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Citations to this article

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer
Aurélie Couturier-Maillard, … , Philip Rosenstiel, Mathias Chamaillard
Aurélie Couturier-Maillard, … , Philip Rosenstiel, Mathias Chamaillard
Published January 2, 2013
Citation Information: J Clin Invest. 2013;123(2):700-711. https://doi.org/10.1172/JCI62236.
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Research Article Oncology Article has an altmetric score of 36

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer

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Abstract

Instability in the composition of gut bacterial communities (dysbiosis) has been linked to common human intestinal disorders, such as Crohn’s disease and colorectal cancer. Here, we show that dysbiosis caused by Nod2 deficiency gives rise to a reversible, communicable risk of colitis and colitis-associated carcinogenesis in mice. Loss of either Nod2 or RIP2 resulted in a proinflammatory microenvironment that enhanced epithelial dysplasia following chemically induced injury. The condition could be improved by treatment with antibiotics or an anti–interleukin-6 receptor–neutralizing antibody. Genotype-dependent disease risk was communicable via maternally transmitted microbiota in both Nod2-deficient and WT hosts. Furthermore, reciprocal microbiota transplantation reduced disease risk in Nod2-deficient mice and led to long-term changes in intestinal microbial communities. Conversely, disease risk was enhanced in WT hosts that were recolonized with dysbiotic fecal microbiota from Nod2-deficient mice. Thus, we demonstrated that licensing of dysbiotic microbiota is a critical component of disease risk. Our results demonstrate that NOD2 has an unexpected role in shaping a protective assembly of gut bacterial communities and suggest that manipulation of dysbiosis is a potential therapeutic approach in the treatment of human intestinal disorders.

Authors

Aurélie Couturier-Maillard, Thomas Secher, Ateequr Rehman, Sylvain Normand, Adèle De Arcangelis, Robert Haesler, Ludovic Huot, Teddy Grandjean, Aude Bressenot, Anne Delanoye-Crespin, Olivier Gaillot, Stefan Schreiber, Yves Lemoine, Bernhard Ryffel, David Hot, Gabriel Nùñez, Grace Chen, Philip Rosenstiel, Mathias Chamaillard

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Total
Citations: 7 14 27 17 23 24 26 29 28 31 30 33 24 313
Citation information
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Citations to this article in year 2015 (30)

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SC Nalle, JR Turner
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Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance
E Denou, K Lolmede, L Garidou, C Pomie, C Chabo, TC Lau, MD Fullerton, G Nigro, A Zakaroff-Girard, E Luche, C Garret, M Serino, J Amar, M Courtney, JF Cavallari, BD Henriksbo, NG Barra, KP Foley, JB McPhee, BM Duggan, HM O'Neill, AJ Lee, P Sansonetti, AA Ashkar, WI Khan, MG Surette, A Bouloumie, GR Steinberg, R Burcelin, JD Schertzer
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LF Buttó, M Schaubeck, D Haller
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S Caballero, EG Pamer
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D Rojo, A Hevia, R Bargiela, P López, A Cuervo, S González, A Suárez, B Sánchez, M Martínez-Martínez, C Milani, M Ventura, C Barbas, A Moya, A Suárez, A Margolles, M Ferrer
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D Srutkova, M Schwarzer, T Hudcovic, Z Zakostelska, V Drab, A Spanova, B Rittich, H Kozakova, I Schabussova, M Chamaillard
PloS one 2015
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JR Hov, H Zhong, B Qin, JA Anmarkrud, K Holm, A Franke, BA Lie, TH Karlsen, BA Wilson
PloS one 2015
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K Kaliannan, B Wang, XY Li, KJ Kim, JX Kang
Scientific Reports 2015
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ILAR journal / National Research Council, Institute of Laboratory Animal Resources 2015
Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs
Y Hu, J Peng, N Tai, C Hu, X Zhang, FS Wong, L Wen
Journal of immunology (Baltimore, Md. : 1950) 2015
Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors
P Canning, Q Ruan, T Schwerd, M Hrdinka, JL Maki, D Saleh, C Suebsuwong, S Ray, PE Brennan, GD Cuny, HH Uhlig, M Gyrd-Hansen, A Degterev, AN Bullock
Chemistry & Biology 2015
The Microbiome and Cancer: Is the ‘Oncobiome’ Mirage Real?
RM Thomas, C Jobin
Trends in Cancer 2015
N-3 Polyunsaturated Fatty Acids (PUFAs) Reverse the Impact of Early-Life Stress on the Gut Microbiota
MM Pusceddu, SE Aidy, F Crispie, O OSullivan, P Cotter, C Stanton, P Kelly, JF Cryan, TG Dinan, J Homberg
PloS one 2015
From Birth to “Immunohealth,” Allergies and Enterocolitis:
PD Houghteling, WA Walker
Journal of Clinical Gastroenterology 2015
Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence
M Schaubeck, T Clavel, J Calasan, I Lagkouvardos, SB Haange, N Jehmlich, M Basic, A Dupont, M Hornef, M Bergen, A Bleich, D Haller
Gut 2015
Fecal microbiota transplantation: in perspective
S Gupta, E Allen-Vercoe, EO Petrof
Therapeutic advances in gastroenterology 2015
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J Babickova
World journal of gastroenterology : WJG 2015
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G Nakatsu, X Li, H Zhou, J Sheng, SH Wong, WK Wu, SC Ng, H Tsoi, Y Dong, N Zhang, Y He, Q Kang, L Cao, K Wang, J Zhang, Q Liang, J Yu, JJ Sung
Nature Communications 2015
Immune–microbiota interactions in health and disease
NW Palm, MR de Zoete, RA Flavell
Clinical Immunology 2015
Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling
M Levy, CA Thaiss, D Zeevi, L Dohnalová, G Zilberman-Schapira, JA Mahdi, E David, A Savidor, T Korem, Y Herzig, M Pevsner-Fischer, H Shapiro, A Christ, A Harmelin, Z Halpern, E Latz, RA Flavell, I Amit, E Segal, E Elinav
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European Journal of Pediatrics 2015
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Tumor Biology 2015

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