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Citations to this article

Essential role for autophagy in life span extension
Frank Madeo, … , Maria Chiara Maiuri, Guido Kroemer
Frank Madeo, … , Maria Chiara Maiuri, Guido Kroemer
Published January 2, 2015
Citation Information: J Clin Invest. 2015;125(1):85-93. https://doi.org/10.1172/JCI73946.
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Review Article has an altmetric score of 72

Essential role for autophagy in life span extension

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Abstract

Life and health span can be prolonged by calorie limitation or by pharmacologic agents that mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient signaling converge on the induction of autophagy, a cytoplasmic recycling process that counteracts the age-associated accumulation of damaged organelles and proteins as it improves the metabolic fitness of cells. Here we review experimental findings indicating that inhibition of the major nutrient and growth-related signaling pathways as well as the upregulation of anti-aging pathways mediate life span extension via the induction of autophagy. Furthermore, we discuss mounting evidence suggesting that autophagy is not only necessary but, at least in some cases, also sufficient for increasing longevity.

Authors

Frank Madeo, Andreas Zimmermann, Maria Chiara Maiuri, Guido Kroemer

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2009 Total
Citations: 4 15 11 17 28 27 27 33 27 19 8 1 217
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2019 (27)

Title and authors Publication Year
Chemical Screening Approaches Enabling Drug Discovery of Autophagy Modulators for Biomedical Applications in Human Diseases
PK Panda, A Fahrner, S Vats, E Seranova, V Sharma, M Chipara, P Desai, J Torresi, T Rosenstock, D Kumar, S Sarkar
Frontiers in Cell and Developmental Biology 2019
α-Ketoglutarate inhibits autophagy
EE Baracco, F Castoldi, S Durand, DP Enot, J Tadic, K Kainz, F Madeo, A Chery, V Izzo, MC Maiuri, F Pietrocola, G Kroemer
Aging 2019
The Effects of Calorie Restriction on Autophagy: Role on Aging Intervention
KW Chung, HY Chung
Nutrients 2019
Therapeutic modulation of autophagy: which disease comes first?
MC Maiuri, G Kroemer
Cell Death and Differentiation 2019
Sarcopenia: Aging-Related Loss of Muscle Mass and Function
L Larsson, H Degens, M Li, L Salviati, Y il Lee, W Thompson, JL Kirkland, M Sandri
Physiological reviews 2019
Resveratrol-Induced Xenophagy Promotes Intracellular Bacteria Clearance in Intestinal Epithelial Cells and Macrophages
JA Azzaz, A Rieu, V Aires, D Delmas, J Chluba, P Winckler, MA Bringer, J Lamarche, D Vervandier-Fasseur, F Dalle, P Lapaquette, J Guzzo
Frontiers in immunology 2019
Diverse Functions of Autophagy in Liver Physiology and Liver Diseases
PY Ke
International journal of molecular sciences 2019
Suppression of autophagic activity by Rubicon is a signature of aging
S Nakamura, M Oba, M Suzuki, A Takahashi, T Yamamuro, M Fujiwara, K Ikenaka, S Minami, N Tabata, K Yamamoto, S Kubo, A Tokumura, K Akamatsu, Y Miyazaki, T Kawabata, M Hamasaki, K Fukui, K Sango, Y Watanabe, Y Takabatake, TS Kitajima, Y Okada, H Mochizuki, Y Isaka, A Antebi, T Yoshimori
Nature Communications 2019
Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion
A Mancini, D Vitucci, MB Randers, JF Schmidt, M Hagman, TR Andersen, E Imperlini, A Mandola, S Orrù, P Krustrup, P Buono
Frontiers in physiology 2019
Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials
E Vernucci, C Tomino, F Molinari, D Limongi, M Aventaggiato, L Sansone, M Tafani, MA Russo
Oxidative medicine and cellular longevity 2019
Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension
B Zhou, J Kreuzer, C Kumsta, L Wu, KJ Kamer, L Cedillo, Y Zhang, S Li, MC Kacergis, CM Webster, G Fejes-Toth, A Naray-Fejes-Toth, S Das, M Hansen, W Haas, AA Soukas
Cell 2019
Autophagy, Apoptosis, and Mitochondria: Molecular Integration and Physiological Relevance in Skeletal Muscle
D Bloemberg, J Quadrilatero
American journal of physiology. Cell physiology 2019
Natural Products in the Promotion of Healthspan and Longevity
Mireia Niso-Santano, Rosa A González-Polo, Marta Paredes-Barquero, José M Fuentes, Michael Aschner
Clinical pharmacology and translational medicine 2019
Adiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevity by regulating autophagy
YL Chen, J Tao, PJ Zhao, W Tang, JP Xu, KQ Zhang, CG Zou
Nature Communications 2019
Transcriptome analysis revealed potential mechanisms of differences in physiological stress responses between caged male and female magpies
Y Wang, J Guo, L Wang, H Tian, J Sui
BMC Genomics 2019
Acetyl-CoA carboxylase 1–dependent lipogenesis promotes autophagy downstream of AMPK
AS Gross, A Zimmermann, T Pendl, S Schroeder, H Schoenlechner, O Knittelfelder, L Lamplmayr, A Santiso, A Aufschnaiter, D Waltenstorfer, SO Lara, S Stryeck, C Kast, C Ruckenstuhl, SJ Hofer, B Michelitsch, M Woelflingseder, R Müller, D Carmona-Gutierrez, T Madl, S Büttner, KU Fröhlich, A Shevchenko, T Eisenberg
The Journal of biological chemistry 2019
A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy
R Khandia, M Dadar, A Munjal, K Dhama, K Karthik, R Tiwari, MI Yatoo, HM Iqbal, KP Singh, SK Joshi, W Chaicumpa
Cells 2019
Blood autophagy defect causes accelerated non-hematopoietic organ aging
Y Fang, L Zhu, N An, G Jiang, J Qian, R Zhao, N Yuan, S Zhang, J Wang
Aging 2019
Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy
D Moreno-Blas, E Gorostieta-Salas, A Pommer-Alba, G Muciño-Hernández, C Gerónimo-Olvera, LA Maciel-Barón, M Konigsberg, L Massieu, S Castro-Obregón
Aging 2019
Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy
T Tezil, M Chamoli, CP Ng, RP Simon, VJ Butler, M Jung, J Andersen, AW Kao, E Verdin
npj Aging and Mechanisms of Disease 2019
Urinary cell-free mitochondrial and nuclear deoxyribonucleic acid correlates with the prognosis of chronic kidney diseases
CC Chang, PF Chiu, CL Wu, CL Kuo, CS Huang, CS Liu, CH Huang
BMC Nephrology 2019
Aging: A cell source limiting factor in tissue engineering
M Khorraminejad-Shirazi, M Dorvash, A Estedlal, AH Hoveidaei, M Mazloomrezaei, P Mosaddeghi
World journal of stem cells 2019
3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors TFE 3 and TFEB
G Chen, W Xie, J Nah, A Sauvat, P Liu, F Pietrocola, V Sica, D CarmonaGutierrez, A Zimmermann, T Pendl, J Tadic, M Bergmann, SJ Hofer, L Domuz, S Lachkar, M Markaki, N Tavernarakis, J Sadoshima, F Madeo, O Kepp, G Kroemer
EMBO Molecular Medicine 2019
Increased Muscleblind levels by chloroquine treatment improve myotonic dystrophy type 1 phenotypes in in vitro and in vivo models
A Bargiela, M Sabater-Arcis, J Espinosa-Espinosa, M Zulaica, AL de Munain, R Artero
Proceedings of the National Academy of Sciences 2019
Extension of Cellular Lifespan by Methionine Restriction Involves Alterations in Central Carbon Metabolism and Is Mitophagy-Dependent
JD Plummer, JE Johnson
Frontiers in Cell and Developmental Biology 2019
Differential Effects of Rapamycin and Metformin in Combination With Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes
CA Wolff, JJ Reid, RV Musci, DR Bruns, MA Linden, AR Konopka, FF Peelor, BF Miller, KL Hamilton, D Lamming
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2019
Metabolic features and regulation in cell senescence
Kwon SM, Hong SM, Lee YK, Min S, Yoon G
BMB Reports 2019

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