Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Lung tumor NF-κB signaling promotes T cell–mediated immune surveillance
Emily L. Hopewell, … , Dung-Tsa Chen, Amer A. Beg
Emily L. Hopewell, … , Dung-Tsa Chen, Amer A. Beg
Published May 1, 2013
Citation Information: J Clin Invest. 2013;123(6):2509-2522. https://doi.org/10.1172/JCI67250.
View: Text | PDF
Research Article Oncology Article has an altmetric score of 31

Lung tumor NF-κB signaling promotes T cell–mediated immune surveillance

  • Text
  • PDF
Abstract

NF-κB is constitutively activated in many cancer types and is a potential key mediator of tumor-associated inflammation, tumor growth, and metastasis. We investigated the role of cancer cell NF-κB activity in T cell–mediated antitumor responses. In tumors rendered immunogenic by model antigen expression or following administration of antitumor vaccines, we found that high NF-κB activity leads to tumor rejection and/or growth suppression in mice. Using a global RNA expression microarray, we demonstrated that NF-κB enhanced expression of several T cell chemokines, including Ccl2, and decreased CCL2 expression was associated with enhanced tumor growth in a mouse lung cancer model. To investigate NF-κB function in human lung tumors, we identified a gene expression signature in human lung adenocarcinoma cell lines that was associated with NF-κB activity level. In patient tumor samples, overall lung tumor NF-κB activity was strongly associated with T cell infiltration but not with cancer cell proliferation. These results therefore indicate that NF-κB activity mediates immune surveillance and promotes antitumor T cell responses in both murine and human lung cancer.

Authors

Emily L. Hopewell, Weipeng Zhao, William J. Fulp, Crystina C. Bronk, Alexis S. Lopez, Michael Massengill, Scott Antonia, Esteban Celis, Eric B. Haura, Steven A. Enkemann, Dung-Tsa Chen, Amer A. Beg

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Total
Citations: 3 7 6 6 7 5 7 7 4 6 7 5 4 74
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2018 (7)

Title and authors Publication Year
NF-κB, inflammation, immunity and cancer: coming of age
K Taniguchi, M Karin
Nature Reviews Immunology 2018
NF-kappaB: Two Sides of the Same Coin
B Pires, R Silva, G Ferreira, E Abdelhay
Genes & development 2018
USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy
YC Wang, YS Wu, CY Hung, SA Wang, MJ Young, TI Hsu, JJ Hung
Nature Communications 2018
Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade
Y Qin, SN Vasilatos, L Chen, H Wu, Z Cao, Y Fu, M Huang, AM Vlad, B Lu, S Oesterreich, NE Davidson, Y Huang
Oncogene 2018
Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization
EE Er, M Valiente, K Ganesh, Y Zou, S Agrawal, J Hu, B Griscom, M Rosenblum, A Boire, E Brogi, FG Giancotti, M Schachner, S Malladi, J Massagué
Nature Cell Biology 2018
Association of tumor-infiltrating T-cell density with molecular subtype, racial ancestry and clinical outcomes in prostate cancer
HB Kaur, LB Guedes, J Lu, L Maldonado, L Reitz, JR Barber, AM Marzo, JJ Tosoian, SA Tomlins, EM Schaeffer, CE Joshu, KS Sfanos, TL Lotan
Modern Pathology 2018
Identification of prognostic genes in colorectal cancer through transcription profiling of multi‑stage carcinogenesis
N An, C Zhao, Z Yu, X Yang
Oncology Letters 2018

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Picked up by 3 news outlets
Posted by 6 X users
On 1 Facebook pages
79 readers on Mendeley
See more details