Mechanosensory hair cells are the receptor cells of hearing and balance. Hair cells are sensitive to death from exposure to therapeutic drugs with ototoxic side effects, including aminoglycoside antibiotics and cisplatin. We recently showed that the induction of heat shock protein 70 (HSP70) inhibits ototoxic drug–induced hair cell death. Here, we examined the mechanisms underlying the protective effect of HSP70. In response to heat shock, HSP70 was induced in glia-like supporting cells but not in hair cells. Adenovirus-mediated infection of supporting cells with
Lindsey A. May, Inga I. Kramarenko, Carlene S. Brandon, Christina Voelkel-Johnson, Soumen Roy, Kristy Truong, Shimon P. Francis, Elyssa L. Monzack, Fu-Shing Lee, Lisa L. Cunningham
Title and authors | Publication | Year |
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Autophagy attenuates noise-induced hearing loss by reducing oxidative stress
H Yuan, X Wang, K Hill, J Chen, J Lemasters, SM Yang, SH Sha |
Antioxidants & Redox Signaling | 2015 |
Live-cell imaging of actin dynamics reveals mechanisms of stereocilia length regulation in the inner ear
MC Drummond, M Barzik, JE Bird, DS Zhang, CP Lechene, DP Corey, LL Cunningham, TB Friedman |
Nature Communications | 2015 |
ILDR1 deficiency causes degeneration of cochlear outer hair cells and disrupts the structure of the organ of Corti: a mouse model for human DFNB42
Q Sang, W Li, Y Xu, R Qu, Z Xu, R Feng, L Jin, L He, H Li, L Wang |
Biology Open | 2015 |
Live imaging the phagocytic activity of inner ear supporting cells in response to hair cell death
EL Monzack, LA May, S Roy, JE Gale, LL Cunningham |
Cell Death and Differentiation | 2015 |
Ototoxicity-induced loss of hearing and inner hair cells is attenuated by HSP70 gene transfer
Y Takada, T Takada, MY Lee, DL Swiderski, LL Kabara, DF Dolan, Y Raphael |
Molecular Therapy — Methods & Clinical Development | 2015 |
Hair Cell Loss, Spiral Ganglion Degeneration, and Progressive Sensorineural Hearing Loss in Mice with Targeted Deletion of Slc44a2/Ctl2
P Kommareddi, T Nair, BN Kakaraparthi, MM Galano, D Miller, I Laczkovich, T Thomas, L Lu, K Rule, L Kabara, A Kanicki, ED Hughes, JM Jones, M Hoenerhoff, SG Fisher, RA Altschuler, D Dolan, DC Kohrman, TL Saunders, TE Carey |
Journal of the Association for Research in Otolaryngology | 2015 |
Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14
JJ Fong, K Sreedhara, L Deng, NM Varki, T Angata, Q Liu, V Nizet, A Varki |
The EMBO Journal | 2015 |