Go to
JCI Insight
Citations to this article
Yu Chen, … , Akiko Maeda, Krzysztof Palczewski
Published November 15, 2013
Citation Information: J Clin Invest. 2013;123(12):5119-5134. https://doi.org/10.1172/JCI69076.
Citation Information: J Clin Invest. 2013;123(12):5119-5134. https://doi.org/10.1172/JCI69076.
Abstract
A systems pharmacological approach that capitalizes on the characterization of intracellular signaling networks can transform our understanding of human diseases and lead to therapy development. Here, we applied this strategy to identify pharmacological targets for the treatment of Stargardt disease, a severe juvenile form of macular degeneration. Diverse GPCRs have previously been implicated in neuronal cell survival, and crosstalk between GPCR signaling pathways represents an unexplored avenue for pharmacological intervention. We focused on this receptor family for potential therapeutic interventions in macular disease. Complete transcriptomes of mouse and human samples were analyzed to assess the expression of GPCRs in the retina. Focusing on adrenergic (AR) and serotonin (5-HT) receptors, we found that adrenoceptor α 2C (
Authors
Yu Chen, Grazyna Palczewska, Debarshi Mustafi, Marcin Golczak, Zhiqian Dong, Osamu Sawada, Tadao Maeda, Akiko Maeda, Krzysztof Palczewski
Total citations by year
Citation information
Citations to this article (57)
| Title and authors | Publication | Year |
|---|---|---|
|
Adenylyl Cyclase in Ocular Health and Disease: A Comprehensive Review
Thompson P, Vilkelyte V, Woronkowicz M, Tavakoli M, Skopinski P, Roberts H |
Biology | 2024 |
|
Synthesis and Biological Analysis of Iso-dimethyltryptamines in a Model of Light-Induced Retinal Degeneration
Pazur EJ, Kalatanova A, Tasker NR, Vainionpää K, Leinonen H, Wipf P |
ACS Medicinal Chemistry Letters | 2024 |
|
Galanin receptor 3 - a new pharmacological target in retina degeneration
Ortega JT, Parmar T, Jastrzebska B |
Pharmacological Research | 2023 |
|
Vitamin A deficiency compromises the barrier function of the retinal pigment epithelium
Moon J, Zhou G, Jankowsky E, von Lintig J |
2023 | |
|
Starburst amacrine cells amplify optogenetic visual restoration through gap junctions
Katada Y, Kunimi H, Serizawa N, Lee D, Kobayashi K, Negishi K, Okano H, Tanaka KF, Tsubota K, Kurihara T |
2023 | |
|
From mouse to human: Accessing the biochemistry of vision in vivo by two-photon excitation.
Palczewska G, Wojtkowski M, Palczewski K |
Progress in Retinal and Eye Research | 2023 |
|
Distinct mouse models of Stargardt disease display differences in pharmacological targeting of ceramides and inflammatory responses.
Engfer ZJ, Lewandowski D, Dong Z, Palczewska G, Zhang J, Kordecka K, Płaczkiewicz J, Panas D, Foik AT, Tabaka M, Palczewski K |
Proceedings of the National Academy of Sciences | 2023 |
|
Lipofuscin, Its Origin, Properties, and Contribution to Retinal Fluorescence as a Potential Biomarker of Oxidative Damage to the Retina
Różanowska MB |
Antioxidants | 2023 |
|
Scavenging of Cation Radicals of the Visual Cycle Retinoids by Lutein, Zeaxanthin, Taurine, and Melanin
Rozanowska M, Edge R, Land EJ, Navaratnam S, Sarna T, Truscott TG |
International journal of molecular sciences | 2023 |
|
Targeting Lipid Metabolism for the Treatment of Age-Related Macular Degeneration: Insights from Preclinical Mouse Models
M Landowski, C Rickman |
Journal of Ocular Pharmacology and Therapeutics | 2022 |
|
GPCR systems pharmacology: a different perspective on the development of biased therapeutics
D Eiger, U Pham, J Gardner, C Hicks, S Rajagopal |
American journal of physiology. Cell physiology | 2022 |
|
The GPCR Antagonistic Drug CM-20 Stimulates Mitochondrial Activity in Human RPE Cells.
Chang Q, Chen S, Yang T |
The open biochemistry journal | 2022 |
|
Drug Discovery Strategies for Inherited Retinal Degenerations
Das A, Imanishi Y |
Biology | 2022 |
|
Chromenone derivatives as novel pharmacological chaperones for retinitis pigmentosa-linked rod opsin mutants
Ortega JT, McKee AG, Roushar FJ, Penn WD, Schlebach JP, Jastrzebska B |
Human Molecular Genetics | 2022 |
|
Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation.
Mavlyutov TA, Li J, Liu X, Shen H, Yang H, McCurdy CR, Pattnaik B, Guo LW |
Genes & development | 2022 |
|
Genetic tuning of β-carotene oxygenase-1 activity rescues cone photoreceptor function in STRA6-deficient mice
Moon J, Ramkumar S, von Lintig J |
Human Molecular Genetics | 2022 |
|
Subtype-dependent regulation of Gβγ signalling
M Tennakoon, K Senarath, D Kankanamge, K Ratnayake, D Wijayaratna, K Olupothage, S Ubeysinghe, K Martins-Cannavino, TE Hébert, A Karunarathne |
Cellular Signalling | 2021 |
|
Drug screening with zebrafish visual behavior identifies carvedilol as a potential treatment for an autosomal dominant form of retinitis pigmentosa
L Ganzen, MJ Ko, M Zhang, R Xie, Y Chen, L Zhang, R James, J Mumm, RM van Rijn, W Zhong, CP Pang, M Zhang, M Tsujikawa, YF Leung |
Scientific Reports | 2021 |
|
The vitamin A transporter STRA6 adjusts the stoichiometry of chromophore and opsins in visual pigment synthesis and recycling
S Ramkumar, V Parmar, I Samuels, N Berger, B Jastrzebska, J von Lintig |
Human Molecular Genetics | 2021 |
|
Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies
Kern TS, Du Y, Tang J, Lee CA, Liu H, Dreffs A, Leinonen H, Antonetti DA, Palczewski K |
Molecular pharmacology | 2021 |
|
Neogenin neutralization prevents photoreceptor loss in inherited retinal degeneration
Jason Charish, Alireza p. Shabanzadeh, Danian Chen, Patrick Mehlen, Santhosh Sethuramanujam, Harada Hidekiyo, Vera L. Bonilha, Gautam Awatramani, Rod Bremner, Philippe P. Monnier |
Journal of Clinical Investigation | 2020 |
|
Retinal Gene Distribution and Functionality Implicated in Inherited Retinal Degenerations Can Reveal Disease-Relevant Pathways for Pharmacologic Intervention
D Mustafi, A Arbabi, H Ameri, K Palczewski |
Pharmaceuticals (Basel, Switzerland) | 2019 |
|
Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones
PD Kiser, AV Kolesnikov, JZ Kiser, Z Dong, B Chaurasia, L Wang, SA Summers, T Hoang, S Blackshaw, NS Peachey, VJ Kefalov, K Palczewski |
The FASEB Journal | 2019 |
|
Modulation of α-adrenoceptor signalling protects photoreceptors after retinal detachment by inhibiting oxidative stress and inflammation: Adrenoceptor ligands for photoreceptor protection
T Li, S Yang, X She, Q Yan, P Zhang, H Zhu, F Wang, X Luo, X Sun |
British Journal of Pharmacology | 2019 |
|
Monomethyl Fumarate Protects the Retina From Light-Induced Retinopathy
D Jiang, RC Ryals, SJ Huang, KK Weller, HE Titus, BM Robb, FW Saad, RA Salam, H Hammad, P Yang, DL Marks, ME Pennesi |
Investigative ophthalmology & visual science | 2019 |
|
The selective estrogen receptor modulator raloxifene mitigates the effect of all- trans -retinal toxicity in photoreceptor degeneration
T Getter, S Suh, T Hoang, JT Handa, Z Dong, X Ma, Y Chen, S Blackshaw, K Palczewski |
The Journal of biological chemistry | 2019 |
|
A Mixture of U.S. Food and Drug Administration–Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness
H Leinonen, EH Choi, A Gardella, VJ Kefalov, K Palczewski |
Investigative ophthalmology & visual science | 2019 |
|
New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models
RM Schur, S Gao, G Yu, Y Chen, A Maeda, K Palczewski, ZR Lu |
The FASEB Journal | 2018 |
|
Long-term intake of Lactobacillus paracasei KW3110 prevents age-related chronic inflammation and retinal cell loss in physiologically aged mice
Y Morita, K Jounai, A Sakamoto, Y Tomita, Y Sugihara, H Suzuki, K Ohshio, M Otake, D Fujiwara, O Kanauchi, M Maruyama |
Aging | 2018 |
|
Human aging and disease: Lessons from age-related macular degeneration
J Luu, K Palczewski |
Proceedings of the National Academy of Sciences | 2018 |
|
Blue light excited retinal intercepts cellular signaling
K Ratnayake, JL Payton, OH Lakmal, A Karunarathne |
Scientific Reports | 2018 |
|
Visual cycle proteins: Structure, function, and roles in human retinal disease
A Tsin, B Betts-Obregon, J Grigsby |
The Journal of biological chemistry | 2018 |
|
Expression of dopamine D2 and D3 receptors in the human retina revealed by positron emission tomography and targeted mass spectrometry
F Caravaggio, E Scifo, EL Sibille, SE Mota, P Gerretsen, G Remington, A Graff-Guerrero |
Experimental Eye Research | 2018 |
|
A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration
Y Chen, Y Chen, B Jastrzebska, M Golczak, S Gulati, H Tang, W Seibel, X Li, H Jin, Y Han, S Gao, J Zhang, X Liu, H Heidari-Torkabadi, PL Stewart, WE Harte, GP Tochtrop, K Palczewski |
Nature Communications | 2018 |
|
The Role of ERK1/2 Activation in Sarpogrelate-Mediated Neuroprotection
CA Ku, RC Ryals, D Jiang, AS Coyner, KK Weller, W Sinha, BM Robb, P Yang, ME Pennesi |
Investigative ophthalmology & visual science | 2018 |
|
Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration
S Gao, T Parmar, G Palczewska, Z Dong, M Golczak, K Palczewski, B Jastrzebska |
Molecular pharmacology | 2018 |
|
Reactive Oxygen Species-Mediated Damage of Retinal Neurons: Drug Development Targets for Therapies of Chronic Neurodegeneration of the Retina
L Rohowetz, J Kraus, P Koulen |
International journal of molecular sciences | 2018 |
|
A Combination of G Protein–Coupled Receptor Modulators Protects Photoreceptors from Degeneration
T Orban, H Leinonen, T Getter, Z Dong, W Sun, S Gao, A Veenstra, H Heidari-Torkabadi, TS Kern, PD Kiser, K Palczewski |
The Journal of pharmacology and experimental therapeutics | 2017 |
|
Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas
D Mustafi, BM Kevany, X Bai, M Golczak, MD Adams, A Wynshaw-Boris, K Palczewski |
Human Molecular Genetics | 2016 |
|
Retinoids and Retinal Diseases
PD Kiser, K Palczewski |
Annual Review of Vision Science | 2016 |
|
Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration
Y Chen, G Palczewska, I Masuho, S Gao, H Jin, Z Dong, L Gieser, MJ Brooks, PD Kiser, TS Kern, KA Martemyanov, A Swaroop, K Palczewski |
Science signaling | 2016 |
|
Retinal Neuroprotective Effects of Flibanserin, an FDA-Approved Dual Serotonin Receptor Agonist-Antagonist
AS Coyner, RC Ryals, CA Ku, CM Fischer, RC Patel, S Datta, P Yang, Y Wen, R Hen, ME Pennesi, T Langmann |
PloS one | 2016 |
|
Eyes on systems pharmacology
Y Chen, TS Kern, PD Kiser, K Palczewski |
Pharmacological Research | 2016 |
|
Molecular pharmacodynamics of emixustat in protection against retinal degeneration
Jianye Zhang, Philip Kiser, Mohsen Badiee, Grazyna Palczewska, Zhiqian Dong, Marcin Golczak, Gregory Tochtrop, Krzysztof Palczewski |
Journal of Clinical Investigation | 2015 |
|
Biology and therapy of inherited retinal degenerative disease: insights from mouse models
S Veleri, CH Lazar, B Chang, PA Sieving, E Banin, A Swaroop |
Disease models & mechanisms | 2015 |
|
Predicting Progression of ABCA4 -Associated Retinal Degenerations Based on Longitudinal Measurements of the Leading Disease Front
AV Cideciyan, M Swider, SB Schwartz, EM Stone, SG Jacobson |
Investigative ophthalmology & visual science | 2015 |
|
Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders
Y Chen, K Palczewski |
Annual Review of Pharmacology and Toxicology | 2015 |
|
Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability
Y Du, M Cramer, CA Lee, J Tang, A Muthusamy, DA Antonetti, H Jin, K Palczewski, TS Kern |
The FASEB Journal | 2015 |
|
Sarpogrelate, a 5-HT 2A Receptor Antagonist, Protects the Retina From Light-Induced Retinopathy
BE Tullis, RC Ryals, AS Coyner, MJ Gale, A Nicholson, C Ku, D Regis, W Sinha, S Datta, Y Wen, P Yang, ME Pennesi |
Investigative ophthalmology & visual science | 2015 |
|
G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets
PA Insel, A Wilderman, AC Zambon, AN Snead, F Murray, N Aroonsakool, DS McDonald, S Zhou, T McCann, L Zhang, K Sriram, AM Chinn, AV Michkov, RM Lynch, AC Overland, R Corriden |
Molecular pharmacology | 2015 |
|
Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments
RM Schur, L Sheng, B Sahu, G Yu, S Gao, X Yu, A Maeda, K Palczewski, ZR Lu |
Investigative ophthalmology & visual science | 2015 |
|
The impact of microRNA gene regulation on the survival and function of mature cell types in the eye
TR Sundermeier, K Palczewski |
The FASEB Journal | 2015 |
|
Serum levels of lipid metabolites in age-related macular degeneration
T Orban, WM Johnson, Z Dong, T Maeda, A Maeda, T Sakai, H Tsuneoka, JJ Mieyal, K Palczewski |
The FASEB Journal | 2015 |
|
Inner and outer retinal changes in retinal degenerations associated with ABCA4 mutations
WC Huang, AV Cideciyan, AJ Roman, A Sumaroka, R Sheplock, SB Schwartz, EM Stone, SG Jacobson |
Investigative ophthalmology & visual science | 2014 |
|
Current Protocols in Mouse Biology: SBF-SEM to Study Retinal Degeneration
D Mustafi, S Kikano, K Palczewski |
Current Protocols in Mouse Biology: SBF-SEM to Study Retinal Degeneration | 2014 |
|
Chemistry and Biology of the Initial Steps in Vision: The Friedenwald Lecture
K Palczewski |
Investigative ophthalmology & visual science | 2014 |
|
All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis
O Sawada, L Perusek, H Kohno, SJ Howell, A Maeda, S Matsuyama, T Maeda |
Experimental Eye Research | 2014 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)