The pancreatic processing enzymes, PC1 and PC2, convert proinsulin to insulin and convert proglucagon to glucagon and glucagon-like peptide 1 (GLP-1). We examined the effect of streptozotocin (STZ) treatment on the regulation of these enzymes and the production of insulin, glucagon, and GLP-1 in the rat. Pancreatic PC1 and PC2 mRNA increased >2-fold and >4-fold, respectively, in rats receiving intraperitoneal STZ (50 mg/kg) daily for 5 days. Immunocytochemistry revealed that, although pancreatic islet cells in the STZ-treated rats were sparse and atrophic PC1, PC2, glucagon, and GLP-1 immunoreactivity increased dramatically in the remaining islet cells. Heightened PC1 and PC2 expression was seen in cells expressing glucagon but not in insulin-expressing cells. Furthermore, in STZ-treated rats, bioactive GLP-17–36 amide accumulated in pancreatic extracts and serum 3- and 2.5-fold, respectively, over control animals. This treatment also caused a 2-fold increase in the ratio of amidated forms of GLP-1 immunoreactivity to total glucagon immunoreactivity in the pancreas but did not affect the ratio of proinsulin to insulin. We conclude that hyperglycemic rats have an increased expression of prohormone converting enzymes in islet α cells, leading to an increase in amidated GLP-1, which can then exert an insulinotropic effect on the remaining β cells.
Ying Nie, Masahiro Nakashima, Patricia L. Brubaker, Qiao-Ling Li, Riccardo Perfetti, Erik Jansen, Yasmeen Zambre, Daniel Pipeleers, Theodore C. Friedman
Title and authors | Publication | Year |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Activation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell mass
B Portha, C Tourrel-Cuzin, J Movassat |
Experimental Diabetes Research | 2011 |
Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus—an adaptive response to hyperglycaemia?
AM Hansen, TB Bödvarsdottir, DN Nordestgaard, RS Heller, CF Gotfredsen, K Maedler, JJ Fels, JJ Holst, AE Karlsen |
Diabetologia | 2011 |
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
H Ellingsgaard, I Hauselmann, B Schuler, AM Habib, LL Baggio, DT Meier, E Eppler, K Bouzakri, S Wueest, YD Muller, AM Hansen, M Reinecke, D Konrad, M Gassmann, F Reimann, PA Halban, J Gromada, DJ Drucker, FM Gribble, JA Ehses, MY Donath |
Nature Medicine | 2011 |
Oxidative Stress and Disease
I Paur, M Carlsen, B Halvorsen, R Blomhoff |
Herbal Medicine | 2011 |
Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival
Z Liu, V Stanojevic, S Avadhani, T Yano, JF Habener |
Diabetologia | 2011 |
Reprogramming gut and pancreas endocrine cells to treat diabetes
E Tudurí, TJ Kieffer |
Diabetes, Obesity and Metabolism | 2011 |
Processing of proglucagon to GLP-1 in pancreatic -cells: is this a paracrine mechanism enabling GLP-1 to act on -cells?
NM Whalley, LE Pritchard, DM Smith, A White |
Journal of Endocrinology | 2011 |