In influenza virus infection, antibodies, memory CD8+ T cells, and CD4+ T cells have all been shown to mediate immune protection, but how they operate and interact with one another to mediate efficient immune responses against virus infection is not well understood. In this issue of the JCI, McKinstry et al. have identified unique functions of memory CD4+ T cells beyond providing “help” for B cell and CD8+ T cell responses during influenza virus infection.
Kobporn Boonnak, Kanta Subbarao
Title and authors | Publication | Year |
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Surface expression of the hRSV nucleoprotein impairs immunological synapse formation with T cells
PF Céspedes, SM Bueno, BA Ramírez, RS Gomez, SA Riquelme, CE Palavecino, JP Mackern-Oberti, JE Mora, D Depoil, C Sacristán, M Cammer, A Creneguy, TH Nguyen, CA Riedel, ML Dustin, AM Kalergis |
Proceedings of the National Academy of Sciences | 2014 |
Intranasal Delivery of Influenza rNP Adjuvanted with c-di-AMP Induces Strong Humoral and Cellular Immune Responses and Provides Protection against Virus Challenge
MV Sanchez, T Ebensen, K Schulze, D Cargnelutti, P Blazejewska, EA Scodeller, CA Guzmán |
PloS one | 2014 |