Mechanosensory hair cells are the receptor cells of hearing and balance. Hair cells are sensitive to death from exposure to therapeutic drugs with ototoxic side effects, including aminoglycoside antibiotics and cisplatin. We recently showed that the induction of heat shock protein 70 (HSP70) inhibits ototoxic drug–induced hair cell death. Here, we examined the mechanisms underlying the protective effect of HSP70. In response to heat shock, HSP70 was induced in glia-like supporting cells but not in hair cells. Adenovirus-mediated infection of supporting cells with
Lindsey A. May, Inga I. Kramarenko, Carlene S. Brandon, Christina Voelkel-Johnson, Soumen Roy, Kristy Truong, Shimon P. Francis, Elyssa L. Monzack, Fu-Shing Lee, Lisa L. Cunningham
Title and authors | Publication | Year |
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Extracellular HSP60 triggers tissue regeneration and wound healing by regulating inflammation and cell proliferation
W Pei, K Tanaka, SC Huang, L Xu, B Liu, J Sinclair, J Idol, GK Varshney, H Huang, S Lin, RB Nussenblatt, R Mori, SM Burgess |
npj Regenerative Medicine | 2016 |
Noise-Induced Loss of Hair Cells and Cochlear Synaptopathy Are Mediated by the Activation of AMPK
K Hill, H Yuan, X Wang, SH Sha |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2016 |
Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration
SG Lee, M Huang, ND Obholzer, S Sun, W Li, M Petrillo, P Dai, Y Zhou, DA Cotanche, SG Megason, H Li, ZY Chen, O Bermingham-McDonogh |
PloS one | 2016 |
c-Jun N-Terminal Phosphorylation: Biomarker for Cellular Stress Rather than Cell Death in the Injured Cochlea
T Anttonen, A Herranen, J Virkkala, A Kirjavainen, P Elomaa, M Laos, X Liang, J Ylikoski, A Behrens, U Pirvola |
eNeuro | 2016 |
Activation of PI3K signaling prevents aminoglycoside-induced hair cell death in the murine cochlea
A Jadali, KY Kwan |
Biology Open | 2016 |
Adenosine A1 Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea
T Kaur, V Borse, S Sheth, K Sheehan, S Ghosh, S Tupal, S Jajoo, D Mukherjea, LP Rybak, V Ramkumar |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2016 |
Axonal maintenance, glia, exosomes, and heat shock proteins
M Tytell, RJ Lasek, H Gainer |
F1000Research | 2016 |