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Citations to this article

Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis
Keqiang Chen, … , Philip M. Murphy, Ji Ming Wang
Keqiang Chen, … , Philip M. Murphy, Ji Ming Wang
Published March 1, 2013
Citation Information: J Clin Invest. 2013;123(4):1694-1704. https://doi.org/10.1172/JCI65569.
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Research Article Oncology Article has an altmetric score of 23

Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis

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Abstract

Commensal bacteria and their products provide beneficial effects to the mammalian gut by stimulating epithelial cell turnover and enhancing wound healing, without activating overt inflammation. We hypothesized that N-formylpeptide receptors, which bind bacterial N-formylpeptides and are expressed by intestinal epithelial cells, may contribute to these processes. Here we report that formylpeptide receptor-2 (FPR2), which we show is expressed on the apical and lateral membranes of colonic crypt epithelial cells, mediates N-formylpeptide–dependent epithelial cell proliferation and renewal. Colonic epithelial cells in FPR2-deficient mice displayed defects in commensal bacterium–dependent homeostasis as shown by the absence of responses to N-formylpeptide stimulation, shortened colonic crypts, reduced acute inflammatory responses to dextran sulfate sodium (DSS) challenge, delayed mucosal restoration after injury, and increased azoxymethane-induced tumorigenesis. These results indicate that FPR2 is critical in mediating homeostasis, inflammation, and epithelial repair processes in the colon.

Authors

Keqiang Chen, Mingyong Liu, Ying Liu, Teizo Yoshimura, Wei Shen, Yingying Le, Scott Durum, Wanghua Gong, Chunyan Wang, Ji-Liang Gao, Philip M. Murphy, Ji Ming Wang

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Total citations by year

Year: 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2009 Total
Citations: 6 7 10 8 6 4 6 2 4 8 3 1 65
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2018 (4)

Title and authors Publication Year
Peptide Hp(2–20) accelerates healing of TNBS-induced colitis in the rat
AG Gravina, N Prevete, C Tuccillo, CD Musis, L Romano, A Federico, A de Paulis, G DArgenio, M Romano
United European gastroenterology journal 2018
Deficiency in Fpr2 results in reduced numbers of Lin − cKit + Sca1 + myeloid progenitor cells
K Chen, VK Singh, P Tang, Z Bao, T He, Y Xiang, W Gong, T Yoshimura, Y Le, L Tessarollo, X Chen, JM Wang
The Journal of biological chemistry 2018
The Antimicrobial Peptide CRAMP Is Essential for Colon Homeostasis by Maintaining Microbiota Balance
T Yoshimura, MH McLean, AK Dzutsev, X Yao, K Chen, J Huang, W Gong, J Zhou, Y Xiang, JH Badger, C O'hUigin, V Thovarai, L Tessarollo, SK Durum, G Trinchieri, X Bian, JM Wang
Journal of immunology (Baltimore, Md. : 1950) 2018
Copper regulates the interactions of antimicrobial piscidin peptides from fish mast cells with formyl peptide receptors and heparin
SY Kim, F Zhang, W Gong, K Chen, K Xia, F Liu, R Gross, JM Wang, RJ Linhardt, ML Cotten
The Journal of biological chemistry 2018

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