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Citations to this article

Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity
Margaret E. Ackerman, … , Chris Scanlan, Galit Alter
Margaret E. Ackerman, … , Chris Scanlan, Galit Alter
Published April 8, 2013
Citation Information: J Clin Invest. 2013;123(5):2183-2192. https://doi.org/10.1172/JCI65708.
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Research Article Immunology Article has an altmetric score of 29

Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity

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Abstract

While the induction of a neutralizing antibody response against HIV remains a daunting goal, data from both natural infection and vaccine-induced immune responses suggest that it may be possible to induce antibodies with enhanced Fc effector activity and improved antiviral control via vaccination. However, the specific features of naturally induced HIV-specific antibodies that allow for the potent recruitment of antiviral activity and the means by which these functions are regulated are poorly defined. Because antibody effector functions are critically dependent on antibody Fc domain glycosylation, we aimed to define the natural glycoforms associated with robust Fc-mediated antiviral activity. We demonstrate that spontaneous control of HIV and improved antiviral activity are associated with a dramatic shift in the global antibody-glycosylation profile toward agalactosylated glycoforms. HIV-specific antibodies exhibited an even greater frequency of agalactosylated, afucosylated, and asialylated glycans. These glycoforms were associated with enhanced Fc-mediated reduction of viral replication and enhanced Fc receptor binding and were consistent with transcriptional profiling of glycosyltransferases in peripheral B cells. These data suggest that B cell programs tune antibody glycosylation actively in an antigen-specific manner, potentially contributing to antiviral control during HIV infection.

Authors

Margaret E. Ackerman, Max Crispin, Xiaojie Yu, Kavitha Baruah, Austin W. Boesch, David J. Harvey, Anne-Sophie Dugast, Erin L. Heizen, Altan Ercan, Ickwon Choi, Hendrik Streeck, Peter A. Nigrovic, Chris Bailey-Kellogg, Chris Scanlan, Galit Alter

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2009 Total
Citations: 7 22 16 26 26 18 20 22 18 18 19 12 12 1 237
Citation information
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Citations to this article in year 2019 (20)

Title and authors Publication Year
Breaking the Glyco-Code of HIV Persistence and Immunopathogenesis
F Colomb, LB Giron, I Trbojevic-Akmacic, G Lauc, M Abdel-Mohsen
Current HIV/AIDS Reports 2019
Fc Mediated Activity of Antibodies: Structural and Functional Diversity
JV Ravetch, F Nimmerjahn
2019
An Inflammatory Story: Antibodies in Tuberculosis Comorbidities
MR McLean, LL Lu, SJ Kent, AW Chung
Frontiers in immunology 2019
Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses
MZ Tay, K Wiehe, J Pollara
Frontiers in immunology 2019
Extra-Neutralizing FcR-Mediated Antibody Functions for a Universal Influenza Vaccine
CM Boudreau, G Alter
Frontiers in immunology 2019
Multi-isotype Glycoproteomic Characterization of Serum Antibody Heavy Chains Reveals Isotype- and Subclass-Specific N -Glycosylation Profiles
KB Chandler, N Mehta, DR Leon, TJ Suscovich, G Alter, CE Costello
Molecular & cellular proteomics : MCP 2019
The Antibodiome—Mapping the Humoral Immune Response to HIV
AL Butler, S Fischinger, G Alter
Current HIV/AIDS Reports 2019
TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes
MH Schleimann, ML Kobberø, LK Vibholm, K Kjær, LB Giron, K Busman-Sahay, CN Chan, M Nekorchuk, M Schmidt, B Wittig, TE Damsgaard, P Ahlburg, MB Hellfritzsch, K Zuwala, FH Rothemejer, R Olesen, P Schommers, F Klein, H Dweep, A Kossenkov, JR Nyengaard, JD Estes, M Abdel-Mohsen, L Østergaard, M Tolstrup, OS Søgaard, PW Denton
EBioMedicine 2019
Response to immune complex vaccine in chronic hepatitis B patients is associated with lower baseline level of serum IgG galactosylation:
J Han, GZ Gong, JH Lei, WJ Qin, RH Qin, XY Wang, JX Gu, SF Ren, YM Wen
Medicine 2019
Streptococcus pyogenes evades adaptive immunity through specific IgG glycan hydrolysis
A Naegeli, E Bratanis, C Karlsson, O Shannon, R Kalluru, A Linder, J Malmström, M Collin
Journal of Experimental Medicine 2019
Multiple viral proteins and immune response pathways act to generate robust long-term immunity in Sudan virus survivors
A Sobarzo, SW Stonier, O Radinsky, S Gelkop, AI Kuehne, A Edri, AS Herbert, S Fedida-Metula, JJ Lutwama, V Yavelsky, C Davis, A Porgador, JM Dye, L Lobel
EBioMedicine 2019
Fc gamma receptor polymorphisms modulated the vaccine effect on HIV-1 risk in the HVTN 505 HIV vaccine trial
SS Li, PB Gilbert, LN Carpp, CW Pyo, H Janes, Y Fong, X Shen, SD Neidich, D Goodman, A deCamp, KW Cohen, G Ferrari, SM Hammer, ME Sobieszczyk, MJ Mulligan, SP Buchbinder, MC Keefer, E DeJesus, RM Novak, I Frank, MJ McElrath, GD Tomaras, DE Geraghty, X Peng
Journal of virology 2019
Understudied Factors Influencing Fc-Mediated Immune Responses against Viral Infections
SP Anand, A Finzi
Human vaccines 2019
IgG Fc glycosylation as an axis of humoral immunity in childhood
HD Cheng, I Tirosh, N de Haan, H Stöckmann, B Adamczyk, CA McManus, R OFlaherty, G Greville, R Saldova, F Bonilla, LD Notarangelo, GJ Driessen, IA Holm, PM Rudd, M Wuhrer, ME Ackerman, PA Nigrovic
Journal of Allergy and Clinical Immunology 2019
Primary Human Natural Killer Cells Retain Proinflammatory IgG1 at the Cell Surface and Express CD16a Glycoforms with Donor-dependent Variability
KR Patel, JD Nott, AW Barb
Molecular & cellular proteomics : MCP 2019
A MUC16 IgG Binding Activity Selects for a Restricted Subset of IgG Enriched for Certain Simian Immunodeficiency Virus Epitope Specificities
JR Schneider, X Shen, C Orlandi, T Nyanhete, S Sawant, AM Carias, AD Smith, NL Kelleher, RS Veazey, GK Lewis, GD Tomaras, TJ Hope, G Silvestri
Journal of virology 2019
Update on Fc-Mediated Antibody Functions Against HIV-1 Beyond Neutralization
B Su, S Dispinseri, V Iannone, T Zhang, H Wu, R Carapito, S Bahram, G Scarlatti, C Moog
Frontiers in immunology 2019
Longitudinal Antibody Responses in People Who Inject Drugs Infected With Similar Human Immunodeficiency Virus Strains
AD Redd, NA Doria-Rose, JA Weiner, M Nason, M Seivers, SD Schmidt, O Laeyendecker, C Martens, D Bruno, BF Keele, N Raju, IS Georgiev, SL Lamers, J Astemborski, GD Kirk, JR Mascola, ME Ackerman, SH Mehta, TC Quinn
The Journal of Infectious Diseases 2019
Engineering the interactions between a plant‐produced HIV antibody and human Fc receptors
S Stelter, MJ Paul, AY Teh, M Grandits, F Altmann, J Vanier, M Bardor, A Castilho, RL Allen, JK Ma
Plant Biotechnology Journal 2019
Monitoring of immunoglobulin N- and O-glycosylation in health and disease
N de Haan, D Falck, M Wuhrer
Glycobiology 2019

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