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Ming Yang, … , Tomoyoshi Soga, Patrick J. Pollard
Published September 3, 2013
Citation Information: J Clin Invest. 2013;123(9):3652-3658. https://doi.org/10.1172/JCI67228.
Citation Information: J Clin Invest. 2013;123(9):3652-3658. https://doi.org/10.1172/JCI67228.
Abstract
The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer. Advances in mass spectrometry and nuclear magnetic resonance technologies have facilitated high-resolution metabolite profiling of cells and tumors and identified the accumulation of metabolites associated with specific gene defects. Here we review the potential roles of such “oncometabolites” in tumor evolution and as clinical biomarkers for the detection of cancers characterized by metabolic dysregulation.
Authors
Ming Yang, Tomoyoshi Soga, Patrick J. Pollard
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Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer
W Guo, BP Zhou |
Genes & Diseases | 2019 |
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Defining a metabolic landscape of tumours: genome meets metabolism
CS Nanda, SV Venkateswaran, N Patani, M Yuneva |
British Journal of Cancer | 2019 |
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Increased 14C-acetate accumulation in IDH-mutated human glioblastoma: implications for detecting IDH-mutated glioblastoma with 11C-acetate PET imaging
S Koyasu, Y Shimizu, A Morinibu, T Saga, Y Nakamoto, K Togashi, H Harada |
Journal of Neuro-Oncology | 2019 |
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Immunometabolism: A new target for improving cancer immunotherapy
Guo C, Chen S, Liu W, Ma Y, Li J, Fisher PB, Fang X, Wang XY |
Advances in cancer research | 2019 |
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Drugging cancer metabolism: Expectations vs. reality.
Montrose DC, Galluzzi L |
International review of cell and molecular biology | 2019 |
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Roles of pyruvate carboxylase in human diseases: from diabetes to cancers and infection
U Lao-On, PV Attwood, S Jitrapakdee |
Journal of Molecular Medicine | 2018 |
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The Influence of Metabolism on Drug Response in Cancer
EA Zaal, CR Berkers |
Frontiers in Oncology | 2018 |
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Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis
P Santofimia-Castaño, W Lan, J Bintz, O Gayet, A Carrier, G Lomberk, JL Neira, A González, R Urrutia, P Soubeyran, J Iovanna |
Scientific Reports | 2018 |
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Metabolic Plasticity of Tumor Cell Mitochondria
G Cannino, F Ciscato, I Masgras, C Sánchez-Martín, A Rasola |
Frontiers in Oncology | 2018 |
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Mitochondrial Metabolism in Major Neurological Diseases
Z Zhou, G Austin, L Young, L Johnson, R Sun |
Cells | 2018 |
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Transcriptional regulation of metabolism in disease: From transcription factors to epigenetics
LJ Hawkins, R Al-attar, KB Storey |
PeerJ | 2018 |
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Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance
B Yan, S Liu, Y Shi, N Liu, L Chen, X Wang, D Xiao, X Liu, C Mao, Y Jiang, W Lai, X Xin, CE Tang, D Luo, T Tan, J Jia, Y Liu, R Yang, J Huang, H Zhou, Y Cheng, Y Cao, W Yu, K Muegge, Y Tao |
Cell Death and Disease | 2018 |
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Regulatory functions of the Mediator kinases CDK8 and CDK19
CB Fant, DJ Taatjes |
Transcription | 2018 |
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Diagnosis of lung tumor types based on metabolomic profiles in lymph node aspirates
D Sappington, S Helms, E Siegel, RB Penney, S Jeffus, T Bartter, T Bartter, G Boysen |
Cancer Treatment and Research Communications | 2018 |
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Gene expression analysis in peripheral blood cells of patients with hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC): identification of NRF2 pathway activation
CA Valencia, LL Kleine, AM Velasco, AY Barreto, CE Diaz |
Familial Cancer | 2018 |
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Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States
D Jia, J Park, K Jung, H Levine, B Kaipparettu |
Cells | 2018 |
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Epigenetic regulation of cell fate reprogramming in aging and disease: A predictive computational model
N Folguera-Blasco, E Cuyàs, JA Menéndez, T Alarcón, SL Pond |
PLoS computational biology | 2018 |
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The emerging roles of ribosomal histidyl hydroxylases in cell biology, physiology and disease
JR Bundred, E Hendrix, ML Coleman |
Cellular and Molecular Life Sciences | 2018 |
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Identification of a metabolic disposal route for the oncometabolite S -(2-succino)cysteine in Bacillus subtilis
TD Niehaus, J Folz, DR McCarty, AJ Cooper, DM Amador, O Fiehn, AD Hanson |
The Journal of biological chemistry | 2018 |
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Metabolic Alterations in Cancer Cells and the Emerging Role of Oncometabolites as Drivers of Neoplastic Change
Z Zhou, E Ibekwe, Y Chornenkyy |
Antioxidants | 2018 |
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Metabolomics of oncogene-specific metabolic reprogramming during breast cancer
C Dai, J Arceo, J Arnold, A Sreekumar, NJ Dovichi, J Li, LE Littlepage |
Cancer & Metabolism | 2018 |
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Identification of key genes and pathways in human clear cell renal cell carcinoma (ccRCC) by co-expression analysis
L Yuan, G Zeng, L Chen, G Wang, X Wang, X Cao, M Lu, X Liu, G Qian, Y Xiao, X Wang |
International journal of biological sciences | 2018 |
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Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM)
RC Bruntz, AN Lane, RM Higashi, TW Fan |
The Journal of biological chemistry | 2017 |
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Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy
S Gupta, A Roy, BS Dwarakanath |
Frontiers in Oncology | 2017 |
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Metabolomic mapping of cancer stem cells for reducing and exploiting tumor heterogeneity
E Cuyàs, S Verdura, S Fernández-Arroyo, J Bosch-Barrera, B Martin-Castillo, J Joven, JA Menendez |
Oncotarget | 2017 |
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Overexpression of ubiquitin specific proteases 44 promotes the malignancy of glioma by stabilizing tumor-promoter securin
Y Zou, G Qiu, L Jiang, Z Cai, W Sun, H Hu, C Lu, W Jin, G Hu |
Oncotarget | 2017 |
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Non-invasive urinary metabolomic profiling discriminates prostate cancer from benign prostatic hyperplasia
C Pérez-Rambla, L Puchades-Carrasco, M García-Flores, J Rubio-Briones, JA López-Guerrero, A Pineda-Lucena |
Metabolomics | 2017 |
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The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells
I Masgras, C Sanchez-Martin, G Colombo, A Rasola |
Frontiers in Oncology | 2017 |
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In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors
L Salamanca-Cardona, H Shah, AJ Poot, FM Correa, VD Gialleonardo, H Lui, VZ Miloushev, KL Granlund, SS Tee, JR Cross, CB Thompson, KR Keshari |
Cell Metabolism | 2017 |
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Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions
AV Guitart, TI Panagopoulou, A Villacreces, M Vukovic, C Sepulveda, L Allen, RN Carter, LN van de Lagemaat, M Morgan, P Giles, Z Sas, MV Gonzalez, H Lawson, J Paris, J Edwards-Hicks, K Schaak, C Subramani, D Gezer, A Armesilla-Diaz, J Wills, A Easterbrook, D Coman, CW So, D OCarroll, D Vernimmen, NP Rodrigues, PJ Pollard, NM Morton, A Finch, KR Kranc |
Journal of Experimental Medicine | 2017 |
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Utility of the succinate:fumarate ratio for assessing SDH dysfunction in different tumor types
E Kim, MJ Wright, L Sioson, T Novos, AJ Gill, DE Benn, C White, T Dwight, RJ Clifton-Bligh |
Molecular Genetics and Metabolism Reports | 2017 |
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UPLC–MS for metabolomics: a giant step forward in support of pharmaceutical research
AF Nassar, T Wu, SF Nassar, AV Wisnewski |
Drug Discovery Today | 2017 |
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Using a biologically annotated library to analyze the anticancer mechanism of serine palmitoyl transferase (SPT) inhibitors
O Sano, K Kazetani, R Adachi, O Kurasawa, T Kawamoto, H Iwata |
FEBS Open Bio | 2017 |
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Cerebral Gluconeogenesis and Diseases
J Yip, X Geng, J Shen, Y Ding |
Frontiers in pharmacology | 2017 |
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NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells
C Bernacchioni, V Ghini, F Cencetti, L Japtok, C Donati, P Bruni, P Turano |
Molecular Oncology | 2017 |
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PPA1 regulates tumor malignant potential and clinical outcome of colon adenocarcinoma through JNK pathways
P Wang, Y Zhou, Q Mei, J Zhao, L Huang, Q Fu |
Oncotarget | 2017 |
|
Succinate: An initiator in tumorigenesis and progression
T Zhao, X Mu, Q You |
Oncotarget | 2017 |
|
Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation
X Mu, T Zhao, C Xu, W Shi, B Geng, J Shen, C Zhang, J Pan, J Yang, S Hu, Y Lv, H Wen, Q You |
Oncotarget | 2017 |
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Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism
E Cuyàs, S Fernández-Arroyo, S Verdura, RÁ García, J Stursa, L Werner, E Blanco-González, M Montes-Bayón, J Joven, B Viollet, J Neuzil, JA Menendez |
Oncogene | 2017 |
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Metabolic Alterations of Thyroid Cancer as Potential Therapeutic Targets
D Ciavardelli, M Bellomo, A Consalvo, C Crescimanno, V Vella |
BioMed Research International | 2017 |
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ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance
RR Begicevic, M Falasca |
International journal of molecular sciences | 2017 |
|
Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma
SA Byron, NL Tran, RF Halperin, JJ Phillips, JG Kuhn, JF de Groot, H Colman, KL Ligon, PY Wen, TF Cloughesy, IK Mellinghoff, NA Butowski, JW Taylor, JL Clarke, SM Chang, MS Berger, AM Molinaro, GM Maggiora, S Peng, S Nasser, WS Liang, JM Trent, ME Berens, JD Carpten, DW Craig, MD Prados |
Clinical cancer research | 2017 |
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Mitochondrial Complex II: At the Crossroads
A Bezawork-Geleta, J Rohlena, L Dong, K Pacak, J Neuzil |
Trends in Biochemical Sciences | 2017 |
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Metabolic Alterations at the Crossroad of Aging and Oncogenesis
Raffaghello L, Longo V |
International review of cell and molecular biology | 2017 |
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Systems Biology to Support Nanomaterial Grouping.
Riebeling C, Jungnickel H, Luch A, Haase A |
Advances in experimental medicine and biology | 2017 |
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Fundamentals of cancer metabolism
RJ DeBerardinis, NS Chandel |
Science Advances | 2016 |
|
Cancer metabolism: a therapeutic perspective
UE Martinez-Outschoorn, M Peiris-Pagés, RG Pestell, F Sotgia, MP Lisanti |
Nature Reviews Clinical Oncology | 2016 |
|
Emerging applications of metabolomics in drug discovery and precision medicine
DS Wishart |
Nature Reviews Drug Discovery | 2016 |
|
Cancer Metabolism: Fueling More than Just Growth
N Lee, D Kim |
Molecules and Cells | 2016 |
|
Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis
MA Kowalik, G Guzzo, A Morandi, A Perra, S Menegon, I Masgras, E Trevisan, MM Angioni, F Fornari, L Quagliata, GM Ledda-Columbano, L Gramantieri, L Terracciano, S Giordano, P Chiarugi, A Rasola, A Columbano |
Oncotarget | 2016 |
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The metabolic co-regulator PGC1α suppresses prostate cancer metastasis
V Torrano, L Valcarcel-Jimenez, AR Cortazar, X Liu, J Urosevic, M Castillo-Martin, S Fernández-Ruiz, G Morciano, A Caro-Maldonado, M Guiu, P Zúñiga-García, M Graupera, A Bellmunt, P Pandya, M Lorente, N Martín-Martín, JD Sutherland, P Sanchez-Mosquera, L Bozal-Basterra, A Zabala-Letona, A Arruabarrena-Aristorena, A Berenguer, N Embade, A Ugalde-Olano, I Lacasa-Viscasillas, A Loizaga-Iriarte, M Unda-Urzaiz, N Schultz, AM Aransay, V Sanz-Moreno, R Barrio, G Velasco, P Pinton, C Cordon-Cardo, JW Locasale, RR Gomis, A Carracedo |
Nature Cell Biology | 2016 |
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The rise of mitochondria in medicine
M Picard, DC Wallace, Y Burelle |
Mitochondrion | 2016 |
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Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells
P Viswanath, MM Chaumeil, SM Ronen |
Frontiers in Oncology | 2016 |
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IsoSeq analysis and functional annotation of the infratentorial ependymoma tumor tissue on PacBio RSII platform
N Singh, DK Sahu, R Chowdhry, A Mishra, MM Goel, M Faheem, C Srivastava, BK Ojha, DK Gupta, R Kant |
Meta Gene | 2016 |
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Oncometabolic Nuclear Reprogramming of Cancer Stemness
JA Menendez, B Corominas-Faja, E Cuyàs, MG García, S Fernández-Arroyo, AF Fernández, J Joven, MF Fraga, T Alarcón |
Stem Cell Reports | 2016 |
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A joint analysis of transcriptomic and metabolomic data uncovers enhanced enzyme-metabolite coupling in breast cancer
N Auslander, K Yizhak, A Weinstock, A Budhu, W Tang, XW Wang, S Ambs, E Ruppin |
Scientific Reports | 2016 |
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A Novel Malate Dehydrogenase 2 Inhibitor Suppresses Hypoxia-Inducible Factor-1 by Regulating Mitochondrial Respiration
HS Ban, X Xu, K Jang, I Kim, BK Kim, K Lee, M Won, JW Lee |
PloS one | 2016 |
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Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer
H Colvin, N Nishida, M Konno, N Haraguchi, H Takahashi, J Nishimura, T Hata, K Kawamoto, A Asai, K Tsunekuni, J Koseki, T Mizushima, T Satoh, Y Doki, M Mori, H Ishii |
Scientific Reports | 2016 |
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Metformin targets histone acetylation in cancer-prone epithelial cells
E Cuyàs, S Fernández-Arroyo, J Joven, JA Menendez |
Cell cycle (Georgetown, Tex.) | 2016 |
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The Poly (ADP-Ribose) Polymerase Inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells
VJ Bhute, Y Ma, X Bao, SP Palecek |
Scientific Reports | 2016 |
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Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein
L Jiang, A Boufersaoui, C Yang, B Ko, D Rakheja, G Guevara, Z Hu, RJ DeBerardinis |
Metabolic Engineering | 2016 |
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Intracerebral Distribution of the Oncometabolite d-2-Hydroxyglutarate in Mice Bearing Mutant Isocitrate Dehydrogenase Brain Tumors: Implications for Tumorigenesis
AJ Pickard, AS Sohn, TF Bartenstein, S He, Y Zhang, JM Gallo |
Frontiers in Oncology | 2016 |
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Pyruvate Carboxylase Is Up-Regulated in Breast Cancer and Essential to Support Growth and Invasion of MDA-MB-231 Cells
P Phannasil, C Thuwajit, M Warnnissorn, JC Wallace, MJ MacDonald, S Jitrapakdee, PK Singh |
PloS one | 2015 |
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DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells
H Kontro, G Cannino, P Rustin, E Dufour, H Kainulainen, M Salvi |
PloS one | 2015 |
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The Warburg effect: Evolving interpretations of an established concept
X Chen, Y Qian, S Wu |
Free radical biology & medicine | 2015 |
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Metabolic control of cancer cell stemness: Lessons from iPS cells
JA Menendez |
Cell cycle (Georgetown, Tex.) | 2015 |
|
Application of Metabolomics in Drug Resistant Breast Cancer Research
A Shajahan-Haq, M Cheema, R Clarke |
Metabolites | 2015 |
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Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma
JL Bayer, DR Spitz, D Christensen, ML McCormick, D Farley, K DeGeest, L Damoush, S Aust, AK Sood, SK Lutgendorf |
Brain, Behavior, and Immunity | 2015 |
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Polymorphisms in Genes of Tricarboxylic Acid Cycle Key Enzymes Are Associated with Early Recurrence of Hepatocellular Carcinoma
S Wan, Y Wu, X Zhou, Y Chen, J An, X Yu, H Zhang, H Yang, J Xing, E Villa |
PloS one | 2015 |
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Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth
AE Commandeur, AK Styer, JM Teixeira |
Human Reproduction Update | 2015 |
|
Metabolic dysregulation in monogenic disorders and cancer — finding method in madness
A Erez, RJ DeBerardinis |
Nature Reviews Cancer | 2015 |
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2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process
A Salminen, A Kauppinen, K Kaarniranta |
Cellular and Molecular Life Sciences | 2015 |
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Modifying the maker: Oxygenases target ribosome biology
Q Zhuang, T Feng, ML Coleman |
Translation | 2015 |
|
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
PC Ho, JD Bihuniak, AN Macintyre, M Staron, X Liu, R Amezquita, YC Tsui, G Cui, G Micevic, JC Perales, SH Kleinstein, ED Abel, KL Insogna, S Feske, JW Locasale, MW Bosenberg, JC Rathmell, SM Kaech |
Cell | 2015 |
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Genetic variations in genes of metabolic enzymes predict postoperational prognosis of patients with colorectal cancer
G Dong, X He, Y Chen, H Cao, J Wang, X Liu, S Wang, S Wan, J Xing |
Molecular Cancer | 2015 |
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SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery
N Saxena, N Maio, DR Crooks, CJ Ricketts, Y Yang, MH Wei, TW Fan, AN Lane, C Sourbier, A Singh, JK Killian, PS Meltzer, CD Vocke, TA Rouault, WM Linehan |
JNCI Journal of the National Cancer Institute | 2015 |
|
Evidence that 2-hydroxyglutarate is not readily metabolized in colorectal carcinoma cells
SJ Gelman, NG Mahieu, K Cho, EM Llufrio, TA Wencewicz, GJ Patti |
Cancer & Metabolism | 2015 |
|
Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism
C Lussey-Lepoutre, KE Hollinshead, C Ludwig, M Menara, A Morin, LJ Castro-Vega, SJ Parker, M Janin, C Martinelli, C Ottolenghi, C Metallo, AP Gimenez-Roqueplo, J Favier, DA Tennant |
Nature Communications | 2015 |
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Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial
DB Liesenfeld, A Botma, N Habermann, R Toth, C Weigel, O Popanda, KD Klika, JD Potter, JW Lampe, CM Ulrich |
Cancer epidemiology, biomarkers & prevention | 2015 |
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Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype
Cuyàs E, Fernández-Arroyo S, Corominas-Faja B, Rodríguez-Gallego E, Bosch-Barrera J, Martin-Castillo B, De Llorens R, Joven J, Menendez JA |
Oncotarget | 2015 |
|
Modeling cancer metabolism on a genome scale.
Yizhak K, Chaneton B, Gottlieb E, Ruppin E |
Molecular Systems Biology | 2015 |
|
Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro
Zhong Y, Li X, Yu D, Li X, Li Y, Long Y, Yuan Y, Ji Z, Zhang M, Wen JG, Nesland JM, Suo Z |
Oncotarget | 2015 |
|
Heterogeneity of glycolysis in cancers and therapeutic opportunities
MO Warmoes, JW Locasale |
Biochemical Pharmacology | 2014 |
|
Metabostemness: A New Cancer Hallmark
JA Menendez, Tà Alarcón |
Frontiers in Oncology | 2014 |
|
Metabolic Profiling Reveals PAFAH1B3 as a Critical Driver of Breast Cancer Pathogenicity
MM Mulvihill, DI Benjamin, X Ji, E Le Scolan, SM Louie, A Shieh, MK Green, T Narasimhalu, PJ Morris, K Luo, DK Nomura |
Chemistry & Biology | 2014 |
|
Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism
P Pollard, M Yang, H Su, T Soga, K Kranc |
Hypoxia | 2014 |
|
Mitochondria and cancer
NS Chandel |
Cancer & Metabolism | 2014 |
|
Targeting mitochondria metabolism for cancer therapy
SE Weinberg, NS Chandel |
Nature Chemical Biology | 2014 |
|
Gerometabolites: The pseudohypoxic aging side of cancer oncometabolites
JA Menendez, T Alarcón, J Joven |
Cell cycle (Georgetown, Tex.) | 2014 |
|
The role of 5-hydroxymethylcytosine in human cancer
GP Pfeifer, W Xiong, MA Hahn, SG Jin |
Cell and Tissue Research | 2014 |
|
Modulating carnitine levels by targeting its biosynthesis – selective inhibition of γ-butyrobetaine hydroxylase
AM Rydzik, R Chowdhury, GT Kochan, ST Williams, MA McDonough, A Kawamura, CJ Schofield |
Chemical Science | 2014 |
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T3DB: the toxic exposome database
D Wishart, D Arndt, A Pon, T Sajed, AC Guo, Y Djoumbou, C Knox, M Wilson, Y Liang, J Grant, Y Liu, SA Goldansaz, SM Rappaport |
Nucleic Acids Research | 2014 |
|
The Succinated Proteome of FH-Mutant Tumours
M Yang, N Ternette, H Su, R Dabiri, B Kessler, J Adam, B Teh, P Pollard |
Metabolites | 2014 |
|
Structures of Human ALKBH5 Demethylase Reveal a Unique Binding Mode for Specific Single-stranded N 6 -Methyladenosine RNA Demethylation
C Xu, K Liu, W Tempel, M Demetriades, WS Aik, CJ Schofield, J Min |
The Journal of biological chemistry | 2014 |
|
Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells
A Rasola, L Neckers, D Picard |
Trends in Cell Biology | 2014 |
|
Metabostemness: Metaboloepigenetic reprogramming of cancer stem-cell functions
Menendez JA, Corominas-Faja B, Cuyàs E, Alarcón T |
Oncoscience | 2014 |
|
Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells.
Guzzo G, Sciacovelli M, Bernardi P, Rasola A |
Oncotarget | 2014 |
|
Exploiting tumor metabolism: challenges for clinical translation
Matthew Vander Heiden |
Journal of Clinical Investigation | 2013 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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