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Citations to this article

Characterizing DNA methylation alterations from The Cancer Genome Atlas
Daniel J. Weisenberger
Daniel J. Weisenberger
Published January 2, 2014
Citation Information: J Clin Invest. 2014;124(1):17-23. https://doi.org/10.1172/JCI69740.
View: Text | PDF
Review Series Article has an altmetric score of 9

Characterizing DNA methylation alterations from The Cancer Genome Atlas

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Abstract

The Cancer Genome Atlas (TCGA) Research Network is an ambitious multi-institutional consortium effort aimed at characterizing sequence, copy number, gene (mRNA) expression, microRNA expression, and DNA methylation alterations in 30 cancer types. TCGA data have become an extraordinary resource for basic, translational, and clinical researchers and have the potential to shape cancer diagnostic and treatment strategies. DNA methylation changes are integral to all aspects of cancer genomics and have been shown to have important associations with gene expression, sequence, and copy number changes. This Review highlights the knowledge gained from DNA methylation alterations in human cancers from TCGA.

Authors

Daniel J. Weisenberger

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Nature Methods 2014
Ras-induced Epigenetic Inactivation of the RRAD (Ras-related Associated with Diabetes) Gene Promotes Glucose Uptake in a Human Ovarian Cancer Model
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The Journal of biological chemistry 2014
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Pathogens and Disease 2014
Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth
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