Go to
JCI Insight
Citations to this article
David J. Hodson, … , Stephen J. Hughes, Guy A. Rutter
Published September 9, 2013
Citation Information: J Clin Invest. 2013;123(10):4182-4194. https://doi.org/10.1172/JCI68459.
Citation Information: J Clin Invest. 2013;123(10):4182-4194. https://doi.org/10.1172/JCI68459.
Abstract
Pancreatic β cell dysfunction is pathognomonic of type 2 diabetes mellitus (T2DM) and is driven by environmental and genetic factors. β cell responses to glucose and to incretins such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are altered in the disease state. While rodent β cells act as a coordinated syncytium to drive insulin release, this property is unexplored in human islets. In situ imaging approaches were therefore used to monitor in real time the islet dynamics underlying hormone release. We found that GLP-1 and GIP recruit a highly coordinated subnetwork of β cells that are targeted by lipotoxicity to suppress insulin secretion. Donor BMI was negatively correlated with subpopulation responses to GLP-1, suggesting that this action of incretin contributes to functional β cell mass in vivo. Conversely, exposure of mice to a high-fat diet unveiled a role for incretin in maintaining coordinated islet activity, supporting the existence of species-specific strategies to maintain normoglycemia. These findings demonstrate that β cell connectedness is an inherent property of human islets that is likely to influence incretin-potentiated insulin secretion and may be perturbed by diabetogenic insults to disrupt glucose homeostasis in humans.
Authors
David J. Hodson, Ryan K. Mitchell, Elisa A. Bellomo, Gao Sun, Laurent Vinet, Paolo Meda, Daliang Li, Wen-Hong Li, Marco Bugliani, Piero Marchetti, Domenico Bosco, Lorenzo Piemonti, Paul Johnson, Stephen J. Hughes, Guy A. Rutter
Total citations by year
Citation information
Citations to this article (129)
| Title and authors | Publication | Year |
|---|---|---|
|
Impact of Olive Oil Components on the Expression of Genes Related to Type 2 Diabetes Mellitus
Munteanu C, Kotova P, Schwartz B |
Nutrients | 2025 |
|
ER calcium stores contribute to glucose-induced Ca2+ waves and intercellular connectivity in mouse pancreatic islets
Delgadillo-Silva LF, Dakessian K, Rutter GA |
bioRxiv | 2025 |
|
Exendin-4 affects calcium signalling predominantly during activation and activity of beta cell networks in acute mouse pancreas tissue slices
Paradiž Leitgeb E, Kerčmar J, Križančić Bombek L, Pohorec V, Skelin Klemen M, Slak Rupnik M, Gosak M, Dolenšek J, Stožer A |
Frontiers in Endocrinology | 2024 |
|
Sex-dependent intra-islet structural rearrangements affecting alpha-to-beta cell interactions lead to adaptive enhancements of Ca(2+) dynamics in prediabetic beta cells.
Visa M, Berggren PO |
Diabetologia | 2024 |
|
Intra-islet glucagon signalling regulates beta-cell connectivity, first-phase insulin secretion and glucose homoeostasis
Suba K, Patel Y, Martin-Alonso A, Hansen B, Xu X, Roberts A, Norton M, Chung P, Shrewsbury J, Kwok R, Kalogianni V, Chen S, Liu X, Kalyviotis K, Rutter GA, Jones B, Minnion J, Owen BM, Pantazis P, Distaso W, Drucker DJ, Tan TM, Bloom SR, Murphy KG, Salem V |
Molecular Metabolism | 2024 |
|
Optogenetic β cell interrogation in vivo reveals a functional hierarchy directing the Ca2+ response to glucose supported by vitamin B6
Delgadillo-Silva LF, Tasöz E, Singh SP, Chawla P, Georgiadou E, Gompf A, Rutter GA, Ninov N |
Science Advances | 2024 |
|
Exploring pancreatic beta-cell subgroups and their connectivity.
Rutter GA, Gresch A, Delgadillo Silva L, Benninger RKP, Rutter GA, Gresch A, Delgadillo Silva L, Benninger RKP |
Nature metabolism | 2024 |
|
Regulated and adaptive in vivo insulin secretion from islets only containing β-cells.
Perez-Frances M, Bru-Tari E, Cohrs C, Abate MV, van Gurp L, Furuyama K, Speier S, Thorel F, Herrera PL |
Nature metabolism | 2024 |
|
Resolving Spatiotemporal Electrical Signaling Within the Islet via CMOS Microelectrode Arrays
Gresch A, Osthues J, Hüwel JD, Briggs JK, Berger T, Koch R, Deickert T, Beecks C, Benninger RK, Düfer M |
Diabetes | 2024 |
|
Divergent acute versus prolonged pharmacological GLP-1R responses in adult beta cell-selective β-arrestin 2 knockout mice
Stavroula Bitsi, Yusman Manchanda, Liliane El Eid, Nimco Mohamed, Ben Hansen, Kinga Suba, Guy Rutter, Victoria Salem, Ben Jones, Alejandra Tomas |
Science Advances | 2023 |
|
Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases
Santos-Marcos JA, Mora-Ortiz M, Tena-Sempere M, Lopez-Miranda J, Camargo A |
Biology of sex differences | 2023 |
|
Functional characteristics of hub and wave-initiator cells in β cell networks.
Šterk M, Dolenšek J, Skelin Klemen M, Križančić Bombek L, Paradiž Leitgeb E, Kerčmar J, Perc M, Slak Rupnik M, Stožer A, Gosak M |
Biophysical Journal | 2023 |
|
The Values and Perspectives of Organoids in the Field of Metabolic Syndrome.
Tan C, Ding M, Zheng YW |
International journal of molecular sciences | 2023 |
|
Impact of an SLC30A8 loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice
Firth G, Georgiadou E, Griffiths A, Amrahli M, Kim J, Yu Z, Hu M, Stewart TJ, Leclerc I, Okamoto H, Gomez D, Blower PJ, Rutter GA |
Frontiers in Endocrinology | 2023 |
|
EP3 signaling is decoupled from the regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance.
Schaid MD, Harrington JM, Kelly GM, Sdao SM, Merrins MJ, Kimple ME |
Islets | 2023 |
|
The effect of forskolin and the role of Epac2A during activation, activity, and deactivation of beta cell networks.
Skelin Klemen M, Dolenšek J, Križančić Bombek L, Pohorec V, Gosak M, Slak Rupnik M, Stožer A |
Frontiers in Endocrinology | 2023 |
|
RESTORING CONNEXIN-36 FUNCTION IN DIABETOGENIC ENVIRONMENTS PRECLUDES MOUSE AND HUMAN ISLET DYSFUNCTION
St. Clair JR, Westacott MJ, Miranda J, Farnsworth NL, Kravets V, Schleicher WE, Dwulet JM, Levitt CH, Heintz A, Ludin NW, Benninger RK |
The Journal of Physiology | 2023 |
|
Islet autoimmunity in human type 1 diabetes: initiation and progression from the perspective of the beta cell.
Thompson PJ, Pipella J, Rutter GA, Gaisano HY, Santamaria P |
Diabetologia | 2023 |
|
Geometric and topological characterization of the cytoarchitecture of islets of Langerhans
Aggarwal M, Striegel DA, Hara M, Periwal V |
PLoS computational biology | 2023 |
|
β-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network
Briggs JK, Gresch A, Marinelli I, Dwulet JM, Albers DJ, Kravets V, Benninger RK |
eLife | 2023 |
|
Human Beta Cell Functional Adaptation and Dysfunction in Insulin Resistance and Its Reversibility
Skelin Klemen M, Kopecky J, Dolenšek J, Stožer A |
Nephron. Clinical practice | 2023 |
|
Dynamic changes in β-cell [Ca2+] regulate NFAT activation, gene transcription, and islet gap junction communication
J Miranda, W Schleicher, K Wells, D Ramirez, S Landgrave, R Benninger |
Molecular Metabolism | 2022 |
|
The Study of Variation of Metabolites by Sleep Deficiency, and Intervention Possibility of Aerobic Exercise
J Park, Y Kim, W Heo, S Kim |
International journal of environmental research and public health | 2022 |
|
Homocysteine Metabolism Pathway Is Involved in the Control of Glucose Homeostasis: A Cystathionine Beta Synthase Deficiency Study in Mouse
Cruciani-Guglielmacci C, Meneyrol K, Denom J, Kassis N, Rachdi L, Makaci F, Migrenne-Li S, Daubigney F, Georgiadou E, Denis RG, Rodriguez Sanchez-Archidona A, Paul JL, Thorens B, Rutter GA, Magnan C, Le Stunff H, Janel N |
Cells | 2022 |
|
Is type 2 diabetes mellitus another intercellular junction-related disorder?
Collares-Buzato CB, Carvalho CP |
Experimental Biology and Medicine | 2022 |
|
From Isles of Königsberg to Islets of Langerhans: Examining the Function of the Endocrine Pancreas Through Network Science
Stožer A, Šterk M, Paradiž Leitgeb E, Markovič R, Skelin Klemen M, Ellis CE, Križančić Bombek L, Dolenšek J, MacDonald PE, Gosak M |
Frontiers in Endocrinology | 2022 |
|
GLP-1 RAs and SGLT-2 Inhibitors for Insulin Resistance in Nonalcoholic Fatty Liver Disease: Systematic Review and Network Meta-Analysis
Yan H, Huang C, Shen X, Li J, Zhou S, Li W |
Frontiers in Endocrinology | 2022 |
|
pH-Dependence of Glucose-Dependent Activity of Beta Cell Networks in Acute Mouse Pancreatic Tissue Slice
Postić S, Gosak M, Tsai WH, Pfabe J, Sarikas S, Stožer A, Korošak D, Yang SB, Slak Rupnik M |
Frontiers in Endocrinology | 2022 |
|
Ca2+ Oscillations, Waves, and Networks in Islets From Human Donors With and Without Type 2 Diabetes.
Gosak M, Yan-Do R, Lin H, MacDonald PE, Stožer A |
Diabetes | 2022 |
|
Liraglutide increases islet Ca2+ oscillation frequency and insulin secretion by activating hyperpolarization-activated cyclic nucleotide-gated channels
Zaborska KE, Jordan KL, Thorson AS, Dadi PK, Schaub CM, Nakhe AY, Dickerson MT, Lynch JC, Weiss AJ, Dobson JR, Jacobson DA |
Diabetes, obesity & metabolism | 2022 |
|
Agonist-independent Gαz activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes
MD Schaid, CL Green, DC Peter, SJ Gallagher, E Guthery, KA Carbajal, JM Harrington, GM Kelly, A Reuter, ML Wehner, AL Brill, JC Neuman, DW Lamming, ME Kimple |
The Journal of biological chemistry | 2021 |
|
Dynamin deficiency causes insulin secretion failure and hyperglycemia
F Fan, Y Wu, M Hara, A Rizk, C Ji, D Nerad, N Tamarina, X Lou |
Proceedings of the National Academy of Sciences | 2021 |
|
The therapeutic potential of GLP‐1 receptor biased agonism
B Jones |
British Journal of Pharmacology | 2021 |
|
Importance of Both Imprinted Genes and Functional Heterogeneity in Pancreatic Beta Cells: Is There a Link?
P Chabosseau, GA Rutter, SJ Millership |
International journal of molecular sciences | 2021 |
|
Assessing Different Temporal Scales of Calcium Dynamics in Networks of Beta Cell Populations
J Zmazek, MS Klemen, R Markovič, J Dolenšek, M Marhl, A Stožer, M Gosak |
Frontiers in physiology | 2021 |
|
Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial–mesenchymal transition in diabetes
DS de Jesus, TC Mak, YF Wang, Y von Ohlen, Y Bai, E Kane, P Chabosseau, CM Chahrour, W Distaso, V Salem, A Tomas, M Stoffel, GA Rutter, M Latreille |
Molecular Metabolism | 2021 |
|
The Role of cAMP in Beta Cell Stimulus–Secretion and Intercellular Coupling
A Stožer, EP Leitgeb, V Pohorec, J Dolenšek, LK Bombek, M Gosak, MS Klemen |
Cells | 2021 |
|
Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis
SN Gharavy, BM Owen, SJ Millership, P Chabosseau, G Pizza, A Martinez-Sanchez, E Tasoez, E Georgiadou, M Hu, NH Fine, DA Jacobson, MT Dickerson, O Idevall-Hagren, A Montoya, H Kramer, Z Mehta, DJ Withers, N Ninov, PJ Gadue, FL Cardenas-Diaz, C Cruciani-Guglielmacci, C Magnan, M Ibberson, I Leclerc, M Voz, GA Rutter |
Diabetologia | 2021 |
|
Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice
E Akalestou, K Suba, L Lopez-Noriega, E Georgiadou, P Chabosseau, A Gallie, A Wretlind, C Legido-Quigley, I Leclerc, V Salem, GA Rutter |
Nature Communications | 2021 |
|
The physiological role of β-cell heterogeneity in pancreatic islet function
RK Benninger, V Kravets |
Nature Reviews Endocrinology | 2021 |
|
Small subpopulations of β-cells do not drive islet oscillatory [Ca2+] dynamics via gap junction communication
JA Dwulet, JK Briggs, RK Benninger, J Rubin |
PLoS computational biology | 2021 |
|
Cell Heterogeneity and Paracrine Interactions in Human Islet Function: A Perspective Focused in β-Cell Regeneration Strategies
E Bru-Tari, D Oropeza, PL Herrera |
Frontiers in Endocrinology | 2021 |
|
The effects of beta-cell mass and function, intercellular coupling, and islet synchrony on $${\text {Ca}}^{2+}$$ dynamics
M Saadati, Y Jamali |
Scientific Reports | 2021 |
|
NMDA receptor inhibition increases, synchronizes, and stabilizes the collective pancreatic beta cell activity: Insights through multilayer network analysis
M Šterk, LK Bombek, MS Klemen, MS Rupnik, M Marhl, A Stožer, M Gosak, S Finley |
PLoS computational biology | 2021 |
|
In Vivo ZIMIR Imaging of Mouse Pancreatic Islet Cells Shows Oscillatory Insulin Secretion
S Chen, ZJ Huang, H Kidd, M Kim, EH Suh, S Xie, EH Zadeh, Y Xu, AD Sherry, PE Scherer, W Li |
Frontiers in Endocrinology | 2021 |
|
Reagents and models for detecting endogenous GLP1R and GIPR
J Ast, J Broichhagen, DJ Hodson |
EBioMedicine | 2021 |
|
The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis
GR Carrat, E Haythorne, A Tomas, L Haataja, A Müller, P Arvan, A Piunti, K Cheng, M Huang, TJ Pullen, E Georgiadou, T Stylianides, NS Amirruddin, V Salem, W Distaso, A Cakebread, KJ Heesom, PA Lewis, DJ Hodson, LJ Briant, AC Fung, RB Sessions, F Alpy, AP Kong, PI Benke, F Torta, AK Teo, I Leclerc, M Solimena, DB Wigley, GA Rutter |
Molecular Metabolism | 2020 |
|
Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation
BA McLean, CK Wong, JE Campbell, DJ Hodson, S Trapp, DJ Drucker |
Endocrine reviews | 2020 |
|
The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice
E Georgiadou, E Haythorne, MT Dickerson, L Lopez-Noriega, TJ Pullen, G da Silva Xavier, SP Davis, A Martinez-Sanchez, F Semplici, R Rizzuto, JA McGinty, PM French, MC Cane, DA Jacobson, I Leclerc, GA Rutter |
Diabetologia | 2020 |
|
Functional analysis of islet cells in vitro, in situ, and in vivo
W Li |
Seminars in Cell & Developmental Biology | 2020 |
|
Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity
GA Rutter, E Georgiadou, A Martinez-Sanchez, TJ Pullen |
Diabetologia | 2020 |
|
Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells
Z Fang, S Chen, Y Manchanda, S Bitsi, P Pickford, A David, MM Shchepinova, IR Corrêa, DJ Hodson, J Broichhagen, EW Tate, F Reimann, V Salem, GA Rutter, T Tan, SR Bloom, A Tomas, B Jones |
International journal of molecular sciences | 2020 |
|
Caloric restriction recovers impaired β-cell-β-cell gap junction coupling, calcium oscillation coordination, and insulin secretion in prediabetic mice
ME do Amaral, V Kravets, JA Dwulet, NL Farnsworth, R Piscopio, WE Schleicher, JG Miranda, RK Benninger |
American journal of physiology. Endocrinology and metabolism | 2020 |
|
Effect of Switching from Linagliptin to Teneligliptin Dipeptidyl Peptidase-4 Inhibitors in Older Patients with Type 2 Diabetes Mellitus E Han, M Lee, Y Lee, HS Kim, B Lee, BS Cha, ES Kang |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy | 2020 |
|
The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists
Z Fang, S Chen, P Pickford, J Broichhagen, DJ Hodson, IR Corrêa, S Kumar, F Görlitz, C Dunsby, PM French, GA Rutter, T Tan, SR Bloom, A Tomas, B Jones |
2020 | |
|
Maternal hypothyroidism in mice influences glucose metabolism in adult offspring
Y Kemkem, D Nasteska, A de Bray, P Bargi-Souza, RA Peliciari-Garcia, A Guillou, P Mollard, DJ Hodson, M Schaeffer |
Diabetologia | 2020 |
|
Effect of free fatty acids on insulin secretion, insulin sensitivity and incretin effect – a narrative review
VB Chueire, E Muscelli |
Archives of Endocrinology and Metabolism | 2020 |
|
Heterogeneity of human pancreatic β-cells
G Dominguez-Gutierrez, Y Xin, J Gromada |
Molecular Metabolism | 2019 |
|
Informing β-cell regeneration strategies using studies of heterogeneity
D Nasteska, K Viloria, L Everett, DJ Hodson |
Molecular Metabolism | 2019 |
|
Early effects of roflumilast on insulin sensitivity in adults with prediabetes and overweight/obesity involve age-associated fat mass loss – results of an exploratory study IM Muo, SD MacDonald, R Madan, SJ Park, AM Gharib, PE Martinez, MF Walter, SB Yang, JA Rodante, AB Courville, PJ Walter, H Cai, M Glicksman, GM Guerrieri, RR Ben-Dor, R Ouwerkerk, S Mao, JH Chung |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy | 2019 |
|
Heterogeneity and Delayed Activation as Hallmarks of Self-Organization and Criticality in Excitable Tissue
A Stožer, R Markovič, J Dolenšek, M Perc, M Marhl, MS Rupnik, M Gosak |
Frontiers in physiology | 2019 |
|
Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo
V Salem, LD Silva, K Suba, E Georgiadou, SN Gharavy, N Akhtar, A Martin-Alonso, DC Gaboriau, SM Rothery, T Stylianides, G Carrat, TJ Pullen, SP Singh, DJ Hodson, I Leclerc, AM Shapiro, P Marchetti, LJ Briant, W Distaso, N Ninov, GA Rutter |
2019 | |
|
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
P Rorsman, FM Ashcroft |
Physiological reviews | 2018 |
|
Exendin-4 overcomes cytokine-induced decreases in gap junction coupling via protein kinase A and Epac2 in mouse and human islets: Exendin-4 overcomes cytokine-induced decreases in gap junction coupling
NL Farnsworth, R Walter, RA Piscopio, WE Schleicher, RK Benninger |
The Journal of Physiology | 2018 |
|
The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis
RK Benninger, C Dorrell, DJ Hodson, GA Rutter |
Current Diabetes Reports | 2018 |
|
The role of beta cell heterogeneity in islet function and insulin release
D Nasteska, DJ Hodson |
Journal of Molecular Endocrinology | 2018 |
|
Beta-cell hubs maintain Ca 2+ oscillations in human and mouse islet simulations
CL Lei, JA Kellard, M Hara, JD Johnson, B Rodriguez, LJ Briant |
Islets | 2018 |
|
New Understanding of β-Cell Heterogeneity and In Situ Islet Function
RK Benninger, DJ Hodson |
Diabetes | 2018 |
|
The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans
C Izzi-Engbeaya, AN Comninos, SA Clarke, A Jomard, L Yang, S Jones, A Abbara, S Narayanaswamy, PC Eng, D Papadopoulou, JK Prague, P Bech, IF Godsland, P Bassett, C Sands, S Camuzeaux, M Gomez-Romero, JT Pearce, MR Lewis, E Holmes, JK Nicholson, T Tan, R Ratnasabapathy, M Hu, G Carrat, L Piemonti, M Bugliani, P Marchetti, PR Johnson, SJ Hughes, AM Shapiro, GA Rutter, WS Dhillo |
Diabetes, obesity & metabolism | 2018 |
|
Targeting GLP-1 receptor trafficking to improve agonist efficacy
B Jones, T Buenaventura, N Kanda, P Chabosseau, BM Owen, R Scott, R Goldin, N Angkathunyakul, IR Corrêa, D Bosco, PR Johnson, L Piemonti, P Marchetti, AM Shapiro, BJ Cochran, AC Hanyaloglu, A Inoue, T Tan, GA Rutter, A Tomas, SR Bloom |
Nature Communications | 2018 |
|
Islet proteomics reveals genetic variation in dopamine production resulting in altered insulin secretion
KA Mitok, EC Freiberger, KL Schueler, ME Rabaglia, DS Stapleton, NW Kwiecien, PA Malec, AS Hebert, AT Broman, RT Kennedy, MP Keller, JJ Coon, AD Attie |
The Journal of biological chemistry | 2018 |
|
Effects of acute NEFA manipulation on incretin-induced insulin secretion in participants with and without type 2 diabetes
B Astiarraga, VB Chueire, AL Souza, R Pereira-Moreira, SM Alegre, A Natali, A Tura, A Mari, E Ferrannini, E Muscelli |
Diabetologia | 2018 |
|
Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology
T Podewin, J Ast, J Broichhagen, NH Fine, D Nasteska, P Leippe, M Gailer, T Buenaventura, N Kanda, BJ Jones, C MKadmi, JL Baneres, J Marie, A Tomas, D Trauner, A Hoffmann-Röder, DJ Hodson |
ACS Central Science | 2018 |
|
Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity
P Ježek, M Jabůrek, B Holendová, L Plecitá-Hlavatá |
Molecules (Basel, Switzerland) | 2018 |
|
Use of human islets to understand islet biology and diabetes: progress, challenges and suggestions
NJ Hart, AC Powers |
Diabetologia | 2018 |
|
Interrogating islets in health and disease with single-cell technologies
AC Carrano, F Mulas, C Zeng, M Sander |
Molecular Metabolism | 2017 |
|
Beta cell heterogeneity: an evolving concept
D Avrahami, A Klochendler, Y Dor, B Glaser |
Diabetologia | 2017 |
|
Critical and Supercritical Spatiotemporal Calcium Dynamics in Beta Cells
M Gosak, A Stožer, R Markovič, J Dolenšek, M Perc, MS Rupnik, M Marhl |
Frontiers in physiology | 2017 |
|
Nutrient regulation of β-cell function: what do islet cell/animal studies tell us?
R Carlessi, KN Keane, C Mamotte, P Newsholme |
European Journal of Clinical Nutrition | 2017 |
|
MiRNAs in β-Cell Development, Identity, and Disease
A Martinez-Sanchez, GA Rutter, M Latreille |
Frontiers in Genetics | 2017 |
|
The Triggering Pathway to Insulin Secretion: Functional Similarities and Differences Between the Human and the Mouse Beta Cells and their Translational Relevance
MS Klemen, J Dolenšek, MS Rupnik, A Stožer |
Islets | 2017 |
|
Age-Dependent Decline in the Coordinated [Ca 2+ ] and Insulin Secretory Dynamics in Human Pancreatic Islets
MJ Westacott, NL Farnsworth, JR st. Clair, G Poffenberger, A Heintz, NW Ludin, NJ Hart, AC Powers, RK Benninger |
Diabetes | 2017 |
|
SNAP-25b-deficiency increases insulin secretion and changes spatiotemporal profile of Ca2+oscillations in β cell networks
T Daraio, LK Bombek, M Gosak, I Valladolid-Acebes, MS Klemen, E Refai, PO Berggren, K Brismar, MS Rupnik, C Bark |
Scientific Reports | 2017 |
|
Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion
NH Fine, CL Doig, YS Elhassan, NC Vierra, P Marchetti, M Bugliani, R Nano, L Piemonti, GA Rutter, DA Jacobson, GG Lavery, DJ Hodson |
Diabetes | 2017 |
|
β-Cells are not uniform after all-Novel insights into molecular heterogeneity of insulin-secreting cells: AVRAHAMI et al
D Avrahami, YJ Wang, A Klochendler, Y Dor, B Glaser, KH Kaestner |
Diabetes Obesity and Metabolism | 2017 |
|
Inadequate Triglyceride Management Worsens the Durability of Dipeptidyl Peptidase-4 Inhibitor in Subjects with Type 2 Diabetes Mellitus
M Shimoda, M Miyoshi-Takai, S Irie, A Tanabe, A Obata, S Okauchi, H Hirukawa, T Kimura, K Kohara, S Kamei, T Mune, K Kaku, H Kaneto |
Journal of Diabetes Research | 2017 |
|
Immaturity of insulin secretion by pancreatic islets isolated from one human neonate
JC Henquin, M Nenquin |
Journal of Diabetes Investigation | 2017 |
|
Spatially Organized β-Cell Subpopulations Control Electrical Dynamics across Islets of Langerhans
MJ Westacott, NW Ludin, RK Benninger |
Biophysical Journal | 2017 |
|
The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca 2+ dynamics in adult mice
RK Mitchell, MS Nguyen-Tu, P Chabosseau, RM Callingham, TJ Pullen, R Cheung, I Leclerc, DJ Hodson, GA Rutter |
The Journal of biological chemistry | 2017 |
|
Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca 2+ Stores
A Marmugi, J Parnis, X Chen, LA Carmichael, J Hardy, N Mannan, P Marchetti, L Piemonti, D Bosco, P Johnson, JA Shapiro, C Cruciani-Guglielmacci, C Magnan, M Ibberson, B Thorens, HH Valdivia, GA Rutter, I Leclerc |
Diabetes | 2016 |
|
Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice
ZB Mehta, N Fine, TJ Pullen, MC Cane, M Hu, P Chabosseau, G Meur, A Velayos-Baeza, AP Monaco, L Marselli, P Marchetti, GA Rutter |
American journal of physiology. Endocrinology and metabolism | 2016 |
|
Decreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise
AM Notary, MJ Westacott, TH Hraha, M Pozzoli, RK Benninger, JJ Saucerman |
PLoS computational biology | 2016 |
|
Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose
NR Johnston, RK Mitchell, E Haythorne, MP Pessoa, F Semplici, J Ferrer, L Piemonti, P Marchetti, M Bugliani, D Bosco, E Berishvili, P Duncanson, M Watkinson, J Broichhagen, D Trauner, GA Rutter, DJ Hodson |
Cell Metabolism | 2016 |
|
Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance
SR Sayers, F Reimann, FM Gribble, H Parker, S Zac-Varghese, SR Bloom, M Foretz, B Viollet, GA Rutter, FC Lynn |
PloS one | 2016 |
|
Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway
H Lu, L Hao, S Li, S Lin, L Lv, Y Chen, H Cui, T Zi, X Chu, L Na, C Sun |
Diabetologia | 2016 |
|
The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca2+ dynamics and insulin secretion
MC Cane, J Parrington, P Rorsman, A Galione, GA Rutter |
Cell Calcium | 2016 |
|
CoA protects against the deleterious effects of caloric overload in Drosophila
LP Musselman, JL Fink, TJ Baranski |
Journal of lipid research | 2016 |
|
Molecular Genetic Regulation of Slc30a8 /ZnT8 Reveals a Positive Association With Glucose Tolerance
RK Mitchell, M Hu, PL Chabosseau, MC Cane, G Meur, EA Bellomo, R Carzaniga, LM Collinson, WH Li, DJ Hodson, GA Rutter |
Molecular Endocrinology | 2016 |
|
Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1
M Seillier, L Pouyet, P N'Guessan, M Nollet, F Capo, F Guillaumond, L Peyta, JF Dumas, A Varrault, G Bertrand, S Bonnafous, A Tran, G Meur, P Marchetti, MA Ravier, S Dalle, P Gual, D Muller, GA Rutter, S Servais, JL Iovanna, A Carrier |
EMBO Molecular Medicine | 2015 |
|
Slow potentials encode intercellular coupling and insulin demand in pancreatic beta cells
F Lebreton, A Pirog, I Belouah, D Bosco, T Berney, P Meda, Y Bornat, B Catargi, S Renaud, M Raoux, J Lang |
Diabetologia | 2015 |
|
Kin of IRRE-like Protein 2 Is a Phosphorylated Glycoprotein That Regulates Basal Insulin Secretion
B Yesildag, T Bock, K Herrmanns, B Wollscheid, M Stoffel |
The Journal of biological chemistry | 2015 |
|
Membrane Potential and Calcium Dynamics in Beta Cells from Mouse Pancreas Tissue Slices: Theory, Experimentation, and Analysis
J Dolenšek, D Špelič, M Klemen, B Žalik, M Gosak, M Rupnik, A Stožer |
Sensors (Basel, Switzerland) | 2015 |
|
Low Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cδ
NL Farnsworth, RL Walter, A Hemmati, MJ Westacott, RK Benninger |
The Journal of biological chemistry | 2015 |
|
Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells
H Soedling, DJ Hodson, AE Adrianssens, FM Gribble, F Reimann, S Trapp, GA Rutter |
Molecular Metabolism | 2015 |
|
Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects
A Swisa, Z Granot, N Tamarina, S Sayers, N Bardeesy, L Philipson, DJ Hodson, JD Wikstrom, GA Rutter, G Leibowitz, B Glaser, Y Dor |
The Journal of biological chemistry | 2015 |
|
The Beta Cell in Its Cluster: Stochastic Graphs of Beta Cell Connectivity in the Islets of Langerhans
DA Striegel, M Hara, V Periwal, MG Pedersen |
PLoS computational biology | 2015 |
|
Genetic Targeting of a Small Fluorescent Zinc Indicator to Cell Surface for Monitoring Zinc Secretion
D Li, L Liu, WH Li |
ACS chemical biology | 2015 |
|
Progressive glucose stimulation of islet beta cells reveals a transition from segregated to integrated modular functional connectivity patterns
R Markovič, A Stožer, M Gosak, J Dolenšek, M Marhl, MS Rupnik |
Scientific Reports | 2015 |
|
Testing Pancreatic Islet Function at the Single Cell Level by Calcium Influx with Associated Marker Expression
JH Kenty, DA Melton, V Sanchez-Margalet |
PloS one | 2015 |
|
The past 10 years—new hormones, new functions, new endocrine organs
R Bouillon, DJ Drucker, E Ferrannini, S Grinspoon, CJ Rosen, P Zimmet |
Nature Reviews Endocrinology | 2015 |
|
Optical Control of Insulin Secretion Using an Incretin Switch
J Broichhagen, T Podewin, H Meyer-Berg, Y von Ohlen, NR Johnston, BJ Jones, SR Bloom, GA Rutter, A Hoffmann-Röder, DJ Hodson, D Trauner |
Angewandte Chemie (International ed. in English) | 2015 |
|
Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells
J Piccand, P Strasser, DJ Hodson, A Meunier, T Ye, C Keime, MC Birling, GA Rutter, G Gradwohl |
Cell Reports | 2014 |
|
Non-alcoholic fatty liver disease and type 2 diabetes mellitus: The liver disease of our age?
G Firneisz |
World journal of gastroenterology : WJG | 2014 |
|
Beta cell connectivity in pancreatic islets: a type 2 diabetes target?
GA Rutter, DJ Hodson |
Cellular and Molecular Life Sciences | 2014 |
|
Selective disruption of Tcf7l2 in the pancreatic cell impairs secretory function and lowers cell mass
RK Mitchell, A Mondragon, L Chen, JA Mcginty, PM French, J Ferrer, B Thorens, DJ Hodson, GA Rutter, GD Xavier |
Human Molecular Genetics | 2014 |
|
Role of MicroRNAs in Islet Beta-Cell Compensation and Failure during Diabetes
V Plaisance, G Waeber, R Regazzi, A Abderrahmani |
Journal of Diabetes Research | 2014 |
|
Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics
RK Benninger, DW Piston |
Trends in Endocrinology & Metabolism | 2014 |
|
New insights into the role of connexins in pancreatic islet function and diabetes
NL Farnsworth, RK Benninger |
FEBS Letters | 2014 |
|
Lipotoxicity in the Pancreatic Beta Cell: Not Just Survival and Function, but Proliferation as Well?
RB Sharma, LC Alonso |
Current Diabetes Reports | 2014 |
|
Optical control of insulin release using a photoswitchable sulfonylurea
J Broichhagen, M Schönberger, SC Cork, JA Frank, P Marchetti, M Bugliani, AM Shapiro, S Trapp, GA Rutter, DJ Hodson, D Trauner |
Nature Communications | 2014 |
|
ADCY5 Couples Glucose to Insulin Secretion in Human Islets
DJ Hodson, RK Mitchell, L Marselli, TJ Pullen, SG Brias, F Semplici, KL Everett, DM Cooper, M Bugliani, P Marchetti, V Lavallard, D Bosco, L Piemonti, PR Johnson, SJ Hughes, D Li, WH Li, AM Shapiro, GA Rutter |
Diabetes | 2014 |
|
JNK3 is required for the cytoprotective effect of exendin 4
H Ezanno, V Pawlowski, S Abdelli, R Boutry, V Gmyr, J Kerr-Conte, C Bonny, F Pattou, A Abderrahmani |
Journal of Diabetes Research | 2014 |
|
Incretin action on bone: An added benefit?
RC Ma, G Xu |
Journal of Diabetes Investigation | 2014 |
|
Phase Transitions in the Multi-cellular Regulatory Behavior of Pancreatic Islet Excitability
TH Hraha, MJ Westacott, M Pozzoli, AM Notary, PM McClatchey, RK Benninger |
PLoS computational biology | 2014 |
|
Intrinsic Islet Heterogeneity and Gap Junction Coupling Determine Spatiotemporal Ca2+ Wave Dynamics
RK Benninger, T Hutchens, WS Head, MJ McCaughey, M Zhang, SJ Le Marchand, LS Satin, DW Piston |
Biophysical Journal | 2014 |
|
Fluorescence recovery after photobleaching reveals regulation and distribution of connexin36 gap junction coupling within mouse islets of Langerhans: Analysis of connexin36 gap junction coupling
NL Farnsworth, A Hemmati, M Pozzoli, RK Benninger |
The Journal of Physiology | 2014 |
|
Incretin-Modulated Beta Cell Energetics in Intact Islets of Langerhans
DJ Hodson, AI Tarasov, SG Brias, RK Mitchell, NR Johnston, S Haghollahi, MC Cane, M Bugliani, P Marchetti, D Bosco, PR Johnson, SJ Hughes, GA Rutter |
Molecular Endocrinology | 2014 |
|
Minireview: Intraislet Regulation of Insulin Secretion in Humans
GA Rutter, DJ Hodson |
Molecular Endocrinology | 2013 |
|
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)