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Frank Madeo, … , Maria Chiara Maiuri, Guido Kroemer
Published January 2, 2015
Citation Information: J Clin Invest. 2015;125(1):85-93. https://doi.org/10.1172/JCI73946.
Citation Information: J Clin Invest. 2015;125(1):85-93. https://doi.org/10.1172/JCI73946.
Abstract
Life and health span can be prolonged by calorie limitation or by pharmacologic agents that mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient signaling converge on the induction of autophagy, a cytoplasmic recycling process that counteracts the age-associated accumulation of damaged organelles and proteins as it improves the metabolic fitness of cells. Here we review experimental findings indicating that inhibition of the major nutrient and growth-related signaling pathways as well as the upregulation of anti-aging pathways mediate life span extension via the induction of autophagy. Furthermore, we discuss mounting evidence suggesting that autophagy is not only necessary but, at least in some cases, also sufficient for increasing longevity.
Authors
Frank Madeo, Andreas Zimmermann, Maria Chiara Maiuri, Guido Kroemer
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Transcriptome analysis revealed potential mechanisms of differences in physiological stress responses between caged male and female magpies
Y Wang, J Guo, L Wang, H Tian, J Sui |
BMC Genomics | 2019 |
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Acetyl-CoA carboxylase 1–dependent lipogenesis promotes autophagy downstream of AMPK
AS Gross, A Zimmermann, T Pendl, S Schroeder, H Schoenlechner, O Knittelfelder, L Lamplmayr, A Santiso, A Aufschnaiter, D Waltenstorfer, SO Lara, S Stryeck, C Kast, C Ruckenstuhl, SJ Hofer, B Michelitsch, M Woelflingseder, R Müller, D Carmona-Gutierrez, T Madl, S Büttner, KU Fröhlich, A Shevchenko, T Eisenberg |
The Journal of biological chemistry | 2019 |
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A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy
R Khandia, M Dadar, A Munjal, K Dhama, K Karthik, R Tiwari, MI Yatoo, HM Iqbal, KP Singh, SK Joshi, W Chaicumpa |
Cells | 2019 |
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Blood autophagy defect causes accelerated non-hematopoietic organ aging
Y Fang, L Zhu, N An, G Jiang, J Qian, R Zhao, N Yuan, S Zhang, J Wang |
Aging | 2019 |
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Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy
D Moreno-Blas, E Gorostieta-Salas, A Pommer-Alba, G Muciño-Hernández, C Gerónimo-Olvera, LA Maciel-Barón, M Konigsberg, L Massieu, S Castro-Obregón |
Aging | 2019 |
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Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy
T Tezil, M Chamoli, CP Ng, RP Simon, VJ Butler, M Jung, J Andersen, AW Kao, E Verdin |
npj Aging and Mechanisms of Disease | 2019 |
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Urinary cell-free mitochondrial and nuclear deoxyribonucleic acid correlates with the prognosis of chronic kidney diseases
CC Chang, PF Chiu, CL Wu, CL Kuo, CS Huang, CS Liu, CH Huang |
BMC Nephrology | 2019 |
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Aging: A cell source limiting factor in tissue engineering
M Khorraminejad-Shirazi, M Dorvash, A Estedlal, AH Hoveidaei, M Mazloomrezaei, P Mosaddeghi |
World journal of stem cells | 2019 |
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3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors TFE 3 and TFEB
G Chen, W Xie, J Nah, A Sauvat, P Liu, F Pietrocola, V Sica, D CarmonaGutierrez, A Zimmermann, T Pendl, J Tadic, M Bergmann, SJ Hofer, L Domuz, S Lachkar, M Markaki, N Tavernarakis, J Sadoshima, F Madeo, O Kepp, G Kroemer |
EMBO Molecular Medicine | 2019 |
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Increased Muscleblind levels by chloroquine treatment improve myotonic dystrophy type 1 phenotypes in in vitro and in vivo models
A Bargiela, M Sabater-Arcis, J Espinosa-Espinosa, M Zulaica, AL de Munain, R Artero |
Proceedings of the National Academy of Sciences | 2019 |
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Extension of Cellular Lifespan by Methionine Restriction Involves Alterations in Central Carbon Metabolism and Is Mitophagy-Dependent
JD Plummer, JE Johnson |
Frontiers in Cell and Developmental Biology | 2019 |
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Differential Effects of Rapamycin and Metformin in Combination With Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes
CA Wolff, JJ Reid, RV Musci, DR Bruns, MA Linden, AR Konopka, FF Peelor, BF Miller, KL Hamilton, D Lamming |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2019 |
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Metabolic features and regulation in cell senescence
Kwon SM, Hong SM, Lee YK, Min S, Yoon G |
BMB Reports | 2019 |
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Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans
RO Walters, E Arias, A Diaz, ES Burgos, F Guan, S Tiano, K Mao, CL Green, Y Qiu, H Shah, D Wang, AD Hudgins, T Tabrizian, V Tosti, D Shechter, L Fontana, IJ Kurland, N Barzilai, AM Cuervo, DE Promislow, DM Huffman |
Cell Reports | 2018 |
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The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions
PY Ke |
International journal of molecular sciences | 2018 |
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Nε-lysine acetylation in the endoplasmic reticulum – a novel cellular mechanism that regulates proteostasis and autophagy
MA Farrugia, L Puglielli |
Journal of cell science | 2018 |
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Targeting Protein Quality Control Mechanisms by Natural Products to Promote Healthy Ageing
S Wedel, M Manola, M Cavinato, I Trougakos, P Jansen-Dürr |
Molecules (Basel, Switzerland) | 2018 |
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Autophagy and aging: Maintaining the proteome through exercise and caloric restriction
KA Escobar, NH Cole, CM Mermier, TA VanDusseldorp |
Aging Cell | 2018 |
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Guidelines and recommendations on yeast cell death nomenclature
D Carmona-Gutierrez, MA Bauer, A Zimmermann, A Aguilera, N Austriaco, K Ayscough, R Balzan, S Bar-Nun, A Barrientos, P Belenky, M Blondel, RJ Braun, M Breitenbach, WC Burhans, S Buettner, D Cavalieri, M Chang, KF Cooper, M Côrte-Real, V Costa, C Cullin, I Dawes, J Dengjel, MB Dickman, T Eisenberg, B Fahrenkrog, N Fasel, KU Froehlich, A Gargouri, S Giannattasio, P Goffrini, CW Gourlay, CM Grant, MT Greenwood, N Guaragnella, T Heger, J Heinisch, E Herker, JM Herrmann, S Hofer, A Jiménez-Ruiz, H Jungwirth, K Kainz, DP Kontoyiannis, P Ludovico, S Manon, E Martegani, C Mazzoni, LA Megeney, C Meisinger, J Nielsen, T Nystroem, HD Osiewacz, TF Outeiro, HO Park, T Pendl, D Petranovic, S Picot, P Polčic, T Powers, M Ramsdale, M Rinnerthaler, P Rockenfeller, C Ruckenstuhl, R Schaffrath, M Segovia, FF Severin, A Sharon, SJ Sigrist, C Sommer-Ruck, MJ Sousa, JM Thevelein, K Thevissen, V Titorenko, MB Toledano, M Tuite, FN Voegtle, B Westermann, J Winderickx, S Wissing, S Woelfl, ZJ Zhang, RY Zhao, B Zhou, L Galluzzi, G Kroemer, F Madeo |
Microbial Cell | 2018 |
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Resveratrol Sensitizes Carfilzomib-Induced Apoptosis via Promoting Oxidative Stress in Multiple Myeloma Cells
Q Li, Y Yue, L Chen, C Xu, Y Wang, L Du, X Xue, Q Liu, Y Wang, F Fan |
Frontiers in pharmacology | 2018 |
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Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States
MP Mattson, TV Arumugam |
Cell Metabolism | 2018 |
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Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype
Y Peng, SL Shapiro, VC Banduseela, IA Dieterich, KJ Hewitt, EH Bresnick, G Kong, J Zhang, KL Schueler, MP Keller, AD Attie, TA Hacker, R Sullivan, E Kielar-Grevstad, SI Apelo, DW Lamming, RM Anderson, L Puglielli |
Aging Cell | 2018 |
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Spermidine delays aging in humans
F Madeo, DC Gutierrez, O Kepp, G Kroemer |
Aging | 2018 |
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Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
RL Smith, MR Soeters, RC Wüst, RH Houtkooper |
Endocrine reviews | 2018 |
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The Role of Free Radicals in Autophagy Regulation: Implications for Ageing
M Pajares, A Cuadrado, N Engedal, Z Jirsova, M Cahova |
Oxidative medicine and cellular longevity | 2018 |
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Recent insights into the cellular and molecular determinants of aging
L Ruan, , R Li |
Journal of cell science | 2018 |
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Yeast as a tool to identify anti-aging compounds
A Zimmermann, S Hofer, T Pendl, K Kainz, F Madeo, D Carmona-Gutierrez |
FEMS Yeast Research | 2018 |
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Autophagy and Rheumatoid Arthritis: Current Knowledges and Future Perspectives
M Vomero, C Barbati, T Colasanti, C Perricone, L Novelli, F Ceccarelli, FR Spinelli, MD Franco, F Conti, G Valesini, C Alessandri |
Frontiers in immunology | 2018 |
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Deletion of Nrip1 Extends Female Mice Longevity, Increases Autophagy, and Delays Cell Senescence
J Wang, X Chen, J Osland, SJ Gerber, C Luan, K Delfino, L Goodwin, R Yuan |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2018 |
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Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism
C Bárcena, PM Quirós, S Durand, P Mayoral, F Rodríguez, XM Caravia, G Mariño, C Garabaya, MT Fernández-García, G Kroemer, JM Freije, C López-Otín |
Cell Reports | 2018 |
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Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice
ÁF Fernández, S Sebti, Y Wei, Z Zou, M Shi, KL McMillan, C He, T Ting, Y Liu, WC Chiang, DK Marciano, GG Schiattarella, G Bhagat, OW Moe, MC Hu, B Levine |
Nature | 2018 |
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Leukocyte telomere length in paediatric critical illness: effect of early parenteral nutrition
S Verstraete, I Vanhorebeek, E van Puffelen, I Derese, C Ingels, SC Verbruggen, PJ Wouters, KF Joosten, J Hanot, GG Guerra, D Vlasselaers, J Lin, GV den Berghe |
Critical Care | 2018 |
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Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging
E Bejarano, JW Murray, X Wang, O Pampliega, D Yin, B Patel, A Yuste, AW Wolkoff, AM Cuervo |
Aging Cell | 2018 |
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ROS is the major player in regulating altered autophagy and lifespan in sin-3 mutants of C. elegans
M Sharma, R Pandey, D Saluja |
Autophagy | 2018 |
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Sex-specific associations between adolescent categories of BMI with cardiovascular and non-cardiovascular mortality in midlife
A Furer, A Afek, O Orr, L Gershovitz, M Landau, E Derazne, O Pinhas-Hamiel, N Fink, A Leiba, A Tirosh, JD Kark, G Twig |
Cardiovascular Diabetology | 2018 |
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Protein restriction, epigenetic diet, intermittent fasting as new approaches for preventing age-associated diseases
NA Hanjani, M Vafa |
International journal of preventive medicine | 2018 |
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pH homeostasis links the nutrient sensing PKA/TORC1/Sch9 ménage-à-trois to stress tolerance and longevity
MA Deprez, E Eskes, T Wilms, P Ludovico, J Winderickx |
Microbial Cell | 2018 |
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UNC-120/SRF independently controls muscle aging and lifespan in Caenorhabditis elegans
AM dit Lamarche, L Molin, L Pierson, MC Mariol, JL Bessereau, K Gieseler, F Solari |
Aging Cell | 2018 |
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Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner
M Tang, C Ji, S Pallo, I Rahman, GV Johnson |
Neurobiology of Aging | 2018 |
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Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases
J Li, D Zhang, M Wiersma, BJ Brundel |
Cells | 2018 |
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Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice
R Coccurello, F Nazio, C Rossi, FD Angelis, V Vacca, G Giacovazzo, P Procacci, V Magnaghi, D Ciavardelli, S Marinelli, S Pandey |
PloS one | 2018 |
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Emerging Anti-Aging Strategies - Scientific Basis and Efficacy
AK Shetty, M Kodali, R Upadhya, LN Madhu |
Aging and disease | 2018 |
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Autophagy delays progression of the two most frequent human monogenetic lethal diseases: cystic fibrosis and Wilson disease
L Maiuri, G Kroemer |
Aging | 2018 |
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Caloric restriction rescues yeast cells from alpha-synuclein toxicity through autophagic control of proteostasis
B Sampaio-Marques, H Pereira, AR Santos, A Teixeira, P Ludovico |
Aging | 2018 |
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Cellular Metabolism and Aging
Catic A |
Progress in molecular biology and translational science | 2018 |
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Metformin as a geroprotector: experimental and clinical evidence.
Piskovatska V, Stefanyshyn N, Storey KB, Vaiserman AM, Lushchak O |
Biogerontology | 2018 |
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The role of autophagy in hepatocellular carcinoma: friend or foe
L Liu, JZ Liao, XX He, PY Li |
Oncotarget | 2017 |
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Herpesvirus and Autophagy: “All Right, Everybody Be Cool, This Is a Robbery!”
M Lussignol, A Esclatine |
Viruses | 2017 |
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The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks
JR Aunan, WC Cho, K Søreide |
Aging and disease | 2017 |
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Dysregulation of autophagy as a common mechanism in lysosomal storage diseases
E Seranova, KJ Connolly, M Zatyka, TR Rosenstock, T Barrett, RI Tuxworth, S Sarkar |
Essays in Biochemistry | 2017 |
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Target acquired: Selective autophagy in cardiometabolic disease
TD Evans, I Sergin, X Zhang, B Razani |
Science signaling | 2017 |
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Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis
L Li, J Sawashita, X Ding, M Yang, Z Xu, H Miyahara, M Mori, K Higuchi, A Cignarella |
PloS one | 2017 |
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Cellular Regulation of Amyloid Formation in Aging and Disease
E Stroo, M Koopman, EA Nollen, A Mata-Cabana |
Frontiers in neuroscience | 2017 |
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Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging
A Plaza-Zabala, V Sierra-Torre, A Sierra |
International journal of molecular sciences | 2017 |
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Caloric Restriction Protects against Lactacystin-Induced Degeneration of Dopamine Neurons Independent of the Ghrelin Receptor
J Coppens, E Bentea, J Bayliss, T Demuyser, L Walrave, G Albertini, JV Liefferinge, L Deneyer, N Aourz, AV Eeckhaut, J Portelli, Z Andrews, A Massie, DD Bundel, I Smolders |
International journal of molecular sciences | 2017 |
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Rapamycin modulation of p70 S6 kinase signaling inhibits Rift Valley fever virus pathogenesis
TM Bell, V Espina, S Senina, C Woodson, A Brahms, B Carey, SC Lin, L Lundberg, C Pinkham, A Baer, C Mueller, EA Chlipala, F Sharman, C la Fuente, L Liotta, K Kehn-Hall |
Antiviral Research | 2017 |
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Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
L Galluzzi, JM Pedro, B Levine, DR Green, G Kroemer |
Nature Reviews Drug Discovery | 2017 |
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Proteostasis, Oxidative Stress and Aging
I Korovila, M Hugo, JP Castro, D Weber, A Höhn, T Grune, T Jung |
Redox Biology | 2017 |
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Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives
A Vaiserman, O Lushchak |
Journal of Translational Medicine | 2017 |
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Exercise leads to unfavourable cardiac remodelling and enhanced metabolic homeostasis in obese mice with cardiac and skeletal muscle autophagy deficiency
Z Yan, A Kronemberger, J Blomme, JA Call, HM Caster, RO Pereira, H Zhao, VU de Melo, RC Laker, M Zhang, VA Lira |
Scientific Reports | 2017 |
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Autophagy in stem cell aging
M Revuelta, A Matheu |
Aging Cell | 2017 |
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Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders
N Salvadores, M Sanhueza, P Manque, FA Court |
Frontiers in neuroscience | 2017 |
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Opposing effects on cardiac function by calorie restriction in different-aged mice
Y Sheng, S Lv, M Huang, Y Lv, J Yu, J Liu, T Tang, H Qi, W Di, G Ding |
Aging Cell | 2017 |
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The Atg8 Family of Proteins—Modulating Shape and Functionality of Autophagic Membranes
I Abdollahzadeh, M Schwarten, T Gensch, D Willbold, OH Weiergräber |
Frontiers in Genetics | 2017 |
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Autophagy modulation: a potential therapeutic approach in cardiac hypertrophy
X Wang, T Cui |
American journal of physiology. Heart and circulatory physiology | 2017 |
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Metabolic effects of fasting on human and mouse blood in vivo
F Pietrocola, Y Demont, F Castoldi, D Enot, S Durand, M Semeraro, EE Baracco, J Pol, JM Pedro, C Bordenave, S Levesque, J Humeau, A Chery, D Métivier, F Madeo, MC Maiuri, G Kroemer |
Autophagy | 2017 |
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Integrative metabolomics as emerging tool to study autophagy regulation
S Stryeck, R Birner-Gruenberger, T Madl |
Microbial Cell | 2017 |
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Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis: Vitamin D deficiency and ageing
MJ Berridge |
The Journal of Physiology | 2017 |
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The integrated stress response in budding yeast lifespan extension
SD Postnikoff, JE Johnson, JK Tyler |
Microbial Cell | 2017 |
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Inhibitor of growth protein 4 interacts with Beclin 1 and represses autophagy
V Sica, JM Pedro, G Chen, G Mariño, S Lachkar, V Izzo, MC Maiuri, M Niso-Santano, G Kroemer |
Oncotarget | 2017 |
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The Mitochondrial Basis of Aging and Age-Related Disorders
S Srivastava |
Genes & development | 2017 |
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Cordyceps militaris improves the survival of Dahl salt-sensitive hypertensive rats possibly via influences of mitochondria and autophagy functions
K Takakura, S Ito, J Sonoda, K Tabata, M Shiozaki, K Nagai, M Shibata, M Koike, Y Uchiyama, T Gotow |
Heliyon | 2017 |
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Regulation of stem cell aging by SIRT1 – Linking metabolic signaling to epigenetic modifications
A Yu, W Dang |
Molecular and Cellular Endocrinology | 2017 |
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Improved proteostasis in the secretory pathway rescues Alzheimer’s disease in the mouse
Y Peng, MJ Kim, R Hullinger, KJ ORiordan, C Burger, M Pehar, L Puglielli |
Brain | 2016 |
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Mitochondrial remodeling: Rearranging, recycling, and reprogramming
RA Gottlieb, D Bernstein |
Cell Calcium | 2016 |
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Advances in Autophagy Regulatory Mechanisms
L Gallagher, L Williamson, E Chan |
Cells | 2016 |
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Aging and Autophagy in the Heart
A Shirakabe, Y Ikeda, S Sciarretta, DK Zablocki, J Sadoshima |
Circulation research | 2016 |
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Reprogramming of energy metabolism as a driver of aging
Z Feng, RW Hanson, NA Berger, A Trubitsyn |
Oncotarget | 2016 |
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Crosstalk of clock gene expression and autophagy in aging
F Kalfalah, L Janke, A Schiavi, J Tigges, A Ix, N Ventura, F Boege, H Reinke |
Aging | 2016 |
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Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed
W Li, J Zou, F Yue, K Song, Q Chen, WL McKeehan, F Wang, G Xu, H Huang, J Yi, L Liu |
Aging Cell | 2016 |
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Dietary fat composition influences glomerular and proximal convoluted tubule cell structure and autophagic processes in kidneys from calorie-restricted mice
M Calvo-Rubio, MI Burón, G López-Lluch, P Navas, R Cabo, JJ Ramsey, JM Villalba, JA González-Reyes |
Aging Cell | 2016 |
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The crucial impact of lysosomes in aging and longevity
D Carmona-Gutierrez, AL Hughes, F Madeo, C Ruckenstuhl |
Ageing Research Reviews | 2016 |
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Inter-organelle ER-endolysosomal contact sites in metabolism and disease across evolution
H Hariri, R Ugrankar, Y Liu, WM Henne |
Communicative & integrative biology | 2016 |
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Cardioprotection and lifespan extension by the natural polyamine spermidine
T Eisenberg, M Abdellatif, S Schroeder, U Primessnig, S Stekovic, T Pendl, A Harger, J Schipke, A Zimmermann, A Schmidt, M Tong, C Ruckenstuhl, C Dammbrueck, AS Gross, V Herbst, C Magnes, G Trausinger, S Narath, A Meinitzer, Z Hu, A Kirsch, K Eller, D Carmona-Gutierrez, S Büttner, F Pietrocola, O Knittelfelder, E Schrepfer, P Rockenfeller, C Simonini, A Rahn, M Horsch, K Moreth, J Beckers, H Fuchs, V Gailus-Durner, F Neff, D Janik, B Rathkolb, J Rozman, MH de Angelis, T Moustafa, G Haemmerle, M Mayr, P Willeit, M Frieling-Salewsky, B Pieske, L Scorrano, T Pieber, R Pechlaner, J Willeit, SJ Sigrist, WA Linke, C Mühlfeld, J Sadoshima, J Dengjel, S Kiechl, G Kroemer, S Sedej, F Madeo |
Nature Medicine | 2016 |
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The impact of autophagy on the development of senescence in primary tubular epithelial cells
A Baisantry, S Bhayana, C Wrede, J Hegermann, H Haller, A Melk, R Schmitt |
Cell cycle (Georgetown, Tex.) | 2016 |
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X-rays and metformin cause increased urinary excretion of cell-free nuclear and mitochondrial DNA in aged rats
A Gaziev, S Abdullaev, G Minkabirova, K Kamenskikh |
Journal of Circulating Biomarkers | 2016 |
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Mitochondrial health, the epigenome and healthspan
MA Aon, S Cortassa, M Juhaszova, SJ Sollott |
Clinical Science | 2016 |
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Autophagy in kidney transplants of sirolimus treated recipients
S Bhayana, A Baisantry, TD Kraemer, C Wrede, J Hegermann, JH Bräsen, C Bockmeyer, JU Becker, M Ochs, W Gwinner, H Haller, A Melk, R Schmitt |
Journal of Nephropathology | 2016 |
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Autophagy: one more Nobel Prize for yeast
A Zimmermann, K Kainz, A Andryushkova, S Hofer, F Madeo, D Carmona-Gutierrez |
Microbial Cell | 2016 |
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H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway
S Zhao, L Li, S Wang, C Yu, B Xiao, L Lin, W Cong, J Cheng, W Yang, W Sun, S Cui |
Oncotarget | 2016 |
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Inhibition of autophagy inhibits the conversion of cardiac fibroblasts to cardiac myofibroblasts
SS Gupta, MR Zeglinski, SG Rattan, NM Landry, S Ghavami, JT Wigle, T Klonisch, AJ Halayko, IM Dixon |
Oncotarget | 2016 |
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It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin
MP Liebl, T Hoppe |
American journal of physiology. Cell physiology | 2016 |
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Autophagy: a druggable process that is deregulated in aging and multiple human diseases
Guido Kroemer |
Journal of Clinical Investigation | 2015 |
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Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease
S Mulugeta, SI Nureki, MF Beers |
American journal of physiology. Lung cellular and molecular physiology | 2015 |
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Systemic sclerosis-associated fibrosis: an accelerated aging phenotype?
TR Luckhardt, VJ Thannickal |
Current Opinion in Rheumatology | 2015 |
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Molecular Mechanisms by Which a Fucus vesiculosus Extract Mediates Cell Cycle Inhibition and Cell Death in Pancreatic Cancer Cells
U Geisen, M Zenthoefer, M Peipp, J Kerber, J Plenge, A Managò, M Fuhrmann, R Geyer, S Hennig, D Adam, L Piker, G Rimbach, H Kalthoff |
Marine drugs | 2015 |
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Measuring In Vivo Mitophagy
N Sun, J Yun, J Liu, D Malide, C Liu, II Rovira, KM Holmström, MM Fergusson, YH Yoo, CA Combs, T Finkel |
Molecular Cell | 2015 |
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Cutting Calories and TXNIP From the Skeletal Muscle to Restore Insulin Sensitivity
EJ Anderson |
Diabetes | 2015 |
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The regulation of autophagy during exercise in skeletal muscle
A Vainshtein, DA Hood |
Journal of applied physiology | 2015 |
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Why are essential genes essential? - The essentiality of Saccharomyces genes
Z Zhang, Q Ren |
Microbial Cell | 2015 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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