt, TM Rossouw 		Mediators of Inflammation 2017
Mucosal Regulatory T Cells and T Helper 17 Cells in HIV-Associated Immune Activation
P Pandiyan, SA Younes, SP Ribeiro, A Talla, D McDonald, N Bhaskaran, AD Levine, A Weinberg, RP Sekaly 		Frontiers in immunology 2016
Stimulation of PBMC and Monocyte-Derived Macrophages via Toll-Like Receptor Activates Innate Immune Pathways in HIV-Infected Patients on Virally Suppressive Combination Antiretroviral Therapy
E Merlini, C Tincati, M Biasin, I Saulle, FA Cazzaniga, AA Monforte, AJ Cappione, J Snyder-Cappione, M Clerici, GC Marchetti 		Frontiers in immunology 2016
Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection
W Fu, C Qiu, M Zhou, L Zhu, Y Yang, C Qiu, L Zhang, X Xu, Y Wang, J Xu, X Zhang 		Scientific Reports 2016
Brief Report: Differential Associations of Interleukin 6 and Intestinal Fatty Acid-Binding Protein With Progressive Untreated HIV-1 Infection in Rakai, Uganda
OA Olwenyi, P Naluyima, F Cham, TC Quinn, D Serwadda, NK Sewankambo, RH Gray, JK Sandberg, NL Michael, F Wabwire-Mangen, ML Robb, MA Eller 		Journal of acquired immune deficiency syndromes (1999) 2016
Statin modulation of monocyte phenotype and function: implications for HIV-1-associated neurocognitive disorders
A Yadav, MR Betts, RG Collman 		Journal of Neurovirology 2016
Ageing with HIV: a multidisciplinary review
A Calcagno, S Nozza, C Muss, BM Celesia, F Carli, S Piconi, GV de Socio, AM Cattelan, G Orofino, D Ripamonti, A Riva, GD Perri 		Infection 2015
CD14+ macrophages that accumulate in the colon of African AIDS patients express pro-inflammatory cytokines and are responsive to lipopolysaccharide
E Cassol, T Rossouw, S Malfeld, P Mahasha, T Slavik, C Seebregts, R Bond, J Plessis, C Janssen, T Roskams, F Nevens, M Alfano, G Poli, SW van der Merwe 		BMC Infectious Diseases 2015
Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIV B’WHU Chronically Infected Chinese Rhesus Macaque
GH Zhang, RD Wu, HY Zheng, XL Zhang, MX Zhang, RR Tian, GM Liu, W Pang, YT Zheng 		Journal of Immunology Research 2015
von Willebrand Factor is elevated in HIV patients with a history of thrombosis
LW van Dries, RA Gruters, SB der Borden, MJ Kruip, MP de Maat, EC van Gorp, ME van der Ende 		Frontiers in microbiology 2015
During stably suppressive antiretroviral therapy integrated HIV-1 DNA load in peripheral blood is associated with the frequency of CD8 cells expressing HLA-DR/DP/DQ
A Ruggiero, WD Spiegelaere, A Cozzi-Lepri, M Kiselinova, G Pollakis, A Beloukas, L Vandekerckhove, M Strain, D Richman, A Phillips, AM Geretti 		EBioMedicine 2015

Advertisement