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Citations to this article

A ketogenic diet suppresses seizures in mice through adenosine A1 receptors
Susan A. Masino, … , Eleonora Aronica, Detlev Boison
Susan A. Masino, … , Eleonora Aronica, Detlev Boison
Published June 23, 2011
Citation Information: J Clin Invest. 2011;121(7):2679-2683. https://doi.org/10.1172/JCI57813.
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Brief Report Article has an altmetric score of 10

A ketogenic diet suppresses seizures in mice through adenosine A1 receptors

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Abstract

A ketogenic diet (KD) is a high-fat, low-carbohydrate metabolic regimen; its effectiveness in the treatment of refractory epilepsy suggests that the mechanisms underlying its anticonvulsive effects differ from those targeted by conventional antiepileptic drugs. Recently, KD and analogous metabolic strategies have shown therapeutic promise in other neurologic disorders, such as reducing brain injury, pain, and inflammation. Here, we have shown that KD can reduce seizures in mice by increasing activation of adenosine A1 receptors (A1Rs). When transgenic mice with spontaneous seizures caused by deficiency in adenosine metabolism or signaling were fed KD, seizures were nearly abolished if mice had intact A1Rs, were reduced if mice expressed reduced A1Rs, and were unaltered if mice lacked A1Rs. Seizures were restored by injecting either glucose (metabolic reversal) or an A1R antagonist (pharmacologic reversal). Western blot analysis demonstrated that the KD reduced adenosine kinase, the major adenosine-metabolizing enzyme. Importantly, hippocampal tissue resected from patients with medically intractable epilepsy demonstrated increased adenosine kinase. We therefore conclude that adenosine deficiency may be relevant to human epilepsy and that KD can reduce seizures by increasing A1R-mediated inhibition.

Authors

Susan A. Masino, Tianfu Li, Panos Theofilas, Ursula S. Sandau, David N. Ruskin, Bertil B. Fredholm, Jonathan D. Geiger, Eleonora Aronica, Detlev Boison

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Total
Citations: 6 10 11 10 20 15 15 9 13 8 7 12 11 16 9 172
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2016 (8)

Title and authors Publication Year
Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity
US Sandau, M Colino-Oliveira, A Jones, B Saleumvong, SQ Coffman, L Liu, C Miranda-Lourenco, C Palminha, VL Batalha, Y Xu, Y Huo, MJ Diogenes, AM Sebastiao, D Boison
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
The Biochemistry and Epigenetics of Epilepsy: Focus on Adenosine and Glycine
D Boison
Frontiers in molecular neuroscience 2016
Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation
K Kiese, J Jablonski, D Boison, K Kobow
Frontiers in molecular neuroscience 2016
Metabolic Therapy for Temporal Lobe Epilepsy in a Dish: Investigating Mechanisms of Ketogenic Diet using Electrophysiological Recordings in Hippocampal Slices
MJ Kawamura, DN Ruskin, SA Masino
Frontiers in molecular neuroscience 2016
An Adenosine-Mediated Glial-Neuronal Circuit for Homeostatic Sleep
TE Bjorness, N Dale, G Mettlach, A Sonneborn, B Sahin, AA Fienberg, M Yanagisawa, JA Bibb, RW Greene
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
The ATP-sensitive K channel is seizure protective and required for effective dietary therapy in a model of mitochondrial encephalomyopathy
KJ Fogle, JI Hertzler, JH Shon, MJ Palladino
Journal of Neurogenetics 2016
Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet
MA Rogawski, W Löscher, JM Rho
Cold Spring Harbor Perspectives in Medicine 2016
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Boison D
Current neuropharmacology 2016

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