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Citations to this article

Chromosomal instability and cancer: a complex relationship with therapeutic potential
Samuel F. Bakhoum, Duane A. Compton
Samuel F. Bakhoum, Duane A. Compton
Published April 2, 2012
Citation Information: J Clin Invest. 2012;122(4):1138-1143. https://doi.org/10.1172/JCI59954.
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Science in Medicine Article has an altmetric score of 4

Chromosomal instability and cancer: a complex relationship with therapeutic potential

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Abstract

Chromosomal instability (CIN) is a hallmark of human neoplasms. Despite its widespread prevalence, knowledge of the mechanisms and contributions of CIN in cancer has been elusive. It is now evident that the role of CIN in tumor initiation and growth is more complex than previously thought. Furthermore, distinguishing CIN, which consists of elevated rates of chromosome missegregation, from aneuploidy, which is a state of abnormal chromosome number, is crucial to understanding their respective contributions in cancer. Collectively, experimental evidence suggests that CIN enables tumor adaptation by allowing tumors to constantly sample the aneuploid fitness landscape. This complex relationship, together with the potential to pharmacologically influence chromosome missegregation frequencies in cancer cells, offers previously unrecognized means to limit tumor growth and its response to therapy.

Authors

Samuel F. Bakhoum, Duane A. Compton

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2009 Total
Citations: 6 7 13 6 12 5 13 15 16 8 22 12 14 6 1 156
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2014 (12)

Title and authors Publication Year
Spindle Microtubule Dysfunction and Cancer Predisposition: SPINDLE MICROTUBULE DYSFUNCTION AND CANCER PREDISPOSITION
J Stumpff, PN Ghule, A Shimamura, JL Stein, M Greenblatt
Journal of Cellular Physiology 2014
Tumor cell plasticity: the challenge to catch a moving target
S Schwitalla
Journal of Gastroenterology 2014
WT1 interacts with MAD2 and regulates mitotic checkpoint function
J Shandilya, E Toska, DJ Richard, KF Medler, SG Roberts
Nature Communications 2014
Genetics and epigenetics of adrenocortical tumors
AM Lerario, A Moraitis, GD Hammer
Molecular and Cellular Endocrinology 2014
Chromosomal Instability, Aneuploidy, and Cancer
SF Bakhoum, C Swanton
Frontiers in Oncology 2014
JNK signaling is needed to tolerate chromosomal instability
HW Wong, Z Shaukat, J Wang, R Saint, SL Gregory
Cell cycle (Georgetown, Tex.) 2014
Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer
F Al-Ejeh, PT Simpson, JM Sanus, K Klein, M Kalimutho, W Shi, M Miranda, J Kutasovic, A Raghavendra, J Madore, L Reid, L Krause, G Chenevix-Trench, SR Lakhani, KK Khanna
Oncogenesis 2014
STK31 is a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells
PL Kuo, YL Huang, CC Hsieh, JC Lee, BW Lin, LY Hung
PloS one 2014
DNA-PKcs activates the Chk2-Brca1 pathway during mitosis to ensure chromosomal stability
Z Shang, L Yu, YF Lin, S Matsunaga, CY Shen, BP Chen
Oncogenesis 2014
The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell–cell adhesion
E Vitiello, JG Ferreira, H Maiato, MS Balda, K Matter
Nature Communications 2014
Chromosomal Instability Selects Gene Copy-Number Variants Encoding Core Regulators of Proliferation in ER+ Breast Cancer
D Endesfelder, RA Burrell, N Kanu, N McGranahan, M Howell, PJ Parker, J Downward, C Swanton, M Kschischo
Cancer research 2014
STAG2 promotes error correction in mitosis by regulating kinetochore-microtubule attachments
M Kleyman, L Kabeche, DA Compton
Journal of cell science 2014

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