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Citations to this article

Essential role for autophagy in life span extension
Frank Madeo, … , Maria Chiara Maiuri, Guido Kroemer
Frank Madeo, … , Maria Chiara Maiuri, Guido Kroemer
Published January 2, 2015
Citation Information: J Clin Invest. 2015;125(1):85-93. https://doi.org/10.1172/JCI73946.
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Review Article has an altmetric score of 72

Essential role for autophagy in life span extension

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Abstract

Life and health span can be prolonged by calorie limitation or by pharmacologic agents that mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient signaling converge on the induction of autophagy, a cytoplasmic recycling process that counteracts the age-associated accumulation of damaged organelles and proteins as it improves the metabolic fitness of cells. Here we review experimental findings indicating that inhibition of the major nutrient and growth-related signaling pathways as well as the upregulation of anti-aging pathways mediate life span extension via the induction of autophagy. Furthermore, we discuss mounting evidence suggesting that autophagy is not only necessary but, at least in some cases, also sufficient for increasing longevity.

Authors

Frank Madeo, Andreas Zimmermann, Maria Chiara Maiuri, Guido Kroemer

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2009 Total
Citations: 3 15 11 17 28 27 27 33 27 19 8 1 216
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2018 (33)

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Cell Reports 2018
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