The life cycles of VLDLs and most LDLs occur within plasma. By contrast, the role of HDLs in cholesterol transport from cells requires that they readily gain access to and function within interstitial fluid. Studies of lymph derived from skin, connective tissue, and adipose tissue have demonstrated that particles as large as HDLs require transport through lymphatics to return to the bloodstream during reverse cholesterol transport. Targeting HDL for therapeutic purposes will require understanding its biology in the extravascular compartment, within the interstitium and lymph, in health and disease, and we herein review the processes that mediate the transport of HDLs and chylomicrons through the lymphatic vasculature.
Gwendalyn J. Randolph, Norman E. Miller
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The Unresolved Pathophysiology of Lymphedema
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The Lymphatic System in Obesity, Insulin Resistance, and Cardiovascular Diseases
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Frontiers in physiology | 2019 |
Arterial Lymphatics in Atherosclerosis: Old Questions, New Insights, and Remaining Challenges
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Journal of Clinical Medicine | 2019 |
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International journal of molecular sciences | 2018 |
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Advances in Skin & Wound Care | 2018 |
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Current Opinion in Lipidology | 2018 |
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Cell Metabolism | 2018 |
In vitro model reveals a role for mechanical stretch in the remodeling response of lymphatic muscle cells
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Microcirculation (New York, N.Y. : 1994) | 2018 |
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Immune Network | 2017 |
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Journal of Experimental Medicine | 2017 |
The Lymphatic System: Integral Roles in Immunity
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Annual Review of Immunology | 2017 |
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Cardiac Lymphatic Vessels, Transport, and Healing of the Infarcted Heart
Huang LH, Lavine KJ, Randolph GJ |
JACC: Basic to Translational Science | 2017 |
Postprandial lymphatic pump function after a high-fat meal: a characterization of contractility, flow, and viscosity
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Cardiovascular Research | 2016 |
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Circulation research | 2016 |
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2016 |
Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function
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Molecular and cellular biology | 2016 |
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The Journal of Physiology | 2016 |
Lipidomic Profiling of Adipose Tissue Reveals an Inflammatory Signature in Cancer-Related and Primary Lymphedema
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PloS one | 2016 |
Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that Serve Mesenteric Lymph Nodes in Crohn Disease
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The American Journal of Pathology | 2016 |
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Journal of Clinical Investigation | 2015 |
Endothelial Expression of Scavenger Receptor Class B, Type I Protects against Development of Atherosclerosis in Mice
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BioMed Research International | 2015 |
From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity
NL Trevaskis, LM Kaminskas, CJ Porter |
Nature Reviews Drug Discovery | 2015 |
The role of the lymphatic system in cholesterol transport
LH Huang, A Elvington, GJ Randolph |
Frontiers in pharmacology | 2015 |
Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity
DM Fonseca, TW Hand, SJ Han, MY Gerner, AG Zaretsky, AL Byrd, OJ Harrison, AM Ortiz, M Quinones, G Trinchieri, JM Brenchley, IE Brodsky, RN Germain, GJ Randolph, Y Belkaid |
Cell | 2015 |
Lymphatic vascular integrity is disrupted in type 2 diabetes due to impaired nitric oxide signalling
JP Scallan, MA Hill, MJ Davis |
Cardiovascular Research | 2015 |
GPIHBP1: Two Get Tangled
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Circulation research | 2015 |
Effects of Surface-Deacetylated Chitin Nanofibers in an Experimental Model of Hypercholesterolemia
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International journal of molecular sciences | 2015 |
Novel Pathways of Apolipoprotein A-I Metabolism in High-Density Lipoprotein of Different Sizes in Humans
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Arteriosclerosis, thrombosis, and vascular biology | 2015 |
The lymphatic vasculature revisited
Dontscho Kerjaschki |
Journal of Clinical Investigation | 2014 |
Primary and secondary lymphatic valve development: Molecular, functional and mechanical insights
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Microvascular Research | 2014 |
LDL and HDL transfer rates across peripheral microvascular endothelium agree with those predicted for passive ultrafiltration in humans
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Journal of lipid research | 2014 |
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