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Inflammatory links between obesity and metabolic disease
Carey N. Lumeng, Alan R. Saltiel
Carey N. Lumeng, Alan R. Saltiel
Published June 1, 2011
Citation Information: J Clin Invest. 2011;121(6):2111-2117. https://doi.org/10.1172/JCI57132.
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Review Series

Inflammatory links between obesity and metabolic disease

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Abstract

The obesity epidemic has forced us to evaluate the role of inflammation in the health complications of obesity. This has led to a convergence of the fields of immunology and nutrient physiology and the understanding that they are inextricably linked. The reframing of obesity as an inflammatory condition has had a wide impact on our conceptualization of obesity-associated diseases. In this Review, we highlight the cellular and molecular mechanisms at play in the generation of obesity-induced inflammation. We also emphasize how defining the immune regulation in metabolic tissues has broadened the understanding of the diversity of inflammatory responses.

Authors

Carey N. Lumeng, Alan R. Saltiel

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