Life and health span can be prolonged by calorie limitation or by pharmacologic agents that mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient signaling converge on the induction of autophagy, a cytoplasmic recycling process that counteracts the age-associated accumulation of damaged organelles and proteins as it improves the metabolic fitness of cells. Here we review experimental findings indicating that inhibition of the major nutrient and growth-related signaling pathways as well as the upregulation of anti-aging pathways mediate life span extension via the induction of autophagy. Furthermore, we discuss mounting evidence suggesting that autophagy is not only necessary but, at least in some cases, also sufficient for increasing longevity.
Frank Madeo, Andreas Zimmermann, Maria Chiara Maiuri, Guido Kroemer
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Chemical Screening Approaches Enabling Drug Discovery of Autophagy Modulators for Biomedical Applications in Human Diseases
PK Panda, A Fahrner, S Vats, E Seranova, V Sharma, M Chipara, P Desai, J Torresi, T Rosenstock, D Kumar, S Sarkar |
Frontiers in Cell and Developmental Biology | 2019 |
α-Ketoglutarate inhibits autophagy
EE Baracco, F Castoldi, S Durand, DP Enot, J Tadic, K Kainz, F Madeo, A Chery, V Izzo, MC Maiuri, F Pietrocola, G Kroemer |
Aging | 2019 |
The Effects of Calorie Restriction on Autophagy: Role on Aging Intervention
KW Chung, HY Chung |
Nutrients | 2019 |
Therapeutic modulation of autophagy: which disease comes first?
MC Maiuri, G Kroemer |
Cell Death and Differentiation | 2019 |
Sarcopenia: Aging-Related Loss of Muscle Mass and Function
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Physiological reviews | 2019 |
Resveratrol-Induced Xenophagy Promotes Intracellular Bacteria Clearance in Intestinal Epithelial Cells and Macrophages
JA Azzaz, A Rieu, V Aires, D Delmas, J Chluba, P Winckler, MA Bringer, J Lamarche, D Vervandier-Fasseur, F Dalle, P Lapaquette, J Guzzo |
Frontiers in immunology | 2019 |
Diverse Functions of Autophagy in Liver Physiology and Liver Diseases
PY Ke |
International journal of molecular sciences | 2019 |
Suppression of autophagic activity by Rubicon is a signature of aging
S Nakamura, M Oba, M Suzuki, A Takahashi, T Yamamuro, M Fujiwara, K Ikenaka, S Minami, N Tabata, K Yamamoto, S Kubo, A Tokumura, K Akamatsu, Y Miyazaki, T Kawabata, M Hamasaki, K Fukui, K Sango, Y Watanabe, Y Takabatake, TS Kitajima, Y Okada, H Mochizuki, Y Isaka, A Antebi, T Yoshimori |
Nature Communications | 2019 |
Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion
A Mancini, D Vitucci, MB Randers, JF Schmidt, M Hagman, TR Andersen, E Imperlini, A Mandola, S Orrù, P Krustrup, P Buono |
Frontiers in physiology | 2019 |
Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials
E Vernucci, C Tomino, F Molinari, D Limongi, M Aventaggiato, L Sansone, M Tafani, MA Russo |
Oxidative medicine and cellular longevity | 2019 |
Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension
B Zhou, J Kreuzer, C Kumsta, L Wu, KJ Kamer, L Cedillo, Y Zhang, S Li, MC Kacergis, CM Webster, G Fejes-Toth, A Naray-Fejes-Toth, S Das, M Hansen, W Haas, AA Soukas |
Cell | 2019 |
Autophagy, Apoptosis, and Mitochondria: Molecular Integration and Physiological Relevance in Skeletal Muscle
D Bloemberg, J Quadrilatero |
American journal of physiology. Cell physiology | 2019 |
Natural Products in the Promotion of Healthspan and Longevity
Mireia Niso-Santano, Rosa A González-Polo, Marta Paredes-Barquero, José M Fuentes, Michael Aschner |
Clinical pharmacology and translational medicine | 2019 |
Adiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevity by regulating autophagy
YL Chen, J Tao, PJ Zhao, W Tang, JP Xu, KQ Zhang, CG Zou |
Nature Communications | 2019 |
Transcriptome analysis revealed potential mechanisms of differences in physiological stress responses between caged male and female magpies
Y Wang, J Guo, L Wang, H Tian, J Sui |
BMC Genomics | 2019 |
Acetyl-CoA carboxylase 1–dependent lipogenesis promotes autophagy downstream of AMPK
AS Gross, A Zimmermann, T Pendl, S Schroeder, H Schoenlechner, O Knittelfelder, L Lamplmayr, A Santiso, A Aufschnaiter, D Waltenstorfer, SO Lara, S Stryeck, C Kast, C Ruckenstuhl, SJ Hofer, B Michelitsch, M Woelflingseder, R Müller, D Carmona-Gutierrez, T Madl, S Büttner, KU Fröhlich, A Shevchenko, T Eisenberg |
The Journal of biological chemistry | 2019 |
A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy
R Khandia, M Dadar, A Munjal, K Dhama, K Karthik, R Tiwari, MI Yatoo, HM Iqbal, KP Singh, SK Joshi, W Chaicumpa |
Cells | 2019 |
Blood autophagy defect causes accelerated non-hematopoietic organ aging
Y Fang, L Zhu, N An, G Jiang, J Qian, R Zhao, N Yuan, S Zhang, J Wang |
Aging | 2019 |
Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy
D Moreno-Blas, E Gorostieta-Salas, A Pommer-Alba, G Muciño-Hernández, C Gerónimo-Olvera, LA Maciel-Barón, M Konigsberg, L Massieu, S Castro-Obregón |
Aging | 2019 |
Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy
T Tezil, M Chamoli, CP Ng, RP Simon, VJ Butler, M Jung, J Andersen, AW Kao, E Verdin |
npj Aging and Mechanisms of Disease | 2019 |
Urinary cell-free mitochondrial and nuclear deoxyribonucleic acid correlates with the prognosis of chronic kidney diseases
CC Chang, PF Chiu, CL Wu, CL Kuo, CS Huang, CS Liu, CH Huang |
BMC Nephrology | 2019 |
Aging: A cell source limiting factor in tissue engineering
M Khorraminejad-Shirazi, M Dorvash, A Estedlal, AH Hoveidaei, M Mazloomrezaei, P Mosaddeghi |
World journal of stem cells | 2019 |
3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors TFE 3 and TFEB
G Chen, W Xie, J Nah, A Sauvat, P Liu, F Pietrocola, V Sica, D CarmonaGutierrez, A Zimmermann, T Pendl, J Tadic, M Bergmann, SJ Hofer, L Domuz, S Lachkar, M Markaki, N Tavernarakis, J Sadoshima, F Madeo, O Kepp, G Kroemer |
EMBO Molecular Medicine | 2019 |
Increased Muscleblind levels by chloroquine treatment improve myotonic dystrophy type 1 phenotypes in in vitro and in vivo models
A Bargiela, M Sabater-Arcis, J Espinosa-Espinosa, M Zulaica, AL de Munain, R Artero |
Proceedings of the National Academy of Sciences | 2019 |
Extension of Cellular Lifespan by Methionine Restriction Involves Alterations in Central Carbon Metabolism and Is Mitophagy-Dependent
JD Plummer, JE Johnson |
Frontiers in Cell and Developmental Biology | 2019 |
Differential Effects of Rapamycin and Metformin in Combination With Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes
CA Wolff, JJ Reid, RV Musci, DR Bruns, MA Linden, AR Konopka, FF Peelor, BF Miller, KL Hamilton, D Lamming |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2019 |
Metabolic features and regulation in cell senescence
Kwon SM, Hong SM, Lee YK, Min S, Yoon G |
BMB Reports | 2019 |