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Usage Information

The immunology of neurodegeneration
Eva Czirr, Tony Wyss-Coray
Eva Czirr, Tony Wyss-Coray
Published April 2, 2012
Citation Information: J Clin Invest. 2012;122(4):1156-1163. https://doi.org/10.1172/JCI58656.
View: Text | PDF
Review

The immunology of neurodegeneration

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Abstract

While immune responses in neurodegeneration were regarded as little more than a curiosity a decade ago, they are now increasingly moving toward center stage. Factors driving this movement include the recognition that most of the relevant immune molecules are produced within the brain, that microglia are proficient immune cells shaping neuronal circuitry and fate, and that systemic immune responses affect brain function. We will review this complex field from the perspective of neurons, extra-neuronal brain cells, and the systemic environment and highlight the possibility that cell intrinsic innate immune molecules in neurons may function in neurodegenerative processes.

Authors

Eva Czirr, Tony Wyss-Coray

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 957 103
PDF 87 22
Figure 107 2
Table 108 0
Citation downloads 76 0
Totals 1,335 127
Total Views 1,462
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