Life and health span can be prolonged by calorie limitation or by pharmacologic agents that mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient signaling converge on the induction of autophagy, a cytoplasmic recycling process that counteracts the age-associated accumulation of damaged organelles and proteins as it improves the metabolic fitness of cells. Here we review experimental findings indicating that inhibition of the major nutrient and growth-related signaling pathways as well as the upregulation of anti-aging pathways mediate life span extension via the induction of autophagy. Furthermore, we discuss mounting evidence suggesting that autophagy is not only necessary but, at least in some cases, also sufficient for increasing longevity.
Frank Madeo, Andreas Zimmermann, Maria Chiara Maiuri, Guido Kroemer
Title and authors | Publication | Year |
---|---|---|
Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans
RO Walters, E Arias, A Diaz, ES Burgos, F Guan, S Tiano, K Mao, CL Green, Y Qiu, H Shah, D Wang, AD Hudgins, T Tabrizian, V Tosti, D Shechter, L Fontana, IJ Kurland, N Barzilai, AM Cuervo, DE Promislow, DM Huffman |
Cell Reports | 2018 |
The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions
PY Ke |
International journal of molecular sciences | 2018 |
Nε-lysine acetylation in the endoplasmic reticulum – a novel cellular mechanism that regulates proteostasis and autophagy
MA Farrugia, L Puglielli |
Journal of cell science | 2018 |
Targeting Protein Quality Control Mechanisms by Natural Products to Promote Healthy Ageing
S Wedel, M Manola, M Cavinato, I Trougakos, P Jansen-Dürr |
Molecules (Basel, Switzerland) | 2018 |
Autophagy and aging: Maintaining the proteome through exercise and caloric restriction
KA Escobar, NH Cole, CM Mermier, TA VanDusseldorp |
Aging Cell | 2018 |
Guidelines and recommendations on yeast cell death nomenclature
D Carmona-Gutierrez, MA Bauer, A Zimmermann, A Aguilera, N Austriaco, K Ayscough, R Balzan, S Bar-Nun, A Barrientos, P Belenky, M Blondel, RJ Braun, M Breitenbach, WC Burhans, S Buettner, D Cavalieri, M Chang, KF Cooper, M Côrte-Real, V Costa, C Cullin, I Dawes, J Dengjel, MB Dickman, T Eisenberg, B Fahrenkrog, N Fasel, KU Froehlich, A Gargouri, S Giannattasio, P Goffrini, CW Gourlay, CM Grant, MT Greenwood, N Guaragnella, T Heger, J Heinisch, E Herker, JM Herrmann, S Hofer, A Jiménez-Ruiz, H Jungwirth, K Kainz, DP Kontoyiannis, P Ludovico, S Manon, E Martegani, C Mazzoni, LA Megeney, C Meisinger, J Nielsen, T Nystroem, HD Osiewacz, TF Outeiro, HO Park, T Pendl, D Petranovic, S Picot, P Polčic, T Powers, M Ramsdale, M Rinnerthaler, P Rockenfeller, C Ruckenstuhl, R Schaffrath, M Segovia, FF Severin, A Sharon, SJ Sigrist, C Sommer-Ruck, MJ Sousa, JM Thevelein, K Thevissen, V Titorenko, MB Toledano, M Tuite, FN Voegtle, B Westermann, J Winderickx, S Wissing, S Woelfl, ZJ Zhang, RY Zhao, B Zhou, L Galluzzi, G Kroemer, F Madeo |
Microbial Cell | 2018 |
Resveratrol Sensitizes Carfilzomib-Induced Apoptosis via Promoting Oxidative Stress in Multiple Myeloma Cells
Q Li, Y Yue, L Chen, C Xu, Y Wang, L Du, X Xue, Q Liu, Y Wang, F Fan |
Frontiers in pharmacology | 2018 |
Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States
MP Mattson, TV Arumugam |
Cell Metabolism | 2018 |
Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype
Y Peng, SL Shapiro, VC Banduseela, IA Dieterich, KJ Hewitt, EH Bresnick, G Kong, J Zhang, KL Schueler, MP Keller, AD Attie, TA Hacker, R Sullivan, E Kielar-Grevstad, SI Apelo, DW Lamming, RM Anderson, L Puglielli |
Aging Cell | 2018 |
Spermidine delays aging in humans
F Madeo, DC Gutierrez, O Kepp, G Kroemer |
Aging | 2018 |
Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
RL Smith, MR Soeters, RC Wüst, RH Houtkooper |
Endocrine reviews | 2018 |
The Role of Free Radicals in Autophagy Regulation: Implications for Ageing
M Pajares, A Cuadrado, N Engedal, Z Jirsova, M Cahova |
Oxidative medicine and cellular longevity | 2018 |
Recent insights into the cellular and molecular determinants of aging
L Ruan, , R Li |
Journal of cell science | 2018 |
Yeast as a tool to identify anti-aging compounds
A Zimmermann, S Hofer, T Pendl, K Kainz, F Madeo, D Carmona-Gutierrez |
FEMS Yeast Research | 2018 |
Autophagy and Rheumatoid Arthritis: Current Knowledges and Future Perspectives
M Vomero, C Barbati, T Colasanti, C Perricone, L Novelli, F Ceccarelli, FR Spinelli, MD Franco, F Conti, G Valesini, C Alessandri |
Frontiers in immunology | 2018 |
Deletion of Nrip1 Extends Female Mice Longevity, Increases Autophagy, and Delays Cell Senescence
J Wang, X Chen, J Osland, SJ Gerber, C Luan, K Delfino, L Goodwin, R Yuan |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2018 |
Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism
C Bárcena, PM Quirós, S Durand, P Mayoral, F Rodríguez, XM Caravia, G Mariño, C Garabaya, MT Fernández-García, G Kroemer, JM Freije, C López-Otín |
Cell Reports | 2018 |
Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice
ÁF Fernández, S Sebti, Y Wei, Z Zou, M Shi, KL McMillan, C He, T Ting, Y Liu, WC Chiang, DK Marciano, GG Schiattarella, G Bhagat, OW Moe, MC Hu, B Levine |
Nature | 2018 |
Leukocyte telomere length in paediatric critical illness: effect of early parenteral nutrition
S Verstraete, I Vanhorebeek, E van Puffelen, I Derese, C Ingels, SC Verbruggen, PJ Wouters, KF Joosten, J Hanot, GG Guerra, D Vlasselaers, J Lin, GV den Berghe |
Critical Care | 2018 |
Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging
E Bejarano, JW Murray, X Wang, O Pampliega, D Yin, B Patel, A Yuste, AW Wolkoff, AM Cuervo |
Aging Cell | 2018 |
ROS is the major player in regulating altered autophagy and lifespan in sin-3 mutants of C. elegans
M Sharma, R Pandey, D Saluja |
Autophagy | 2018 |
Sex-specific associations between adolescent categories of BMI with cardiovascular and non-cardiovascular mortality in midlife
A Furer, A Afek, O Orr, L Gershovitz, M Landau, E Derazne, O Pinhas-Hamiel, N Fink, A Leiba, A Tirosh, JD Kark, G Twig |
Cardiovascular Diabetology | 2018 |
Protein restriction, epigenetic diet, intermittent fasting as new approaches for preventing age-associated diseases
NA Hanjani, M Vafa |
International journal of preventive medicine | 2018 |
pH homeostasis links the nutrient sensing PKA/TORC1/Sch9 ménage-à-trois to stress tolerance and longevity
MA Deprez, E Eskes, T Wilms, P Ludovico, J Winderickx |
Microbial Cell | 2018 |
UNC-120/SRF independently controls muscle aging and lifespan in Caenorhabditis elegans
AM dit Lamarche, L Molin, L Pierson, MC Mariol, JL Bessereau, K Gieseler, F Solari |
Aging Cell | 2018 |
Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner
M Tang, C Ji, S Pallo, I Rahman, GV Johnson |
Neurobiology of Aging | 2018 |
Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases
J Li, D Zhang, M Wiersma, BJ Brundel |
Cells | 2018 |
Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice
R Coccurello, F Nazio, C Rossi, FD Angelis, V Vacca, G Giacovazzo, P Procacci, V Magnaghi, D Ciavardelli, S Marinelli, S Pandey |
PloS one | 2018 |
Emerging Anti-Aging Strategies - Scientific Basis and Efficacy
AK Shetty, M Kodali, R Upadhya, LN Madhu |
Aging and disease | 2018 |
Autophagy delays progression of the two most frequent human monogenetic lethal diseases: cystic fibrosis and Wilson disease
L Maiuri, G Kroemer |
Aging | 2018 |
Caloric restriction rescues yeast cells from alpha-synuclein toxicity through autophagic control of proteostasis
B Sampaio-Marques, H Pereira, AR Santos, A Teixeira, P Ludovico |
Aging | 2018 |
Cellular Metabolism and Aging
Catic A |
Progress in molecular biology and translational science | 2018 |
Metformin as a geroprotector: experimental and clinical evidence.
Piskovatska V, Stefanyshyn N, Storey KB, Vaiserman AM, Lushchak O |
Biogerontology | 2018 |