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Abstract
Cardiovascular disease is the leading cause of death worldwide. As such, there is great interest in identifying novel mechanisms that govern the cardiovascular response to disease-related stress. First described in failing hearts, autophagy within the cardiovascular system has been widely characterized in cardiomyocytes, cardiac fibroblasts, endothelial cells, vascular smooth muscle cells, and macrophages. In all cases, a window of optimal autophagic activity appears to be critical to the maintenance of cardiovascular homeostasis and function; excessive or insufficient levels of autophagic flux can each contribute to heart disease pathogenesis. In this Review, we discuss the potential for targeting autophagy therapeutically and our vision for where this exciting biology may lead in the future.
Authors
Sergio Lavandero, Mario Chiong, Beverly A. Rothermel, Joseph A. Hill
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Citations to this article (152)
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PARP1 promote autophagy in cardiomyocytes via modulating FoxO3a transcription
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Impaired Endothelial Autophagy Promotes Liver Fibrosis By Aggravating The Oxidative Stress Response During Acute Liver Injury
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The role of autophagy in asparaginase-induced immune suppression of macrophages
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Frontiers in Cardiovascular Medicine | 2017 |
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Cytokine-induced autophagy promotes long-term VCAM-1 but not ICAM-1 expression by degrading late-phase IκBα
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Scientific Reports | 2017 |
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Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy
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TLR3 contributes to persistent autophagy and heart failure in mice after myocardial infarction
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Journal of Cellular and Molecular Medicine | 2017 |
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Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure
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Defective Protein Catabolism in Atherosclerotic Vascular Inflammation
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Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model
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Journal of Molecular and Cellular Cardiology | 2016 |
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Autophagy as an emerging therapy target for ovarian carcinoma
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The Journal of Physiology | 2016 |
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Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2016 |
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Drp1 and Mitochondrial Autophagy Lend a Helping Hand in Adaptation to Pressure Overload
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Circulation | 2016 |
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Autophagy protects cardiomyocytes from the myocardial ischaemia-reperfusion injury through the clearance of CLP36
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Pdcd4 deficiency enhances macrophage lipoautophagy and attenuates foam cell formation and atherosclerosis in mice
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Journal of Molecular and Cellular Cardiology | 2016 |
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Store-operated calcium entry-activated autophagy protects EPC proliferation via the CAMKK2-MTOR pathway in ox-LDL exposure
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A role for autophagy in carotid atherosclerosis
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European Stroke Journal | 2016 |
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Autophagy: a druggable process that is deregulated in aging and multiple human diseases
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Journal of Clinical Investigation | 2015 |
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Readers, Writers, and Erasers: Chromatin as the Whiteboard of Heart Disease
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Circulation research | 2015 |
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Inhibition of Hypertrophy Is a Good Therapeutic Strategy in Ventricular Pressure Overload
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Circulation | 2015 |
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Ongoing controversies surrounding cardiac remodeling: is it black and white—or rather fifty shades of gray?
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Frontiers in physiology | 2015 |
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Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis
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Autophagy | 2015 |
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Therapeutic targeting of autophagy in cardiovascular disease
GG Schiattarella, JA Hill |
Journal of Molecular and Cellular Cardiology | 2015 |
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Pulmonary surfactant: an immunological perspective
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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