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Rubin M. Tuder, Irina Petrache
Published August 1, 2012
Citation Information: J Clin Invest. 2012;122(8):2749-2755. https://doi.org/10.1172/JCI60324.
Citation Information: J Clin Invest. 2012;122(8):2749-2755. https://doi.org/10.1172/JCI60324.
Abstract
The current epidemic of chronic obstructive pulmonary disease (COPD) has produced a worldwide health care burden, approaching that imposed by transmittable infectious diseases. COPD is a multidimensional disease, with varied intermediate and clinical phenotypes. This Review discusses the pathogenesis of COPD, with particular focus on emphysema, based on the concept that pulmonary injury involves stages of initiation (by exposure to cigarette smoke, pollutants, and infectious agents), progression, and consolidation. Tissue damage entails complex interactions among oxidative stress, inflammation, extracellular matrix proteolysis, and apoptotic and autophagic cell death. Lung damage by cigarette smoke ultimately leads to self-propagating processes, resulting in macromolecular and structural alterations — features similar to those seen in aging.
Authors
Rubin M. Tuder, Irina Petrache
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Citations to this article (233)
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B Kosmider, CR Lin, L Vlasenko, N Marchetti, S Bolla, GJ Criner, E Messier, N Reisdorph, RL Powell, M Madesh, S Kelsen, N Xander, KA Correll, RJ Mason, K Bahmed |
Scientific Reports | 2019 |
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Expression, activity and localization of lysosomal sulfatases in Chronic Obstructive Pulmonary Disease
J Weidner, P Jogdand, L Jarenbäck, I Åberg, D Helihel, J Ankerst, G Westergren-Thorsson, L Bjermer, JS Erjefält, E Tufvesson |
Scientific Reports | 2019 |
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S100A8 Protects Human Primary Alveolar Type II Cells against Injury and Emphysema
CR Lin, K Bahmed, GJ Criner, N Marchetti, RM Tuder, S Kelsen, S Bolla, C Mandapati, B Kosmider |
American journal of respiratory cell and molecular biology | 2019 |
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Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape
M Serra, F Marongiu, MG Pisu, M Serra, E Laconi |
Aging | 2019 |
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Cerebrovascular and Neurological Disorders: Protective Role of NRF2
F Sivandzade, A Bhalerao, L Cucullo |
International journal of molecular sciences | 2019 |
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Lipopolysaccharide enhances DNA‑induced IFN‑β expression and autophagy by upregulating cGAS expression in A549 cells
R Wang, W Wang, A Li, Y Wang, J Jin, Z Huang, G Huang |
Experimental and therapeutic medicine | 2019 |
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Objectively Measured Chronic Lung Injury on Chest CT
R Harmouche, SY Ash, RK Putman, GM Hunninghake, RS Estepar, FJ Martinez, AM Choi, DA Lynch, H Hatabu, ML Han, RP Bowler, R Kalhan, IO Rosas, GR Washko, RS Estepar |
Chest | 2019 |
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The relationship between DJ-1 and S100A8 in human primary alveolar type II cells in emphysema
CR Lin, K Bahmed, D Tomar, N Marchetti, GJ Criner, S Bolla, MA Wilson, M Madesh, B Kosmider |
American journal of physiology. Lung cellular and molecular physiology | 2019 |
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Targeting HDAC Complexes in Asthma and COPD
M Zwinderman, S de Weerd, F Dekker |
Epigenomes | 2019 |
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Personalized medicine for patients with COPD: where are we?
Franssen FM, Alter P, Bar N, Benedikter BJ, Iurato S, Maier D, Maxheim M, Roessler FK, Spruit MA, Vogelmeier CF, Wouters EF, Schmeck B |
International journal of chronic obstructive pulmonary disease | 2019 |
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Chronic obstructive pulmonary disease (COPD) and lung cancer: common pathways for pathogenesis
Parris BA, O\u2019Farrell HE, Fong KM, Yang IA |
Journal of Thoracic Disease | 2019 |
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Oxidative Stress Mechanisms in the Pathogenesis of Environmental Lung Diseases
Thimmulappa RK, Chattopadhyay I, Rajasekaran S |
2019 | |
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Peripheral blood CD4+ T cell populations by CD25 and Foxp3 expression as a potential biomarker: reflecting inflammatory activity in chronic obstructive pulmonary disease.
Meng ZJ, Wu JH, Zhou M, Sun SW, Miao SY, Han HL, Chen L, Xiong XZ |
International journal of chronic obstructive pulmonary disease | 2019 |
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Chronic Obstructive Pulmonary Disease and Risk of Dementia and Mortality in Lower to Middle Income Countries
Cherbuin N, Walsh EI, Prina AM |
Journal of Alzheimer's disease : JAD | 2019 |
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Beclin-1 Regulates Cigarette Smoke-Induced Kidney Injury in a Murine Model of Chronic Obstructive Pulmonary Disease
MARIA PABON, Edwin Patino, Divya Bhatia, Joselyn Rojas-Quintero, Kevin C Ma, Eli Finkelsztein, Juan C. Osorio, Faryal Malick, Francesca Polverino, Caroline A. Owen, Stefan W. Ryter, Augustine Choi, Suzanne M. Cloonan, Mary E Choi |
JCI Insight | 2018 |
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Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype
chaoqun wang, Nabora Soledad Reyes de Mochel, Stephanie Christenson, Monica Cassandras, Rebecca Moon, Alexis Brumwell, Lauren Byrnes, Alfred Li, Yasuyuki Yokosaki, Peiying Shan, Julie Sneddon, David Jablons, Patty J. Lee, Michael A. Matthay, Harold Chapman, Tien Peng |
Journal of Clinical Investigation | 2018 |
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Bringing Light to Chronic Obstructive Pulmonary Disease Pathogenesis and Resilience
RM Tuder |
Annals of the American Thoracic Society | 2018 |
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Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists
MA Bewley, RC Budd, E Ryan, J Cole, P Collini, J Marshall, U Kolsum, G Beech, RD Emes, I Tcherniaeva, GA Berbers, SR Walmsley, G Donaldson, JA Wedzicha, I Kilty, W Rumsey, Y Sanchez, CE Brightling, LE Donnelly, PJ Barnes, D Singh, MK Whyte, DH Dockrell |
American journal of respiratory and critical care medicine | 2018 |
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Xeroderma Pigmentosum Group C Deficiency Alters Cigarette Smoke DNA Damage Cell Fate and Accelerates Emphysema Development
CR Sears, H Zhou, MJ Justice, AJ Fisher, J Saliba, I Lamb, J Wicker, KS Schweitzer, I Petrache |
American journal of respiratory cell and molecular biology | 2018 |
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Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure
K Mizumura, MJ Justice, KS Schweitzer, S Krishnan, I Bronova, EV Berdyshev, WC Hubbard, Y Pewzner-Jung, AH Futerman, AM Choi, I Petrache |
The FASEB Journal | 2018 |
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Acute Moraxella catarrhalis airway infection of chronically smoke-exposed mice increases mechanisms of emphysema development: A pilot study
K Fischer, JM Doehn, C Herr, C Lachner, A Heinrich, O Kershaw, M Voss, MH Jacobson, AD Gruber, M Clauss, M Witzenrath, R Bals, B Gutbier, H Slevogt |
European Journal of Microbiology and Immunology | 2018 |
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Reactive Oxygen Species in Chronic Obstructive Pulmonary Disease
S Boukhenouna, MA Wilson, K Bahmed, B Kosmider |
Oxidative medicine and cellular longevity | 2018 |
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The cytoprotective role of DJ-1 and p45 NFE2 against human primary alveolar type II cell injury and emphysema
LH Tan, K Bahmed, CR Lin, N Marchetti, S Bolla, GJ Criner, S Kelsen, M Madesh, B Kosmider |
Scientific Reports | 2018 |
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Building predictive in vitro pulmonary toxicity assays using high-throughput imaging and artificial intelligence
JY Lee, JA Miller, S Basu, TZ Kee, LH Loo |
Archives of Toxicology | 2018 |
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Cholesterol metabolism promotes B‐cell positioning during immune pathogenesis of chronic obstructive pulmonary disease
J Jia, TM Conlon, RS Sarker, D Taşdemir, NF Smirnova, B Srivastava, SE Verleden, G Güneş, X Wu, C Prehn, J Gao, K Heinzelmann, J Lintelmann, M Irmler, S Pfeiffer, M Schloter, R Zimmermann, MH de Angelis, J Beckers, J Adamski, H Bayram, O Eickelberg, AÖ Yildirim |
EMBO Molecular Medicine | 2018 |
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Activation of p70S6 Kinase-1 in Mesenchymal Stem Cells Is Essential to Lung Tissue Repair: p70S6 Kinase-1 in Mesenchymal Stem Cells
K Takeda, F Ning, J Domenico, M Okamoto, S Ashino, SH Kim, YY Jeong, Y Shiraishi, N Terada, ER Sutherland, EW Gelfand |
Stem Cells Translational Medicine | 2018 |
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Autoantibodies in Chronic Obstructive Pulmonary Disease
L Wen, S Krauss-Etschmann, F Petersen, X Yu |
Frontiers in immunology | 2018 |
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SIRT1 Activity in Peripheral Blood Mononuclear Cells Correlates with Altered Lung Function in Patients with Chronic Obstructive Pulmonary Disease
V Conti, G Corbi, V Manzo, P Malangone, C Vitale, A Maglio, R Cotugno, D Capaccio, L Marino, C Selleri, C Stellato, A Filippelli, A Vatrella |
Oxidative medicine and cellular longevity | 2018 |
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A Genome-Wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos
KM Burkart, T Sofer, SJ London, A Manichaikul, FP Hartwig, Q Yan, MS Artigas, L Avila, W Chen, SD Thomas, AA Diaz, IP Hall, BL Horta, RC Kaplan, CC Laurie, AM Menezes, JV Morrison, EC Oelsner, D Rastogi, SS Rich, M Soto-Quiros, AM Stilp, MD Tobin, LV Wain, JC Celedón, RG Barr |
American journal of respiratory and critical care medicine | 2018 |
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Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives
P Paliogiannis, AG Fois, S Sotgia, AA Mangoni, E Zinellu, P Pirina, S Negri, C Carru, A Zinellu |
European Respiratory Review | 2018 |
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A Drosophila model of cigarette smoke induced COPD identifies Nrf2 signaling as an expedient target for intervention
R Prange, M Thiedmann, A Bhandari, N Mishra, A Sinha, R Häsler, P Rosenstiel, K Uliczka, C Wagner, AÖ Yildirim, C Fink, T Roeder |
Aging | 2018 |
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Endoplasmic reticulum, Golgi, and lysosomes are disorganized in lung fibroblasts from chronic obstructive pulmonary disease patients
Weidner J, Jarenbäck L, Åberg I, Westergren\u2010Thorsson G, Ankerst J, Bjermer L, Tufvesson E |
Physiological Reports | 2018 |
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Identification of novel candidate genes involved in the progression of emphysema by bioinformatic methods.
Hu WP, Zeng YY, Zuo YH, Zhang J |
International journal of chronic obstructive pulmonary disease | 2018 |
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Impact of Various Types of Comorbidities on the Outcomes of Laparoscopic Total Gastrectomy in Patients with Gastric Carcinoma
Jeong O, Jung MR, Ryu SY |
Journal of Gastric Cancer | 2018 |
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Free Desmosine is a Sensitive Marker of Smoke-Induced Emphysema.
Cantor J, Ochoa A, Ma S, Liu X, Turino G |
Lung | 2018 |
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Nucleosides isolated from Ophiocordyceps sinensis inhibit cigarette smoke extract-induced inflammation via the SIRT1-nuclear factor-κB/p65 pathway in RAW264.7 macrophages and in COPD mice.
Sun X, Dong Z, Li N, Feng X, Liu Y, Li A, Zhu X, Li C, Zhao Z |
International journal of chronic obstructive pulmonary disease | 2018 |
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Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung
PT King, R Sharma, KM OSullivan, J Callaghan, L Dousha, B Thomas, S Ruwanpura, S Lim, MW Farmer, BR Jennings, M Finsterbusch, G Brooks, S Selemidis, GP Anderson, SR Holdsworth, PG Bardin |
Scientific Reports | 2017 |
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Resveratrol inhibits hypoxia-induced proliferation and migration of pulmonary artery vascular smooth muscle cells by inhibiting the phosphoinositide 3-kinase/protein kinase B signaling pathway
Z Guan, L Shen, H Liang, H Yu, B Hei, X Meng, L Yang |
Molecular medicine reports | 2017 |
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Pulmonary Vasculature Redox Signaling in Health and Disease
YX Wang |
Pulmonary Vasculature Redox Signaling in Health and Disease | 2017 |
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COPD as an endothelial disorder: endothelial injury linking lesions in the lungs and other organs? (2017 Grover Conference Series)
F Polverino, BR Celli, CA Owen |
Pulmonary circulation | 2017 |
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Receptor for advanced glycation endproducts (RAGE) maintains pulmonary structure and regulates the response to cigarette smoke
L Wolf, C Herr, J Niederstraßer, C Beisswenger, R Bals, TH Thatcher |
PloS one | 2017 |
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RTP801 Amplifies Nicotinamide Adenine Dinucleotide Phosphate Oxidase-4–Dependent Oxidative Stress Induced by Cigarette Smoke
D Hernández-Saavedra, L Sanders, MJ Perez, B Kosmider, LP Smith, JD Mitchell, T Yoshida, RM Tuder |
American journal of respiratory cell and molecular biology | 2017 |
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Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages
MA Bewley, JA Preston, M Mohasin, HM Marriott, RC Budd, J Swales, P Collini, DR Greaves, RW Craig, CE Brightling, LE Donnelly, PJ Barnes, D Singh, SD Shapiro, MK Whyte, DH Dockrell |
American journal of respiratory and critical care medicine | 2017 |
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Exposure to Ambient Particulate Matter Induced COPD in a Rat Model and a Description of the Underlying Mechanism
F He, B Liao, J Pu, C Li, M Zheng, L Huang, Y Zhou, D Zhao, B Li, P Ran |
Scientific Reports | 2017 |
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When Is an Alveolar Type 2 Cell an Alveolar Type 2 Cell? A Conundrum for Lung Stem Cell Biology and Regenerative Medicine
MF Beers, Y Moodley |
American journal of respiratory cell and molecular biology | 2017 |
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Genetic Control of Fatty Acid β-Oxidation in Chronic Obstructive Pulmonary Disease
Z Jiang, NH Knudsen, G Wang, W Qiu, ZZ Naing, Y Bai, X Ai, CH Lee, X Zhou |
American journal of respiratory cell and molecular biology | 2017 |
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A novel pathway-based distance score enhances assessment of disease heterogeneity in gene expression
X Yan, A Liang, J Gomez, L Cohn, H Zhao, GL Chupp |
BMC bioinformatics | 2017 |
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Cardiovascular risk in patients with alpha-1-antitrypsin deficiency
S Fähndrich, F Biertz, A Karch, B Kleibrink, A Koch, H Teschler, T Welte, HU Kauczor, S Janciauskiene, RA Jörres, T Greulich, CF Vogelmeier, R Bals |
Respiratory Research | 2017 |
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The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1
DN Meijles, S Sahoo, IA Ghouleh, JH Amaral, R Bienes-Martinez, HE Knupp, S Attaran, JC Sembrat, SM Nouraie, MM Rojas, EM Novelli, MT Gladwin, JS Isenberg, E Cifuentes-Pagano, PJ Pagano |
Science signaling | 2017 |
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Serum levels of IGFBP7 are elevated during acute exacerbation in COPD patients
W Ruan, M Wu, L Shi, F Li, L Dong, Y Qiu, X Wu, K Ying |
International journal of chronic obstructive pulmonary disease | 2017 |
|
Novel mechanisms for crotonaldehyde-induced lung edema
Y Li, J Chang, Y Cui, R Zhao, Y Ding, Y Hou, Z Zhou, HL Ji, H Nie |
Oncotarget | 2017 |
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Can Youthful Mesenchymal Stem Cells from Wharton’s Jelly Bring a Breath of Fresh Air for COPD?
A Janczewski, J Wojtkiewicz, E Malinowska, A Doboszyńska |
International journal of molecular sciences | 2017 |
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Tubeimoside I attenuates inflammation and oxidative damage in a mice model of PM2.5‑induced pulmonary injury
JB Zhang, L Zhang, SQ Li, AH Hou, WC Liu, LL Dai |
Experimental and therapeutic medicine | 2017 |
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Rapid decline in lung function is temporally associated with greater metabolically active adiposity in a longitudinal study of healthy adults.
Moualla M, Qualls C, Arynchyn A, Thyagarajan B, Kalhan R, Smith LJ, Carr JJ, Jacobs DR, Sood A |
Thorax | 2017 |
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[Clinical Characteristics of 118 Cases of Chronic Obstructive Pulmonary Disease Complicated with Primary Bronchopulmonary Carcinoma].
Zhao S, Nie X, Zhang L, Zhang W, Xiao H |
Zhongguo fei ai za zhi = Chinese journal of lung cancer | 2017 |
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The Effects of Resveratrol on Inflammation and Oxidative Stress in a Rat Model of Chronic Obstructive Pulmonary Disease.
Wang XL, Li T, Li JH, Miao SY, Xiao XZ |
Molecules (Basel, Switzerland) | 2017 |
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Neutrophil/lymphocyte ratio is a more sensitive systemic inflammatory response biomarker than platelet/lymphocyte ratio in the prognosis evaluation of unresectable pancreatic cancer
Gao Y, Wang WJ, Zhi Q, Shen M, Jiang M, Bian X, Gong FR, Zhou C, Lian L, Wu MY, Feng J, Tao M, Li W |
Oncotarget | 2017 |
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A prospective randomized controlled study: Theophylline on oxidative stress and steroid sensitivity in chronic obstructive pulmonary disease patients.
Ranjani R, Vinotha ATS |
International Journal of Pharmaceutical Investigation | 2017 |
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慢性阻塞性肺疾病合并原发性支气管肺癌118例临床特征分析
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2017 | |
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Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases
Gang Liu, Marion Cooley, andrew Jarnicki, Alan Hsu, Prema Nair, Tatt Jhong Haw, Michael Fricker, Shaan Gellatly, Richard Kim, Mark Inman, Gavin Tjin, Peter Wark, Marjorie Walker, Jay Horvat, Brian Oliver, W Scott Argraves, Darryl Knight, Janette Burgess, Philip Hansbro |
JCI Insight | 2016 |
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Structural and functional characterization of endothelial microparticles released by cigarette smoke
KA Serban, S Rezania, DN Petrusca, C Poirier, D Cao, MJ Justice, M Patel, I Tsvetkova, K Kamocki, A Mikosz, KS Schweitzer, S Jacobson, A Cardoso, N Carlesso, WC Hubbard, K Kechris, B Dragnea, EV Berdyshev, J McClintock, I Petrache |
Scientific Reports | 2016 |
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Alpha-1 Antitrypsin Investigations Using Animal Models of Emphysema
K Ni, KA Serban, C Batra, I Petrache |
Annals of the American Thoracic Society | 2016 |
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Treatment with intranasal iloprost reduces disease manifestations in a murine model of previously established COPD
MR Lammi, MA Ghonim, K Pyakurel, AS Naura, SV Ibba, CJ Davis, SC Okpechi, KI Happel, BP deBoisblanc, J Shellito, AH Boulares |
American journal of physiology. Lung cellular and molecular physiology | 2016 |
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Bax-induced apoptosis shortens the life span of DNA repair defect Ku70-knockout mice by inducing emphysema
S Matsuyama, J Palmer, A Bates, I Poventud-Fuentes, K Wong, J Ngo, M Matsuyama |
Experimental biology and medicine (Maywood, N.J.) | 2016 |
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Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD
MA Bewley, KB Belchamber, KK Chana, RC Budd, G Donaldson, JA Wedzicha, CE Brightling, I Kilty, LE Donnelly, PJ Barnes, D Singh, MK Whyte, DH Dockrell, UA Maus |
PloS one | 2016 |
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Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency
BW Richmond, RM Brucker, W Han, RH Du, Y Zhang, DS Cheng, L Gleaves, R Abdolrasulnia, D Polosukhina, PE Clark, SR Bordenstein, TS Blackwell, VV Polosukhin |
Nature Communications | 2016 |
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The Mucus Barrier to Inhaled Gene Therapy
GA Duncan, J Jung, J Hanes, JS Suk |
Molecular Therapy | 2016 |
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Hhip haploinsufficiency sensitizes mice to age-related emphysema
T Lao, Z Jiang, J Yun, W Qiu, F Guo, C Huang, JD Mancini, K Gupta, ME Laucho-Contreras, ZZ Naing, L Zhang, MA Perrella, CA Owen, EK Silverman, X Zhou |
Proceedings of the National Academy of Sciences | 2016 |
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Lost in Trans-IL-6 Signaling: Alveolar Type II Cell Death in Emphysema
I Petrache, K Serban |
American journal of respiratory and critical care medicine | 2016 |
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Association of MicroRNA-196a2 Variant with Response to Short-Acting β2-Agonist in COPD: An Egyptian Pilot Study
MS Fawzy, MH Hussein, EZ Abdelaziz, HA Yamany, HM Ismail, EA Toraih, XY Guan |
PloS one | 2016 |
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Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity
PN Tsao, C Matsuoka, SC Wei, A Sato, S Sato, K Hasegawa, H Chen, TY Ling, M Mori, WV Cardoso, M Morimoto |
Proceedings of the National Academy of Sciences | 2016 |
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Exogenous Glutamine in Respiratory Diseases: Myth or Reality?
G Oliveira, M Abreu, P Pelosi, P Rocco |
Nutrients | 2016 |
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The formation and function of tertiary lymphoid follicles in chronic pulmonary inflammation
K Yadava, P Bollyky, MA Lawson |
Immunology | 2016 |
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The asthma–COPD overlap syndrome: do we really need another syndrome in the already complex matrix of airway disease?
K Kostikas, A Clemens, F Patalano |
International journal of chronic obstructive pulmonary disease | 2016 |
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Role of nitro-oxidative stress in the pathogenesis of experimental rat periodontitis
BA Boșca, V Miclăuș, A Ilea, RS Câmpian, V Rus, F Ruxanda, C Rațiu, A Uifălean, AE Pârvu |
Clujul Medical | 2016 |
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A Paradox: α-Klotho Levels and Smoking Intensity.
Verde Z, González-Moro JM, Chicharro LM, Reinoso-Barbero L, Bandrés F, Gómez-Gallego F, Santiago C |
Lung | 2016 |
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The Pattern of Elastic Fiber Breakdown in Bleomycin-Induced Pulmonary Fibrosis May Reflect Microarchitectural Changes.
Liu X, Ma S, Turino G, Cantor J |
Lung | 2016 |
|
Suppression of NLRX1 in Chronic Obstructive Pulmonary Disease
Min-Jong Kang, Chang Min Yoon, Bo Hye Kim, Chang-Min Lee, Yang Zhou, Maor Sauler, Robert Homer, Anish Dhamija, Daniel Boffa, A. Phillip West, Gerald Shadel, Jenny Ting, John Tedrow, Naftali Kaminski, Woo Jin Kim, Chun Geun Lee, Yeon-Mok Oh, Jack A. Elias |
Journal of Clinical Investigation | 2015 |
|
Resolvin D1 Reduces Emphysema and Chronic Inflammation
HM Hsiao, TH Thatcher, RA Colas, CN Serhan, RP Phipps, PJ Sime |
The American Journal of Pathology | 2015 |
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Telomere dysfunction causes alveolar stem cell failure
JK Alder, CE Barkauskas, N Limjunyawong, SE Stanley, F Kembou, RM Tuder, BL Hogan, W Mitzner, M Armanios |
Proceedings of the National Academy of Sciences | 2015 |
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Why Do We Need a Nonhuman Primate Model of Smoking-Induced COPD?
JL Curtis, CM Freeman |
The American Journal of Pathology | 2015 |
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Inflammation in chronic obstructive pulmonary disease and its role in cardiovascular disease and lung cancer
PT King |
Clinical and Translational Medicine | 2015 |
|
Imbalance of dendritic cell co-stimulation in COPD
P Stoll, M Ulrich, K Bratke, K Garbe, JC Virchow, M Lommatzsch |
Respiratory Research | 2015 |
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The Ratio of Free to Bound Desmosine and Isodesmosine May Reflect Emphysematous Changes in COPD
X Liu, S Ma, S Liu, M Liu, G Turino, J Cantor |
Pneumologie - Pneumology | 2015 |
|
Nontypeable Haemophilus influenzae Induces Sustained Lung Oxidative Stress and Protease Expression
PT King, R Sharma, K O’Sullivan, S Selemidis, S Lim, N Radhakrishna, C Lo, J Prasad, J Callaghan, P McLaughlin, M Farmer, D Steinfort, B Jennings, J Ngui, BR Broughton, B Thomas, AT Essilfie, M Hickey, PW Holmes, P Hansbro, PG Bardin, SR Holdsworth, N Palaniyar |
PloS one | 2015 |
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Sleep Disorders in Chronic Obstructive Pulmonary Disease: Etiology, Impact, and Management
R Budhiraja, TA Siddiqi, SF Quan |
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine | 2015 |
|
Nanomedicine delivers promising treatments for rheumatoid arthritis
LK Prasad, H O'Mary, Z Cui |
Nanomedicine | 2015 |
|
Comorbid Influences on Generic Health-Related Quality of Life in COPD: A Systematic Review
MB Huber, ME Wacker, CF Vogelmeier, R Leidl, H Watz |
PloS one | 2015 |
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Blunt Chest Trauma in Mice after Cigarette Smoke-Exposure: Effects of Mechanical Ventilation with 100 % O2
K Wagner, M Gröger, O McCook, A Scheuerle, P Asfar, B Stahl, M Huber-Lang, A Ignatius, B Jung, M Duechs, P Möller, M Georgieff, E Calzia, P Radermacher, F Wagner, M Griensven |
PloS one | 2015 |
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Pulmonary Microvascular Blood Flow in Mild Chronic Obstructive Pulmonary Disease and Emphysema. The MESA COPD Study
K Hueper, J Vogel-Claussen, MA Parikh, JH Austin, DA Bluemke, J Carr, J Choi, TA Goldstein, AS Gomes, EA Hoffman, SM Kawut, J Lima, ED Michos, WS Post, MJ Po, MR Prince, K Liu, D Rabinowitz, J Skrok, BM Smith, K Watson, Y Yin, AM Zambeli-Ljepovic, RG Barr |
American journal of respiratory and critical care medicine | 2015 |
|
Soluble extracellular Klotho decreases sensitivity to cigarette smoke induced cell death in human lung epithelial cells
DJ Blake, CM Reese, M Garcia, EA Dahlmann, A Dean |
Toxicology in Vitro | 2015 |
|
Resolvins Attenuate Inflammation and Promote Resolution in Cigarette Smoke-Exposed Human Macrophages
A Croasdell, TH Thatcher, RM Kottmann, RA Colas, J Dalli, CN Serhan, PJ Sime, RP Phipps |
American journal of physiology. Lung cellular and molecular physiology | 2015 |
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Pathobiology of tobacco smoking and neurovascular disorders: untied strings and alternative products
P Naik, L Cucullo |
Fluids and barriers of the CNS | 2015 |
|
Evaluation of the Pulmonary Toxicity of Ambient Particulate Matter From Camp Victory, Iraq
KL Porter, FH Green, RA Harley, V Vallyathan, V Castranova, NR Waldron, SS Leonard, DE Nelson, JA Lewis, DA Jackson |
Journal of Toxicology and Environmental Health, Part A | 2015 |
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Association between Psoriasis and Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
X Li, L Kong, F Li, C Chen, R Xu, H Wang, S Peng, M Zhou, B Li, AV Alekseyenko |
PloS one | 2015 |
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Candidate genes for COPD: current evidence and research
SD Lee, WJ Kim |
International journal of chronic obstructive pulmonary disease | 2015 |
|
CD4+ T-Cell Profiles and Peripheral Blood Ex-Vivo Responses to T-Cell Directed Stimulation Delineate COPD Phenotypes
ME Roberts, BW Higgs, P Brohawn, F Pilataxi, X Guo, M Kuziora, RP Bowler, WI White |
Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation | 2015 |
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The role of microparticles in chronic obstructive pulmonary disease
T Takahashi, H Kubo |
International journal of chronic obstructive pulmonary disease | 2014 |
|
Linking Acute Infection to Chronic Lung Disease. The Role of IL-33–Expressing Epithelial Progenitor Cells
MJ Holtzman, DE Byers, JA Brett, AC Patel, E Agapov, X Jin, K Wu |
Annals of the American Thoracic Society | 2014 |
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Oxidants in Acute and Chronic Lung Disease
P Mannam |
Journal of Blood & Lymph | 2014 |
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Myb Permits Multilineage Airway Epithelial Cell Differentiation: Myb Permits Airway Epithelial Differentiation
JH Pan, TL Adair-Kirk, AC Patel, T Huang, NS Yozamp, J Xu, EP Reddy, DE Byers, RA Pierce, MJ Holtzman, SL Brody |
Stem Cells | 2014 |
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Cathepsin E Promotes Pulmonary Emphysema via Mitochondrial Fission
X Zhang, P Shan, R Homer, Y Zhang, I Petrache, P Mannam, PJ Lee |
The American Journal of Pathology | 2014 |
|
Space radiation-associated lung injury in a murine model
M Christofidou-Solomidou, RA Pietrofesa, E Arguiri, KS Schweitzer, EV Berdyshev, M McCarthy, A Corbitt, JS Alwood, Y Yu, RK Globus, CC Solomides, RL Ullrich, I Petrache |
American journal of physiology. Lung cellular and molecular physiology | 2014 |
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Smoking Exposure Induces Human Lung Endothelial Cell Adaptation to Apoptotic Stress
DN Petrusca, MV Demark, Y Gu, MJ Justice, A Rogozea, WC Hubbard, I Petrache |
American journal of respiratory cell and molecular biology | 2014 |
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Increased ectodomain shedding of cell adhesion molecule 1 from pancreatic islets in type 2 diabetic pancreata: correlation with hemoglobin a1c levels
T Inoue, M Hagiyama, A Yoneshige, T Kato, E Enoki, O Maenishi, T Chikugo, M Kimura, T Satou, A Ito |
PloS one | 2014 |
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FEV1 inversely correlates with metalloproteinases 1, 7, 9 and CRP in COPD by biomass smoke exposure
M Montaño, RH Sansores, C Becerril, J Cisneros, G González-Avila, B Sommer, L Ochoa, I Herrera, A Ramírez-Venegas, C Ramos |
Respiratory Research | 2014 |
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Stanniocalcin-1 is induced by hypoxia inducible factor in rat alveolar epithelial cells
Y Ito, R Zemans, K Correll, IV Yang, A Ahmad, B Gao, RJ Mason |
Biochemical and Biophysical Research Communications | 2014 |
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PlGF mediates neutrophil elastase-induced airway epithelial cell apoptosis and emphysema
HH Hou, SL Cheng, KP Chung, SC Wei, PN Tsao, HH Lu, HC Wang, CJ Yu |
Respiratory Research | 2014 |
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Systemic Oxidative Stress Biomarkers in Chronic Periodontitis: A Meta-Analysis
Z Liu, Y Liu, Y Song, X Zhang, S Wang, Z Wang |
Disease Markers | 2014 |
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One-Year Safety and Efficacy Study of Arformoterol Tartrate in Patients With Moderate to Severe COPD
JF Donohue, NA Hanania, B Make, MC Miles, DA Mahler, L Curry, R Tosiello, A Wheeler, DP Tashkin |
Chest | 2014 |
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Hypoxia-induced glucose-6-phosphate dehydrogenase overexpression and -activation in pulmonary artery smooth muscle cells: implication in pulmonary hypertension
S Chettimada, R Gupte, D Rawat, SA Gebb, IF McMurtry, SA Gupte |
American journal of physiology. Lung cellular and molecular physiology | 2014 |
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The Diagnosis of Chronic Obstructive Pulmonary Disease
R Burkhardt, W Pankow |
Deutsches Ärzteblatt international | 2014 |
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RETRACTED ARTICLE: ATF3 and Extracellular Matrix-Related Genes Associated with the Process of Chronic Obstructive Pulmonary
J Ye, L Wen, DL Liu, G Lai |
Lung | 2014 |
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Sulfated caffeic acid dehydropolymer attenuates elastase and cigarette smoke extract-induced emphysema in rats: sustained activity and a need of pulmonary delivery.
Saluja B, Li H, Desai UR, Voelkel NF, Sakagami M |
Lung | 2014 |
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Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease
Derek Byers, Jennifer Alexander-Brett, Anand Patel, Eugene Agapov, Geoffrey Dang-Vu, Xiaohua Jin, Kangyun Wu, Yingjian You, Yael Alevy, Jean-Philippe Girard, Thaddeus Stappenbeck, G. Alexander Patterson, Richard Pierce, Steven Brody, Michael Holtzman |
Journal of Clinical Investigation | 2013 |
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Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD
J Heidler, A Fysikopoulos, F Wempe, M Seimetz, T Bangsow, A Tomasovic, F Veit, S Scheibe, A Pichl, F Weisel, KC Lloyd, P Jaksch, W Klepetko, N Weissmann, H Melchner |
Disease models & mechanisms | 2013 |
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Nonmicrobial-mediated inflammatory airway diseases—an update
PB Babu, P Krishnamoorthy |
Journal of Physiology and Biochemistry | 2013 |
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Cadmium-Induced Pathologies: Where Is the Oxidative Balance Lost (or Not)?
A Nair, O DeGheselle, K Smeets, EV Kerkhove, A Cuypers |
International journal of molecular sciences | 2013 |
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Dysfunctional lung anatomy and small airways degeneration in COPD
C Martin, J Frija, PR Burgel |
International journal of chronic obstructive pulmonary disease | 2013 |
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Airway oxidative stress in chronic cough
HO Koskela, MK Purokivi |
Cough (London, England) | 2013 |
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A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation
HM Hsiao, RE Sapinoro, TH Thatcher, A Croasdell, EP Levy, RA Fulton, KC Olsen, SJ Pollock, CN Serhan, RP Phipps, PJ Sime |
PloS one | 2013 |
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Cerium oxide nanoparticles protect rodent lungs from hypobaric hypoxia-induced oxidative stress and inflammation
A Arya, NK Sethy, SK Singh, M Das, K Bhargava |
International Journal of Nanomedicine | 2013 |
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Pulmonary emphysema in cystic fibrosis detected by densitometry on chest multidetector computed tomography
MO Wielpütz, O Weinheimer, M Eichinger, M Wiebel, J Biederer, HU Kauczor, CP Heußel, MA Mall, M Puderbach |
PloS one | 2013 |
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Pouring salt on a wound: Pseudomonas aeruginosa virulence factors alter Na+ and Cl- flux in the lung
AE Ballok, GA O'Toole |
Journal of bacteriology | 2013 |
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DAMPs activating innate and adaptive immune responses in COPD
SD Pouwels, IH Heijink, NH ten Hacken, P Vandenabeele, DV Krysko, MC Nawijn, AJ van Oosterhout |
Mucosal Immunology | 2013 |
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Take a Deep Breath: Pulmonary Research Inspires
Paul W. Noble |
Journal of Clinical Investigation | 2012 |
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Next-generation personalized drug discovery: the tripeptide GHK hits center stage in chronic obstructive pulmonary disease
S Meiners, O Eickelberg |
Genome Medicine | 2012 |
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