The development of emphysema in humans and mice exposed to cigarette smoke is promoted by activation of an adaptive immune response. Lung myeloid dendritic cells (mDCs) derived from cigarette smokers activate autoreactive Th1 and Th17 cells. mDC-dependent activation of T cell subsets requires expression of the
Ming Shan, Ran You, Xiaoyi Yuan, Michael V. Frazier, Paul Porter, Alexander Seryshev, Jeong-Soo Hong, Li-zhen Song, Yiqun Zhang, Susan Hilsenbeck, Lawrence Whitehead, Nazanin Zarinkamar, Sarah Perusich, David B. Corry, Farrah Kheradmand
Title and authors | Publication | Year |
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Protective role of γδ T cells in cigarette smoke and influenza infection
MJ Hong, BH Gu, MC Madison, C Landers, HY Tung, M Kim, X Yuan, R You, AA Machado, BE Gilbert, P Soroosh, M Elloso, L Song, M Chen, DB Corry, G Diehl, F Kheradmand |
Mucosal Immunology | 2017 |
Emerging pharmaceutical therapies for COPD
S Lakshmi, A Reddy, R Reddy |
International journal of chronic obstructive pulmonary disease | 2017 |
Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway
X Xu, Y Wang, Z Wei, W Wei, P Zhao, B Tong, Y Xia, Y Dai |
Cell Death and Disease | 2017 |
Peroxisome proliferator-activated receptor-γ in induced sputum is correlated with MMP-9/TIMP-1 imbalance and formation of emphysema in COPD patients
XM Zhou, G Hou, DX Gu, QY Wang, L Zhao |
Journal of Thoracic Disease | 2017 |