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Robert Kridel, … , Laurie H. Sehn, Randy D. Gascoyne
Published October 1, 2012
Citation Information: J Clin Invest. 2012;122(10):3424-3431. https://doi.org/10.1172/JCI63186.
Citation Information: J Clin Invest. 2012;122(10):3424-3431. https://doi.org/10.1172/JCI63186.
Abstract
The hallmark t(14;18)(q32;q21) in follicular lymphoma (FL) results in constitutive overexpression of the BCL2 protein, allowing B cells to abrogate the default germinal center apoptotic program. Most tumors are characterized by recurrent secondary genetic alterations including genomic gains, losses, and mutations, some providing a growth advantage, including alterations in MLL2, EPHA7, TNFRSF14, and EZH2. The sequence in which these events occur and how they contribute to progression and ultimately to transformation is unclear. Lastly, crosstalk between neoplastic B cells and non-neoplastic immune and stromal cells in the microenvironment plays an important role in sustaining tumor cell growth, cultivating immune privilege, and promoting transformation.
Authors
Robert Kridel, Laurie H. Sehn, Randy D. Gascoyne
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Citation information
Citations to this article (152)
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Low absolute CD4+ T cell counts in peripheral blood are associated with inferior survival in follicular lymphoma
L He, JH Liang, JZ Wu, Y Li, SC Qin, Y Miao, YJ Wu, Y Wang, L Wang, L Fan, JY Li, W Xu |
Tumor Biology | 2016 |
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Clinicogenetic risk models predict early progression of follicular lymphoma after first-line immunochemotherapy
V Jurinovic, R Kridel, AM Staiger, M Szczepanowski, H Horn, MH Dreyling, A Rosenwald, G Ott, W Klapper, AD Zelenetz, PM Barr, JW Friedberg, S Ansell, LH Sehn, JM Connors, RD Gascoyne, W Hiddemann, M Unterhalt, DM Weinstock, O Weigert |
Blood | 2016 |
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A study of the mutational landscape of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma
MG Ozawa, A Bhaduri, KM Chisholm, SA Baker, L Ma, JL Zehnder, S Luna-Fineman, MP Link, JD Merker, DA Arber, RS Ohgami |
Modern Pathology | 2016 |
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Recurrent somatic mutations affecting B-cell receptor signaling pathway genes in follicular lymphoma
K Krysiak, F Gomez, BS White, M Matlock, CA Miller, L Trani, CC Fronick, RS Fulton, F Kreisel, AF Cashen, KR Carson, MM Berrien-Elliott, NL Bartlett, M Griffith, OL Griffith, TA Fehniger |
Blood | 2016 |
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Detection of chromosomal abnormalities by G-banding and prognostic impact in follicular lymphoma in the rituximab era
T Tsukamoto, M Kiyota, E Kawata, N Uoshima, S Tatekawa, Y Chinen, H Nagoshi, S Mizutani, Y Shimura, M Yamamoto-Sugitani, T Kobayashi, S Horiike, S Yasukawa, A Yanagisawa, M Taniwaki, J Kuroda |
International Journal of Hematology | 2016 |
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Prevalence of BCL-2/J(H) Translocation in Healthy African Americans
G Colon-Otero, SA van Wier, GJ Ahmann, E Braggio, ML Albertie, JA Weis, S Ailawadhi, JR Cerhan, P Vishnu, MS Jorgensen, JM Foran, CS Thomas, R Fonseca |
Annals of Hematology | 2016 |
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Recommendations for Clinical Trial Development in Follicular Lymphoma
K Maddocks, PM Barr, BD Cheson, RF Little, L Baizer, BS Kahl, JP Leonard, N Fowler, LI Gordon, BK Link, JW Friedberg, SM Ansell |
JNCI Journal of the National Cancer Institute | 2016 |
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Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA
F Scherer, DM Kurtz, AM Newman, H Stehr, AF Craig, MS Esfahani, AF Lovejoy, JJ Chabon, DM Klass, CL Liu, L Zhou, C Glover, BC Visser, GA Poultsides, RH Advani, LS Maeda, NK Gupta, R Levy, RS Ohgami, CA Kunder, M Diehn, AA Alizadeh |
Science Translational Medicine | 2016 |
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INFECTIONS AND FOLLICULAR LYMPHOMA: IS THERE A LINK?
F Zallio, G Limberti, M Ladetto |
Mediterranean journal of hematology and infectious diseases | 2016 |
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Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma
ZX Ying, M Jin, LF Peterson, D Bernard, K Saiya-Cork, M Yildiz, S Wang, MS Kaminski, AE Chang, DJ Klionsky, SN Malek |
Clinical cancer research | 2016 |
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Follicular Lymphoma: The Role of the Tumor Microenvironment in Prognosis
Sugimoto T, Watanabe T |
2016 | |
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Highly clonal regulatory T-cell population in follicular lymphoma – inverse correlation with the diversity of CD8 + T cells
X Liu, G Venkataraman, J Lin, K Kiyotani, S Smith, M Montoya, Y Nakamura, J Kline |
OncoImmunology | 2015 |
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To Each Its Own: Linking the Biology and Epidemiology of NHL Subtypes
JL Koff, D Chihara, A Phan, LJ Nastoupil, JN Williams, CR Flowers |
Current Hematologic Malignancy Reports | 2015 |
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Lectin-like transcript 1 is a marker of germinal center-derived B-cell non-Hodgkin's lymphomas dampening natural killer cell functions
C Germain, T Guillaudeux, ED Galsgaard, C Hervouet, N Tekaya, AS Gallouet, J Fassy, F Bihl, G Poupon, A Lazzari, P Spee, F Anjuère, C Pangault, K Tarte, P Tas, L Xerri, VM Braud |
OncoImmunology | 2015 |
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Recurrent somatic loss of TNFRSF14 in classical Hodgkin lymphoma: TNFRSF14 LOSS IN CLASSICAL HODGKIN LYMPHOMA
SJ Salipante, A Adey, A Thomas, C Lee, YJ Liu, A Kumar, AP Lewis, D Wu, JR Fromm, J Shendure |
Genes Chromosomes and Cancer | 2015 |
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Histologically transformed follicular lymphoma exhibits protein profiles different from both non-transformed follicular and de novo diffuse large B-cell lymphoma
M Ludvigsen, C Madsen, P Kamper, SJ Hamilton-Dutoit, K Bendix, F d'Amore, B Honoré |
Blood Cancer Journal | 2015 |
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Germinal centres and B cell lymphomagenesis
K Basso, R Dalla-Favera |
Nature Reviews Immunology | 2015 |
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Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation
MR Green, S Kihira, CL Liu, RV Nair, R Salari, AJ Gentles, J Irish, H Stehr, C Vicente-Dueñas, I Romero-Camarero, I Sanchez-Garcia, SK Plevritis, DA Arber, S Batzoglou, R Levy, AA Alizadeh |
Proceedings of the National Academy of Sciences | 2015 |
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Risk of follicular lymphoma associated with BCL2 translocations in peripheral blood
C Hirt, MC Camargo, KJ Yu, SM Hewitt, G Dölken, CS Rabkin |
Leukemia & Lymphoma | 2015 |
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The genotype of MLH1 identifies a subgroup of follicular lymphoma patients who do not benefit from doxorubicin: FIL-FOLL study
D Rossi, A Bruscaggin, PL Cava, S Galimberti, E Ciabatti, S Luminari, L Rigacci, A Tucci, A Pulsoni, G Bertoldero, D Vallisa, C Rusconi, M Spina, L Arcaini, F Angrilli, C Stelitano, F Merli, G Gaidano, M Federico, GA Palumbo |
Haematologica | 2015 |
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Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells
K Sugimoto, F Hayakawa, S Shimada, T Morishita, K Shimada, T Katakai, A Tomita, H Kiyoi, T Naoe |
Scientific Reports | 2015 |
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The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development
A Ortega-Molina, IW Boss, A Canela, H Pan, Y Jiang, C Zhao, M Jiang, D Hu, X Agirre, I Niesvizky, JE Lee, HT Chen, D Ennishi, DW Scott, A Mottok, C Hother, S Liu, XJ Cao, W Tam, R Shaknovich, BA Garcia, RD Gascoyne, K Ge, A Shilatifard, O Elemento, A Nussenzweig, AM Melnick, HG Wendel |
Nature Medicine | 2015 |
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Short-Circuiting Gene Regulatory Networks: Origins of B Cell Lymphoma
OI Koues, EM Oltz, JE Payton |
Trends in Genetics | 2015 |
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Indolent lymphomas in the pediatric population: follicular lymphoma, IRF4/MUM1+ lymphoma, nodal marginal zone lymphoma and chronic lymphocytic leukemia
L Quintanilla-Martinez, B Sander, JK Chan, L Xerri, G Ott, E Campo, SH Swerdlow |
Virchows Archiv | 2015 |
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The heterogeneity of follicular lymphomas: from early development to transformation
L Xerri, S Dirnhofer, L Quintanilla-Martinez, B Sander, JK Chan, E Campo, SH Swerdlow, G Ott |
Virchows Archiv | 2015 |
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Follicular lymphoma: in vitro effects of combining lymphokine-activated killer (LAK) cell-induced cytotoxicity and rituximab- and obinutuzumab-dependent cellular cytotoxicity (ADCC) activity
R García-Muñoz, A López-Díaz-de-Cerio, J Feliu, A Panizo, P Giraldo, M Rodríguez-Calvillo, C Grande, E Pena, M Olave, C Panizo, S Inogés |
Immunologic Research | 2015 |
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Similar clinical features in follicular lymphomas with and without breaks in the BCL2 locus
E Leich, E Hoster, M Wartenberg, M Unterhalt, R Siebert, K Koch, W Klapper, M Engelhard, B Puppe, H Horn, AM Staiger, C Stuhlmann-Laeisz, HW Bernd, AC Feller, M Hummel, D Lenze, H Stein, S Hartmann, ML Hansmann, P Möller, W Hiddemann, M Dreyling, G Ott, A Rosenwald |
Leukemia | 2015 |
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THE ROLE OF AUTOLOGOUS AND ALLOGENEIC STEM CELL TRANSPLANTATION IN FOLLICULAR LYMPHOMA IN THE NEW DRUGS ERA
F Maura, L Farina, P Corradini |
Mediterranean journal of hematology and infectious diseases | 2015 |
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The Expression of CD9 and PIK3CD is Associated with Prognosis of Follicular Lymphoma
T Dong, Z Liu, S Zhao, C Hu, Y Liu, WJ Ma, Q Zhang |
Journal of Cancer | 2015 |
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Follicular Lymphoma: A Clinicopathological Analysis from a Tertiary care Institute in Southern India
MT Sylvia, B Dey, D Basu, SE Jacob, R Kar, B Dubashi |
Mediterranean journal of hematology and infectious diseases | 2015 |
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SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders
G Simonetti, MT Bertilaccio, TV Rodriguez, B Apollonio, A Dagklis, M Rocchi, A Innocenzi, S Casola, TH Winkler, L Nitschke, M Ponzoni, F Caligaris-Cappio, P Ghia |
Haematologica | 2014 |
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The tumour microenvironment in B cell lymphomas
DW Scott, RD Gascoyne |
Nature Reviews Cancer | 2014 |
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Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial
JR Westin, F Chu, M Zhang, LE Fayad, LW Kwak, N Fowler, J Romaguera, F Hagemeister, M Fanale, F Samaniego, L Feng, V Baladandayuthapani, Z Wang, W Ma, Y Gao, M Wallace, LM Vence, L Radvanyi, T Muzzafar, R Rotem-Yehudar, RE Davis, SS Neelapu |
The Lancet Oncology | 2014 |
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A Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literature
J Taverna, A Nair, S Yun, S Paulson, JH Schatz, D Persky, D Fuchs, S Puvvada |
Case Reports in Hematology | 2014 |
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Genetics of Follicular Lymphoma Transformation
L Pasqualucci, H Khiabanian, M Fangazio, M Vasishtha, M Messina, AB Holmes, P Ouillette, V Trifonov, D Rossi, F Tabbò, M Ponzoni, A Chadburn, VV Murty, G Bhagat, G Gaidano, G Inghirami, SN Malek, R Rabadan, R Dalla-Favera |
Cell Reports | 2014 |
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How we manage follicular lymphoma
W Hiddemann, BD Cheson |
Leukemia | 2014 |
|
Assessing the prognostic impact of immune cell infiltrates in follicular lymphoma
F Fend, L Quintanilla-Martínez |
Haematologica | 2014 |
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Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development
T Miyai, S Hojyo, T Ikawa, M Kawamura, T Irie, H Ogura, A Hijikata, BH Bin, T Yasuda, H Kitamura, M Nakayama, O Ohara, H Yoshida, H Koseki, K Mishima, T Fukada |
Proceedings of the National Academy of Sciences | 2014 |
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Activating STAT6 mutations in follicular lymphoma
M Yildiz, H Li, D Bernard, NA Amin, P Ouillette, S Jones, K Saiya-Cork, B Parkin, K Jacobi, K Shedden, S Wang, AE Chang, MS Kaminski, SN Malek |
Blood | 2014 |
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Genetic diversity of newly diagnosed follicular lymphoma
YW Asmann, MJ Maurer, C Wang, V Sarangi, SM Ansell, AL Feldman, GS Nowakowski, M Manske, T Price-Troska, ZZ Yang, SL Slager, TM Habermann, JR Cerhan, AJ Novak |
Blood Cancer Journal | 2014 |
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BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma
C Correia, PA Schneider, H Dai, A Dogan, MJ Maurer, AK Church, AJ Novak, AL Feldman, X Wu, H Ding, XW Meng, JR Cerhan, SL Slager, WR Macon, TM Habermann, JE Karp, SD Gore, NE Kay, DF Jelinek, TE Witzig, GS Nowakowski, SH Kaufmann |
Blood | 2014 |
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Inter- and intratumoral heterogeneity of BCL2 correlates with IgH expression and prognosis in follicular lymphoma
A Barreca, C Martinengo, L Annaratone, L Righi, A Chiappella, M Ladetto, A Demurtas, L Chiusa, A Stacchini, N Crosetto, A Oudenaarden, R Chiarle |
Blood Cancer Journal | 2014 |
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Replication initiation and genome instability: a crossroads for DNA and RNA synthesis
JH Barlow, A Nussenzweig |
Cellular and Molecular Life Sciences | 2014 |
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Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway
K Sadahira, M Sagawa, T Nakazato, H Uchida, Y Ikeda, S Okamoto, H Nakajima, M Kizaki |
International journal of oncology | 2014 |
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Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations
F Tirode, D Surdez, X Ma, M Parker, MC le Deley, A Bahrami, Z Zhang, E Lapouble, S Grossetete-Lalami, M Rusch, S Reynaud, T Rio-Frio, E Hedlund, G Wu, X Chen, G Pierron, O Oberlin, S Zaidi, G Lemmon, P Gupta, B Vadodaria, J Easton, M Gut, L Ding, ER Mardis, RK Wilson, S Shurtleff, V Laurence, J Michon, P Marec-Berard, I Gut, J Downing, M Dyer, J Zhang, O Delattre |
Cancer Discovery | 2014 |
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Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma
H Li, MS Kaminski, Y Li, M Yildiz, P Ouillette, S Jones, H Fox, K Jacobi, K Saiya-Cork, D Bixby, D Lebovic, D Roulston, K Shedden, M Sabel, L Marentette, V Cimmino, AE Chang, SN Malek |
Blood | 2014 |
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Somatic alterations and dysregulation of epigenetic modifiers in cancers
S Aumann, O Abdel-Wahab |
Biochemical and Biophysical Research Communications | 2014 |
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Chromatin Remodeling Defects in Pediatric and Young Adult Glioblastoma: A Tale of a Variant Histone 3 Tail: Chromatin Remodeling Defects in Pediatric and Young Adult Glioblastoma
AM Fontebasso, XY Liu, D Sturm, N Jabado |
Brain Pathology | 2013 |
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Genomics of lymphoid malignancies reveal major activation pathways in lymphocytes
B Knoechel, JG Lohr |
Journal of Autoimmunity | 2013 |
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Radioimmunotherapy combined with maintenance anti-CD20 antibody may trigger long-term protective T cell immunity in follicular lymphoma patients
F Buchegger, SM Larson, JP Mach, Y Chalandon, PY Dietrich, A Cairoli, JO Prior, P Romero, DE Speiser |
Clinical & developmental immunology | 2013 |
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Molecular Pathogenesis of B-Cell Posttransplant Lymphoproliferative Disorder: What Do We Know So Far?
J Morscio, D Dierickx, T Tousseyn |
Clinical and Developmental Immunology | 2013 |
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Genome-wide copy-number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma
A Bouska, TW McKeithan, KE Deffenbacher, C Lachel, GW Wright, J Iqbal, LM Smith, W Zhang, C Kucuk, A Rinaldi, F Bertoni, J Fitzgibbon, K Fu, DD Weisenburger, TC Greiner, BJ Dave, RD Gascoyne, A Rosenwald, G Ott, E Campo, LM Rimsza, J Delabie, ES Jaffe, RM Braziel, JM Connors, LM Staudt, WC Chan |
Blood | 2013 |
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Early lesions of follicular lymphoma: a genetic perspective
E Mamessier, JY Song, FC Eberle, S Pack, C Drevet, B Chetaille, Z Abdullaev, J Adelaïde, D Birnbaum, M Chaffanet, S Pittaluga, S Roulland, A Chott, ES Jaffe, B Nadel |
Haematologica | 2013 |
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Follicular lymphomas: a tapestry of common and contrasting threads
ES Jaffe |
Haematologica | 2013 |
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Functional genomics lead to new therapies in follicular lymphoma
E Oricchio, HG Wendel |
Annals of the New York Academy of Sciences | 2013 |
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Lymphoid malignancies: many tumor types, many altered genes, many therapeutic challenges
Riccardo Dalla-Favera |
Journal of Clinical Investigation | 2012 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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