Single-minded 1 (SIM1) is a basic helix-loop-helix transcription factor involved in the development and function of the paraventricular nucleus of the hypothalamus. Obesity has been reported in
Shwetha Ramachandrappa, Anne Raimondo, Anna M.G. Cali, Julia M. Keogh, Elana Henning, Sadia Saeed, Amanda Thompson, Sumedha Garg, Elena G. Bochukova, Soren Brage, Victoria Trowse, Eleanor Wheeler, Adrienne E. Sullivan, Mehul Dattani, Peter E. Clayton, Vippan Datta, John B. Bruning, Nick J. Wareham, Stephen O’Rahilly, Daniel J. Peet, Ines Barroso, Murray L. Whitelaw, I. Sadaf Farooqi
Title and authors | Publication | Year |
---|---|---|
A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity
J Philippe, P Stijnen, D Meyre, FD Graeve, D Thuillier, J Delplanque, G Gyapay, O Sand, JW Creemers, P Froguel, A Bonnefond |
International Journal of Obesity | 2014 |
Incomplete penetrance and phenotypic variability of 6q16 deletions including SIM1
LE Khattabi, F Guimiot, E Pipiras, J Andrieux, C Baumann, S Bouquillon, AL Delezoide, B Delobel, F Demurger, H Dessuant, S Drunat, C Dubourg, C Dupont, L Faivre, M Holder-Espinasse, S Jaillard, H Journel, S Lyonnet, V Malan, A Masurel, N Marle, C Missirian, A Moerman, A Moncla, S Odent, O Palumbo, P Palumbo, A Ravel, S Romana, AC Tabet, M Valduga, M Vermelle, M Carella, JM Dupont, A Verloes, B Benzacken, A Delahaye |
European Journal of Human Genetics | 2014 |
Gene-Environment Interactions Controlling Energy and Glucose Homeostasis and the Developmental Origins of Obesity
S Bouret, BE Levin, SE Ozanne |
Physiological reviews | 2014 |
Genetic strategies to understand physiological pathways regulating body weight
S Farooqi |
Mammalian Genome | 2014 |
Neurobiology of food intake in health and disease
GJ Morton, TH Meek, MW Schwartz |
Nature Reviews Neuroscience | 2014 |
Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function
DC Bersten, JB Bruning, DJ Peet, ML Whitelaw |
PloS one | 2014 |
Inducible Neuronal Inactivation of Sim1 in Adult Mice Causes Hyperphagic Obesity
KP Tolson, T Gemelli, D Meyer, U Yazdani, J Kozlitina, AR Zinn |
Endocrinology | 2014 |
Hindbrain Oxytocin Receptors Contribute to the Effects of Circulating Oxytocin on Food Intake in Male Rats
JM Ho, VT Anekonda, BW Thompson, M Zhu, RW Curry, BH Hwang, GJ Morton, MW Schwartz, DG Baskin, SM Appleyard, JE Blevins |
Endocrinology | 2014 |