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Citations to this article

Pathogenesis of chronic obstructive pulmonary disease
Rubin M. Tuder, Irina Petrache
Rubin M. Tuder, Irina Petrache
Published August 1, 2012
Citation Information: J Clin Invest. 2012;122(8):2749-2755. https://doi.org/10.1172/JCI60324.
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Review Series Article has an altmetric score of 4

Pathogenesis of chronic obstructive pulmonary disease

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Abstract

The current epidemic of chronic obstructive pulmonary disease (COPD) has produced a worldwide health care burden, approaching that imposed by transmittable infectious diseases. COPD is a multidimensional disease, with varied intermediate and clinical phenotypes. This Review discusses the pathogenesis of COPD, with particular focus on emphysema, based on the concept that pulmonary injury involves stages of initiation (by exposure to cigarette smoke, pollutants, and infectious agents), progression, and consolidation. Tissue damage entails complex interactions among oxidative stress, inflammation, extracellular matrix proteolysis, and apoptotic and autophagic cell death. Lung damage by cigarette smoke ultimately leads to self-propagating processes, resulting in macromolecular and structural alterations — features similar to those seen in aging.

Authors

Rubin M. Tuder, Irina Petrache

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Total
Citations: 5 16 12 12 28 26 21 22 23 18 20 17 11 2 233
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

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