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Citations to this article

Transepithelial migration of neutrophils into the lung requires TREM-1
Julia Klesney-Tait, … , Joseph Zabner, Marco Colonna
Julia Klesney-Tait, … , Joseph Zabner, Marco Colonna
Published December 17, 2012
Citation Information: J Clin Invest. 2013;123(1):138-149. https://doi.org/10.1172/JCI64181.
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Research Article Immunology Article has an altmetric score of 17

Transepithelial migration of neutrophils into the lung requires TREM-1

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Abstract

Acute respiratory infections are responsible for more than 4 million deaths each year. Neutrophils play an essential role in the innate immune response to lung infection. These cells have an armamentarium of pattern recognition molecules and antimicrobial agents that identify and eliminate pathogens. In the setting of infection, neutrophil triggering receptor expressed on myeloid cells 1 (TREM-1) amplifies inflammatory signaling. Here we demonstrate for the first time that TREM-1 also plays an important role in transepithelial migration of neutrophils into the airspace. We developed a TREM-1/3–deficient mouse model of pneumonia and found that absence of TREM-1/3 markedly increased mortality following Pseudomonas aeruginosa challenge. Unexpectedly, TREM-1/3 deficiency resulted in increased local and systemic cytokine production. TREM-1/3–deficient neutrophils demonstrated intact bacterial killing, phagocytosis, and chemotaxis; however, histologic examination of TREM-1/3–deficient lungs revealed decreased neutrophil infiltration of the airways. TREM-1/3–deficient neutrophils effectively migrated across primary endothelial cell monolayers but failed to migrate across primary airway epithelia grown at the air-liquid interface. These data define a new function for TREM-1 in neutrophil migration across airway epithelial cells and suggest that it amplifies inflammation through targeted neutrophil migration into the lung.

Authors

Julia Klesney-Tait, Kathy Keck, Xiaopeng Li, Susan Gilfillan, Karel Otero, Sankar Baruah, David K. Meyerholz, Steven M. Varga, Cory J. Knudson, Thomas O. Moninger, Jessica Moreland, Joseph Zabner, Marco Colonna

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2009 Total
Citations: 1 7 3 6 8 1 8 6 8 10 15 8 6 1 88
Citation information
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Citations to this article in year 2018 (6)

Title and authors Publication Year
The innate immune receptor TREM-1 promotes liver injury and fibrosis
Anh Thu Nguyen-Lefebvre, Ashwin Ajith, Vera Portik-Dobos, Daniel Horuzsko, Ali Arbab, Amiran Dzutsev, Ramses Sadek, Giorgio Trinchieri, Anatolij Horuzsko
Journal of Clinical Investigation 2018
Translational Medicine in Pulmonary-Renal Crosstalk: Therapeutic Targeting of p-Cresyl Sulfate Triggered Nonspecific ROS and Chemoattractants in Dyspneic Patients with Uremic Lung Injury
JF Chang, SS Liang, P Thanasekaran, HW Chang, LL Wen, CH Chen, JC Liou, JC Yeh, SH Liu, HM Dai, WN Lin
Journal of Clinical Medicine 2018
Triggering Receptor Expressed on Myeloid Cells-1 Signaling: Protective and Pathogenic Roles on Streptococcal Toxic-Shock-Like Syndrome Caused by Streptococcus suis
L Han, L Fu, Y Peng, A Zhang
Frontiers in immunology 2018
Assessment of Serum sTREM-1 as a Marker of Subclinical Inflammation in Diarrhea-Predominant Patients with Irritable Bowel Syndrome
C Du, L Peng, G Kou, P Wang, L Lu, Y Li
Digestive Diseases and Sciences 2018
A first-in-man safety and pharmacokinetics study of nangibotide, a new modulator of innate immune response through TREM-1 receptor inhibition: Safety and pharmacokinetics of the TREM-1 inhibitor, nangibotide
V Cuvier, U Lorch, S Witte, A Olivier, S Gibot, I Delor, JJ Garaud, M Derive, M Salcedo-Magguilli
British Journal of Clinical Pharmacology 2018
Repetitive Exposure of IL-17 Into the Murine Air Pouch Favors the Recruitment of Inflammatory Monocytes and the Release of IL-16 and TREM-1 in the Inflammatory Fluids
F Maione, AJ Iqbal, F Raucci, M Letek, M Bauer, F D'Acquisto
Frontiers in immunology 2018

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