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Abstract
Cardiovascular disease is the leading cause of death worldwide. As such, there is great interest in identifying novel mechanisms that govern the cardiovascular response to disease-related stress. First described in failing hearts, autophagy within the cardiovascular system has been widely characterized in cardiomyocytes, cardiac fibroblasts, endothelial cells, vascular smooth muscle cells, and macrophages. In all cases, a window of optimal autophagic activity appears to be critical to the maintenance of cardiovascular homeostasis and function; excessive or insufficient levels of autophagic flux can each contribute to heart disease pathogenesis. In this Review, we discuss the potential for targeting autophagy therapeutically and our vision for where this exciting biology may lead in the future.
Authors
Sergio Lavandero, Mario Chiong, Beverly A. Rothermel, Joseph A. Hill
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Citations to this article (156)
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Hydrogen Sulfide Alleviates Acute Myocardial Ischemia Injury by Modulating Autophagy and Inflammation Response under Oxidative Stress
Y Bai, Y Yang, X Mu, G Lin, Y Wang, S Jin, Y Chen, M Wang, Y Zhu |
Oxidative medicine and cellular longevity | 2018 |
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Compromised phagosome maturation underlies RPE pathology in cell culture and whole animal models of Smith-Lemli-Opitz Syndrome
SR Rao, BA Pfeffer, NM Gómez, LA Skelton, U Keiko, JR Sparrow, AM Rowsam, CH Mitchell, SJ Fliesler |
Autophagy | 2018 |
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Small-Vessel Vasculopathy Due to Aberrant Autophagy in LAMP-2 Deficiency
HT Nguyen, S Noguchi, K Sugie, Y Matsuo, CT Nguyen, H Koito, I Shiojima, I Nishino, H Tsukaguchi |
Scientific Reports | 2018 |
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Epigenetic control of lipid metabolism: implications for lifespan and healthspan
GG Schiattarella, JA Hill |
Cardiovascular Research | 2018 |
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CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1
X Hu, Z Lu, S Yu, J Reilly, F Liu, D Jia, Y Qin, S Han, X Liu, Z Qu, Y Lv, J Li, Y Huang, T Jiang, H Jia, Q Wang, J Liu, X Shu, Z Tang, M Liu |
Autophagy | 2018 |
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The physiological roles of autophagy in the mammalian life cycle: Autophagy in the mammal life cycle
L Wang, X Ye, T Zhao |
Biological reviews of the Cambridge Philosophical Society | 2018 |
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PARP1 promote autophagy in cardiomyocytes via modulating FoxO3a transcription
C Wang, W Xu, Y Zhang, F Zhang, K Huang |
Cell Death and Disease | 2018 |
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Impaired Endothelial Autophagy Promotes Liver Fibrosis By Aggravating The Oxidative Stress Response During Acute Liver Injury
M Ruart, L Chavarria, G Campreciós, N Suárez-Herrera, C Montironi, S Guixé-Muntet, J Bosch, SL Friedman, JC Garcia-Pagán, V Hernández-Gea |
Journal of Hepatology | 2018 |
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Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin
MA Gubbiotti, E Seifert, U Rodeck, JB Hoek, RV Iozzo |
The Journal of biological chemistry | 2018 |
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Functional variants of the ATG7 gene promoter in acute myocardial infarction
P Zhang, J Zhang, Y Zhang, S Wang, S Pang, B Yan |
Molecular Genetics & Genomic Medicine | 2018 |
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The role of autophagy in asparaginase-induced immune suppression of macrophages
P Song, Z Wang, X Zhang, J Fan, Y Li, Q Chen, S Wang, P Liu, J Luan, L Ye, D Ju |
Cell Death and Disease | 2017 |
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Gαq Signaling in the Regulation of Autophagy and Heart Failure:
MA Kolpakov, DG Tilley, A Sabri |
Journal of Cardiovascular Pharmacology | 2017 |
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Role of Endoplasmic Reticulum Stress, Autophagy, and Inflammation in Cardiovascular Disease
C Zhang, TW Syed, R Liu, J Yu |
Frontiers in Cardiovascular Medicine | 2017 |
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Cytokine-induced autophagy promotes long-term VCAM-1 but not ICAM-1 expression by degrading late-phase IκBα
LY Chu, YC Hsueh, HL Cheng, KK Wu |
Scientific Reports | 2017 |
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Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy
F Li, F Lang, H Zhang, L Xu, Y Wang, C Zhai, E Hao |
Oxidative medicine and cellular longevity | 2017 |
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TLR3 contributes to persistent autophagy and heart failure in mice after myocardial infarction
T Gao, SP Zhang, JF Wang, L Liu, Y Wang, ZY Cao, QK Hu, WJ Yuan, L Lin |
Journal of Cellular and Molecular Medicine | 2017 |
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HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy
MK Gupta, R Kaminski, B Mullen, J Gordon, TH Burdo, JY Cheung, AM Feldman, M Madesh, K Khalili |
Scientific Reports | 2017 |
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Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure
P Wu, X Yuan, F Li, J Zhang, W Zhu, M Wei, J Li, X Wang |
Circulation. Heart failure | 2017 |
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MicroRNA-199a acts as a potential suppressor of cardiomyocyte autophagy through targeting Hspa5
L Chen, FY Wang, ZY Zeng, L Cui, J Shen, XW Song, P Li, XX Zhao, YW Qin |
Oncotarget | 2017 |
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Protoporphyrin IX-mediated sonodynamic therapy promotes autophagy in vascular smooth muscle cells
Q Li, J Kang, X Xiong, Y Liu, W Cao, Y Liu, Y Li |
Oncology Letters | 2017 |
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Endothelial Cell Autophagy Maintains Shear Stress–Induced Nitric Oxide Generation via Glycolysis-Dependent Purinergic Signaling to Endothelial Nitric Oxide Synthase
LP Bharath, JM Cho, SK Park, T Ruan, Y Li, R Mueller, T Bean, V Reese, RS Richardson, J Cai, A Sargsyan, K Pires, PV Babu, S Boudina, TE Graham, JD Symons |
Arteriosclerosis, thrombosis, and vascular biology | 2017 |
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Defective Protein Catabolism in Atherosclerotic Vascular Inflammation
T Miyazaki, A Miyazaki |
Frontiers in Cardiovascular Medicine | 2017 |
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Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6 S10F mutant
GS Liu, H Zhu, WF Cai, X Wang, M Jiang, K Essandoh, E Vafiadaki, K Haghighi, CK Lam, G Gardner, G Adly, P Nicolaou, D Sanoudou, Q Liang, J Rubinstein, GC Fan, EG Kranias |
Autophagy | 2017 |
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The spectrum of myocardial homeostasis mechanisms in the settings of cardiac surgery procedures (Review)
E Papadakis, M Kanakis, A Kataki, D Spandidos |
Molecular medicine reports | 2017 |
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Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling
Y Wang, B Liang, WB Lau, Y Du, R Guo, Z Yan, L Gan, W Yan, J Zhao, E Gao, W Koch, XL Ma |
Autophagy | 2017 |
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Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model
P Zhu, CJ Sieben, X Xu, PC Harris, X Lin |
Human Molecular Genetics | 2016 |
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Nutrient-sensing mTORC1: Integration of metabolic and autophagic signals
VP Tan, S Miyamoto |
Journal of Molecular and Cellular Cardiology | 2016 |
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Autophagy as an emerging therapy target for ovarian carcinoma
L Zhan, Y Zhang, W Wang, E Song, Y Fan, J Li, B Wei |
Oncotarget | 2016 |
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Mitochondrial dynamics, mitophagy and cardiovascular disease: Mitochondria and cardiovascular disease
C Vásquez-Trincado, I García-Carvajal, C Pennanen, V Parra, JA Hill, BA Rothermel, S Lavandero |
The Journal of Physiology | 2016 |
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BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo
SJ Bultman, DW Holley, GG de Ridder, SV Pizzo, TN Sidorova, KT Murray, BC Jensen, Z Wang, A Bevilacqua, X Chen, MT Quintana, M Tannu, GB Rosson, K Pandya, MS Willis |
Cardiovascular Pathology | 2016 |
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Chronic heart failure: Ca2+, catabolism, and catastrophic cell death
GW Cho, F Altamirano, JA Hill |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2016 |
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Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis
GG Schiattarella, F Cattaneo, G Pironti, F Magliulo, G Carotenuto, M Pirozzi, R Polishchuk, D Borzacchiello, R Paolillo, M Oliveti, N Boccella, M Avvedimento, M Sepe, A Lombardi, RA Busiello, B Trimarco, G Esposito, A Feliciello, C Perrino, SV Prasad |
PloS one | 2016 |
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Endolysosomal two-pore channels regulate autophagy in cardiomyocytes: TPCs regulate autophagy in cardiomyocytes
V García-Rúa, S Feijóo-Bandín, D Rodríguez-Penas, A Mosquera-Leal, E Abu-Assi, A Beiras, LM Seoane, P Lear, J Parrington, M Portolés, E Roselló-Lletí, M Rivera, O Gualillo, V Parra, JA Hill, B Rothermel, JR González-Juanatey, F Lago |
The Journal of Physiology | 2016 |
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Drp1 and Mitochondrial Autophagy Lend a Helping Hand in Adaptation to Pressure Overload
S Miyamoto, JH Brown |
Circulation | 2016 |
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Autophagy protects cardiomyocytes from the myocardial ischaemia-reperfusion injury through the clearance of CLP36
S Li, C Liu, L Gu, L Wang, Y Shang, Q Liu, J Wan, J Shi, F Wang, Z Xu, G Ji, W Li |
Open Biology | 2016 |
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Heart failure—potential new targets for therapy
A Nabeebaccus, S Zheng, AM Shah |
British Medical Bulletin | 2016 |
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Pdcd4 deficiency enhances macrophage lipoautophagy and attenuates foam cell formation and atherosclerosis in mice
L Wang, Y Jiang, X Song, C Guo, F Zhu, X Wang, Q Wang, Y Shi, J Wang, F Gao, W Zhao, YH Chen, L Zhang |
Cell Death and Disease | 2016 |
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Regulation of cardiomyocyte autophagy by calcium
S Shaikh, R Troncoso, A Criollo, R Bravo-Sagua, E Morselli, L Garcia, AF Quest, M Cifuentes, JA Hill, S Lavandero |
American journal of physiology. Endocrinology and metabolism | 2016 |
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Neurohormonal activation in heart failure with reduced ejection fraction
J Hartupee, DL Mann |
Nature Reviews Cardiology | 2016 |
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Calcineurin signaling in the heart: The importance of time and place
V Parra, BA Rothermel |
Journal of Molecular and Cellular Cardiology | 2016 |
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Store-operated calcium entry-activated autophagy protects EPC proliferation via the CAMKK2-MTOR pathway in ox-LDL exposure
J Yang, J Yu, D Li, S Yu, J Ke, L Wang, Y Wang, Y Qiu, X Gao, J Zhang, L Huang |
Autophagy | 2016 |
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Mitochondrial Dynamics in Mitochondrial Diseases
J Suárez-Rivero, M Villanueva-Paz, P la Cruz-Ojeda, M la Mata, D Cotán, M Oropesa-Ávila, I Lavera, M Álvarez-Córdoba, R Luzón-Hidalgo, J Sánchez-Alcázar |
Diseases | 2016 |
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A role for autophagy in carotid atherosclerosis
I Alloza, H Goikuria, M del Mar Freijo, K Vandenbroeck |
European Stroke Journal | 2016 |
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Autophagy: a druggable process that is deregulated in aging and multiple human diseases
Guido Kroemer |
Journal of Clinical Investigation | 2015 |
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Readers, Writers, and Erasers: Chromatin as the Whiteboard of Heart Disease
TG Gillette, JA Hill |
Circulation research | 2015 |
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Inhibition of Hypertrophy Is a Good Therapeutic Strategy in Ventricular Pressure Overload
GG Schiattarella, JA Hill |
Circulation | 2015 |
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Ongoing controversies surrounding cardiac remodeling: is it black and white—or rather fifty shades of gray?
S Spaich |
Frontiers in physiology | 2015 |
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Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis
MO Grootaert, PA da Martins, N Bitsch, I Pintelon, GR de Meyer, W Martinet, DM Schrijvers |
Autophagy | 2015 |
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Therapeutic targeting of autophagy in cardiovascular disease
GG Schiattarella, JA Hill |
Journal of Molecular and Cellular Cardiology | 2015 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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