Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
A tribute to Michael S. Neuberger
Patricia J. Gearhart, Garnett Kelsoe
Patricia J. Gearhart, Garnett Kelsoe
Published January 2, 2014
Citation Information: J Clin Invest. 2014;124(1):3-5. https://doi.org/10.1172/JCI74366.
View: Text | PDF
Obituary Article has an altmetric score of 4

A tribute to Michael S. Neuberger

  • Text
  • PDF
Abstract

Authors

Patricia J. Gearhart, Garnett Kelsoe

×

Figure 2

The standard model for AID-mediated immunoglobulin gene diversification from the seminal work of the Neuberger laboratory (2).

Options: View larger image (or click on image) Download as PowerPoint
The standard model for AID-mediated immunoglobulin gene diversification ...
The formation of point mutations in the variable region of antibody genes, templated insertion of DNA sequence (gene conversion), and immunoglobulin class switching are all outcomes of a single basic process. AID catalyzes the deamination of cytosine to uracil, followed by removal of the uracil base by uracil-DNA glycosylase and repair bymismatch-repair enzymes and DNA polymerase η, homologous recombination with a nonfunctional V gene segment (V-pseudogene), or class-switch recombination mediated by DNA-dependent protein kinase (DNA-PK) and KU70/80. AP, apyrimidinic; dRPase, deoxyribophosphodiesterase; MSH2, mutS homolog 2, mismatch repair enzyme; MSH6, mutS homolog 6, mismatch repair enzyme; RAD51B, homologous recombination repair protein; XRCC2, X-ray repair cross-complementing group 2, homologous recombination repair protein; XRCC3, X-ray repair cross-complementing group 3, homologous recombination repair protein. Figure reproduced with permission from Nature.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Posted by 1 X users
Referenced in 2 Wikipedia pages
3 readers on Mendeley
See more details