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Charles G. Mullighan
Published October 1, 2012
Citation Information: J Clin Invest. 2012;122(10):3407-3415. https://doi.org/10.1172/JCI61203.
Citation Information: J Clin Invest. 2012;122(10):3407-3415. https://doi.org/10.1172/JCI61203.
Abstract
B-precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood tumor and the leading cause of cancer-related death in children and young adults. The majority of B-ALL cases are aneuploid or harbor recurring structural chromosomal rearrangements that are important initiating events in leukemogenesis but are insufficient to explain the biology and heterogeneity of disease. Recent studies have used microarrays and sequencing to comprehensively identify all somatic genetic alterations in acute lymphoblastic leukemia (ALL). These studies have identified cryptic or submicroscopic genetic alterations that define new ALL subtypes, cooperate with known chromosomal rearrangements, and influence prognosis. This article reviews these advances, discusses results from ongoing second-generation sequencing studies of ALL, and highlights challenges and opportunities for future genetic profiling approaches.
Authors
Charles G. Mullighan
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Citations to this article (123)
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LNK(SH2B3) Regulates IL-7 Receptor Signaling in Normal and Malignant B-Progenitors
Ying Cheng, Kudakwashe, R. Chikwava, Chao Wu, Haibing Zhang, Anchit Bhagat, Dehua Pei, John Choi, Wei Tong |
Journal of Clinical Investigation | 2016 |
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Synergism of FAK and tyrosine kinase inhibition in Ph+ B-ALL
Michelle L. Churchman, Kathryn Evans, Jennifer Richmond, Alissa Robbins, Luke Jones, Irina M. Shapiro, Jonathan Pachter, David Weaver, Peter Houghton, Malcolm A. Smith, Richard Lock, Charles G. Mullighan |
JCI Insight | 2016 |
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[Bioinformatics analysis of microRNA comprehensive regulatory network in B- cell acute lymphoblastic leukemia]
M N Zeng, W L Ma, W L Zheng |
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi | 2016 |
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Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia
K Oshima, H Khiabanian, AC da Silva-Almeida, G Tzoneva, F Abate, A Ambesi-Impiombato, M Sanchez-Martin, Z Carpenter, A Penson, A Perez-Garcia, C Eckert, C Nicolas, M Balbin, ML Sulis, M Kato, K Koh, M Paganin, G Basso, JM Gastier-Foster, M Devidas, ML Loh, R Kirschner-Schwabe, T Palomero, R Rabadan, AA Ferrando |
Proceedings of the National Academy of Sciences | 2016 |
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Eye on the B-ALL: B-cell receptor repertoires reveal persistence of numerous B-lymphoblastic leukemia subclones from diagnosis to relapse
RJ Bashford-Rogers, KA Nicolaou, J Bartram, NJ Goulden, L Loizou, L Koumas, J Chi, M Hubank, P Kellam, PA Costeas, GS Vassiliou |
Leukemia | 2016 |
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Differentiation resistance through altered retinoblastoma protein function in acute lymphoblastic leukemia: in silico modeling of the deregulations in the G1/S restriction point pathway
E Ouzounoglou, D Dionysiou, GS Stamatakos |
BMC Systems Biology | 2016 |
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The formation of an aberrant PAX5 transcript in a patient with mixed phenotype acute leukemia harboring der(9)t(7;9)(q11.2;p13)
J Amaki, H Matsushita, Y Kitamura, R Nagao, H Murayama, M Kojima, K Ando |
Leukemia research reports | 2016 |
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A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology
EA Hungate, SR Vora, ER Gamazon, T Moriyama, T Best, I Hulur, Y Lee, TJ Evans, E Ellinghaus, M Stanulla, J Rudant, L Orsi, J Clavel, E Milne, RJ Scott, CH Pui, NJ Cox, ML Loh, JJ Yang, AD Skol, K Onel |
Nature Communications | 2016 |
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Advances in Experimental Medicine and Biology
NR Harrison, FJ Laroche, A Gutierrez, H Feng |
Advances in experimental medicine and biology | 2016 |
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Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia
C Hicks, C Hicks, R Ramani, C Karlson, J Sitthi-Amorn, J Douglas, V Vijayakumar, J Chipeta, G Megason, L Miele |
Clinical Medicine Insights. Oncology | 2016 |
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TESTIN Induces Rapid Death and Suppresses Proliferation in Childhood B Acute Lymphoblastic Leukaemia Cells
RJ Weeks, JL Ludgate, G LeMée, IM Morison, L Bendall |
PloS one | 2016 |
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Genomic characterization of paediatric acute lymphoblastic leukaemia: an opportunity for precision medicine therapeutics
SK Tasian, SP Hunger |
British Journal of Haematology | 2016 |
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Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia
LW Ding, QY Sun, KT Tan, W Chien, AM Thippeswamy, AE Yeoh, N Kawamata, Y Nagata, JF Xiao, XY Loh, DC Lin, M Garg, YY Jiang, L Xu, SL Lim, LZ Liu, V Madan, M Sanada, LT Fernández, H Preethi, M Lill, HM Kantarjian, SM Kornblau, S Miyano, DC Liang, S Ogawa, LY Shih, H Yang, HP Koeffler |
Cancer research | 2016 |
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Superenhancer reprogramming drives a B-cell–epithelial transition and high-risk leukemia
Y Hu, Z Zhang, M Kashiwagi, T Yoshida, I Joshi, N Jena, R Somasundaram, AO Emmanuel, M Sigvardsson, J Fitamant, N El-Bardeesy, F Gounari, RA van Etten, K Georgopoulos |
Genes & development | 2016 |
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International reference analysis of outcomes in adults with B-precursor Ph-negative relapsed/refractory acute lymphoblastic leukemia
N Gokbuget, H Dombret, JM Ribera, AK Fielding, A Advani, R Bassan, V Chia, M Doubek, S Giebel, D Hoelzer, N Ifrah, A Katz, M Kelsh, G Martinelli, M Morgades, S OBrien, JM Rowe, J Stieglmaier, M Wadleigh, H Kantarjian |
Haematologica | 2016 |
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Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes
Messina M, Chiaretti S, Wang J, Fedullo AL, Peragine N, Gianfelici V, Piciocchi A, Brugnoletti F, Di Giacomo F, Pauselli S, Holmes AB, Puzzolo MC, Ceglie G, Apicella V, Mancini M, te Kronnie G, Testi AM, Vitale A, Vignetti M, Guarini A, Rabadan R, Foà R |
Oncotarget | 2016 |
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LncRNA Expression Discriminates Karyotype and Predicts Survival in B-lymphoblastic Leukemia
TR Fernando, NI Rodriguez-Malave, EV Waters, W Yan, D Casero, G Basso, M Pigazzi, DS Rao |
Molecular cancer research : MCR | 2015 |
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CXCL12/CXCR4 axis in the pathogenesis of acute lymphoblastic leukemia (ALL): a possible therapeutic target
AL Perim, MK Amarante, RL Guembarovski, CE de Oliveira, MA Watanabe |
Cellular and Molecular Life Sciences | 2015 |
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Integration of cytogenomic data for furthering the characterization of pediatric B-cell acute lymphoblastic leukemia: a multi-institution, multi-platform microarray study
LB Baughn, JA Biegel, ST South, TA Smolarek, S Volkert, AJ Carroll, NA Heerema, KR Rabin, PA Zweidler-McKay, M Loh, B Hirsch |
Cancer Genetics | 2015 |
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Childhood acute lymphoblastic leukemia: Integrating genomics into therapy: Childhood ALL Genomics
SK Tasian, ML Loh, SP Hunger |
Cancer | 2015 |
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Transcriptome Analysis of Minimal Residual Disease in Subtypes of Pediatric B Cell Acute Lymphoblastic Leukemia
C Hicks, B Herrington, G Megason, S Hogan, T Koganti, J Pullen, C Gordon, J Sitthi-amorn |
Clinical Medicine Insights. Oncology | 2015 |
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Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemia
L der Weyden, G Giotopoulos, K Wong, AG Rust, CD Robles-Espinoza, H Osaki, BJ Huntly, DJ Adams |
BMC Cancer | 2015 |
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BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia
NI Rodríguez-Malavé, TR Fernando, PC Patel, JR Contreras, JK Palanichamy, TM Tran, J Anguiano, MJ Davoren, MO Alberti, KT Pioli, S Sandoval, GM Crooks, DS Rao |
Molecular Cancer | 2015 |
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A ceRNA approach may unveil unexpected contributors to deletion syndromes, the model of 5q- syndrome
Arancio W, Genovese SI, Bongiovanni L, Tripodo C |
Oncoscience | 2015 |
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Genetically engineered mouse models of human B-cell precursor leukemias
J Hauer, A Borkhardt, I Sánchez-García, C Cobaleda |
Cell cycle (Georgetown, Tex.) | 2014 |
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Ikaros deletions in BCR-ABL-negative childhood acute lymphoblastic leukemia are associated with a distinct gene expression signature but do not result in intrinsic chemoresistance: IKZF1 Deleted B-ALL Gene Expression
NA Vitanza, W Zaky, R Blum, JA Meyer, J Wang, T Bhatla, DJ Morrison, EA Raetz, WL Carroll |
Pediatric Blood & Cancer | 2014 |
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Midkine as a regulator of B cell survival in health and disease: Midkine in B cell survival
S Cohen, I Shachar |
British Journal of Pharmacology | 2014 |
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Childhood B-acute lymphoblastic leukemia: a genetic update
JS Woo, MO Alberti, CA Tirado |
Experimental Hematology and Oncology | 2014 |
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Targeted therapy with MXD3 siRNA, anti-CD22 antibody and nanoparticles for precursor B-cell acute lymphoblastic leukaemia
N Satake, C Duong, C Chen, GA Barisone, E Diaz, J Tuscano, DM Rocke, J Nolta, N Nitin |
British Journal of Haematology | 2014 |
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Prognostification of ALL by Cytogenetics
A Hakeem, AA Shiekh, GM Bhat, AR Lone |
Indian Journal of Hematology and Blood Transfusion | 2014 |
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Murine B-1 B Cell Progenitors Initiate B-Acute Lymphoblastic Leukemia with Features of High-Risk Disease
E Montecino-Rodriguez, K Li, M Fice, K Dorshkind |
Journal of immunology (Baltimore, Md. : 1950) | 2014 |
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Effect of GSTM1 null genotype on risk of childhood acute leukemia: a meta-analysis
Y Ma, Y Sui, L Wang, H Li |
Tumor Biology | 2013 |
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Genomics of racial and ethnic disparities in childhood acute lymphoblastic leukemia: Genomics and Childhood ALL Disparities
JY Lim, S Bhatia, LL Robison, JJ Yang |
Cancer | 2013 |
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Analysis of Patterns of Gene Expression Variation within and between Ethnic Populations in Pediatric B-ALL
C Hicks, L Miele, T Koganti, L Young-Gaylor, D Rogers, V Vijayakumar, G Megason |
Cancer informatics | 2013 |
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Applicability of gene expression profile of childhood acute lymphoblastic leukemia at diagnosis and at the end of the induction phase of chemotherapy at a cancer hospital in the state of Goiás (Brazil)
LB Minasi, FR Godoy, D de M. e Silva, TC Vieira, CC da Silva, AD da Cruz |
Tumor Biology | 2013 |
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Lymphoid malignancies: many tumor types, many altered genes, many therapeutic challenges
Riccardo Dalla-Favera |
Journal of Clinical Investigation | 2012 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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