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Yann Malato, … , Dirk Grimm, Holger Willenbring
Published November 21, 2011
Citation Information: J Clin Invest. 2011;121(12):4850-4860. https://doi.org/10.1172/JCI59261.
Citation Information: J Clin Invest. 2011;121(12):4850-4860. https://doi.org/10.1172/JCI59261.
Abstract
Recent evidence has contradicted the prevailing view that homeostasis and regeneration of the adult liver are mediated by self duplication of lineage-restricted hepatocytes and biliary epithelial cells. These new data suggest that liver progenitor cells do not function solely as a backup system in chronic liver injury; rather, they also produce hepatocytes after acute injury and are in fact the main source of new hepatocytes during normal hepatocyte turnover. In addition, other evidence suggests that hepatocytes are capable of lineage conversion, acting as precursors of biliary epithelial cells during biliary injury. To test these concepts, we generated a hepatocyte fate-tracing model based on timed and specific Cre recombinase expression and marker gene activation in all hepatocytes of adult Rosa26 reporter mice with an adenoassociated viral vector. We found that newly formed hepatocytes derived from preexisting hepatocytes in the normal liver and that liver progenitor cells contributed minimally to acute hepatocyte regeneration. Further, we found no evidence that biliary injury induced conversion of hepatocytes into biliary epithelial cells. These results therefore restore the previously prevailing paradigms of liver homeostasis and regeneration. In addition, our new vector system will be a valuable tool for timed, efficient, and specific loop out of floxed sequences in hepatocytes.
Authors
Yann Malato, Syed Naqvi, Nina Schürmann, Raymond Ng, Bruce Wang, Joan Zape, Mark A. Kay, Dirk Grimm, Holger Willenbring
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NL Vora, MR Grace, L Smeester, SK Dotters-Katz, RC Fry, V Bae-Jump, K Boggess |
Reproductive sciences (Thousand Oaks, Calif.) | 2018 |
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Endothelial Wnts regulate β-catenin signaling in murine liver zonation and regeneration: A sequel to the Wnt-Wnt situation: PREZIOSI ET AL
M Preziosi, H Okabe, M Poddar, S Singh, SP Monga |
Hepatology Communications | 2018 |
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Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration
S Bangru, W Arif, J Seimetz, A Bhate, J Chen, EH Rashan, RP Carstens, S Anakk, A Kalsotra |
Nature Structural & Molecular Biology | 2018 |
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Contribution of Resident Stem Cells to Liver and Biliary Tree Regeneration in Human Diseases
D Overi, G Carpino, V Cardinale, A Franchitto, S Safarikia, P Onori, D Alvaro, E Gaudio |
International journal of molecular sciences | 2018 |
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Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration
JM Tsai, IL Weissman, Y Rinkevich |
Journal of visualized experiments : JoVE | 2018 |
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Constitutive and Inducible Systems for Genetic In Vivo Modification of Mouse Hepatocytes Using Hydrodynamic Tail Vein Injection
EK Hubner, C Lechler, TN Rösner, B Kohnke-Ertel, RM Schmid, U Ehmer |
Journal of visualized experiments : JoVE | 2018 |
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Repairing the lungs one breath at a time: How dedicated or facultative are you?
JP Leach, EE Morrisey |
Genes & development | 2018 |
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Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration
SN Greenhalgh, KP Matchett, RS Taylor, K Huang, JT Li, K Saeteurn, MC Donnelly, EE Simpson, JL Pollack, A Atakilit, KJ Simpson, JJ Maher, JP Iredale, D Sheppard, NC Henderson |
The American Journal of Pathology | 2018 |
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Molecular regulation of mammalian hepatic architecture
Stacey S Huppert, Makiko Iwafuchi-Doi |
Current topics in developmental biology | 2018 |
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Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells
KS Tummala, M Brandt, A Teijeiro, O Graña, RF Schwabe, C Perna, N Djouder |
Cell Reports | 2017 |
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FOXA2 alleviates CCl4-induced liver fibrosis by protecting hepatocytes in mice
W Wang, LJ Yao, W Shen, K Ding, PM Shi, F Chen, J He, J Ding, X Zhang, WF Xie |
Scientific Reports | 2017 |
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Fate tracing of hepatocytes in mouse liver
X Gu, D Huang, L Ci, J Shi, M Zhang, H Yang, Z Wang, Z Sheng, R Sun, J Fei |
Scientific Reports | 2017 |
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Metformin use in pregnancy: promises and uncertainties
RS Lindsay, MR Loeken |
Diabetologia | 2017 |
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Cellular Mechanisms of Liver Regeneration and Cell-Based Therapies of Liver Diseases
IV Kholodenko, KN Yarygin |
BioMed Research International | 2017 |
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Using Zebrafish to Model Liver Diseases-Where Do We Stand?
DH Pham, C Zhang, C Yin |
Current Pathobiology Reports | 2017 |
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Platelets prime hematopoietic–vascular niche to drive angiocrine-mediated liver regeneration
K Shido, D Chavez, Z Cao, JL Ko, S Rafii, BS Ding |
Signal Transduction and Targeted Therapy | 2017 |
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Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
D Yuan, S Huang, E Berger, L Liu, N Gross, F Heinzmann, M Ringelhan, TO Connor, M Stadler, M Meister, J Weber, R Öllinger, N Simonavicius, F Reisinger, D Hartmann, R Meyer, M Reich, M Seehawer, V Leone, B Höchst, D Wohlleber, S Jörs, M Prinz, D Spalding, U Protzer, T Luedde, L Terracciano, M Matter, T Longerich, P Knolle, T Ried, V Keitel, F Geisler, K Unger, E Cinnamon, E Pikarsky, N Hüser, RJ Davis, DF Tschaharganeh, R Rad, A Weber, L Zender, D Haller, M Heikenwalder |
Cancer Cell | 2017 |
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Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway
HW Chao, M Doi, JM Fustin, H Chen, K Murase, Y Maeda, H Hayashi, R Tanaka, M Sugawa, N Mizukuchi, Y Yamaguchi, J Yasunaga, M Matsuoka, M Sakai, M Matsumoto, S Hamada, H Okamura |
Nature Communications | 2017 |
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Regenerative Medicine and the Biliary Tree
TD Assuncao, N Jalan-Sakrikar, R Huebert |
Seminars in liver disease | 2017 |
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The hepatocyte-specific HNF4α/miR-122 pathway contributes to iron overload–mediated hepatic inflammation
M Li, Y Tang, L Wu, F Mo, X Wang, H Li, R Qi, H Zhang, A Srivastava, C Ling |
Blood | 2017 |
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A label-retaining but unipotent cell population resides in biliary compartment of mammalian liver
J Viil, M Klaas, K Valter, D Belitškin, S Ilmjärv, V Jaks |
Scientific Reports | 2017 |
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Progressive induction of hepatocyte progenitor cells in chronically injured liver
N Tanimizu, N Ichinohe, M Yamamoto, H Akiyama, Y Nishikawa, T Mitaka |
Scientific Reports | 2017 |
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Genetic tracing of hepatocytes in liver homeostasis, injury, and regeneration
Y Wang, XZ Huang, L He, W Pu, Y Li, Q Liu, Y Li, L Zhang, W Yu, H Zhao, Y Zhou, B Zhou |
The Journal of biological chemistry | 2017 |
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tomm22 Knockdown-Mediated Hepatocyte Damages Elicit Both the Formation of Hybrid Hepatocytes and Biliary Conversion to Hepatocytes in Zebrafish Larvae
J Wu, TY Choi, D Shin |
Gene expression | 2017 |
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Notch signaling and progenitor/ductular reaction in steatohepatitis
CM Morell, R Fiorotto, M Meroni, A Raizner, B Torsello, M Cadamuro, G Spagnuolo, E Kaffe, S Sutti, E Albano, M Strazzabosco, MA Avila |
PloS one | 2017 |
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An in vivo transfection system for inducible gene expression and gene silencing in murine hepatocytes
Hubner EK, Lechler C, Kohnke-Ertel B, Zmoos AF, Sage J, Schmid RM, Ehmer U |
The Journal of Gene Medicine | 2017 |
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Liver immunology and its role in inflammation and homeostasis
MW Robinson, C Harmon, C OFarrelly |
Cellular and Molecular Immunology | 2016 |
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Advances in Liver Regeneration: Revisiting Hepatic Stem/Progenitor Cells and Their Origin
AR Sadri, MG Jeschke, S Amini-Nik |
Stem Cells International | 2016 |
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Liver progenitor cells-mediated liver regeneration in liver cirrhosis
H Shang, Z Wang, Y Song |
Hepatology International | 2016 |
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Molecular mechanisms of Sox transcription factors during the development of liver, bile duct, and pancreas
C Yin |
Seminars in Cell & Developmental Biology | 2016 |
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Stem cells versus plasticity in liver and pancreas regeneration
JL Kopp, M Grompe, M Sander |
Nature Cell Biology | 2016 |
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Emerging advancements in liver regeneration and organogenesis as tools for liver replacement:
SS Huppert, KM Campbell |
Current Opinion in Organ Transplantation | 2016 |
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Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration
W Pu, H Zhang, X Huang, X Tian, L He, Y Wang, L Zhang, Q Liu, Y Li, Y Li, H Zhao, K Liu, J Lu, Y Zhou, P Huang, Y Nie, Y Yan, L Hui, KO Lui, B Zhou |
Nature Communications | 2016 |
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Variation in relapse frequency and the transmission potential of Plasmodium vivax malaria
MT White, G Shirreff, S Karl, AC Ghani, I Mueller |
Proceedings of the Royal Society B: Biological Sciences | 2016 |
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Frequency and Pathophysiology of Acute Liver Failure in Ornithine Transcarbamylase Deficiency (OTCD)
A Laemmle, RC Gallagher, A Keogh, T Stricker, M Gautschi, JM Nuoffer, MR Baumgartner, J Häberle, P Mukhopadhyay |
PloS one | 2016 |
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Immunohistochemical analyses of cell cycle progression and gene expression of biliary epithelial cells during liver regeneration after partial hepatectomy of the mouse
T Fukuda, T Fukuchi, S Yagi, N Shiojiri |
Experimental Animals | 2016 |
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Stem/Progenitor Cell Niches Involved in Hepatic and Biliary Regeneration
G Carpino, A Renzi, A Franchitto, V Cardinale, P Onori, L Reid, D Alvaro, E Gaudio |
Stem Cells International | 2016 |
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Ductular reactions in the liver regeneration process with local inflammation after physical partial hepatectomy
Y Suzuki, H Katagiri, T Wang, K Kakisaka, K Kume, SS Nishizuka, Y Takikawa |
Laboratory Investigation | 2016 |
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Molecular Survey of Cell Source Usage during Subtotal Hepatectomy-Induced Liver Regeneration in Rats
A Elchaninov, T Fatkhudinov, N Usman, E Kananykhina, I Arutyunyan, A Makarov, G Bolshakova, D Goldshtein, G Sukhikh, MA Avila |
PloS one | 2016 |
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Cellular plasticity in the adult liver and stomach: Cellular plasticity in the adult liver and stomach
L Aloia, MA McKie, M Huch |
The Journal of Physiology | 2016 |
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Repair of liver mediated by adult mouse liver neuro-glia antigen 2-positive progenitor cell transplantation in a mouse model of cirrhosis
H Zhang, CT Siegel, L Shuai, J Lai, L Zeng, Y Zhang, X Lai, P Bie, L Bai |
Scientific Reports | 2016 |
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Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling Networks
S Lin, YA Yin, X Jiang, N Sahni, S Yi |
BioMed Research International | 2016 |
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Environmental Ligands of the Aryl Hydrocarbon Receptor and Their Effects in Models of Adult Liver Progenitor Cells
J Vondráček, M Machala |
Stem Cells International | 2016 |
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Regenerating the liver: not so simple after all?
MR Alison, WR Lin |
F1000Research | 2016 |
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Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice
N Ding |
World journal of gastroenterology : WJG | 2016 |
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p53 on the crossroad between regeneration and cancer
M Charni, R Aloni-Grinstein, A Molchadsky, V Rotter |
Cell Death and Differentiation | 2016 |
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Lineage Fate of Ductular Reactions in Liver Injury and Carcinogenesis
Simone Jörs, Petia Jeliazkova, Marc Ringelhan, Julian Thalhammer, Stephanie Dürl, Jorge Ferrer, Maike Sander, Mathias Heikenwälder, Roland M. Schmid, Jens T. Siveke, Fabian Geisler |
Journal of Clinical Investigation | 2015 |
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Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment
Xueru Mu, Regina Espanol-Suner, Ingmar Mederacke, Silvia Affo, Rita Manco, Christine Sempoux, Frederic P. Lemaigre, Arlind Adili, Detian Yuan, Achim Weber, Kristian Unger, Mathias Heikenwälder, Isabelle A. Leclercq, Robert Schwabe |
Journal of Clinical Investigation | 2015 |
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Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury
KM Irvine, AD Clouston, VL Gadd, GC Miller, WY Wong, M Melino, MR Maradana, K MacDonald, RA Lang, MJ Sweet, A Blumenthal, EE Powell |
Fibrogenesis & Tissue Repair | 2015 |
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Cre-ativity in the liver: Transgenic approaches to targeting hepatic nonparenchymal cells: GREENHALGH ET AL
SN Greenhalgh, KP Conroy, NC Henderson |
Hepatology | 2015 |
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Precise let-7 expression levels balance organ regeneration against tumor suppression: ( A ) Schema of the liver-specific inducible LAP-MYC +/- let-7S21L cancer model. ( B ) let-7S21L is a chimeric construct containing the let-7g stem, miR-21 loop, and let-7g flanking sequences. ( C ) Schema showing that LAP-MYC +/- let-7S21L mice were induced at 14 days of age, tissues were collected at 90 days of age, and survival was followed. ( D ) Ninety-day old mice bearing tumors in the LAP-MYC (87.5%, 7/8) and LAP-MYC + let-7S21L (27.3%, 3/11) mouse models. ( E ) Livers showing tumors from the above mice. ( F ) Liver surface area occupied by tumor. ( G ) Kaplan-Meier curve of LAP-MYC alone and LAP-MYC + let-7S21L mice. ( H ) Mature let-7 expression levels in as determined by RT-qPCR. ( I ) Human c-MYC mRNA expressionin tumors as determined by RT-qPCR. ( J ) Heat map of let-7 target gene expression in WT normal livers, MYC tumors, and MYC + let-7S21L tumors as measured by RT-qPCR. Red is higher and blue is lower relative mRNA expression. ( K ) Gene expression plotted as bar graphs to show relative changes. ( L ) Evolutionarily conserved let-7 target sites within 3’UTRs (Targetscan.org). All data in this figure are represented as mean ± SEM. *p
L Wu, LH Nguyen, K Zhou, TY de Soysa, L Li, JB Miller, J Tian, J Locker, S Zhang, G Shinoda, MT Seligson, LR Zeitels, A Acharya, SC Wang, JT Mendell, X He, J Nishino, SJ Morrison, DJ Siegwart, GQ Daley, N Shyh-Chang, H Zhu |
eLife | 2015 |
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Site-Directed Mutagenesis of Surface-Exposed Lysine Residues Leads to Improved Transduction by AAV2, But Not AAV8, Vectors in Murine Hepatocytes In Vivo
B Li, W Ma, C Ling, KV Vliet, LY Huang, M Agbandje-McKenna, A Srivastava, GV Aslanidi |
Human Gene Therapy Methods | 2015 |
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Cellular Homeostasis and Repair in the Mammalian Liver
BZ Stanger |
Annual Review of Physiology | 2015 |
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An HNF1α-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells
H Qian, X Deng, ZW Huang, J Wei, CH Ding, RX Feng, X Zeng, YX Chen, J Ding, L Qiu, ZL Hu, X Zhang, HY Wang, JP Zhang, WF Xie |
Cell Research | 2015 |
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Regenerative biology: Maintaining liver mass
KS Zaret |
Nature | 2015 |
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Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer
J Font-Burgada, S Shalapour, S Ramaswamy, B Hsueh, D Rossell, A Umemura, K Taniguchi, H Nakagawa, MA Valasek, L Ye, JL Kopp, M Sander, H Carter, K Deisseroth, IM Verma, M Karin |
Cell | 2015 |
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Contribution of Mature Hepatocytes to Biliary Regeneration in Rats with Acute and Chronic Biliary Injury
YH Chen, HL Chen, CS Chien, SH Wu, YT Ho, CH Yu, MH Chang, WK Syn |
PloS one | 2015 |
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Hepatic progenitor cells of biliary origin with liver repopulation capacity
WY Lu, TG Bird, L Boulter, A Tsuchiya, AM Cole, T Hay, RV Guest, D Wojtacha, TY Man, A Mackinnon, RA Ridgway, T Kendall, MJ Williams, T Jamieson, A Raven, DC Hay, JP Iredale, AR Clarke, OJ Sansom, SJ Forbes |
Nature Cell Biology | 2015 |
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Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver
B Wang, L Zhao, M Fish, CY Logan, R Nusse |
Nature | 2015 |
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Regenerative medicine: Hepatic progenitor cells up their game in the therapeutic stakes
MR Alison, WR Lin |
Nature Reviews Gastroenterology & Hepatology | 2015 |
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Functional and genetic deconstruction of the cellular origin in liver cancer
JU Marquardt, JB Andersen, SS Thorgeirsson |
Nature Reviews Cancer | 2015 |
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Advances in hepatic stem/progenitor cell biology
Stefaan Verhulst, Jan Best, Leo A. van Grunsven, Laurent Dollé |
EXCLI J | 2015 |
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A Critical Examination of the "Bad Luck" Explanation of Cancer Risk
AI Rozhok, GM Wahl, J DeGregori |
Cancer prevention research (Philadelphia, Pa.) | 2015 |
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A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver
AN Mattis, G Song, K Hitchner, RY Kim, AY Lee, AD Sharma, Y Malato, MT McManus, CC Esau, E Koller, S Koliwad, LP Lim, JJ Maher, RL Raffai, H Willenbring |
Hepatology | 2014 |
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Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis
H Nakagawa, Y Hikiba, Y Hirata, J Font-Burgada, K Sakamoto, Y Hayakawa, K Taniguchi, A Umemura, H Kinoshita, K Sakitani, Y Nishikawa, K Hirano, T Ikenoue, H Ijichi, D Dhar, W Shibata, M Akanuma, K Koike, M Karin, S Maeda |
Proceedings of the National Academy of Sciences | 2014 |
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Strategies for immortalization of primary hepatocytes
E Ramboer, BD Craene, JD Kock, T Vanhaecke, G Berx, V Rogiers, M Vinken |
Journal of Hepatology | 2014 |
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Loss of α-catenin elicits a cholestatic response and impairs liver regeneration
KJ Herr, YN Tsang, JW Ong, Q Li, LL Yap, W Yu, H Yin, RL Bogorad, JE Dahlman, YG Chan, BH Bay, R Singaraja, DG Anderson, V Koteliansky, V Viasnoff, JP Thiery |
Scientific Reports | 2014 |
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Novel Aspects of the Liver Microenvironment in Hepatocellular Carcinoma Pathogenesis and Development
T Tu, M Budzinska, A Maczurek, R Cheng, AD Bartolomeo, F Warner, G McCaughan, S McLennan, N Shackel |
International journal of molecular sciences | 2014 |
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Current Topics in Developmental Biology
S Shin, KH Kaestner |
Current topics in developmental biology | 2014 |
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The versatile functions of Sox9 in development, stem cells, and human diseases
A Jo, S Denduluri, B Zhang, Z Wang, L Yin, Z Yan, R Kang, LL Shi, J Mok, MJ Lee, RC Haydon |
Genes & Diseases | 2014 |
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Brief Report: Parthenogenetic Embryonic Stem Cells are an Effective Cell Source for Therapeutic Liver Repopulation: Liver Regeneration with Parthenogenetic ESCs
S Espejel, S Eckardt, J Harbell, GR Roll, KJ McLaughlin, H Willenbring |
Stem Cells | 2014 |
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Re-evaluation of liver stem/progenitor cells
N Tanimizu, T Mitaka |
Organogenesis | 2014 |
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The Liver Is a Peculiar Organ When It Comes to Stem Cells
GK Michalopoulos |
The American Journal of Pathology | 2014 |
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Bile Acid flux is necessary for normal liver regeneration
WE Naugler |
PloS one | 2014 |
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Extensive Conversion of Hepatic Biliary Epithelial Cells to Hepatocytes After Near Total Loss of Hepatocytes in Zebrafish
TY Choi, N Ninov, DY Stainier, D Shin |
Gastroenterology | 2014 |
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Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice
RL Bogorad, H Yin, A Zeigerer, H Nonaka, VM Ruda, M Zerial, DG Anderson, V Koteliansky |
Nature Communications | 2014 |
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Fibroblast growth factor signaling regulates the expansion of A6-expressing hepatocytes in association with AKT-dependent β-catenin activation
S Utley, D James, N Mavila, MV Nguyen, C Vendryes, SM Salisbury, J Phan, KS Wang |
Journal of Hepatology | 2014 |
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Clonal tracing of Sox9 + liver progenitors in mouse oval cell injury
BD Tarlow, MJ Finegold, M Grompe |
Hepatology | 2014 |
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Elucidating the Metabolic Regulation of Liver Regeneration
J Huang, DA Rudnick |
The American Journal of Pathology | 2014 |
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Hippo Pathway Activity Influences Liver Cell Fate
D Yimlamai, C Christodoulou, GG Galli, K Yanger, B Pepe-Mooney, B Gurung, K Shrestha, P Cahan, BZ Stanger, FD Camargo |
Cell | 2014 |
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Cell turnover in the repopulated rat liver: distinct lineages for hepatocytes and the biliary epithelium
F Marongiu, MP Serra, M Sini, M Marongiu, A Contini, E Laconi |
Cell and Tissue Research | 2014 |
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Hydrodynamic delivery of Cre protein to lineage-mark or time-stamp mouse hepatocytes in situ
KM Sonsteng, JR Prigge, EA Talago, RK June, EE Schmidt |
PloS one | 2014 |
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Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer
SK Saha, CA Parachoniak, KS Ghanta, J Fitamant, KN Ross, MS Najem, S Gurumurthy, EA Akbay, D Sia, H Cornella, O Miltiadous, C Walesky, V Deshpande, AX Zhu, AF Hezel, KE Yen, KS Straley, J Travins, J Popovici-Muller, C Gliser, CR Ferrone, U Apte, JM Llovet, KK Wong, S Ramaswamy, N Bardeesy |
Nature | 2014 |
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Clustering nuclear receptors in liver regeneration identifies candidate modulators of hepatocyte proliferation and hepatocarcinoma
M Vacca, S D'Amore, G Graziano, A D'Orazio, M Cariello, V Massafra, L Salvatore, N Martelli, S Murzilli, GL Sasso, R Mariani-Costantini, A Moschetta |
PloS one | 2014 |
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Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation
K Yanger, D Knigin, Y Zong, L Maggs, G Gu, H Akiyama, E Pikarsky, BZ Stanger |
Cell Stem Cell | 2014 |
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Characterisation of a Novel Fc Conjugate of Macrophage Colony-stimulating Factor
DJ Gow, KA Sauter, C Pridans, L Moffat, A Sehgal, BM Stutchfield, S Raza, PM Beard, YT Tsai, G Bainbridge, PL Boner, G Fici, D Garcia-Tapia, RA Martin, T Oliphant, JA Shelly, R Tiwari, TL Wilson, LB Smith, NA Mabbott, DA Hume |
Molecular Therapy | 2014 |
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Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury
JR Schaub, Y Malato, C Gormond, H Willenbring |
Cell Reports | 2014 |
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Modelling the contribution of the hypnozoite reservoir to Plasmodium vivax transmission: Time to first relapse infection from the within-host model fitted to data from three ecological zones with tropical strains of P. vivax (Battle et al., 2014). The red curves show the model fits with estimated posterior median parameters
MT White, S Karl, KE Battle, SI Hay, I Mueller, AC Ghani |
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Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes
BD Tarlow, C Pelz, WE Naugler, L Wakefield, EM Wilson, MJ Finegold, M Grompe |
Cell Stem Cell | 2014 |
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Emerging roles of Notch signaling in liver disease
F Geisler, M Strazzabosco |
Hepatology | 2014 |
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MBSJ MCC Young Scientist Award 2012 Liver regeneration: a unique and flexible reaction depending on the type of injury
A Suzuki |
Genes to Cells | 2014 |
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Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers
KC Nikolaou, P Moulos, G Chalepakis, P Hatzis, H Oda, D Reinberg, I Talianidis |
The EMBO Journal | 2014 |
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Sry HMG Box Protein 9-positive (Sox9 + ) Epithelial Cell Adhesion Molecule-negative (EpCAM − ) Biphenotypic Cells Derived from Hepatocytes Are Involved in Mouse Liver Regeneration
N Tanimizu, Y Nishikawa, N Ichinohe, H Akiyama, T Mitaka |
The Journal of biological chemistry | 2014 |
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Sox9 and programming of liver and pancreatic progenitors
Yoshiya Kawaguchi |
Journal of Clinical Investigation | 2013 |
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Liver sinusoidal endothelial cells and liver regeneration
Laurie D. DeLeve |
Journal of Clinical Investigation | 2013 |
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Role of liver progenitors in acute liver injury
J Best, L Dollé, P Manka, J Coombes, LA van Grunsven, WK Syn |
Frontiers in physiology | 2013 |
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Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target
A Saborowski, M Saborowski, MA Davare, BJ Druker, DS Klimstra, SW Lowe |
Proceedings of the National Academy of Sciences | 2013 |
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Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice
GW Nace, H Huang, JR Klune, RE Eid, BR Rosborough, S Korff, S Li, RA Shapiro, DB Stolz, CP Sodhi, DJ Hackam, DA Geller, TR Billiar, A Tsung |
Hepatology | 2013 |
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Concise review: Clinical programs of stem cell therapies for liver and pancreas: Stem Cell Therapies for Liver and Pancreas
G Lanzoni, T Oikawa, Y Wang, CB Cui, G Carpino, V Cardinale, D Gerber, M Gabriel, J Dominguez-Bendala, ME Furth, E Gaudio, D Alvaro, L Inverardi, LM Reid |
Stem Cells | 2013 |
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Recent advances in the morphological and functional heterogeneity of the biliary epithelium
Y Han, S Glaser, F Meng, H Francis, M Marzioni, K McDaniel, D Alvaro, J Venter, G Carpino, P Onori, E Gaudio, G Alpini, A Franchitto |
Experimental biology and medicine (Maywood, N.J.) | 2013 |
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Role of hepatic progenitor cells in nonalcoholic fatty liver disease development: cellular cross-talks and molecular networks
G Carpino, A Renzi, P Onori, E Gaudio |
International journal of molecular sciences | 2013 |
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Failure of Fibrotic Liver Regeneration in Mice is Linked to a Severe Fibrogenic Response Driven by Hepatic Progenitor Cell Activation
K Kuramitsu, DY Sverdlov, SB Liu, E Csizmadia, L Burkly, D Schuppan, DW Hanto, LE Otterbein, Y Popov |
The American Journal of Pathology | 2013 |
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Immunohistochemical Characterization of the Hepatic Progenitor Cell Compartment in Medaka (Oryzias latipes) following Hepatic Injury
AJ Wettere, SW Kullman, DE Hinton, JM Law |
Journal of Comparative Pathology | 2013 |
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Expansion of Hepatic Stem Cell Compartment Boosts Liver Regeneration
V Papp, A Rókusz, K Dezső, E Bugyik, V Szabó, Z Pávai, S Paku, P Nagy |
Stem Cells and Development | 2013 |
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Robust cellular reprogramming occurs spontaneously during liver regeneration
K Yanger, Y Zong, LR Maggs, SN Shapira, R Maddipati, NM Aiello, SN Thung, RG Wells, LE Greenbaum, BZ Stanger |
Genes & development | 2013 |
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Temporal mapping of CEBPA and CEBPB binding during liver regeneration reveals dynamic occupancy and specific regulatory codes for homeostatic and cell cycle gene batteries
JS Jakobsen, J Waage, N Rapin, HC Bisgaard, FS Larsen, BT Porse |
Genome research | 2013 |
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A novel role of nucleostemin in maintaining the genome integrity of dividing hepatocytes during mouse liver development and regeneration
T Lin, W Ibrahim, CY Peng, MJ Finegold, RY Tsai |
Hepatology | 2013 |
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FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration
HM Takase, T Itoh, S Ino, T Wang, T Koji, S Akira, Y Takikawa, A Miyajima |
Genes & development | 2013 |
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Nuclear double-fluorescent reporter for in vivo and ex vivo analyses of biological transitions in mouse nuclei
JR Prigge, JA Wiley, EA Talago, EM Young, LL Johns, JA Kundert, KM Sonsteng, WP Halford, MR Capecchi, EE Schmidt |
Mammalian Genome | 2013 |
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A replicative self-renewal model for long-lived plasma cells: questioning irreversible cell cycle exit
RM Tooze |
Frontiers in immunology | 2013 |
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Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology
I Mederacke, CC Hsu, JS Troeger, P Huebener, X Mu, DH Dapito, JP Pradere, RF Schwabe |
Nature Communications | 2013 |
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Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy
M Swiderska-Syn, WK Syn, G Xie, L Kruger, MV Machado, G Karaca, GA Michelotti, SS Choi, RT Premont, AM Diehl |
Gut | 2013 |
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Cholangiocellular carcinomas can originate from hepatocytes in mice
Biao Fan, Yann Malato, Diego F Calvisi, Syed Naqvi, Nataliya Razumilava, Silvia Ribback, Gregory J Gores, Frank Dombrowski, Matthias Evert, Xin Chen, Holger Willenbring |
Journal of Clinical Investigation | 2012 |
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Tissue Stem Cells: New Tools and Functional Diversity
M Grompe |
Cell Stem Cell | 2012 |
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The role of paracrine signals during liver regeneration
BZ Stanger, L Greenbaum, RJ Groszmann, Y Iwakiri, TH Taddei |
Hepatology | 2012 |
|
Phenotypic Fidelity (or not?) of Epithelial Cells in the Liver
GK Michalopoulos |
Hepatology | 2012 |
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On the Origin of the Liver
Klaus Kaestner, Joshua Friedman |
Journal of Clinical Investigation | 2011 |
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