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Ana Bratic, Nils-Göran Larsson
Published March 1, 2013
Citation Information: J Clin Invest. 2013;123(3):951-957. https://doi.org/10.1172/JCI64125.
Citation Information: J Clin Invest. 2013;123(3):951-957. https://doi.org/10.1172/JCI64125.
Abstract
Over the last decade, accumulating evidence has suggested a causative link between mitochondrial dysfunction and major phenotypes associated with aging. Somatic mitochondrial DNA (mtDNA) mutations and respiratory chain dysfunction accompany normal aging, but the first direct experimental evidence that increased mtDNA mutation levels contribute to progeroid phenotypes came from the mtDNA mutator mouse. Recent evidence suggests that increases in aging-associated mtDNA mutations are not caused by damage accumulation, but rather are due to clonal expansion of mtDNA replication errors that occur during development. Here we discuss the caveats of the traditional mitochondrial free radical theory of aging and highlight other possible mechanisms, including insulin/IGF-1 signaling (IIS) and the target of rapamycin pathways, that underlie the central role of mitochondria in the aging process.
Authors
Ana Bratic, Nils-Göran Larsson
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Yang M, Luo S, Chen W, He L, Liu D, Wang X, Xiao L, Sun L |
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Bonetto V, Ferraresi A, Sampò S, Isidoro C |
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|
Beneficial Effects of Low-Grade Mitochondrial Stress on Metabolic Diseases and Aging
Min SH, Kang GM, Park JW, Kim MS |
Yonsei Medical Journal | 2024 |
|
Mitochondrial function in peripheral blood cells across the human lifespan.
Ehinger JK, Westerlund E, Frostner EÅ, Karlsson M, Paul G, Sjövall F, Elmér E |
2024 | |
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Mourokh L, Friedman J |
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He W, Liu X, Feng Y, Ding H, Sun H, Li Z, Shi B |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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Wang Q, Yuan Y, Liu J, Li C, Jiang X |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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San-Millán I |
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|
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|
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Ravenhill SM, Evans AH, Crewther SG |
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|
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|
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Shavit M, Iniesta-Cuerda M, Nevoral J |
2023 | |
|
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Vue Z, Vang C, Neikirk K, Garza-Lopez E, Shao JQ, Mungai M, Vang L, Beasley H, Marshall AG, Crabtree A, Stephens D, McReynolds M, Murray SA, Katti P, Damo S, Gaddy JA, Hinton A Jr |
2023 | |
|
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Ragni M, Fenaroli F, Ruocco C, Segala A, D\u2019Antona G, Nisoli E, Valerio A |
Frontiers in neuroscience | 2023 |
|
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Machihara K, Oki S, Maejima Y, Kageyama S, Onda A, Koseki Y, Imai Y, Namba T |
iScience | 2023 |
|
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Li Z, Zhang K, Zhou Y, Zhao J, Wang J, Lu W |
Molecules (Basel, Switzerland) | 2023 |
|
Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca(2+) overload in Caenorhabditis elegans.
Wu X, Seida M, Abe T, Higashitani A |
2023 | |
|
Hepatic protein kinase Cbeta deficiency mitigates late-onset obesity
Shu Y, Gumma N, Hassan F, Branch DA, Baer LA, Ostrowski MC, Stanford KI, Baskin KK, Mehta KD |
The Journal of biological chemistry | 2023 |
|
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Rosoff DB, Mavromatis LA, Bell AS, Wagner J, Jung J, Marioni RE, Davey Smith G, Horvath S, Lohoff FW |
2023 | |
|
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Napolitano G, Fasciolo G, Muscari Tomajoli MT, Venditti P |
International journal of molecular sciences | 2023 |
|
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Crabtree A, Neikirk K, Marshall AG, Vang L, Whiteside AJ, Williams Q, Altamura CT, Owens TC, Stephens D, Shao B, Koh A, Killion M, Lopez EG, Lam J, Rodriguez B, Mungai M, Stanley J, Dean ED, Koh HJ, Gaddy JA, Scudese E, Sweetwyne M, Davis J, Zaganjor E, Murray SA, Katti P, Damo SM, Vue Z, Hinton A Jr |
2023 | |
|
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Song S, Satta S, Sharma MB, Hugo C, Kossyvakis A, Sen Roy S, Kelesidis T |
The Journal of Infectious Diseases | 2023 |
|
Mechanisms of Extraorbital Lacrimal Gland Aging in Mice: An Integrative Analysis of the Temporal Transcriptome
Liu J, Si H, Huang D, Lu D, Zou S, Qi D, Pei X, Huang S, Li Z |
Investigative ophthalmology & visual science | 2023 |
|
Mitophagy in renal interstitial fibrosis.
Sun J, Liu C, Liu YY, Guo ZA |
International Urology and Nephrology | 2023 |
|
The Role of Mitochondrial Dysfunction in Idiopathic Pulmonary Fibrosis: New Perspectives for a Challenging Disease
Cala-Garcia JD, Medina-Rincon GJ, Sierra-Salas PA, Rojano J, Romero F |
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|
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Lomas-Soria C, Rodríguez-González GL, Ibáñez CA, Reyes-Castro LA, Nathanielsz PW, Zambrano E |
Biology | 2023 |
|
Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways
Flowers S, Kothari R, Torres Cleuren YN, Alcorn MR, Ewe CK, Alok G, Fiallo SL, Joshi PM, Rothman JH |
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|
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|
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Wang H, Lu J, Stevens T, Roberts A, Mandel J, Avula R, Ma B, Wu Y, Wang J, Van\u2019t Land C, Finkel T, Vockley JE, Airik M, Airik R, Muzumdar R, Gong Z, Torbenson MS, Prochownik EV |
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|
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Song H, Zhang X, Wang J, Wu Y, Xiong T, Shen J, Lin R, Xiao T, Lin W |
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|
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Parkhitko AA, Filine E, Tatar M |
2023 | |
|
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Feng S, Yang M, Liu S, He Y, Deng S, Gong Y |
2023 | |
|
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Goodman C, Podolsky RH, Childers KL, Roberts R, Katz R, Waseem R, Paruchuri A, Stanek J, Berkowitz BA |
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|
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|
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Cai L, Shi L, Peng Z, Sun Y, Chen J |
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|
Failure to repair endogenous DNA damage in β-cells causes adult-onset diabetes in mice.
Yousefzadeh MJ, Huerta Guevara AP, Postmus AC, Flores RR, Sano T, Jurdzinski A, Angelini L, McGowan SJ, O'Kelly RD, Wade EA, Gonzalez-Espada LV, Henessy-Wack D, Howard S, Rozgaja TA, Trussoni CE, LaRusso NF, Eggen BJL, Jonker JW, Robbins PD, Niedernhofer LJ, Kruit JK |
2023 | |
|
3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights into MFN-2 Mediated Changes.
Scudese E, Vue Z, Katti P, Marshall A, Vang L, Garza López E, Neikirk K, Stephens D, Hall DD, Rostami R, Shao JQ, Mungai M, AshShareef ST, Hicsasmaz I, Manus S, Wanjalla C, Whiteside A, Williams C, Damo SM, Gaddy JA, Kirabo A, Glancy B, Dantas EHM, Kinder A, Scartoni F, Baffi M, McReynolds MR, Phillips MA, Cooper A, Murray SA, Exil V, Mobley BC, Hinton A |
bioRxiv : the preprint server for biology | 2023 |
|
Complex II ambiguities—FADH2 in the electron transfer system
Gnaiger E |
The Journal of biological chemistry | 2023 |
|
Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives
Kal S, Mahata S, Jati S, Mahata SK |
Peptides | 2023 |
|
Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue
Crabtree A, Neikirk K, Marshall AG, Vang L, Whiteside AJ, Williams Q, Altamura CT, Owens TC, Stephens D, Shao B, Koh A, Killion M, Lopez EG, Lam J, Rodriguez B, Mungai M, Stanley J, Dean ED, Koh HJ, Gaddy JA, Scudese E, Sweetwyne MT, Davis J, Zaganjor E, Murray SA, Katti P, Damo SM, Vue Z, Hinton A Jr |
2023 | |
|
How soon do metabolic alterations and oxidative distress precede the reduction of muscle mass and strength in Wistar rats in aging process?
Lima MCAM, Zazula MF, Martins LF, Carvalhal SR, Guimarães ATB, Fernandes LC, Naliwaiko K |
Biogerontology | 2023 |
|
In pre-clinical study fetal hypoxia caused autophagy and mitochondrial impairment in ovary granulosa cells mitigated by melatonin supplement.
Zhang L, Liu K, Liu Z, Tao H, Fu X, Hou J, Jia G, Hou Y |
Journal of advanced research | 2023 |
|
Connecting Aging Biology and Inflammation in the Omics Era
Keenan A Walker, Nathan Basisty, David M Wilson, III, Luigi Ferrucci |
Journal of Clinical Investigation | 2022 |
|
Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice
E Vacurova, J Trnovska, P Svoboda, V Skop, V Novosadova, D Reguera, S Petrezselyová, B Piavaux, B Endaya, F Spoutil, D Zudova, J Stursa, M Melcova, Z Bielcikova, L Werner, J Prochazka, R Sedlacek, M Huttl, S Hubackova, M Haluzik, J Neuzil |
Nature Communications | 2022 |
|
Endoplasmic Reticulum (ER) Stress and Its Role in Pancreatic β-Cell Dysfunction and Senescence in Type 2 Diabetes
J Lee, J Lee |
International journal of molecular sciences | 2022 |
|
Physical activity and COVID-19. The basis for an efficient intervention in times of COVID-19 pandemic
VJ Clemente-Suárez, AI Beltrán-Velasco, DJ Ramos-Campo, J Mielgo-Ayuso, PA Nikolaidis, N Belando, JF Tornero-Aguilera |
Physiology & Behavior | 2022 |
|
Dietary Phytochemicals that Can Extend Longevity by Regulation of Metabolism
J Shen, J Shan, L Zhong, B Liang, D Zhang, M Li, H Tang |
Plant Foods for Human Nutrition | 2022 |
|
Sex‐ and strain‐specific effects of mitochondrial uncoupling on age‐related metabolic diseases in high‐fat diet‐fed mice
L Goedeke, K Murt, A Francesco, J Camporez, A Nasiri, Y Wang, X Zhang, G Cline, R de Cabo, G Shulman |
Aging Cell | 2022 |
|
Targeting regulation of ATP synthase 5 alpha/beta dimerization alleviates senescence
Y Lee, D Choi, G Jang, J Park, E Song, H Lee, M Kuk, J Joo, S Ahn, Y Byun, J Park |
Aging | 2022 |
|
Experimental demonstration of prenatal programming of mitochondrial aerobic metabolism lasting until adulthood
A Stier, P Monaghan, N Metcalfe |
Proceedings of the Royal Society B: Biological Sciences | 2022 |
|
Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer’s Disease
B León, S Kang, G Franca-Solomon, P Shang, D Choi |
Frontiers in behavioral neuroscience | 2022 |
|
Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro
Yue X, Liu SL, Guo JN, Meng TG, Zhang XR, Li HX, Song CY, Wang ZB, Schatten H, Sun QY, Guo XP |
Aging | 2022 |
|
Mitochondrial Reactive Oxygen Species Elicit Acute and Chronic Itch via Transient Receptor Potential Canonical 3 Activation in Mice
Kim SA, Jang JH, Kim W, Lee PR, Kim YH, Vang H, Lee K, Oh SB |
Neuroscience Bulletin | 2022 |
|
Effect of Long-Term Supplementation with Acetic Acid on the Skeletal Muscle of Aging Sprague Dawley Rats
Maruta H, Abe R, Yamashita H |
International journal of molecular sciences | 2022 |
|
Accelerated Cardiac Aging in Patients With Congenital Heart Disease
Iacobazzi D, Alvino VV, Caputo M, Madeddu P |
Frontiers in Cardiovascular Medicine | 2022 |
|
SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice
Soares RN, Ramirez-Perez FI, Cabral-Amador FJ, Morales-Quinones M, Foote CA, Ghiarone T, Sharma N, Power G, Smith JA, Rector RS, Martinez-Lemus LA, Padilla J, Manrique-Acevedo C |
GeroScience | 2022 |
|
The impact of dietary calcium and phosphorus on mitochondrial-linked gene expression in five tissues of laying hens
Dreyling C, Hasselmann M |
PloS one | 2022 |
|
Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives
Hajam YA, Rani R, Ganie SY, Sheikh TA, Javaid D, Qadri SS, Pramodh S, Alsulimani A, Alkhanani MF, Harakeh S, Hussain A, Haque S, Reshi MS |
Cells | 2022 |
|
Loss of legumain induces premature senescence and mediates aging‐related renal fibrosis
Wang D, Kang L, Chen C, Guo J, Du L, Zhou D, Li G, Zhang Y, Mi X, Zhang M, Liu S, Tan X |
Aging Cell | 2022 |
|
Accurate Proteomewide Measurement of Methionine Oxidation in Aging Mouse Brains
Bettinger JQ, Simon M, Korotkov A, Welle KA, Hryhorenko JR, Seluanov A, Gorbunova V, Ghaemmaghami S |
Journal of Proteome Research | 2022 |
|
Treatment of age-related visual impairment with a peptide acting on mitochondria
Alam NM, Douglas RM, Prusky GT |
Disease models & mechanisms | 2022 |
|
Biochemical clusters predict mortality and reported inability to work 10 years later
Bertele N, Karabatsiakis A, Talmon A, Buss C |
2022 | |
|
Mitochondrial dysfunction in mandibular hypoplasia, deafness and progeroid features with concomitant lipodystrophy (MDPL) patients
Murdocca M, Spitalieri P, Cappello A, Colasuonno F, Moreno S, Candi E, D'Apice MR, Novelli G, Sangiuolo F |
Aging | 2022 |
|
Urolithin A attenuates auditory cell senescence by activating mitophagy
Cho SI, Jo ER, Song H |
Scientific Reports | 2022 |
|
Dietary Supplements and Natural Products: An Update on Their Clinical Effectiveness and Molecular Mechanisms of Action During Accelerated Biological Aging
Chen Y, Hamidu S, Yang X, Yan Y, Wang Q, Li L, Oduro PK, Li Y |
Frontiers in Genetics | 2022 |
|
An extract of Rosaceae, Solanaceae and Zingiberaceae increases health span and mobility in Caenorhabditis elegans
Hughes S, Kolsters N, van de Klashorst D, Kreuter E, Berger Büter K |
BMC Nutrition | 2022 |
|
The dynamics of mitochondrial-linked gene expression among tissues and life stages in two contrasting strains of laying hens
Dreyling C, Hasselmann M |
PloS one | 2022 |
|
Age-Related Mitochondrial Impairment and Renal Injury Is Ameliorated by Sulforaphane via Activation of Transcription Factor NRF2
Mohammad RS, Lokhandwala MF, Banday AA |
Antioxidants | 2022 |
|
Ageing induces tissue‐specific transcriptomic changes in Caenorhabditis elegans
Wang X, Jiang Q, Song Y, He Z, Zhang H, Song M, Zhang X, Dai Y, Karalay O, Dieterich C, Antebi A, Wu L, Han JJ, Shen Y |
The EMBO Journal | 2022 |
|
Transcriptomic signals of mitochondrial dysfunction and OXPHOS dynamics in fast-growth chicken.
Hubert S, Athrey G |
PeerJ | 2022 |
|
The PICLS high-throughput screening method for agents extending cellular longevity identifies 2,5-anhydro-D-mannitol as novel anti-aging compound.
Alfatah M, Eisenhaber F |
GeroScience | 2022 |
|
CUL3 and COPS5 Related to the Ubiquitin-Proteasome Pathway Are Potential Genes for Muscle Atrophy in Mice
Xu Q, Li J, Yang J, Xu Z |
Evidence-based complementary and alternative medicine : eCAM | 2022 |
|
Horizons in Human Aging Neuroscience: From Normal Neural Aging to Mental (Fr)Agility
Ridderinkhof KR, Krugers HJ |
Frontiers in human neuroscience | 2022 |
|
Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice
Yeh CH, Shen ZQ, Wang TW, Kao CH, Teng YC, Yeh TK, Lu CK, Tsai TF |
Journal of biomedical science | 2022 |
|
Activation of the Mitochondrial Unfolded Protein Response: A New Therapeutic Target?
Suárez-Rivero JM, Pastor-Maldonado CJ, Povea-Cabello S, Álvarez-Córdoba M, Villalón-García I, Talaverón-Rey M, Suárez-Carrillo A, Munuera-Cabeza M, Reche-López D, Cilleros-Holgado P, Piñero-Pérez R, Sánchez-Alcázar JA |
Biomedicines | 2022 |
|
Mechanism of Cone Degeneration in Retinitis Pigmentosa.
Song DJ, Bao XL, Fan B, Li GY |
Cellular and Molecular Neurobiology | 2022 |
|
Potential Roles of PTEN on Longevity in Two Closely Related Argopecten Scallops With Distinct Lifespans.
Xu H, Lu X, Wang C, Ning J, Chen M, Wang Y, Yuan K |
Frontiers in physiology | 2022 |
|
Regulation of the lysosome by sphingolipids: Potential role in aging
Tang H, Huang X, Pang S |
The Journal of biological chemistry | 2022 |
|
Effect of Low-Dose Persistent Organic Pollutants on Mitochondrial Function: Human and in Vitro Evidence
Kim SA, Lee H, Park SM, Kim MJ, Lee YM, Yoon YR, Lee HK, Moon HB, Lee IK, Lee DH |
Diabetes & Metabolism Journal | 2022 |
|
Downregulating Mitochondrial DNA Polymerase γ in the Muscle Stimulated Autophagy, Apoptosis, and Muscle Aging-Related Phenotypes in Drosophila Adults
Ozaki M, Le TD, Inoue YH |
Biomolecules | 2022 |
|
Mitochondrial and redox modifications in early stages of Huntington's disease
Lopes C, Ferreira IL, Maranga C, Beatriz M, Mota SI, Sereno J, Castelhano J, Abrunhosa A, Oliveira F, De Rosa M, Hayden M, Laço MN, Januário C, Castelo Branco M, Rego AC |
Redox Biology | 2022 |
|
Exercise as an Aging Mimetic: A New Perspective on the Mechanisms Behind Exercise as Preventive Medicine Against Age-Related Chronic Disease.
Lefferts WK, Davis MM, Valentine RJ |
Frontiers in physiology | 2022 |
|
GSK3 Is a Central Player in Retinal Degenerative Diseases but a Challenging Therapeutic Target
Hottin C, Perron M, Roger JE |
Cells | 2022 |
|
Premature aging is associated with higher levels of 8-oxoguanine and increased DNA damage in the Polg mutator mouse.
Yu T, Slone J, Liu W, Barnes R, Opresko PL, Wark L, Mai S, Horvath S, Huang T |
Aging Cell | 2022 |
|
Links of Cytoskeletal Integrity with Disease and Aging.
Kim YJ, Cho MJ, Yu WD, Kim MJ, Kim SY, Lee JH |
Cells | 2022 |
|
Physiological Systems in Promoting Frailty
Perazza LR, Brown-Borg HM, Thompson LV |
Comprehensive Physiology | 2022 |
|
Anti-Müllerian hormone independently affect mtDNA copy number in human granulosa cells
Bowolaksono A, Sundari AM, Fauzi M, Maidarti M, Wiweko B, Mutia K, Iffanolida PA, Febri RR, Dwiranti A, Funahashi H |
Journal of Ovarian Research | 2022 |
|
MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases
Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC |
International journal of molecular sciences | 2022 |
|
Mitophagy in the aging nervous system.
Rappe A, McWilliams TG |
Frontiers in Cell and Developmental Biology | 2022 |
|
Lotus germ extract rejuvenates aging fibroblasts via restoration of disrupted proteostasis by the induction of autophagy.
Machihara K, Kageyama S, Oki S, Makino H, Sasaki M, Iwahashi H, Namba T |
Aging | 2022 |
|
Mitochondrial toxicity evaluation of traditional Chinese medicine injections with a dual in vitro approach
Shen Y, Guo K, Ma A, Huang Z, Du J, Chen J, Lin Q, Wei C, Wang Z, Zhang F, Zhang J, Lin W, Feng N, Ma W |
Frontiers in pharmacology | 2022 |
|
Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins
Tabibzadeh S |
Aging and disease | 2022 |
|
Mitochondria and G-quadruplex evolution: An intertwined relationship
Sahayasheela VJ, Yu Z, Hidaka T, Pandian GN, Sugiyama H |
Trends in genetics : TIG | 2022 |
|
Disruption of Multiple Overlapping Functions Following Stepwise Inactivation of the Extended Myc Network
Wang H, Stevens T, Lu J, Airik M, Airik R, Prochownik EV |
Cells | 2022 |
|
Periodontitis and cognitive impairment in older adults: The mediating role of mitochondrial dysfunction.
Li A, Du M, Chen Y, Marks LAM, Visser A, Xu S, Tjakkes GE |
Journal of Periodontology | 2022 |
|
Aging Influence on Pulmonary and Systemic Inflammation and Neural Metabolomics Arising from Pulmonary Multi-walled Carbon Nanotube Exposure in Apolipoprotein E-Deficient and C57BL/6 Female Mice
Young TL, Scieszka D, Begay JG, Lucas SN, Herbert G, Zychowski K, Hunter R, Salazar R, Ottens AK, Erdely A, Gu H, Campen MJ |
Inhalation Toxicology | 2022 |
|
Mitochondria-derived small RNAs as diagnostic biomarkers in lung cancer patients through a novel ratio-based expression analysis methodology
Yu Z, Chen S, Tang Z, Tang Y, Ling Z, Wang H, Gong T, Gao Z, Devendra G, Huang G, Chen W, Deng Y |
Genes & Diseases | 2022 |
|
Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging
Mau T, Lui LY, Distefano G, Kramer PA, Ramos SV, Toledo FG, Santanasto AJ, Shankland EG, Marcinek DJ, Jurczak MJ, Sipula I, Bello FM, Duchowny KA, Molina AJ, Sparks LM, Goodpaster BH, Hepple RT, Kritchevsky SB, Newman AB, Cawthon PM, Cummings SR, Coen PM |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2022 |
|
Targeting Premature Renal Aging: from Molecular Mechanisms of Cellular Senescence to Senolytic Trials
R Franzin, A Stasi, E Ranieri, GS Netti, V Cantaluppi, L Gesualdo, G Stallone, G Castellano |
Frontiers in pharmacology | 2021 |
|
Carotenoids in the Management of Glaucoma: A Systematic Review of the Evidence
DW Lem, DL Gierhart, PG Davey |
Nutrients | 2021 |
|
A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan
I Mohammed, MD Hollenberg, H Ding, CR Triggle |
Frontiers in Endocrinology | 2021 |
|
Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer’s Disease
DP Jayatunga, E Hone, H Khaira, T Lunelli, H Singh, GJ Guillemin, B Fernando, ML Garg, G Verdile, RN Martins |
Nutrients | 2021 |
|
HIV TAT-mediated microglial senescence: Role of SIRT3-dependent mitochondrial oxidative stress
A Thangaraj, ET Chivero, A Tripathi, S Singh, F Niu, ML Guo, P Pillai, P Periyasamy, S Buch |
Redox Biology | 2021 |
|
Modulation of Autophagy: A Novel “Rejuvenation” Strategy for the Aging Liver
F Xu, HM Tautenhahn, O Dirsch, U Dahmen, MS Álvarez |
Oxidative Medicine & Cellular Longevity | 2021 |
|
Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues
R Singh, A Barrios, G Dirakvand, S Pervin |
Cells | 2021 |
|
Embryo and Its Mitochondria
P May-Panloup, M Boguenet, HE Hachem, PE Bouet, P Reynier |
Antioxidants | 2021 |
|
Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice
TD Saccon, R Nagpal, H Yadav, MB Cavalcante, AD de Carvalho Nunes, A Schneider, A Gesing, B Hughes, M Yousefzadeh, T Tchkonia, JL Kirkland, LJ Niedernhofer, PD Robbins, MM Masternak, RM Anderson |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2021 |
|
Insights into the Mitochondrial and Nuclear Genome Diversity of Two High Yielding Strains of Laying Hens
C Heumann-Kiesler, V Sommerfeld, H Iffland, J Bennewitz, M Rodehutscord, M Hasselmann |
Animals | 2021 |
|
The Impact of Vitamin D on Skin Aging
G Bocheva, RM Slominski, AT Slominski |
International journal of molecular sciences | 2021 |
|
Assessing the Potential of Nutraceuticals as Geroprotectors on Muscle Performance and Cognition in Aging Mice
Z Singlár, P Szentesi, J Fodor, Á Angyal, L Csernoch, M Sztretye |
Antioxidants | 2021 |
|
Pathogenic Mitochondrial DNA Mutation Load Inversely Correlates with Malignant Features in Familial Oncocytic Parathyroid Tumors Associated with Hyperparathyroidism-Jaw Tumor Syndrome
MD Luise, L Iommarini, L Marchio, G Tedesco, CA Coadă, A Repaci, D Turchetti, ML Tardio, N Salfi, U Pagotto, I Kurelac, AM Porcelli, G Gasparre |
Cells | 2021 |
|
Leucine augments specific skeletal muscle mitochondrial respiratory pathways during recovery following 7 days of physical inactivity in older adults
EJ Arentson-Lantz, J Mikovic, N Bhattarai, CS Fry, S Lamon, C Porter, D Paddon-Jones |
Journal of applied physiology | 2021 |
|
Role of RONS and eIFs in Cancer Progression
YA Salaheldin, SS Mahmoud, EE Ngowi, VA Gbordzor, T Li, DD Wu, XY Ji, K Singh |
Oxidative Medicine & Cellular Longevity | 2021 |
|
An In-Silico, In-Vitro and In-Vivo Combined Approach to Identify NMNATs as Potential Protein Targets of ProEGCG for Treatment of Endometriosis
SW Hung, B Liang, Y Gao, R Zhang, Z Tan, T Zhang, PW Chung, TH Chan, CC Wang |
Frontiers in pharmacology | 2021 |
|
The assembly, regulation and function of the mitochondrial respiratory chain
I Vercellino, LA Sazanov |
Nature Reviews Molecular Cell Biology | 2021 |
|
Lactate and Pyruvate Activate Autophagy and Mitophagy that Protect Cells in Toxic Model of Parkinson’s Disease
EI Fedotova, LP Dolgacheva, AY Abramov, AV Berezhnov |
Molecular Neurobiology | 2021 |
|
Deletion of Neuronal CuZnSOD Accelerates Age-Associated Muscle Mitochondria and Calcium Handling Dysfunction That Is Independent of Denervation and Precedes Sarcopenia
Y Su, DR Claflin, M Huang, CS Davis, PC Macpherson, A Richardson, HV Remmen, SV Brooks |
International journal of molecular sciences | 2021 |
|
YAF2-Mediated YY1-Sirtuin6 Interactions Responsible for Mitochondrial Downregulation in Aging Tunicates
K Kawamura, T Higuchi, S Fujiwara |
Molecular and cellular biology | 2021 |
|
Comparison of the transcriptome in circulating leukocytes in early lactation between primiparous and multiparous cows provides evidence for age-related changes
L Buggiotti, Z Cheng, M Salavati, CD Wathes, A Fahey, A Crisà, A Fouladi, A Wylie, A Vanlierde, A Fogh, A Santoro, A Cromie, AS Laere, A Pearn, A Evertson, A Laine, BS Bernardo, B Moioli, B Vanranst, C Bastin, C Gaillard, C Tan, C Elsik, C Marchitelli, C Wathes, C Grelet, C Byrne, C Ferris, D Matthews, D Triant, D Werling, E Matthews, E Meyer, E Froidmont, F Signorelli, F Carter, F Napolitano, F Kearney, F Becker, F Colinet, F Dehareng, G Conant, G Opsomer, G Pollott, G Wang, G Hua, H Bogaert, H Takeda, H Hammami, H Chen, J Vandepitte, J Rothmann, J Ettema, JD Koster, J McClure, J Taylor, J Hoglund, J Zhao, K Ingvartsen, K Hermans, L Vandevelde, L Foldager, L Yang, L Kosten, L Buttazzoni, MR Pamplona, M Crowe, M Sciarretta, M Schulze, MT Sorensen, M Bell, M McClure, M Lucy, M Salavati, M Bonneau, M Georges, M Vaneetvelde, M Hostens, M Krogh, N McLoughlin, N Gengler, P Rudd, R Mota, R OFlaherty, SN Darbagshahi, S Moerman, SP Vera, S Zhang, S Hallinan, S Ostergaard, S Dahl, T Andersen, T Rousing, T Larsen, VH de Oliveira, X Chen, Z Cheng |
BMC Genomics | 2021 |
|
Impact of Silibinin A on Bioenergetics in PC12APPsw Cells and Mitochondrial Membrane Properties in Murine Brain Mitochondria
C Esselun, B Bruns, S Hagl, R Grewal, GP Eckert |
Antioxidants | 2021 |
|
Mitochondrial links between brain aging and Alzheimer’s disease
HM Wilkins, RH Swerdlow |
Translational Neurodegeneration | 2021 |
|
Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19
C Tindle, MK Fuller, A Fonseca, S Taheri, SR Ibeawuchi, N Beutler, GD Katkar, A Claire, V Castillo, M Hernandez, H Russo, J Duran, LE Alexander, A Tipps, G Lin, PA Thistlethwaite, R Chattopadhyay, TF Rogers, D Sahoo, P Ghosh, S Das |
eLife | 2021 |
|
Aging-Related Changes in the Ultrastructure of Hepatocytes and Cardiomyocytes of Elderly Mice Are Enhanced in ApoE-Deficient Animals
M Łysek-Gładysińska, A Wieczorek, A Jóźwik, A Walaszczyk, K Jelonek, G Szczukiewicz-Markowska, OK Horbańczuk, M Pietrowska, P Widłak, D Gabryś |
Cells | 2021 |
|
Metabolic programs define dysfunctional immune responses in severe COVID-19 patients
EA Thompson, K Cascino, AA Ordonez, W Zhou, A Vaghasia, A Hamacher-Brady, NR Brady, IH Sun, R Wang, AZ Rosenberg, M Delannoy, R Rothman, K Fenstermacher, L Sauer, K Shaw-Saliba, EM Bloch, AD Redd, AA Tobian, M Horton, K Smith, A Pekosz, FR DAlessio, S Yegnasubramanian, H Ji, AL Cox, JD Powell |
Cell Reports | 2021 |
|
The multifaceted roles of DNA repair and replication proteins in aging and obesity
AM DAmico, KM Vasquez |
DNA repair | 2021 |
|
Multi-Omics Approach to Mitochondrial DNA Damage in Human Muscle Fibers
M Elstner, K Olszewski, H Prokisch, T Klopstock, M Murgia |
International journal of molecular sciences | 2021 |
|
Deubiquitinating enzyme USP30 negatively regulates mitophagy and accelerates myocardial cell senescence through antagonism of Parkin
W Pan, Y Wang, X Bai, Y Yin, L Dai, H Zhou, Q Wu, Y Wang |
Cell Death Discovery | 2021 |
|
Self‐assembly of multi‐component mitochondrial nucleoids via phase separation
M Feric, TG Demarest, J Tian, DL Croteau, VA Bohr, T Misteli |
The EMBO Journal | 2021 |
|
Sleep Disorders in Mitochondrial Diseases
V Brunetti, GD Marca, S Servidei, G Primiano |
Current Neurology and Neuroscience Reports | 2021 |
|
Evidence of two deeply divergent co-existing mitochondrial genomes in the Tuatara reveals an extremely complex genomic organization
JR Macey, S Pabinger, CG Barbieri, ES Buring, VL Gonzalez, DG Mulcahy, DP DeMeo, L Urban, PM Hime, S Prost, AN Elliott, NJ Gemmell |
2021 | |
|
Nutmeg extract potentially alters characteristics of white adipose tissue in rats
R Lesmana, M Siannoto, GI Nugraha, H Goenawan, AK Feinisa, YS Pratiwi, F Veronica, VM Tarawan, S Susianti, U Supratman |
Veterinary Medicine and Science | 2021 |
|
MICU3 regulates mitochondrial Ca2+-dependent antioxidant response in skeletal muscle aging
YF Yang, W Yang, ZY Liao, YX Wu, Z Fan, A Guo, J Yu, QN Chen, JH Wu, J Zhou, Q Xiao |
Cell Death and Disease | 2021 |
|
An Analysis of Metabolic Changes in the Retina and Retinal Pigment Epithelium of Aging Mice
KA Tsantilas, WM Cleghorn, CM Bisbach, JA Whitson, DT Hass, BM Robbings, M Sadilek, JD Linton, AM Rountree, AP Valencia, MT Sweetwyne, MD Campbell, H Zhang, CS Jankowski, IR Sweet, DJ Marcinek, PS Rabinovitch, JB Hurley |
Investigative ophthalmology & visual science | 2021 |
|
Directly Reprogrammed Human Neurons to Understand Age-Related Energy Metabolism Impairment and Mitochondrial Dysfunction in Healthy Aging and Neurodegeneration
C Gudenschwager, I Chavez, C Cardenas, C Gonzalez-Billault, AC Gasparovic |
Oxidative Medicine & Cellular Longevity | 2021 |
|
Temporal Profiling of the Cortical Synaptic Mitochondrial Proteome Identifies Ageing Associated Regulators of Stability
LC Graham, RA Kline, DJ Lamont, TH Gillingwater, NA Mabbott, PA Skehel, TM Wishart |
Cells | 2021 |
|
5‐Aminolevulinic acid and sodium ferrous citrate ameliorate muscle aging and extend healthspan in Drosophila
N Nozawa, M Noguchi, K Shinno, M Tajima, S Aizawa, T Saito, A Asada, T Ishii, M Ishizuka, K Iijima, K Ando |
FEBS Open Bio | 2021 |
|
New insights of epigenetics in vascular and cellular senescence
M Zhu, Q Ding, Z Lin, X Chen, S Chen, Y Zhu |
Journal of Translational Internal Medicine | 2021 |
|
Protocols for Generating Surfaces and Measuring 3D Organelle Morphology Using Amira
Garza-Lopez E, Vue Z, Katti P, Neikirk K, Biete M, Lam J, Beasley HK, Marshall AG, Rodman TA, Christensen TA, Salisbury JL, Vang L, Mungai M, AshShareef S, Murray SA, Shao J, Streeter J, Glancy B, Pereira RO, Abel ED, Hinton A Jr |
Cells | 2021 |
|
A New Insight into an Alternative Therapeutic Approach to Restore Redox Homeostasis and Functional Mitochondria in Neurodegenerative Diseases
Hyun DH, Lee J |
Antioxidants | 2021 |
|
A coarse-grained NADH redox model enables inference of subcellular metabolic fluxes from fluorescence lifetime imaging
Yang X, Ha G, Needleman DJ |
eLife | 2021 |
|
Contributions of alveolar epithelial cell quality control to pulmonary fibrosis
Jeremy Katzen, Michael F. Beers |
Journal of Clinical Investigation | 2020 |
|
Endoplasmic reticulum stress and glutathione therapeutics in chronic lung diseases
Y Janssen-Heininger, NL Reynaert, A van der Vliet, V Anathy |
Redox Biology | 2020 |
|
The ageing lung under stress
M Korfei, BA MacKenzie, S Meiners |
European Respiratory Review | 2020 |
|
Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality
OD Ilie, A Ciobica, S Riga, N Dhunna, J McKenna, I Mavroudis, B Doroftei, AM Ciobanu, D Riga |
MED LITH | 2020 |
|
Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila
I Bjedov, HM Cochemé, A Foley, D Wieser, NS Woodling, JI Castillo-Quan, P Norvaisas, C Lujan, JC Regan, JM Toivonen, MP Murphy, J Thornton, KJ Kinghorn, TP Neufeld, F Cabreiro, L Partridge, NG Larsson |
PLoS genetics | 2020 |
|
Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell
E Mick, DV Titov, OS Skinner, R Sharma, AA Jourdain, VK Mootha |
eLife | 2020 |
|
Moderation of mitochondrial respiration mitigates metabolic syndrome of aging
M Tavallaie, R Voshtani, X Deng, Y Qiao, F Jiang, JP Collman, L Fu |
Proceedings of the National Academy of Sciences | 2020 |
|
Monocytes present age‐related changes in phospholipid concentration and decreased energy metabolism
M Saare, L Tserel, L Haljasmägi, E Taalberg, N Peet, M Eimre, R Vetik, K Kingo, K Saks, R Tamm, L Milani, K Kisand, P Peterson |
Aging Cell | 2020 |
|
Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy
H Wu, H Wei, D Zhang, SA Sehgal, D Zhang, X Wang, Y Qin, L Liu, Q Chen |
Redox Biology | 2020 |
|
The Underlying Role of Mitophagy in Different Regulatory Mechanisms of Chronic Obstructive Pulmonary Disease JY Liu, MY Zhang, YQ Qu |
International journal of chronic obstructive pulmonary disease | 2020 |
|
Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart
MH No, JW Heo, SZ Yoo, CJ Kim, DH Park, JH Kang, DY Seo, J Han, HB Kwak |
Pflügers Archiv - European Journal of Physiology | 2020 |
|
Ginseng-Sanqi-Chuanxiong (GSC) Extracts Ameliorate Diabetes-Induced Endothelial Cell Senescence through Regulating Mitophagy via the AMPK Pathway
X Wang, JQ Zhang, CK Xiu, J Yang, JY Fang, Y Lei |
Oxidative medicine and cellular longevity | 2020 |
|
Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans
L Espada, A Dakhovnik, P Chaudhari, A Martirosyan, L Miek, T Poliezhaieva, Y Schaub, A Nair, N Döring, N Rahnis, O Werz, A Koeberle, J Kirkpatrick, A Ori, MA Ermolaeva |
2020 | |
|
The C3HC type zinc-finger protein (ZFC3) interacting with Lon/MAP1 is important for mitochondrial gene regulation, infection hypha development and longevity of Magnaporthe oryzae
S Liu, Y Wei, SH Zhang |
BMC Microbiology | 2020 |
|
Nutritional Status as a Mediator of Fatigue and Its Underlying Mechanisms in Older People
D Azzolino, B Arosio, E Marzetti, R Calvani, M Cesari |
Nutrients | 2020 |
|
miR-181a regulates p62/SQSTM1, parkin, and protein DJ-1 promoting mitochondrial dynamics in skeletal muscle aging
K Goljanek-Whysall, A Soriano-Arroquia, R McCormick, C Chinda, B McDonagh |
Aging Cell | 2020 |
|
Effects of Cholesterol in Stress-Related Neuronal Death—A Statistical Analysis Perspective
MA Dayeh, G Livadiotis, F Aminian, KH Cheng, JL Roberts, N Viswasam, S Elaydi |
International journal of molecular sciences | 2020 |
|
Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss
MA Olesen, AK Torres, C Jara, MP Murphy, C Tapia-Rojas |
Redox Biology | 2020 |
|
Cerebral Mitochondrial Function and Cognitive Performance during Aging: A Longitudinal Study in NMRI Mice
M Reutzel, R Grewal, B Dilberger, C Silaidos, A Joppe, GP Eckert |
Oxidative medicine and cellular longevity | 2020 |
|
Assessment of Nuclear and Mitochondrial DNA, Expression of Mitochondria-Related Genes in Different Brain Regions in Rats after Whole-Body X-ray Irradiation
S Abdullaev, N Gubina, T Bulanova, A Gaziev |
International journal of molecular sciences | 2020 |
|
The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis
A Ammar, K Trabelsi, P Müller, B Bouaziz, O Boukhris, JM Glenn, N Bott, T Driss, H Chtourou, N Müller, A Hökelmann |
Journal of Clinical Medicine | 2020 |
|
“Mitochondrial Toolbox” – A Review of Online Resources to Explore Mitochondrial Genomics
R Cappa, C de Campos, AP Maxwell, AJ McKnight |
Frontiers in Genetics | 2020 |
|
Comparison of senescence-related changes between three- and two-dimensional cultured adipose-derived mesenchymal stem cells
Q Yin, N Xu, D Xu, M Dong, X Shi, Y Wang, Z Hao, S Zhu, D Zhao, H Jin, W Liu |
Stem Cell Research & Therapy | 2020 |
|
Stem Cells of the Aging Brain
AM Nicaise, CM Willis, SJ Crocker, S Pluchino |
Frontiers in aging neuroscience | 2020 |
|
Mitochondrial Import of Dengue Virus NS3 Protease and Cleavage of GrpEL1, a Cochaperone of Mitochondrial Hsp70
C Gandikota, F Mohammed, L Gandhi, D Maisnam, U Mattam, D Rathore, A Chatterjee, K Mallick, A Billoria, VS Prasad, NB Sepuri, M Venkataramana, S López |
Journal of virology | 2020 |
|
Decoding the Rosetta Stone of Mitonuclear Communication
J English, JM Son, MD Cardamone, C Lee, V Perissi |
Pharmacological research : the official journal of the Italian Pharmacological Society | 2020 |
|
Metabolic regulation of neurodifferentiation in the adult brain
C Maffezzini, J Calvo-Garrido, A Wredenberg, C Freyer |
Cellular and Molecular Life Sciences | 2020 |
|
Leukocyte mitochondrial DNA copy number and built environment in Mexican Americans: a cross-sectional study
H Zhao, J Shen, E Leung, X Zhang, WH Chow, K Zhang |
Scientific Reports | 2020 |
|
Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations
Y Guo, SW Cho, D Saxena, X Li |
Endocrinology and Metabolism | 2020 |
|
Protein signatures from blood plasma and urine suggest changes in vascular function and IL-12 signaling in elderly with a history of chronic diseases compared with an age-matched healthy cohort
Y Yu, H Singh, K Kwon, T Tsitrin, J Petrini, KE Nelson, R Pieper |
GeroScience | 2020 |
|
Mitochondrial Glutathione: Recent Insights and Role in Disease
M Marí, E de Gregorio, C de Dios, V Roca-Agujetas, B Cucarull, A Tutusaus, A Morales, A Colell |
Antioxidants | 2020 |
|
Oxidative Stress and Microglial Response in Retinitis Pigmentosa
Y Murakami, Y Nakabeppu, KH Sonoda |
International journal of molecular sciences | 2020 |
|
Treatment with Laevo (l)-carnitine reverses the mitochondrial function of human embryos
N Morimoto, S Hashimoto, M Yamanaka, M Satoh, Y Nakaoka, A Fukui, Y Morimoto, H Shibahara |
Journal of Assisted Reproduction and Genetics | 2020 |
|
SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagy
Y Wang, H Wang, Y Zhuo, Y Hu, Z Zhang, J Ye, L Liu, L Luo, C Zhao, Q Zhou, P Li |
Aging | 2020 |
|
Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction
S van der Rijt, M Molenaars, RL McIntyre, GE Janssens, RH Houtkooper |
Frontiers in Cell and Developmental Biology | 2020 |
|
Construction of a highly error-prone DNA polymerase for developing organelle mutation systems
J Ji, A Day |
Nucleic Acids Research | 2020 |
|
Mitophagy: A New Player in Stem Cell Biology
G Cairns, M Thumiah-Mootoo, Y Burelle, M Khacho |
Biology : open access journal | 2020 |
|
Effects of cellular senescence on metabolic pathways in non-immune and immune cells
D Frasca, YB Saada, D Garcia, B Friguet |
Mechanisms of Ageing and Development | 2020 |
|
Metabolic dysfunction in human skin: Restoration of mitochondrial integrity and metabolic output by nicotinamide (niacinamide) in primary dermal fibroblasts from older aged donors
JE Oblong, A Bowman, HA Rovito, BB Jarrold, JD Sherrill, MR Black, G Nelson, AB Kimball, MA BirchMachin |
Aging Cell | 2020 |
|
Temperament influences mitochondrial capacity in skeletal muscle from 8 through 18 mo of age in Brahman heifers
RN Owen, CM Latham, CR Long, RD Randel, TH Welsh, SH White-Springer |
Journal of animal science | 2020 |
|
Biological characteristics of aging in human acute myeloid leukemia cells: the possible importance of aldehyde dehydrogenase, the cytoskeleton and altered transcriptional regulation
M Hernandez-Valladares, E Aasebø, F Berven, F Selheim, Ø Bruserud |
Aging | 2020 |
|
A looming role of mitochondrial calcium in dictating the lung epithelial integrity and pathophysiology of lung diseases
A Ray, A Jaiswal, J Dutta, S Singh, U Mabalirajan |
Mitochondrion | 2020 |
|
Stress and Psychiatric Disorders: The Role of Mitochondria
TE Daniels, EM Olsen, AR Tyrka |
Annual Review of Clinical Psychology | 2020 |
|
A Plasma Proteomic Signature of Skeletal Muscle Mitochondrial Function
M Zampino, T Tanaka, C Ubaida-Mohien, G Fantoni, J Candia, RD Semba, L Ferrucci |
International journal of molecular sciences | 2020 |
|
Mitochondrial physiology varies with parity and body mass in the laboratory mouse (Mus musculus)
NR Park, HA Taylor, VA Andreasen, AS Williams, K Niitepõld, KN Yap, AN Kavazis, WR Hood |
Journal of Comparative Physiology B | 2020 |
|
Tart Cherry Increases Lifespan in Caenorhabditis elegans by Altering Metabolic Signaling Pathways
S Jayarathne, L Ramalingam, H Edwards, SA Vanapalli, N Moustaid-Moussa |
Nutrients | 2020 |
|
Changes in the Expression of Mitochondrial Morphology-Related Genes during the Differentiation of Murine Embryonic Stem Cells
JE Lee, BJ Seo, MJ Han, YJ Hong, K Hong, H Song, JW Lee, JT Do |
Stem Cells International | 2020 |
|
Mitochondrial DNA Haplotypes Influence Energy Metabolism across Chicken Transmitochondrial Cybrids
M Kong, H Xiang, J Wang, J Liu, X Zhang, X Zhao |
Genes & development | 2020 |
|
N-Acetylcysteine Nanocarriers Protect against Oxidative Stress in a Cellular Model of Parkinson’s Disease
L Mursaleen, B Noble, SH Chan, S Somavarapu, MG Zariwala |
Antioxidants | 2020 |
|
Structural and Functional Changes in the Coupling of Fascial Tissue, Skeletal Muscle, and Nerves During Aging
A Zullo, J Fleckenstein, R Schleip, K Hoppe, S Wearing, W Klingler |
Frontiers in physiology | 2020 |
|
Mitochondrial dysfunction triggers catabolic response in chondrocytes via ROS mediated activation of JNK/AP1 pathway
MY Ansari, N Ahmad, S Voleti, SJ Wase, K Novak, TM Haqqi |
Journal of cell science | 2020 |
|
Alterations of mitochondria and related metabolic pathways in leukemia: A narrative review
EA Ageeli |
2020 | |
|
Targeting metabolic pathways for extension of lifespan and healthspan across multiple species
Parkhitko AA, Filine E, Mohr SE, Moskalev A, Perrimon N |
Ageing Research Reviews | 2020 |
|
Macrophage Immunometabolism and Inflammaging: Roles of Mitochondrial Dysfunction, Cellular Senescence, CD38, and NAD
Yarbro JR, Emmons RS, Pence BD |
Immunometabolism | 2020 |
|
Metabolic programs define dysfunctional immune responses in severe COVID-19 patients
Thompson EA, Cascino K, Ordonez AA, Zhou W, Vaghasia A, Hamacher-Brady A, Brady NR, Sun IH, Wang R, Rosenberg AZ, Delannoy M, Rothman R, Fenstermacher K, Sauer L, Shaw-Saliba K, Bloch EM, Redd AD, Tobian AA, Horton M, Smith K, Pekosz A, D\u2019Alessio FR, Yegnasubramanian S, Ji H, Cox AL, Powell JD |
2020 | |
|
Accumulation of damaged mitochondria in alveolar macrophages with reduced OXPHOS related gene expression in IPF
E Tsitoura, E Vasarmidi, E Bibaki, A Trachalaki, C Koutoulaki, G Papastratigakis, S Papadogiorgaki, G Chalepakis, N Tzanakis, KM Antoniou |
Respiratory Research | 2019 |
|
Mitochondrial biology in airway pathogenesis and the role of NRF2
HY Cho, SR Kleeberger |
Archives of Pharmacal Research | 2019 |
|
Mitochondrial Dysfunction in the Transition from NASH to HCC
M Léveillé, JL Estall |
Metabolites | 2019 |
|
Methylation-Based Biological Age and Breast Cancer Risk
JK Kresovich, Z Xu, KM OBrien, CR Weinberg, DP Sandler, JA Taylor |
JNCI Journal of the National Cancer Institute | 2019 |
|
Breast cancer treatment and its effects on aging
L Chang, LS Weiner, SJ Hartman, S Horvath, D Jeste, PS Mischel, DM Kado |
Journal of Geriatric Oncology | 2019 |
|
The Puzzling Role of Neuron-Specific PMCA Isoforms in the Aging Process
T Boczek, T Radzik, B Ferenc, L Zylinska |
International journal of molecular sciences | 2019 |
|
Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics
PT Brinkkoetter, T Bork, S Salou, W Liang, A Mizi, C Özel, S Koehler, HH Hagmann, C Ising, A Kuczkowski, S Schnyder, A Abed, B Schermer, T Benzing, O Kretz, VG Puelles, S Lagies, M Schlimpert, B Kammerer, C Handschin, C Schell, TB Huber |
Cell Reports | 2019 |
|
Metabolism of sleep and aging: Bridging the gap using metabolomics
A Sengupta, AM Weljie |
Nutrition and Healthy Aging | 2019 |
|
Autophagy Attenuation Hampers Progesterone Synthesis during the Development of Pregnant Corpus Luteum
Z Tang, Z Zhang, H Zhang, Y Wang, Y Zhang, J Zhao, H Yang, Z Wang |
Cells | 2019 |
|
Systems Biology Approaches Toward Understanding Primary Mitochondrial Diseases
EM Maldonado, F Taha, J Rahman, S Rahman |
Frontiers in Genetics | 2019 |
|
Chronological Aging Standard Curves of Telomere Length and Mitochondrial DNA Copy Number in Twelve Tissues of C57BL/6 Male Mouse
J Baek, H Son, YH Jeong, S Park, H Kim |
Cells | 2019 |
|
mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism
H Tang, K Inoki, SV Brooks, H Okazawa, M Lee, J Wang, M Kim, CL Kennedy, PC Macpherson, X Ji, SV Roekel, DA Fraga, K Wang, J Zhu, Y Wang, ZD Sharp, RA Miller, TA Rando, D Goldman, KL Guan, JB Shrager |
Aging Cell | 2019 |
|
Cardiovascular Manifestations of Mitochondrial Disease
J Duran, A Martinez, E Adler |
Biology : open access journal | 2019 |
|
Mitochondrial DNA mutations and respiratory chain dysfunction in idiopathic and connective tissue disease-related lung fibrosis
VK Jaeger, D Lebrecht, AG Nicholson, A Wells, H Bhayani, A Gazdhar, M Tamm, N Venhoff, T Geiser, UA Walker |
Scientific Reports | 2019 |
|
Drug-Induced Mitochondrial Toxicity in the Geriatric Population: Challenges and Future Directions
Y Will, JE Shields, KB Wallace |
Biology : open access journal | 2019 |
|
Autophagy accounts for approximately one-third of mitochondrial protein turnover and is protein selective
ES Vincow, RE Thomas, GE Merrihew, NJ Shulman, TK Bammler, JW MacDonald, MJ MacCoss, LJ Pallanck |
Autophagy | 2019 |
|
Pathology and mechanisms of cochlear aging
EM Keithley |
Journal of Neuroscience Research | 2019 |
|
Neuroendocrine Aspects of Skin Aging
G Bocheva, RM Slominski, AT Slominski |
International journal of molecular sciences | 2019 |
|
A nanoscale, multi-parametric flow cytometry-based platform to study mitochondrial heterogeneity and mitochondrial DNA dynamics
JA MacDonald, AM Bothun, SN Annis, H Sheehan, S Ray, Y Gao, AR Ivanov, K Khrapko, JL Tilly, DC Woods |
2019 | |
|
Renormalized basal metabolic rate describes the human aging process and longevity
Y Kitazoe, H Kishino, K Tanisawa, K Udaka, M Tanaka |
Aging Cell | 2019 |
|
Dual Role of Reactive Oxygen Species in Muscle Function: Can Antioxidant Dietary Supplements Counteract Age-Related Sarcopenia?
S Damiano, E Muscariello, GL Rosa, MD Maro, P Mondola, M Santillo |
International journal of molecular sciences | 2019 |
|
Longevity-associated mitochondrial DNA 5178 C/A polymorphism modifies effect of aging on renal function in male Japanese health checkup examinees: an exploratory cross-sectional study
I Ohtsu, M Ishikawa, N Matsunaga, K Karita, M Yoshida, H Ochiai, T Shirasawa, T Yoshimoto, A Minoura, S Sai, A Kokaze |
Journal of PHYSIOLOGICAL ANTHROPOLOGY | 2019 |
|
Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype?
ND Saenen, DS Martens, KY Neven, R Alfano, H Bové, BG Janssen, HA Roels, M Plusquin, K Vrijens, TS Nawrot |
Clinical Epigenetics | 2019 |
|
Temporal Control of Axonal Transport: The Extreme Case of Organismal Ageing
F Mattedi, A Vagnoni |
Frontiers in cellular neuroscience | 2019 |
|
Mitochondria orchestrate proteostatic and metabolic stress responses
C Andréasson, M Ott, S Büttner |
EMBO reports | 2019 |
|
Phosphorylation of mitochondrial matrix proteins regulates their selective mitophagic degradation
P Kolitsida, J Zhou, M Rackiewicz, V Nolic, J Dengjel, H Abeliovich |
Proceedings of the National Academy of Sciences | 2019 |
|
Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty
NJ Rattray, DK Trivedi, Y Xu, T Chandola, CH Johnson, AD Marshall, K Mekli, Z Rattray, G Tampubolon, B Vanhoutte, IR White, FC Wu, N Pendleton, J Nazroo, R Goodacre |
Nature Communications | 2019 |
|
Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders
H Tani, T Mito, V Velagapudi, K Ishikawa, M Umehara, K Nakada, A Suomalainen, JI Hayashi |
Scientific Reports | 2019 |
|
Gastro-intestinal and oral microbiome signatures associated with healthy aging
H Singh, MG Torralba, KJ Moncera, L DiLello, J Petrini, KE Nelson, R Pieper |
GeroScience | 2019 |
|
MOTS‐c: A Mitochondrial‐Encoded Regulator of the Nucleus
BA Benayoun, C Lee |
BioEssays : news and reviews in molecular, cellular and developmental biology | 2019 |
|
The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation
Y Li, Y Shen, K Jin, Z Wen, W Cao, B Wu, R Wen, L Tian, GJ Berry, JJ Goronzy, CM Weyand |
Cell Metabolism | 2019 |
|
Effects of Dual Exposure to the Herbicides Atrazine and Paraquat on Adult Climbing Ability and Longevity in Drosophila melanogaster
Lovejoy, Fiumera |
Insects | 2019 |
|
Signaling and Regulation of the Mitochondrial Unfolded Protein Response
NU Naresh, CM Haynes |
Cold Spring Harbor perspectives in biology | 2019 |
|
Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities
E Migliavacca, SK Tay, HP Patel, T Sonntag, G Civiletto, C McFarlane, T Forrester, SJ Barton, MK Leow, E Antoun, A Charpagne, YS Chong, P Descombes, L Feng, P Francis-Emmanuel, ES Garratt, MP Giner, CO Green, S Karaz, N Kothandaraman, J Marquis, S Metairon, S Moco, G Nelson, S Ngo, T Pleasants, F Raymond, AA Sayer, CM Sim, J Slater-Jefferies, HE Syddall, PF Tan, P Titcombe, C Vaz, LD Westbury, G Wong, W Yonghui, C Cooper, A Sheppard, KM Godfrey, KA Lillycrop, N Karnani, JN Feige |
Nature Communications | 2019 |
|
Prefabricated Skin Excision in Face Lift: A Simplified Technique
A Kalantar-Hormozi, S Shahrokh, A Abbaszadeh-kasbi, NR Davai |
World Journal of Plastic Surgery | 2019 |
|
Therapeutic mesenchymal stromal stem cells: Isolation, characterization and role in equine regenerative medicine and metabolic disorders
MA Naem, L Bourebaba, K Kucharczyk, M Röcken, K Marycz |
Stem Cell Reviews and Reports | 2019 |
|
Strength training and aerobic exercise alter mitochondrial parameters in brown adipose tissue and equally reduce body adiposity in aged rats
A Thirupathi, BL da Silva Pieri, JA Queiroz, MS Rodrigues, G de Bem Silveira, DR de Souza, TF Luciano, PC Silveira, CT Souza |
Journal of Physiology and Biochemistry | 2019 |
|
Development of AD-Like Pathology in Skeletal Muscle.
Chen X, Miller NM, Afghah Z, Geiger JD |
Journal of Parkinson's disease and Alzheimer's disease | 2019 |
|
The multifaceted contributions of mitochondria to cellular metabolism
JB Spinelli, MC Haigis |
Nature Cell Biology | 2018 |
|
Endoplasmic reticulum stress in pulmonary fibrosis
A Burman, H Tanjore, TS Blackwell |
Matrix biology : journal of the International Society for Matrix Biology | 2018 |
|
PINK1-PARK2-mediated mitophagy in COPD and IPF pathogeneses
K Tsubouchi, J Araya, K Kuwano |
Inflammation and Regeneration | 2018 |
|
Mitochondrial Quality Control in COPD and IPF
H Hara, K Kuwano, J Araya |
Cells | 2018 |
|
Recent insights into the cellular and molecular determinants of aging
L Ruan, , R Li |
Journal of cell science | 2018 |
|
Yeast as a tool to identify anti-aging compounds
A Zimmermann, S Hofer, T Pendl, K Kainz, F Madeo, D Carmona-Gutierrez |
FEMS Yeast Research | 2018 |
|
Genetic cartography of longevity in humans and mice: Current landscape and horizons
M Hook, S Roy, EG Williams, MB Sleiman, K Mozhui, JF Nelson, L Lu, J Auwerx, RW Williams |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2018 |
|
The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity
SN Chaudhari, ET Kipreos |
BioEssays : news and reviews in molecular, cellular and developmental biology | 2018 |
|
Senescent Microvesicles: A Novel Advance in Molecular Mechanisms of Atherosclerotic Calcification
M Alique, R Ramírez-Carracedo, G Bodega, J Carracedo, R Ramírez |
International journal of molecular sciences | 2018 |
|
Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway–PPAR Gamma, Energy Metabolism and Circadian Rhythms
A Vallée, Y Lecarpentier, R Guillevin, JN Vallée |
NeuroMolecular Medicine | 2018 |
|
Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance
M Gulshan, K Yaku, K Okabe, A Mahmood, T Sasaki, M Yamamoto, K Hikosaka, I Usui, T Kitamura, K Tobe, T Nakagawa |
Aging Cell | 2018 |
|
Mitochondria and aging: A role for the mitochondrial transition pore?
M Panel, B Ghaleh, D Morin |
Aging Cell | 2018 |
|
Analyses of Mitochondrial DNA and Immune Phenotyping Suggest Accelerated T-Cell Turnover in Treated HIV:
M Massanella, MY Karris, J Pérez-Santiago, C Yek, A Vitomirov, SR Mehta |
Journal of acquired immune deficiency syndromes (1999) | 2018 |
|
Global mapping of transcription factor motifs in human aging
D Alfego, U Rodeck, A Kriete, K Roemer |
PloS one | 2018 |
|
The Aging Mitochondria
P Theurey, P Pizzo |
Genes & development | 2018 |
|
Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal
H Tani, S Ohnishi, H Shitara, T Mito, M Yamaguchi, H Yonekawa, O Hashizume, K Ishikawa, K Nakada, JI Hayashi |
Scientific Reports | 2018 |
|
The mitochondrial ATP synthase is a shared drug target for aging and dementia
J Goldberg, A Currais, M Prior, W Fischer, C Chiruta, E Ratliff, D Daugherty, R Dargusch, K Finley, PB Esparza-Moltó, JM Cuezva, P Maher, M Petrascheck, D Schubert |
Aging Cell | 2018 |
|
Aging aggravates hepatic ischemia-reperfusion injury in mice by impairing mitophagy with the involvement of the EIF2α-parkin pathway
Y Li, D Ruan, C Jia, J Zheng, G Wang, H Zhao, Q Yang, W Liu, S Yi, H Li, G Wang, Y Yang, G Chen, Q Zhang |
Aging | 2018 |
|
Deep-Coverage MPS Analysis of Heteroplasmic Variants within the mtGenome Allows for Frequent Differentiation of Maternal Relatives
M Holland, K Makova, J McElhoe |
Genes & development | 2018 |
|
Rejuvenating Aged Hematopoietic Stem Cells Through Improvement of Mitochondrial Function
J Moon, HR Kim, MG Shin |
Annals of Laboratory Medicine | 2018 |
|
Bioenergetic Health Assessment of a Single Caenorhabditis elegans from Postembryonic Development to Aging Stages via Monitoring Changes in the Oxygen Consumption Rate within a Microfluidic Device
SH Huang, YW Lin |
Sensors (Basel, Switzerland) | 2018 |
|
Mitochondrial dysfunction reduces yeast replicative lifespan by elevating RAS-dependent ROS production by the ER-localized NADPH oxidase Yno1
DG Yi, S Hong, WK Huh, M Bryk |
PloS one | 2018 |
|
Longevity extension in Drosophila through gut-brain communication
S Westfall, N Lomis, S Prakash |
Scientific Reports | 2018 |
|
The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
KH Kim, JM Son, BA Benayoun, C Lee |
Cell Metabolism | 2018 |
|
Redox responses are preserved across muscle fibres with differential susceptibility to aging
NT Smith, A Soriano-Arroquia, K Goljanek-Whysall, MJ Jackson, B McDonagh |
Journal of Proteomics | 2018 |
|
Mitochondria: Central Organelles for Melatonin′s Antioxidant and Anti-Aging Actions
R Reiter, D Tan, S Rosales-Corral, A Galano, X Zhou, B Xu |
Molecules (Basel, Switzerland) | 2018 |
|
Gene expression hallmarks of cellular ageing
S Frenk, J Houseley |
Biogerontology | 2018 |
|
Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile
Y Kim, X Zheng, Z Ansari, MC Bunnell, JR Herdy, L Traxler, H Lee, AC Paquola, C Blithikioti, M Ku, JC Schlachetzki, J Winkler, F Edenhofer, CK Glass, AA Paucar, BN Jaeger, S Pham, L Boyer, BC Campbell, T Hunter, J Mertens, FH Gage |
Cell Reports | 2018 |
|
Vitamin D Receptor Is Necessary for Mitochondrial Function and Cell Health
C Ricca, A Aillon, L Bergandi, D Alotto, C Castagnoli, F Silvagno |
International journal of molecular sciences | 2018 |
|
Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function
B Singh, TR Schoeb, P Bajpai, A Slominski, KK Singh |
Cell Death and Disease | 2018 |
|
Mitochondrial DNA copy number is associated with psychosis severity and anti-psychotic treatment
P Kumar, P Efstathopoulos, V Millischer, E Olsson, YB Wei, O Brüstle, M Schalling, JC Villaescusa, U Ösby, C Lavebratt |
Scientific Reports | 2018 |
|
Short-Duration Swimming Exercise after Myocardial Infarction Attenuates Cardiac Dysfunction and Regulates Mitochondrial Quality Control in Aged Mice
D Zhao, Y Sun, Y Tan, Z Zhang, Z Hou, C Gao, P Feng, X Zhang, W Yi, F Gao |
Oxidative medicine and cellular longevity | 2018 |
|
Influence of Maternal Aging on Mitochondrial Heterogeneity, Inheritance, and Function in Oocytes and Preimplantation Embryos
D Woods, K Khrapko, J Tilly |
Genes & development | 2018 |
|
Parallelized, real-time, metabolic-rate measurements from individual Drosophila
A Fiorino, D Thompson, S Yadlapalli, C Jiang, OT Shafer, P Reddy, E Meyhofer |
Scientific Reports | 2018 |
|
Genetic inhibition of an ATP synthase subunit extends lifespan in C. elegans
C Xu, W Hwang, DE Jeong, Y Ryu, CM Ha, SJ Lee, L Liu, ZM He |
Scientific Reports | 2018 |
|
Bioenergetics in fibroblasts of patients with Huntington disease are associated with age at onset
SL Gardiner, C Milanese, MW Boogaard, RA Buijsen, M Hogenboom, RA Roos, PG Mastroberardino, WM van Roon-Mom, NA Aziz |
Neurology Genetics | 2018 |
|
In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization
K Takahashi, Y Miura, I Ohsawa, T Shirasawa, M Takahashi |
Scientific Reports | 2018 |
|
Age-associated decline in Nrf2 signaling and associated mtDNA damage may be involved in the degeneration of the auditory cortex: Implications for central presbycusis
Y Li, X Zhao, Y Hu, H Sun, Z He, J Yuan, H Cai, Y Sun, X Huang, W Kong, W Kong |
International journal of molecular medicine | 2018 |
|
Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease
ES Chocron, E Munkácsy, AM Pickering |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2018 |
|
Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases
J Mertens, D Reid, S Lau, Y Kim, FH Gage |
Annual Review of Genetics | 2018 |
|
A Heterologous Cell Model for Studying the Role of T-Cell Intracellular Antigen 1 in Welander Distal Myopathy
I Carrascoso, C Sánchez-Jiménez, E Silion, J Alcalde, JM Izquierdo |
Molecular and cellular biology | 2018 |
|
Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ
CL Samstag, JG Hoekstra, CH Huang, MJ Chaisson, RJ Youle, SR Kennedy, LJ Pallanck, P Chinnery |
PLoS genetics | 2018 |
|
Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function
M Wortham, JR Benthuysen, M Wallace, JN Savas, F Mulas, AS Divakaruni, F Liu, V Albert, BL Taylor, Y Sui, E Saez, AN Murphy, JR Yates, CM Metallo, M Sander |
Cell Reports | 2018 |
|
Association of mitochondrial DNA copy number with self-rated health status
PY Takahashi, GD Jenkins, BP Welkie, SK McDonnell, JM Evans, JR Cerhan, JE Olson, SN Thibodeau, MS Cicek, E Ryu |
The Application of Clinical Genetics | 2018 |
|
Aging and aging-associated diseases: a microRNA-based endocrine regulation hypothesis
S Umansky |
Aging | 2018 |
|
NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy
N Furuya, S Kakuta, K Sumiyoshi, M Ando, R Nonaka, A Suzuki, S Kazuno, S Saiki, N Hattori |
EMBO reports | 2018 |
|
Mito-mice∆ and mitochondrial DNA mutator mice as models of human osteoporosis caused not by aging but by hyperparathyroidism
T Mito, H Tani, M Suzuki, K Ishikawa, K Nakada, JI Hayashi |
Experimental Animals | 2018 |
|
Cellular Metabolism and Aging
Catic A |
Progress in molecular biology and translational science | 2018 |
|
The interrelation between idiopathic pulmonary fibrosis and aging
Ana Mora, Marta Bueno, Mauricio Rojas |
Journal of Clinical Investigation | 2017 |
|
Hepatocyte Growth Factor Improves the Therapeutic Efficacy of Human Bone Marrow Mesenchymal Stem Cells via RAD51
EJ Lee, I Hwang, JY Lee, JN Park, KC Kim, GH Kim, CM Kang, I Kim, SY Lee, HS Kim |
Molecular Therapy | 2017 |
|
New approach to generating insights for aging research based on literature mining and knowledge integration
Y Kwon, Y Natori, M Tanokura, C Caruso |
PloS one | 2017 |
|
Effect of aging on stem cells
AS Ahmed, MH Sheng, S Wasnik, DJ Baylink, KH Lau |
World Journal of Experimental Medicine | 2017 |
|
Evidence that S6K1, but not 4E-BP1, mediates skeletal muscle pathology associated with loss of A-type lamins
CY Liao, SS Anderson, NH Chicoine, JR Mayfield, BJ Garrett, CS Kwok, EC Academia, YM Hsu, DM Miller, AM Bair, JA Wilson, G Tannady, EM Stewart, SS Adamson, J Wang, DJ Withers, BK Kennedy |
Cell Discovery | 2017 |
|
The age-associated loss of ischemic preconditioning in the kidney is accompanied by mitochondrial dysfunction, increased protein acetylation and decreased autophagy
SS Jankauskas, IB Pevzner, NV Andrianova, LD Zorova, VA Popkov, DN Silachev, NG Kolosova, EY Plotnikov, DB Zorov |
Scientific Reports | 2017 |
|
Chemical screening identifies ROCK as a target for recovering mitochondrial function in Hutchinson-Gilford progeria syndrome
HT Kang, JT Park, K Choi, HJ Choi, CW Jung, GR Kim, YS Lee, SC Park |
Aging Cell | 2017 |
|
Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging
L Serebryannyy, T Misteli |
The Journal of Cell Biology | 2017 |
|
Lack of Parkin anticipates the phenotype and affects mitochondrial morphology and mtDNA levels in a mouse model of Parkinson's Disease
M Pinto, N Nissanka, CT Moraes |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2017 |
|
Telomere length as a potential biomarker of coronary artery disease
Joyeeta Bhattacharyya, Keichiro Mihara, Deborshi Bhattacharjee, Manjarí Mukherjee |
The Indian journal of medical research | 2017 |
|
DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway
J Bai, C Cervantes, J Liu, S He, H Zhou, B Zhang, H Cai, D Yin, D Hu, Z Li, H Chen, X Gao, F Wang, JC OConnor, Y Xu, M Liu, LQ Dong, F Liu |
Proceedings of the National Academy of Sciences | 2017 |
|
Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability
Z Gao, Y Li, F Wang, T Huang, K Fan, Y Zhang, J Zhong, Q Cao, T Chao, J Jia, S Yang, L Zhang, Y Xiao, JY Zhou, XH Feng, J Jin |
Nature Communications | 2017 |
|
Loss of BOSS Causes Shortened Lifespan with Mitochondrial Dysfunction in Drosophila
A Kohyama-Koganeya, M Kurosawa, Y Hirabayashi, F Missirlis |
PloS one | 2017 |
|
Neuronal Ryanodine Receptors in Development and Aging
N Abu-Omar, J Das, V Szeto, ZP Feng |
Molecular Neurobiology | 2017 |
|
Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice
AM Gusdon, J Callio, G Distefano, RM O'Doherty, BH Goodpaster, PM Coen, CT Chu |
Experimental Gerontology | 2017 |
|
Mitophagy in neurodegeneration and aging
EM Fivenson, S Lautrup, N Sun, M Scheibye-Knudsen, TV Stevnsner, H Nilsen, VA Bohr, EF Fang |
Neurochemistry International | 2017 |
|
Evolution and inheritance of animal mitochondrial DNA: rules and exceptions
ED Ladoukakis, E Zouros |
Journal of Biological Research-Thessaloniki | 2017 |
|
Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress
T Kamogashira, K Hayashi, C Fujimoto, S Iwasaki, T Yamasoba |
npj Aging and Mechanisms of Disease | 2017 |
|
Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4
J Castex, D Willmann, T Kanouni, L Arrigoni, Y Li, M Friedrich, M Schleicher, S Wöhrle, M Pearson, N Kraut, M Méret, T Manke, E Metzger, R Schüle, T Günther |
Cell Death and Disease | 2017 |
|
Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson’s disease
HF Liu, PW Ho, GC Leung, CS Lam, SY Pang, L Li, MH Kung, DB Ramsden, SL Ho |
Scientific Reports | 2017 |
|
Dietary restriction increases variability in longevity
A M., S Nakagawa, D Raubenheimer, SJ Simpson, DW Noble |
Biology Letters | 2017 |
|
Mitochondrial Control and Guidance of Cellular Activities of T Cells
PC Ho, T Chao, H Wang |
Frontiers in immunology | 2017 |
|
Amyloid β Modification: A Key to the Sporadic Alzheimer's Disease?
EP Barykin, VA Mitkevich, SA Kozin, AA Makarov |
Frontiers in Genetics | 2017 |
|
Mitophagy Transcriptome: Mechanistic Insights into Polyphenol-Mediated Mitophagy
S Tan, E Wong |
Oxidative medicine and cellular longevity | 2017 |
|
Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways
SN Chaudhari, ET Kipreos |
Nature Communications | 2017 |
|
Regulation of Mitochondrial Structure and Dynamics by the Cytoskeleton and Mechanical Factors
E Bartolák-Suki, J Imsirovic, Y Nishibori, R Krishnan, B Suki |
International journal of molecular sciences | 2017 |
|
Molecular and biochemical evidence on the protective role of ellagic acid and silybin against oxidative stress-induced cellular aging
M Baeeri, S Mohammadi-Nejad, M Rahimifard, M Navaei-Nigjeh, S Moeini-Nodeh, R Khorasani, M Abdollahi |
Molecular and Cellular Biochemistry | 2017 |
|
SG-ADVISER mtDNA: a web server for mitochondrial DNA annotation with data from 200 samples of a healthy aging cohort
M Rueda, A Torkamani |
BMC bioinformatics | 2017 |
|
Epigallocatechin-3-gallate promotes healthy lifespan through mitohormesis during early-to-mid adulthood in Caenorhabditis elegans
LG Xiong, YJ Chen, JW Tong, YS Gong, JA Huang, ZH Liu |
Redox Biology | 2017 |
|
Standardized Kaempferia parviflora Extract Inhibits Intrinsic Aging Process in Human Dermal Fibroblasts and Hairless Mice by Inhibiting Cellular Senescence and Mitochondrial Dysfunction
JE Park, SW Woo, MB Kim, C Kim, JK Hwang |
Evidence-Based Complementary and Alternative Medicine | 2017 |
|
In vivo imaging reveals mitophagy independence in the maintenance of axonal mitochondria during normal aging
X Cao, H Wang, Z Wang, Q Wang, S Zhang, Y Deng, Y Fang |
Aging Cell | 2017 |
|
Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis
R Uzhachenko, K Boyd, D Olivares-Villagomez, Y Zhu, JS Goodwin, T Rana, A Shanker, WJ Tan, T Bondar, R Medzhitov, AV Ivanova |
Aging | 2017 |
|
Mitochondrial determinants of mammalian longevity
Y Kitazoe, M Hasegawa, M Tanaka, M Futami, J Futami |
Open Biology | 2017 |
|
Oxidative Stress in Stem Cell Aging
F Chen, Y Liu, NK Wong, J Xiao, KF So |
Cell Transplantation | 2017 |
|
The mitochondrial UPR: mechanisms, physiological functions and implications in ageing
T Shpilka, CM Haynes |
Nature Reviews Molecular Cell Biology | 2017 |
|
Independent impacts of aging on mitochondrial DNA quantity and quality in humans
R Zhang, Y Wang, K Ye, M Picard, Z Gu |
BMC Genomics | 2017 |
|
Tight co-twin similarity of monozygotic twins for hTERT protein level of T cell subsets, for telomere length and mitochondrial DNA copy number, but not for telomerase activity
D Melicher, A Illés, É Pállinger, ÁF Kovács, L Littvay, ÁD Tárnoki, DL Tárnoki, A Bikov, MJ Molnár, EI Buzás, A Falus |
Cellular and Molecular Life Sciences | 2017 |
|
Preparation of Plasma Membrane Vesicles from Bone Marrow Mesenchymal Stem Cells for Potential Cytoplasm Replacement Therapy
L Xu, M Lin, Y Li, S Li, S Chen, C Wei |
Journal of visualized experiments : JoVE | 2017 |
|
Biophysical and biomolecular determination of cellular age in humans
JM Phillip, PH Wu, DM Gilkes, W Williams, S McGovern, J Daya, J Chen, I Aifuwa, JS Lee, R Fan, J Walston, D Wirtz |
Nature Biomedical Engineering | 2017 |
|
A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance.
Tain LS, Sehlke R, Jain C, Chokkalingam M, Nagaraj N, Essers P, Rassner M, Grönke S, Froelich J, Dieterich C, Mann M, Alic N, Beyer A, Partridge L |
Molecular Systems Biology | 2017 |
|
Targeting glucose metabolism for healthy aging
RA Brewer, VK Gibbs, DL Smith |
Nutrition and Healthy Aging | 2016 |
|
Global gene profiling of aging lungs in Atp8b1 mutant mice
R Soundararajan, T Stearns, A Czachor, J Fukumoto, C Turn, E Westermann-Clark, M Breitzig, L Tan, R Lockey, B King, N Kolliputi |
Aging | 2016 |
|
Molecular insights into the premature aging disease progeria
S Vidak, R Foisner |
Histochemistry and Cell Biology | 2016 |
|
Astrocyte elevated gene-1 (AEG-1) and the A(E)Ging HIV/AIDS-HAND
N Vartak-Sharma, S Nooka, A Ghorpade |
Progress in Neurobiology | 2016 |
|
Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice
C Song, W Peng, S Yin, J Zhao, B Fu, J Zhang, T Mao, H Wu, Y Zhang |
Scientific Reports | 2016 |
|
Staying young at heart: autophagy and adaptation to cardiac aging
LJ Leon, ÅB Gustafsson |
Journal of Molecular and Cellular Cardiology | 2016 |
|
GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging
B Martin, W Chadwick, J Janssens, RT Premont, R Schmalzigaug, KG Becker, E Lehrmann, WH Wood, Y Zhang, S Siddiqui, SS Park, W Cong, CM Daimon, S Maudsley |
Frontiers in Endocrinology | 2016 |
|
Simple and effective exercise design for assessing in vivo mitochondrial function in clinical applications using 31P magnetic resonance spectroscopy
A Sleigh, V Lupson, A Thankamony, DB Dunger, DB Savage, TA Carpenter, GJ Kemp |
Scientific Reports | 2016 |
|
Mitochondria and oxidative stress in heart aging
B Martín-Fernández, R Gredilla |
AGE | 2016 |
|
MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism
C Lee, KH Kim, P Cohen |
Free radical biology & medicine | 2016 |
|
Mfn2 deficiency links age‐related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway
D Sebastián, E Sorianello, J Segalés, A Irazoki, V RuizBonilla, D Sala, E Planet, A BerenguerLlergo, JP Muñoz, M SánchezFeutrie, N Plana, MI HernándezÁlvarez, AL Serrano, M Palacín, A Zorzano |
The EMBO Journal | 2016 |
|
Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes
JA Collins, ST Wood, KJ Nelson, MA Rowe, CS Carlson, S Chubinskaya, LB Poole, CM Furdui, RF Loeser |
The Journal of biological chemistry | 2016 |
|
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease
C Lood, LP Blanco, MM Purmalek, C Carmona-Rivera, SS de Ravin, CK Smith, HL Malech, JA Ledbetter, KB Elkon, MJ Kaplan |
Nature Medicine | 2016 |
|
Epigenetic Mechanisms of Longevity and Aging
P Sen, PP Shah, R Nativio, SL Berger |
Cell | 2016 |
|
Amla Enhances Mitochondrial Spare Respiratory Capacity by Increasing Mitochondrial Biogenesis and Antioxidant Systems in a Murine Skeletal Muscle Cell Line
H Yamamoto, K Morino, L Mengistu, T Ishibashi, K Kiriyama, T Ikami, H Maegawa |
Oxidative medicine and cellular longevity | 2016 |
|
Barth Syndrome: From Mitochondrial Dysfunctions Associated with Aberrant Production of Reactive Oxygen Species to Pluripotent Stem Cell Studies
A Saric, K Andreau, AS Armand, IM Møller, PX Petit |
Frontiers in Genetics | 2016 |
|
Drosophila mitochondrial topoisomerase III alpha affects the aging process via maintenance of mitochondrial function and genome integrity
HZ Tsai, RK Lin, TS Hsieh |
Journal of Biomedical Science | 2016 |
|
Mitochondrial DNA Sequence and Lack of Response to Anoxia in the Annual Killifish Austrofundulus limnaeus
JT Wagner, FH Chavez, JE Podrabsky |
Frontiers in physiology | 2016 |
|
Mood, stress and longevity: convergence on ANK3
S Rangaraju, DF Levey, K Nho, N Jain, KD Andrews, H Le-Niculescu, DR Salomon, AJ Saykin, M Petrascheck, AB Niculescu |
Molecular Psychiatry | 2016 |
|
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases
P Davalli, T Mitic, A Caporali, A Lauriola, D DArca |
Oxidative medicine and cellular longevity | 2016 |
|
Biomarkers of Aging: From Function to Molecular Biology
KH Wagner, D Cameron-Smith, B Wessner, B Franzke |
Nutrients | 2016 |
|
Mitochondrial oxygen metabolism in primary human lens epithelial cells: Association with age, diabetes and glaucoma
M Kubota, YB Shui, M Liu, F Bai, AJ Huang, N Ma, DC Beebe, CJ Siegfried |
Free radical biology & medicine | 2016 |
|
Rising Energetic Cost of Walking Predicts Gait Speed Decline With Aging
JA Schrack, V Zipunnikov, EM Simonsick, S Studenski, L Ferrucci |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2016 |
|
Are aberrant phase transitions a driver of cellular aging?
S Alberti, AA Hyman |
BioEssays | 2016 |
|
A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae
WM Pernice, JD Vevea, LA Pon |
Nature Communications | 2016 |
|
Grape Powder Improves Age-Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats
I Pokkunuri, Q Ali, M Asghar |
Oxidative medicine and cellular longevity | 2016 |
|
Mitochondria in pluripotent stem cells: stemness regulators and disease targets
CD Folmes, H Ma, S Mitalipov, A Terzic |
Current Opinion in Genetics & Development | 2016 |
|
Differential Regulation of the Extracellular Cysteine/Cystine Redox State (E h CySS) by Lung Fibroblasts from Young and Old Mice
WH Watson, TJ Burke, IN Zelko, E Torres-González, JD Ritzenthaler, J Roman |
Oxidative medicine and cellular longevity | 2016 |
|
Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
D Ryu, L Mouchiroud, PA Andreux, E Katsyuba, N Moullan, AA Nicolet-dit-Félix, EG Williams, P Jha, GL Sasso, D Huzard, P Aebischer, C Sandi, C Rinsch, J Auwerx |
Nature Medicine | 2016 |
|
Biology and Metabolism of Sepsis: Innate Immunity, Bioenergetics, and Autophagy
AJ Lewis, TR Billiar, MR Rosengart |
Surgical Infections | 2016 |
|
Glaucoma: the retina and beyond
BM Davis, L Crawley, M Pahlitzsch, F Javaid, MF Cordeiro |
Acta Neuropathologica | 2016 |
|
Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule
T Yamamoto, Y Takabatake, T Kimura, A Takahashi, T Namba, J Matsuda, S Minami, J Kaimori, I Matsui, H Kitamura, T Matsusaka, F Niimura, M Yanagita, Y Isaka, H Rakugi |
Autophagy | 2016 |
|
Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis
Y Okuchi, M Imajo, R Mizuno, Y Kamioka, H Miyoshi, MM Taketo, S Nagayama, Y Sakai, M Matsuda, M Plateroti |
PloS one | 2016 |
|
Mitochondrial DNA Rearrangement Spectrum in Brain Tissue of Alzheimer’s Disease: Analysis of 13 Cases
Y Chen, C Liu, WD Parker, H Chen, TG Beach, X Liu, GE Serrano, Y Lu, J Huang, K Yang, C Wang, D Mishmar |
PloS one | 2016 |
|
Methods for Efficient Elimination of Mitochondrial DNA from Cultured Cells
D Spadafora, N Kozhukhar, VN Chouljenko, KG Kousoulas, MF Alexeyev, Y Bai |
PloS one | 2016 |
|
Presequence-Independent Mitochondrial Import of DNA Ligase Facilitates Establishment of Cell Lines with Reduced mtDNA Copy Number
D Spadafora, N Kozhukhar, MF Alexeyev, Y Bai |
PloS one | 2016 |
|
The short-lived African turquoise killifish: an emerging experimental model for ageing
Y Kim, HG Nam, DR Valenzano |
Disease models & mechanisms | 2016 |
|
The age factor in axonal repair after spinal cord injury: A focus on neuron-intrinsic mechanisms
CG Geoffroy, JM Meves, B Zheng |
Neuroscience Letters | 2016 |
|
Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
C Dölle, I Flønes, GS Nido, H Miletic, N Osuagwu, S Kristoffersen, PK Lilleng, JP Larsen, OB Tysnes, K Haugarvoll, LA Bindoff, C Tzoulis |
Nature Communications | 2016 |
|
Genome maintenance and bioenergetics of the long-lived hypoxia-tolerant and cancer-resistant blind mole rat, Spalax: a cross-species analysis of brain transcriptome
A Malik, V Domankevich, H Lijuan, F Xiaodong, A Korol, A Avivi, I Shams |
Scientific Reports | 2016 |
|
The Role of Mitochondrial Non-Enzymatic Protein Acylation in Ageing
SY Hong, LT Ng, LF Ng, T Inoue, NS Tolwinski, T Hagen, J Gruber, A Imhof |
PloS one | 2016 |
|
Humanin skeletal muscle protein levels increase after resistance training in men with impaired glucose metabolism
EK Gidlund, F Walden, M Venojärvi, U Risérus, OJ Heinonen, J Norrbom, CJ Sundberg |
Physiological Reports | 2016 |
|
FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders
JM Lehtonen, S Forsström, E Bottani, C Viscomi, OR Baris, H Isoniemi, K Höckerstedt, P Österlund, M Hurme, J Jylhävä, S Leppä, R Markkula, T Heliö, G Mombelli, J Uusimaa, R Laaksonen, H Laaksovirta, M Auranen, M Zeviani, J Smeitink, RJ Wiesner, K Nakada, P Isohanni, A Suomalainen |
Neurology | 2016 |
|
Proteomic profiling of mitochondria: what does it tell us about the ageing brain?
T Ingram, L Chakrabarti |
Aging | 2016 |
|
The Role of Oxidative Stress in Etiopathogenesis of Chemotherapy Induced Cognitive Impairment (CICI)-“Chemobrain”
AM Gaman, A Uzoni, A Popa-Wagner, A Andrei, EB Petcu |
Aging and disease | 2016 |
|
Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function
Yi JK, Xu R, Jeong E, Mileva I, Truman JP, Lin CL, Wang K, Snider J, Wen S, Obeid LM, Hannun YA, Mao C |
Oncotarget | 2016 |
|
Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: Implications for chronic obstructive pulmonary disease
T Ahmad, IK Sundar, CA Lerner, J Gerloff, AM Tormos, H Yao, I Rahman |
The FASEB Journal | 2015 |
|
Deregulation of selective autophagy during aging and pulmonary fibrosis: the role of TGFβ1
ML Sosulski, R Gongora, S Danchuk, C Dong, F Luo, CG Sanchez |
Aging Cell | 2015 |
|
Systemic sclerosis-associated fibrosis: an accelerated aging phenotype?
TR Luckhardt, VJ Thannickal |
Current Opinion in Rheumatology | 2015 |
|
New roles for mitochondrial proteases in health, ageing and disease
PM Quirós, T Langer, C López-Otín |
Nature Reviews Molecular Cell Biology | 2015 |
|
Measuring In Vivo Mitophagy
N Sun, J Yun, J Liu, D Malide, C Liu, II Rovira, KM Holmström, MM Fergusson, YH Yoo, CA Combs, T Finkel |
Molecular Cell | 2015 |
|
Autologous Stem Cell Therapy: How Aging and Chronic Diseases Affect Stem and Progenitor Cells
AY Efimenko, TN Kochegura, ZA Akopyan, YV Parfyonova |
BioResearch Open Access | 2015 |
|
Mechanisms linking mtDNA damage and aging
M Pinto, CT Moraes |
Free radical biology & medicine | 2015 |
|
Dietary restriction, mitochondrial function and aging: from yeast to humans
A Ruetenik, A Barrientos |
Biochimica et Biophysica Acta (BBA) - Bioenergetics | 2015 |
|
Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria
ZM Xiong, JY Choi, K Wang, H Zhang, Z Tariq, D Wu, E Ko, C LaDana, H Sesaki, K Cao |
Aging Cell | 2015 |
|
Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure
C Ising, S Koehler, S Brahler, C Merkwirth, M Hohne, OR Baris, H Hagmann, M Kann, F Fabretti, C Dafinger, W Bloch, B Schermer, A Linkermann, JC Bruning, CE Kurschat, RU Muller, RJ Wiesner, T Langer, T Benzing, PT Brinkkoetter |
EMBO Molecular Medicine | 2015 |
|
Tipping the metabolic scales towards increased longevity in mammals
CE Riera, A Dillin |
Nature Cell Biology | 2015 |
|
New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases
MH Disatnik, S Hwang, JC Ferreira, D Mochly-Rosen |
Journal of Molecular Medicine | 2015 |
|
Drosophila melanogaster Hsp22: a mitochondrial small heat shock protein influencing the aging process
G Morrow, RM Tanguay |
Frontiers in Genetics | 2015 |
|
Alterations of Mitochondrial DNA Copy Number and Telomere Length with Early Adversity and Psychopathology
AR Tyrka, SH Parade, LH Price, HT Kao, B Porton, NS Philip, ES Welch, LL Carpenter |
Biological Psychiatry | 2015 |
|
The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance
C Lee, J Zeng, BG Drew, T Sallam, A Martin-Montalvo, J Wan, SJ Kim, H Mehta, AL Hevener, R de Cabo, P Cohen |
Cell Metabolism | 2015 |
|
Mitochondria: Much ado about nothing? How dangerous is reactive oxygen species production?
E Holzerová, H Prokisch |
The International Journal of Biochemistry & Cell Biology | 2015 |
|
Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging
NK Koehler, E Stransky, M Meyer, S Gaertner, M Shing, M Schnaidt, MS Celej, TM Jovin, T Leyhe, C Laske, A Batra, G Buchkremer, AJ Fallgatter, D Wernet, E Richartz-Salzburger, P Lewis |
PloS one | 2015 |
|
C11orf83, a Mitochondrial Cardiolipin-Binding Protein Involved in bc 1 Complex Assembly and Supercomplex Stabilization
M Desmurs, M Foti, E Raemy, FM Vaz, JC Martinou, A Bairoch, L Lane |
Molecular and cellular biology | 2015 |
|
Nonsense and missense mutation of mitochondrial ND6 gene promotes cell migration and invasion in human lung adenocarcinoma
Y Yuan, W Wang, H Li, Y Yu, J Tao, S Huang, Z Zeng |
BMC Cancer | 2015 |
|
Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects
O Hashizume, S Ohnishi, T Mito, A Shimizu, K Iashikawa, K Nakada, M Soda, H Mano, S Togayachi, H Miyoshi, K Okita, JI Hayashi |
Scientific Reports | 2015 |
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Mechanisms by Which Different Functional States of Mitochondria Define Yeast Longevity
A Beach, A Leonov, A Arlia-Ciommo, V Svistkova, V Lutchman, V Titorenko |
International journal of molecular sciences | 2015 |
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Muscle wasting in myotonic dystrophies: a model of premature aging
AJ Mateos-Aierdi, M Goicoechea, A Aiastui, R Fernández-Torrón, M Garcia-Puga, A Matheu, AL de Munain |
Frontiers in aging neuroscience | 2015 |
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The unpredictability of prolonged activation of stress response pathways
LT Lamech, CM Haynes |
The Journal of Cell Biology | 2015 |
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Mitochondrial dysfunction in cardiac aging
A Tocchi, EK Quarles, N Basisty, L Gitari, PS Rabinovitch |
Biochimica et Biophysica Acta (BBA) - Bioenergetics | 2015 |
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Rapid parallel measurements of macroautophagy and mitophagy in mammalian cells using a single fluorescent biosensor
A Sargsyan, J Cai, LB Fandino, ME Labasky, T Forostyan, LK Colosimo, SJ Thompson, TE Graham |
Scientific Reports | 2015 |
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Inhibition of peroxisome fission, but not mitochondrial fission, increases yeast chronological lifespan
SD Lefevre, S Kumar, IJ van der Klei |
Cell cycle (Georgetown, Tex.) | 2015 |
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Mitochondrial quality control pathways as determinants of metabolic health
NM Held, RH Houtkooper |
BioEssays | 2015 |
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Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease
I Beerman, DJ Rossi |
Cell Stem Cell | 2015 |
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Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer
PD Adams, H Jasper, KL Rudolph |
Cell Stem Cell | 2015 |
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Mitochondrial Biogenesis Is Impaired in Osteoarthritis Chondrocytes but Reversible via Peroxisome Proliferator-Activated Receptor γ Coactivator 1α: ACTIVATION OF AMPK/SIRT-1/PGC-1α PATHWAY REVERSES IMPAIRED MITOCHONDRIAL BIOGENESIS
Y Wang, X Zhao, M Lotz, R Terkeltaub, R Liu-Bryan |
Arthritis & Rheumatology | 2015 |
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Slow mitochondrial repair of 5′-AMP renders mtDNA susceptible to damage in APTX deficient cells
M Akbari, P Sykora, VA Bohr |
Scientific Reports | 2015 |
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Target of rapamycin activation predicts lifespan in fruit flies
F Scialo, A Sriram, A Naudí, V Ayala, M Jové, R Pamplona, A Sanz |
Cell cycle (Georgetown, Tex.) | 2015 |
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Apoptosis and necrosis mediate skeletal muscle fiber loss in age-induced mitochondrial enzymatic abnormalities
N Cheema, A Herbst, D McKenzie, JM Aiken |
Aging Cell | 2015 |
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Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging Dendritic Cells Is Associated with Mitochondrial Dysfunction
CA Chougnet, RI Thacker, HM Shehata, CM Hennies, MA Lehn, CS Lages, EM Janssen |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
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Accumulation of Mitochondrial DNA Mutations Disrupts Cardiac Progenitor Cell Function and Reduces Survival
AM Orogo, ER Gonzalez, DA Kubli, IL Baptista, SB Ong, TA Prolla, MA Sussman, AN Murphy, ÅB Gustafsson |
The Journal of biological chemistry | 2015 |
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Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
SH Yang, W Li, N Sumien, M Forster, JW Simpkins, R Liu |
Progress in Neurobiology | 2015 |
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The transcriptional landscape of age in human peripheral blood
MJ Peters, R Joehanes, LC Pilling, C Schurmann, KN Conneely, J Powell, E Reinmaa, GL Sutphin, A Zhernakova, K Schramm, YA Wilson, S Kobes, T Tukiainen, MA Nalls, DG Hernandez, MR Cookson, RJ Gibbs, J Hardy, A Ramasamy, AB Zonderman, A Dillman, B Traynor, C Smith, DL Longo, D Trabzuni, J Troncoso, M der Brug, ME Weale, R O'Brien, R Johnson, R Walker, RH Zielke, S Arepalli, M Ryten, AB Singleton, YF Ramos, HH Göring, M Fornage, Y Liu, SA Gharib, BE Stranger, PL de Jager, A Aviv, D Levy, JM Murabito, PJ Munson, T Huan, A Hofman, AG Uitterlinden, F Rivadeneira, J Rooij, L Stolk, L Broer, MM Verbiest, M Jhamai, P Arp, A Metspalu, L Tserel, L Milani, NJ Samani, P Peterson, S Kasela, V Codd, A Peters, CK Ward-Caviness, C Herder, M Waldenberger, M Roden, P Singmann, S Zeilinger, T Illig, G Homuth, HJ Grabe, H Völzke, L Steil, T Kocher, A Murray, D Melzer, H Yaghootkar, S Bandinelli, EK Moses, JW Kent, JE Curran, MP Johnson, S Williams-Blangero, HJ Westra, AF McRae, JA Smith, SL Kardia, I Hovatta, M Perola, S Ripatti, V Salomaa, AK Henders, NG Martin, AK Smith, D Mehta, EB Binder, KM Nylocks, EM Kennedy, T Klengel, J Ding, AM Suchy-Dicey, DA Enquobahrie, J Brody, JI Rotter, YD Chen, J Houwing-Duistermaat, M Kloppenburg, PE Slagboom, Q Helmer, W Hollander, S Bean, T Raj, N Bakhshi, QP Wang, LJ Oyston, BM Psaty, RP Tracy, GW Montgomery, ST Turner, J Blangero, I Meulenbelt, KJ Ressler, J Yang, L Franke, J Kettunen, PM Visscher, GG Neely, R Korstanje, RL Hanson, H Prokisch, L Ferrucci, T Esko, A Teumer, JB van Meurs, AD Johnson |
Nature Communications | 2015 |
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Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson’s disease
D Haddad, K Nakamura |
FEBS Letters | 2015 |
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Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron–sulfur protein
G Jafari, BM Wasko, A Tonge, N Schurman, C Dong, Z Li, R Peters, EB Kayser, JN Pitt, PG Morgan, MM Sedensky, AR Crofts, M Kaeberlein |
Proceedings of the National Academy of Sciences | 2015 |
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Structure and function of mitochondrial membrane protein complexes
W Kühlbrandt |
BMC Biology | 2015 |
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Integration of Posttranscriptional Gene Networks into Metabolic Adaptation and Biofilm Maturation in Candida albicans
J Verma-Gaur, Y Qu, PF Harrison, TL Lo, T Quenault, MJ Dagley, M Bellousoff, DR Powell, TH Beilharz, A Traven, G Butler |
PLoS genetics | 2015 |
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Autologous Germline Mitochondrial Energy Transfer (AUGMENT) in Human Assisted Reproduction
D Woods, J Tilly |
Seminars in reproductive medicine | 2015 |
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Mitochondrial Efficiency-Dependent Viability of Saccharomyces cerevisiae Mutants Carrying Individual Electron Transport Chain Component Deletions
Kwon YY, Choi KM, Cho C, Lee CK |
Molecules and Cells | 2015 |
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PINK1 deficiency impairs mitochondrial homeostasis promoting lung fibrosis
Marta Bueno, Yen-Chun Lai, Yair Romero, Judith Brands, Claudette St. Croix, Christelle Kamga, Catherine Corey, Jose Herazo-Maya, John Sembrat, Janet Lee, Steven Duncan, Mauricio Rojas, Sruti Shiva, Charleen Chu, Ana Mora |
Journal of Clinical Investigation | 2014 |
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Mitochondrial DNA: Impacting Central and Peripheral Nervous Systems
V Carelli, DC Chan |
Neuron | 2014 |
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Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging
A Kowald, TB Kirkwood |
Proceedings of the National Academy of Sciences | 2014 |
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Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans
HL Baines, JB Stewart, C Stamp, A Zupanic, TB Kirkwood, NG Larsson, DM Turnbull, LC Greaves |
Mechanisms of Ageing and Development | 2014 |
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Stem cell aging: mechanisms, regulators and therapeutic opportunities
J Oh, YD Lee, AJ Wagers |
Nature Medicine | 2014 |
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Interleukin-6 directly impairs the erythroid development of human TF-1 erythroleukemic cells
BJ McCranor, MJ Kim, NM Cruz, QL Xue, AE Berger, JD Walston, CI Civin, CN Roy |
Blood Cells, Molecules, and Diseases | 2014 |
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Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)
M Ristow, K Schmeisser |
Dose-Response | 2014 |
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Recent Progress in Metabolic Signaling Pathways Regulating Aging and Life Span
CB Newgard, JE Pessin |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2014 |
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Cellular mechanisms of somatic stem cell aging
Y Jung, AS Brack |
Current topics in developmental biology | 2014 |
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Antagonistic functions of LMNA isoforms in energy expenditure and lifespan
IC Lopez-Mejia, M Toledo, C Chavey, L Lapasset, P Cavelier, C Lopez-Herrera, K Chebli, P Fort, G Beranger, L Fajas, EZ Amri, F Casas, J Tazi |
EMBO reports | 2014 |
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Obesity and lifespan health--importance of the fetal environment
AF Tarantal, L Berglund |
Nutrients | 2014 |
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Ageing is a risk factor in imatinib mesylate cardiotoxicity: Ageing is a risk factor in imatinib mesylate cardiotoxicity
W Maharsy, A Aries, O Mansour, H Komati, M Nemer |
European Journal of Heart Failure | 2014 |
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First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics: Cardiolipin therapeutic restores bioenergetics
HH Szeto |
British Journal of Pharmacology | 2014 |
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Mitochondrial Stress Signaling Promotes Cellular Adaptations
JA Barbour, N Turner |
International Journal of Cell Biology | 2014 |
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Aging and injury: alterations in cellular energetics and organ function
N Poulose, R Raju |
Aging and disease | 2014 |
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Mitochondrial Oxidative Stress in the Retinal Pigment Epithelium Leads to Localized Retinal Degeneration
H Mao, SJ Seo, MR Biswal, H Li, M Conners, A Nandyala, K Jones, YZ Le, AS Lewin |
Investigative ophthalmology & visual science | 2014 |
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Bioenergetic medicine: Bioenergetic medicine
RH Swerdlow |
British Journal of Pharmacology | 2014 |
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Effect of aging on microRNAs and regulation of pathogen recognition receptors
F Olivieri, AD Procopio, RR Montgomery |
Current Opinion in Immunology | 2014 |
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Development of pharmacological strategies for mitochondrial disorders: Mitochondrial disease pharmacological strategies
M Kanabus, SJ Heales, S Rahman |
British Journal of Pharmacology | 2014 |
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Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans
CF Bennett, HV Wende, M Simko, S Klum, S Barfield, H Choi, VV Pineda, M Kaeberlein |
Nature Communications | 2014 |
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The role of TDP1 and APTX in mitochondrial DNA repair
M Meagher, RN Lightowlers |
Biochimie | 2014 |
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A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology
MT Burstein, VI Titorenko |
Redox Biology | 2014 |
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Cytoplasmic hybrid (cybrid) cell lines as a practical model for mitochondriopathies
HM Wilkins, SM Carl, RH Swerdlow |
Redox Biology | 2014 |
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Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats
H Khraiwesh, JA López-Domínguez, LF Río, E Gutierrez-Casado, G López-Lluch, P Navas, R Cabo, JJ Ramsey, MI Burón, JM Villalba, JA González-Reyes |
Experimental Gerontology | 2014 |
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Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease
AR Silva, AC Santos, JM Farfel, LT Grinberg, RE Ferretti, AH Campos, IW Cunha, MD Begnami, RM Rocha, DM Carraro, CA de Pereira, W Jacob-Filho, H Brentani |
PloS one | 2014 |
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The role of mitochondria in longevity and healthspan
MD Brand |
Longevity & Healthspan | 2014 |
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Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain
DN Hauser, AA Dillman, J Ding, Y Li, MR Cookson |
PloS one | 2014 |
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Repair of endogenous DNA base lesions modulate lifespan in mice
LB Meira, JA Calvo, D Shah, J Klapacz, CA Moroski-Erkul, RT Bronson, LD Samson |
DNA repair | 2014 |
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IGF-I regulates the age-dependent signaling peptide humanin
C Lee, J Wan, B Miyazaki, Y Fang, J Guevara-Aguirre, K Yen, V Longo, A Bartke, P Cohen |
Aging Cell | 2014 |
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Peptide Targeting of Mitochondria Elicits Testosterone Formation
M Campanella |
Molecular Therapy | 2014 |
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Effects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s Disease
G Fata, P Weber, M Mohajeri |
Nutrients | 2014 |
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Comparing amyloid-β deposition, neuroinflammation, glucose metabolism, and mitochondrial complex I activity in brain: a PET study in aged monkeys
H Tsukada, S Nishiyama, H Ohba, M Kanazawa, T Kakiuchi, N Harada |
European Journal of Nuclear Medicine and Molecular Imaging | 2014 |
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Regulation of Endothelial Cell Metabolism: Just Go With the Flow
X Sun, MW Feinberg |
Arteriosclerosis, thrombosis, and vascular biology | 2014 |
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DNA Sequences Proximal to Human Mitochondrial DNA Deletion Breakpoints Prevalent in Human Disease Form G-quadruplexes, a Class of DNA Structures Inefficiently Unwound by the Mitochondrial Replicative Twinkle Helicase
SK Bharti, JA Sommers, J Zhou, DL Kaplan, JN Spelbrink, JL Mergny, RM Brosh |
The Journal of biological chemistry | 2014 |
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Energy Metabolism and the Burden of Multimorbidity in Older Adults: Results From the Baltimore Longitudinal Study of Aging
E Fabbri, Y An, JA Schrack, M Gonzalez-Freire, M Zoli, EM Simonsick, JM Guralnik, CM Boyd, SA Studenski, L Ferrucci |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2014 |
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Mitochondria Modify Exercise-Induced Development of Stem Cell-Derived Neurons in the Adult Brain
K Steib, I Schaffner, R Jagasia, B Ebert, DC Lie |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2014 |
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Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase
Fukuoh A, Cannino G, Gerards M, Buckley S, Kazancioglu S, Scialo F, Lihavainen E, Ribeiro A, Dufour E, Jacobs HT |
Molecular Systems Biology | 2014 |
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Coming of age: molecular drivers of aging and therapeutic opportunities
Christopher Newgard, Norman Sharpless |
Journal of Clinical Investigation | 2013 |
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Hallmarks of a new era in mitochondrial biochemistry
DJ Pagliarini, J Rutter |
Genes & development | 2013 |
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Twin mitochondrial sequence analysis
Y Bouhlal, S Martinez, H Gong, K Dumas, JT Shieh |
Molecular Genetics & Genomic Medicine | 2013 |
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Mitochondria as a Target of Environmental Toxicants
JN Meyer, MC Leung, JP Rooney, A Sendoel, MO Hengartner, GE Kisby, AS Bess |
Toxicological Sciences | 2013 |
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Mitochondrial genome linearization is a causative factor for cardiomyopathy in mice and Drosophila
Y Chen, M Sparks, P Bhandari, SJ Matkovich, GW Dorn |
Antioxidants & Redox Signaling | 2013 |
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Somatic mtDNA mutation spectra in the aging human putamen
SL Williams, DC Mash, S Züchner, CT Moraes |
PLoS genetics | 2013 |
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The emergence of the mitochondrial genome as a partial regulator of nuclear function is providing new insights into the genetic mechanisms underlying age-related complex disease
MP Horan, DN Cooper |
Human Genetics | 2013 |
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The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific
N Raule, F Sevini, S Li, A Barbieri, F Tallaro, L Lomartire, D Vianello, A Montesanto, JS Moilanen, V Bezrukov, H Blanché, A Hervonen, K Christensen, L Deiana, ES Gonos, TB Kirkwood, P Kristensen, A Leon, PG Pelicci, M Poulain, IM Rea, J Remacle, JM Robine, S Schreiber, E Sikora, PE Slagboom, L Spazzafumo, MA Stazi, O Toussaint, JW Vaupel, G Rose, K Majamaa, M Perola, TE Johnson, L Bolund, H Yang, G Passarino, C Franceschi |
Aging Cell | 2013 |
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Evaluation of 18F-BCPP-EF for mitochondrial complex 1 imaging in the brain of conscious monkeys using PET
H Tsukada, H Ohba, M Kanazawa, T Kakiuchi, N Harada |
European Journal of Nuclear Medicine and Molecular Imaging | 2013 |
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Mitochondrial DNA damage patterns and aging: revising the evidences for humans and mice
N Kazachkova, A Ramos, C Santos, M Lima |
Aging and disease | 2013 |
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Possible mechanisms of fullerene C₆₀ antioxidant action
VA Chistyakov, YO Smirnova, EV Prazdnova, AV Soldatov |
BioMed Research International | 2013 |
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Replicating animal mitochondrial DNA
EA McKinney, MT Oliveira |
Genetics and molecular biology | 2013 |
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Mitochondrial genomes as living 'fossils'
I Small |
BMC Biology | 2013 |
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Adenine Nucleotide Translocase, Mitochondrial Stress, and Degenerative Cell Death
Y Liu, XJ Chen |
Oxidative medicine and cellular longevity | 2013 |
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Mitochondrial membrane lipidome defines yeast longevity
Beach A, Richard VR, Leonov A, Burstein MT, Bourque SD, Koupaki O, Juneau M, Feldman R, Iouk T, Titorenko VI |
Aging | 2013 |
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Current Protocols in Mouse Biology
J Auwerx, SL Ackerman, SD Brown, MJ Justice, J Nadeau |
Current Protocols in Mouse Biology | 2011 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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