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Insight into the heterogeneity of breast cancer through next-generation sequencing
Hege G. Russnes, … , James Hicks, Anne-Lise Borresen-Dale
Hege G. Russnes, … , James Hicks, Anne-Lise Borresen-Dale
Published October 3, 2011
Citation Information: J Clin Invest. 2011;121(10):3810-3818. https://doi.org/10.1172/JCI57088.
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Insight into the heterogeneity of breast cancer through next-generation sequencing

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Abstract

Rapid and sophisticated improvements in molecular analysis have allowed us to sequence whole human genomes as well as cancer genomes, and the findings suggest that we may be approaching the ability to individualize the diagnosis and treatment of cancer. This paradigmatic shift in approach will require clinicians and researchers to overcome several challenges including the huge spectrum of tumor types within a given cancer, as well as the cell-to-cell variations observed within tumors. This review discusses how next-generation sequencing of breast cancer genomes already reveals insight into tumor heterogeneity and how it can contribute to future breast cancer classification and management.

Authors

Hege G. Russnes, Nicholas Navin, James Hicks, Anne-Lise Borresen-Dale

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Figure 1

Different study designs for array-based gene expression studies.

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Different study designs for array-based gene expression studies.
(A) Stu...
(A) Studies aimed at identifying different subgroups investigate a mixed population of patients to group tumors with similar alterations together, and markers that recognize each type can then be identified. (B) This in contrast to studies that search for markers for prediction of therapy response or outcome; here, selected groups of patients are analyzed to identify the most discriminating alterations.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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