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Citations to this article

Inner ear supporting cells protect hair cells by secreting HSP70
Lindsey A. May, … , Fu-Shing Lee, Lisa L. Cunningham
Lindsey A. May, … , Fu-Shing Lee, Lisa L. Cunningham
Published July 25, 2013
Citation Information: J Clin Invest. 2013;123(8):3577-3587. https://doi.org/10.1172/JCI68480.
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Research Article Article has an altmetric score of 62

Inner ear supporting cells protect hair cells by secreting HSP70

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Abstract

Mechanosensory hair cells are the receptor cells of hearing and balance. Hair cells are sensitive to death from exposure to therapeutic drugs with ototoxic side effects, including aminoglycoside antibiotics and cisplatin. We recently showed that the induction of heat shock protein 70 (HSP70) inhibits ototoxic drug–induced hair cell death. Here, we examined the mechanisms underlying the protective effect of HSP70. In response to heat shock, HSP70 was induced in glia-like supporting cells but not in hair cells. Adenovirus-mediated infection of supporting cells with Hsp70 inhibited hair cell death. Coculture with heat-shocked utricles protected nonheat-shocked utricles against hair cell death. When heat-shocked utricles from Hsp70–/– mice were used in cocultures, protection was abolished in both the heat-shocked utricles and the nonheat-shocked utricles. HSP70 was detected by ELISA in the media surrounding heat-shocked utricles, and depletion of HSP70 from the media abolished the protective effect of heat shock, suggesting that HSP70 is secreted by supporting cells. Together our data indicate that supporting cells mediate the protective effect of HSP70 against hair cell death, and they suggest a major role for supporting cells in determining the fate of hair cells exposed to stress.

Authors

Lindsey A. May, Inga I. Kramarenko, Carlene S. Brandon, Christina Voelkel-Johnson, Soumen Roy, Kristy Truong, Shimon P. Francis, Elyssa L. Monzack, Fu-Shing Lee, Lisa L. Cunningham

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Total
Citations: 2 4 5 7 9 3 4 9 7 7 3 2 62
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2016 (7)

Title and authors Publication Year
Extracellular HSP60 triggers tissue regeneration and wound healing by regulating inflammation and cell proliferation
W Pei, K Tanaka, SC Huang, L Xu, B Liu, J Sinclair, J Idol, GK Varshney, H Huang, S Lin, RB Nussenblatt, R Mori, SM Burgess
npj Regenerative Medicine 2016
Noise-Induced Loss of Hair Cells and Cochlear Synaptopathy Are Mediated by the Activation of AMPK
K Hill, H Yuan, X Wang, SH Sha
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration
SG Lee, M Huang, ND Obholzer, S Sun, W Li, M Petrillo, P Dai, Y Zhou, DA Cotanche, SG Megason, H Li, ZY Chen, O Bermingham-McDonogh
PloS one 2016
c-Jun N-Terminal Phosphorylation: Biomarker for Cellular Stress Rather than Cell Death in the Injured Cochlea
T Anttonen, A Herranen, J Virkkala, A Kirjavainen, P Elomaa, M Laos, X Liang, J Ylikoski, A Behrens, U Pirvola
eNeuro 2016
Activation of PI3K signaling prevents aminoglycoside-induced hair cell death in the murine cochlea
A Jadali, KY Kwan
Biology Open 2016
Adenosine A1 Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea
T Kaur, V Borse, S Sheth, K Sheehan, S Ghosh, S Tupal, S Jajoo, D Mukherjea, LP Rybak, V Ramkumar
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
Axonal maintenance, glia, exosomes, and heat shock proteins
M Tytell, RJ Lasek, H Gainer
F1000Research 2016

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