Rapid and sophisticated improvements in molecular analysis have allowed us to sequence whole human genomes as well as cancer genomes, and the findings suggest that we may be approaching the ability to individualize the diagnosis and treatment of cancer. This paradigmatic shift in approach will require clinicians and researchers to overcome several challenges including the huge spectrum of tumor types within a given cancer, as well as the cell-to-cell variations observed within tumors. This review discusses how next-generation sequencing of breast cancer genomes already reveals insight into tumor heterogeneity and how it can contribute to future breast cancer classification and management.
Hege G. Russnes, Nicholas Navin, James Hicks, Anne-Lise Borresen-Dale
Title and authors | Publication | Year |
---|---|---|
Forcing the code: tension modulates signaling to drive morphogenesis and malignancy
Narain R, Muncie-Vasic JM, Weaver VM |
Genes & Development | 2025 |
Unveiling the role of SYNGR4 in breast cancer development: a novel target for immunotherapy
Ma J, Wang H, Gui Z, Yang Y |
Frontiers in Oncology | 2025 |
Multimodal diagnostic models and subtype analysis for neoadjuvant therapy in breast cancer
Ye Z, Yuan J, Hong D, Xu P, Liu W |
Frontiers in Immunology | 2025 |
A Bayesian framework to study tumor subclone–specific expression by combining bulk DNA and single-cell RNA sequencing data
Qiao Y, Huang X, Moos PJ, Ahmann JM, Pomicter AD, Deininger MW, Byrd JC, Woyach JA, Stephens DM, Marth GT |
Genome research | 2024 |
(18)F-FDG Dedicated Breast PET Complementary to Breast MRI for Evaluating Early Response to Neoadjuvant Chemotherapy.
Diwanji D, Onishi N, Hathi DK, Lawhn-Heath C, Kornak J, Li W, Guo R, Molina-Vega J, Seo Y, Flavell RR, Heditsian D, Brain S, Esserman LJ, Joe BN, Hylton NM, Jones EF, Ray KM |
2024 | |
Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring.
Kuzmin E, Baker TM, Lesluyes T, Monlong J, Abe KT, Coelho PP, Schwartz M, Del Corpo J, Zou D, Morin G, Pacis A, Yang Y, Martinez C, Barber J, Kuasne H, Li R, Bourgey M, Fortier AM, Davison PG, Omeroglu A, Guiot MC, Morris Q, Kleinman CL, Huang S, Gingras AC, Ragoussis J, Bourque G, Van Loo P, Park M |
Cell Reports | 2024 |
[18F]F-Poly(ADP-Ribose) Polymerase Inhibitor Radiotracers for Imaging PARP Expression and Their Potential Clinical Applications in Oncology
Ndlovu H, Lawal IO, Mdanda S, Kgatle MM, Mokoala KM, Al-Ibraheem A, Sathekge MM |
Journal of Clinical Medicine | 2024 |
Comprehensive genomic profiling and therapeutic implications for Taiwanese patients with treatment‐naïve breast cancer
Chen S, Tse K, Lu Y, Chen S, Tian Y, Tan KT, Li C |
Cancer Medicine | 2024 |
Immunohistochemical Evaluation of Cathepsin B, L, and S Expression in Breast Cancer Patients.
Linders DGJ, Bijlstra OD, Fallert LC, Dekker-Ensink NG, March TL, Pool M, Walker E, Straight B, Basilion JP, Bogyo M, Burggraaf J, Hilling DE, Vahrmeijer AL, Kuppen PJK, Crobach ASLP |
Molecular imaging and biology | 2024 |
Texture analysis of CT colonography to develop a novel imaging biomarker for the management of colorectal cancer
Mamiya H, Tochigi T, Hayano K, Ohira G, Imanishi S, Maruyama T, Kurata Y, Takahashi Y, Hirata A, Matsubara H |
Annals of Gastroenterological Surgery | 2024 |
A Pilot Study on Biochemical Profile of Follicular Fluid in Breast Cancer Patients.
Castiglione Morelli MA, Iuliano A, Matera I, Viggiani L, Schettini SCA, Colucci P, Ostuni A |
Metabolites | 2023 |
Breast Cancer Statistics in Korea, 2019.
Choi JE, Kim Z, Park CS, Park EH, Lee SB, Lee SK, Choi YJ, Han J, Jung KW, Kim HJ, Kim HA |
Journal of Breast Cancer | 2023 |
Omics Technologies Improving Breast Cancer Research and Diagnostics
Orsini A, Diquigiovanni C, Bonora E |
International journal of molecular sciences | 2023 |
Global Increase in Breast Cancer Incidence: Risk Factors and Preventive Measures
Kashyap D, Pal D, Sharma R, Garg VK, Goel N, Koundal D, Zaguia A, Koundal S, Belay A |
BioMed Research International | 2022 |
A Novel YTHDF3-Based Model to Predict Prognosis and Therapeutic Response in Breast Cancer
Liu J, Zhu J, Wang X, Zhou Z, Liu H, Zhu D |
Frontiers in Molecular Biosciences | 2022 |
Transcriptional Factor Repertoire of Breast Cancer in 3D Cell Culture Models
Özkan H, Öztürk DG, Korkmaz G |
Cancers | 2022 |
MOCA for Integrated Analysis of Gene Expression and Genetic Variation in Single Cells
Huzar J, Kim H, Kumar S, Miura S |
Frontiers in Genetics | 2022 |
Fate decisions of breast cancer stem cells in cancer progression
Xu H, Zhang F, Gao X, Zhou Q, Zhu L |
Frontiers in Oncology | 2022 |
High levels of unfolded protein response component CHAC1 associates with cancer progression signatures in malignant breast cancer tissues.
Mehta V, Suman P, Chander H |
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico | 2022 |
Combination treatment with hENT1 and miR-143 reverses gemcitabine resistance in triple-negative breast cancer.
Xi Y, Li T, Xi Y, Zeng X, Miao Y, Guo R, Zhang M, Li B |
Cancer Cell International | 2022 |
Rational Approach to Finding Genes Encoding Molecular Biomarkers: Focus on Breast Cancer
Schneider N, Reed E, Kamel F, Ferrari E, Soloviev M |
Genes & development | 2022 |
Exosomal hsa-miR-21-5p is a biomarker for breast cancer diagnosis
M Liu, F Mo, X Song, Y He, Y Yuan, J Yan, Y Yang, J Huang, S Zhang |
PeerJ | 2021 |
A Bayesian nonparametric model for inferring subclonal populations from structured DNA sequencing data
S He, A Schein, V Sarsani, P Flaherty |
The Annals of Applied Statistics | 2021 |
Deregulation of Transcriptional Enhancers in Cancer
FM Azad, Y Atlasi |
Cancers | 2021 |
Intratumor heterogeneity of breast cancer detected by epialleles shows association with hypoxic microenvironment
Y Wang, Y Zhang, Y Huang, C Chen, X Zhang, Y Xing, Y Gu, M Zhang, L Cai, S Xu, B Sun |
Theranostics | 2021 |
An adaptive method of defining negative mutation status for multi-sample comparison using next-generation sequencing
N Hutson, F Zhan, J Graham, M Murakami, H Zhang, S Ganaparti, Q Hu, L Yan, C Ma, S Liu, J Xie, L Wei |
BMC Medical Genomics | 2021 |
Breast cancer heterogeneity through the lens of single-cell analysis and spatial pathologies
N Zhao, J Rosen |
Seminars in Cancer Biology | 2021 |
Can NF-κB Be Considered a Valid Drug Target in Neoplastic Diseases? Our Point of View
M Labbozzetta, M Notarbartolo, P Poma |
International journal of molecular sciences | 2020 |
Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments
U Testa, G Castelli, E Pelosi |
Medical Sciences | 2020 |
Bioinformatics and Computational Tools for Next-Generation Sequencing Analysis in Clinical Genetics
R Pereira, J Oliveira, M Sousa |
Journal of Clinical Medicine | 2020 |
Characterization and comparison of genomic profiles between primary cancer cell lines and parent atypical meningioma tumors
E Kim, M Kim, K So, YS Park, CG Woo, SH Hyun |
Cancer Cell International | 2020 |
Metastatic breast cancer patient perceptions of somatic tumor genomic testing
EJ Adams, S Asad, R Reinbolt, KA Collier, M Abdel-Rasoul, S Gillespie, JL Chen, MA Cherian, AM Noonan, S Sardesai, J VanDeusen, R Wesolowski, N Williams, CL Shapiro, ER Macrae, R Pilarski, AE Toland, L Senter, B Ramaswamy, CN Lee, MB Lustberg, DG Stover |
BMC Cancer | 2020 |
Genome-Wide Estrogen Receptor Activity in Breast Cancer
AM Farcas, S Nagarajan, S Cosulich, JS Carroll |
Endocrinology | 2020 |
Autophagy Inhibition Induces the Secretion of Macrophage Migration Inhibitory Factor (MIF) with Autocrine and Paracrine Effects on the Promotion of Malignancy in Breast Cancer
I Cotzomi-Ortega, A Rosas-Cruz, D Ramírez-Ramírez, J Reyes-Leyva, M Rodriguez-Sosa, P Aguilar-Alonso, P Maycotte |
Biology : open access journal | 2020 |
Current State of Radiolabeled Heterobivalent Peptidic Ligands in Tumor Imaging and Therapy
B Judmann, D Braun, B Wängler, R Schirrmacher, G Fricker, C Wängler |
Pharmaceuticals (Basel, Switzerland) | 2020 |
Hepatic resection for breast cancer liver metastases: Impact of intrinsic subtypes
YS Chun, T Mizuno, JM Cloyd, MJ Ha, K Omichi, CW Tzeng, TA Aloia, NT Ueno, HM Kuerer, CH Barcenas, JN Vauthey |
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology | 2020 |
Initial experience of dedicated breast PET imaging of ER+ breast cancers using [F-18]fluoroestradiol
EF Jones, KM Ray, W Li, AJ Chien, RA Mukhtar, LJ Esserman, BL Franc, Y Seo, MH Pampaloni, BN Joe, NM Hylton |
npj Breast Cancer | 2019 |
The Detection and Morphological Analysis of Circulating Tumor and Host Cells in Breast Cancer Xenograft Models
Cleris, Daidone, Fina, Cappelletti |
Cells | 2019 |
Paclitaxel Response Can Be Predicted With Interpretable Multi-Variate Classifiers Exploiting DNA-Methylation and miRNA Data
A Bomane, A Gonçalves, PJ Ballester |
Frontiers in Genetics | 2019 |
A pipeline for identification and validation of tumor-specific antigens in a mouse model of metastatic breast cancer
CI DeVette, H Gundlapalli, SC Lai, CP McMurtrey, AR Hoover, HR Gurung, WR Chen, AL Welm, WH Hildebrand |
OncoImmunology | 2019 |
Dhaka: variational autoencoder for unmasking tumor heterogeneity from single cell genomic data
Rashid S, Shah S, Bar-Joseph Z, Pandya R |
Bioinformatics | 2019 |
Overview on Clinical Relevance of Intra-Tumor Heterogeneity
G Stanta, S Bonin |
Frontiers in Medicine | 2018 |
Intratumoral heterogeneity characterized by pretreatment PET in non-small cell lung cancer patients predicts progression-free survival on EGFR tyrosine kinase inhibitor
S Park, S Ha, SH Lee, JC Paeng, B Keam, TM Kim, DW Kim, DS Heo, JG Gelovani |
PloS one | 2018 |
Characterization of tumor heterogeneity by latent haplotypes: a sequential Monte Carlo approach
OE Ogundijo, X Wang |
PeerJ | 2018 |
Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers
T Guo, L Li, Q Zhong, NJ Rupp, K Charmpi, CE Wong, U Wagner, JH Rueschoff, W Jochum, CD Fankhauser, K Saba, C Poyet, PJ Wild, R Aebersold, A Beyer |
2018 | |
Single drug biomarker prediction for ER− breast cancer outcome from chemotherapy
YZ Chen, Y Kim, HH Soliman, GG Ying, JK Lee |
Endocrine Related Cancer | 2018 |
Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation: Breast cancer risk by grade and proliferation
M Abubakar, J Chang-Claude, HR Ali, N Chatterjee, P Coulson, F Daley, F Blows, J Benitez, RL Milne, H Brenner, C Stegmaier, A Mannermaa, A Rudolph, P Sinn, FJ Couch, P Devilee, RA Tollenaar, C Seynaeve, J Figueroa, J Lissowska, S Hewitt, MJ Hooning, A Hollestelle, R Foekens, LB Koppert, kConFab Investigators, MK Bolla, Q Wang, ME Jones, MJ Schoemaker, R Keeman, DF Easton, AJ Swerdlow, ME Sherman, MK Schmidt, PD Pharoah, M Garcia-Closas |
International Journal of Cancer | 2018 |
Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression
K Roarty, AD Pfefferle, CJ Creighton, CM Perou, JM Rosen |
Oncogene | 2017 |
A monograph proposing the use of canine mammary tumours as a model for the study of hereditary breast cancer susceptibility genes in humans
K Goebel, ND Merner |
Veterinary Medicine and Science | 2017 |
Integrated analysis of somatic mutations and immune microenvironment of multiple regions in breast cancers
T Kato, JH Park, K Kiyotani, Y Ikeda, Y Miyoshi, Y Nakamura |
Oncotarget | 2017 |
Screening effective differential expression genes for hepatic carcinoma with metastasis in the peripheral blood mononuclear cells by RNA-seq
Y Shen, L Bu, R Li, Z Chen, F Tian, N Lu, Q Ge, Y Bai, Z Lu |
Oncotarget | 2017 |
Progress and challenges of sequencing and analyzing circulating tumor cells
Z Zhu, S Qiu, K Shao, Y Hou |
Cell Biology and Toxicology | 2017 |
Study of the tumor microenvironment during breast cancer progression
R Eftekhari, R Esmaeili, R Mirzaei, K Bidad, S Lima, M Ajami, H Shirzad, J Hadjati, K Majidzadeh-A |
Cancer Cell International | 2017 |
Medulloblastoma stem cells: Promising targets in medulloblastoma therapy
GH Huang, QF Xu, YH Cui, N Li, XW Bian, SQ Lv |
Cancer Science | 2016 |
Tumour heterogeneity: principles and practical consequences
G Stanta, SW Jahn, S Bonin, G Hoefler |
Virchows Archiv | 2016 |
Bayesian inference for intratumour heterogeneity in mutations and copy number variation
J Lee, P Müller, S Sengupta, K Gulukota, Y Ji |
Applied Statistics | 2016 |
Cancer Cell Fusion: Mechanisms Slowly Unravel
F Noubissi, B Ogle |
International journal of molecular sciences | 2016 |
Decoding Intratumoral Heterogeneity of Breast Cancer by Multiparametric In Vivo Imaging: A Translational Study
J Schmitz, J Schwab, J Schwenck, Q Chen, L Quintanilla-Martinez, M Hahn, B Wietek, N Schwenzer, A Staebler, U Kohlhofer, OH Aina, NE Hubbard, G Reischl, AD Borowsky, S Brucker, K Nikolaou, C Fougère, RD Cardiff, BJ Pichler, AM Schmid |
Cancer research | 2016 |
The Role of MicroRNAs as Predictors of Response to Tamoxifen Treatment in Breast Cancer Patients
N Egeland, S Lunde, K Jonsdottir, T Lende, D Cronin-Fenton, B Gilje, E Janssen, H Søiland |
International journal of molecular sciences | 2015 |
Clinical management of breast cancer heterogeneity
D Zardavas, A Irrthum, C Swanton, M Piccart |
Nature Reviews Clinical Oncology | 2015 |
Molecular characterization and targeted therapeutic approaches in breast cancer
A Toss, M Cristofanilli |
Breast Cancer Research | 2015 |
Mutant Allele Tumor Heterogeneity (MATH) and Head and Neck Squamous Cell Carcinoma
JW Rocco |
Head and Neck Pathology | 2015 |
Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer
CN Johnstone, YE Smith, Y Cao, AD Burrows, RS Cross, X Ling, RP Redvers, JP Doherty, BL Eckhardt, AL Natoli, CM Restall, E Lucas, HB Pearson, S Deb, KL Britt, A Rizzitelli, J Li, JH Harmey, N Pouliot, RL Anderson |
Disease models & mechanisms | 2015 |
Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1
LV Rhodes, CR Tate, VT Hoang, HE Burks, D Gilliam, EC Martin, S Elliott, DB Miller, A Buechlein, D Rusch, H Tang, KP Nephew, ME Burow, BM Collins-Burow |
Oncogenesis | 2015 |
Molecular subtyping for clinically defined breast cancer subgroups
X Zhao, EA Rødland, R Tibshirani, S Plevritis |
Breast Cancer Research | 2015 |
In stage II/III lymph node-positive breast cancer patients less than 55 years of age, keratin 8 expression in lymph node metastases but not in the primary tumour is an indicator of better survival
S Bonin, D Pracella, R Barbazza, S Sulfaro, G Stanta |
Virchows Archiv | 2015 |
Axillary lymph node management in breast cancer with positive sentinel lymph node biopsy
IA Voutsadakis |
World journal of clinical oncology | 2015 |
Cell-lineage heterogeneity and driver mutation recurrence in pre-invasive breast neoplasia
Z Weng, N Spies, SX Zhu, DE Newburger, D Kashef-Haghighi, S Batzoglou, A Sidow, RB West |
Genome Medicine | 2015 |
Epidermal growth factor receptor immunohistochemistry: new opportunities in metastatic colorectal cancer
RA Hutchinson, RA Adams, DG McArt, M Salto-Tellez, B Jasani, PW Hamilton |
Journal of Translational Medicine | 2015 |
Molecular Heterogeneity in Primary Breast Carcinomas and Axillary Lymph Node Metastases Assessed by Genomic Fingerprinting Analysis
D Ellsworth, R Ellsworth, A Toro, H Blackburn, A Decewicz, B Deyarmin, K Mamula, N Costantino, C Shriver, J Hooke |
Cancer Growth and Metastasis | 2015 |
Cell injury, retrodifferentiation and the cancer treatment paradox
J Uriel |
Tumor Biology | 2015 |
Ultra-fast local-haplotype variant calling using paired-end DNA-sequencing data reveals somatic mosaicism in tumor and normal blood samples
S Sengupta, K Gulukota, Y Zhu, C Ober, K Naughton, W Wentworth-Sheilds, Y Ji |
Nucleic Acids Research | 2015 |
Detection of Clonal and Subclonal Copy-Number Variants in Cell-Free DNA from Patients with Breast Cancer Using a Massively Multiplexed PCR Methodology
E Kirkizlar, B Zimmermann, T Constantin, R Swenerton, B Hoang, N Wayham, JE Babiarz, Z Demko, RJ Pelham, S Kareht, AL Simon, KN Jinnett, M Rabinowitz, S Sigurjonsson, M Hill |
Translational oncology | 2015 |
Genome and transcriptome delineation of two major oncogenic pathways governing invasive ductal breast cancer development
Aswad L, Yenamandra SP, Ow GS, Grinchuk O, Ivshina AV, Kuznetsov VA |
Oncotarget | 2015 |
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
T Wang, DM Gilkes, N Takano, L Xiang, W Luo, CJ Bishop, P Chaturvedi, JJ Green, GL Semenza |
Proceedings of the National Academy of Sciences | 2014 |
Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells
D Samanta, DM Gilkes, P Chaturvedi, L Xiang, GL Semenza |
Proceedings of the National Academy of Sciences | 2014 |
Allogeneic tumor cell vaccines: The promise and limitations in clinical trials
S Srivatsan, JM Patel, EN Bozeman, IE Imasuen, S He, D Daniels, P Selvaraj |
Human Vaccines & Immunotherapeutics | 2014 |
Statistical measures of transcriptional diversity capture genomic heterogeneity of cancer
T Jiang, W Shi, R Natowicz, SN Ononye, VB Wali, Y Kluger, L Pusztai, C Hatzis |
BMC Genomics | 2014 |
Combining functional genomics strategies identifies modular heterogeneity of breast cancer intrinsic subtypes
N Pouladi, R Cowper-Sallari, JH Moore |
BioData mining | 2014 |
Integrative gene set analysis of multi-platform data with sample heterogeneity
J Hu, JY Tzeng |
Bioinformatics | 2014 |
Intratumoral Heterogeneity, Its Contribution to Therapy Resistance and Methodological Caveats to Assessment
M Renovanz, EL Kim |
Frontiers in Oncology | 2014 |
A New Toolbox for Assessing Single Cells
K Tsioris, AJ Torres, TB Douce, JC Love |
Annual Review of Chemical and Biomolecular Engineering | 2014 |
Ensemble analyses improve signatures of tumour hypoxia and reveal inter-platform differences
NS Fox, MH Starmans, S Haider, P Lambin, PC Boutros |
BMC bioinformatics | 2014 |
Changing genetic paradigms: creating next-generation genetic databases as tools to understand the emerging complexities of genotype/phenotype relationships
B Gottlieb, LK Beitel, M Trifiro |
Human genomics | 2014 |
PARP inhibitor reduces proliferation and increases apoptosis in breast cancer cells
Y Shi, F Zhou, F Jiang, H Lu, J Wang, C Cheng |
Chinese Journal of Cancer Research | 2014 |
Identification of structural variation in mouse genomes
TM Keane, K Wong, DJ Adams, J Flint, A Reymond, B Yalcin |
Frontiers in Genetics | 2014 |
Modeling luminal breast cancer heterogeneity: combination therapy to suppress a hormone receptor-negative, cytokeratin 5-positive subpopulation in luminal disease
AJ Knox, AL Scaling, MP Pinto, BS Bliesner, JM Haughian, HA Abdel-Hafiz, KB Horwitz |
Breast Cancer Research | 2014 |
The multitude of molecular analyses in cancer: the opening of Pandora’s box
HG Russnes, PE Lønning, AL Børresen-Dale, OC Lingjærde |
Genome biology | 2014 |
Cancer stem cells - the current status of an old concept: literature review and clinical approaches
L Fulawka, P Donizy, A Halon |
Biological research | 2014 |
BRCA2 inhibition enhances cisplatin-mediated alterations in tumor cell proliferation, metabolism, and metastasis
M Rytelewski, JG Tong, A Buensuceso, HS Leong, SM Vareki, R Figueredo, CD Cresce, SY Wu, SM Herbrich, KA Baggerly, L Romanow, T Shepherd, BJ Deroo, AK Sood, AF Chambers, M Vincent, PJ Ferguson, J Koropatnick |
Molecular Oncology | 2014 |
Mapping of actionable mutations to histological subtype domains in lung adenocarcinoma: implications for precision medicine.
Wright GM, Do H, Weiss J, Alam NZ, Rathi V, Walkiewicz M, John T, Russell PA, Dobrovic A |
Oncotarget | 2014 |
Anastrozole and everolimus in advanced gynecologic and breast malignancies: activity and molecular alterations in the PI3K/AKT/mTOR pathway.
Wheler JJ, Moulder SL, Naing A, Janku F, Piha-Paul SA, Falchook GS, Zinner R, Tsimberidou AM, Fu S, Hong DS, Atkins JT, Yelensky R, Stephens PJ, Kurzrock R |
Oncotarget | 2014 |
Secreted heat shock protein gp96-Ig: next-generation vaccines for cancer and infectious diseases
N Strbo, A Garcia-Soto, TH Schreiber, ER Podack |
Immunologic Research | 2013 |
Tumour heterogeneity and immune-modulation
M Jamal-Hanjani, E Thanopoulou, KS Peggs, SA Quezada, C Swanton |
Current Opinion in Pharmacology | 2013 |
Peroxisome proliferator activated receptor-α/hypoxia inducible factor-1α interplay sustains carbonic anhydrase IX and apoliprotein E expression in breast cancer stem cells
A Papi, G Storci, T Guarnieri, SD Carolis, S Bertoni, N Avenia, A Sanguinetti, A Sidoni, D Santini, C Ceccarelli, M Taffurelli, M Orlandi, M Bonafé |
PloS one | 2013 |
Molecular and Cellular Heterogeneity in Breast Cancer
AG Rivenbark, SM OConnor, WB Coleman |
The American Journal of Pathology | 2013 |
Emerging targeted agents in metastatic breast cancer
D Zardavas, J Baselga, M Piccart |
Nature Reviews Clinical Oncology | 2013 |
High intra-tumor genetic heterogeneity is related to worse outcome in head and neck squamous cell carcinoma
EA Mroz, AD Tward, CR Pickering, JN Myers, RL Ferris, JW Rocco |
Cancer | 2013 |
Phenotypic Drift as a Cause for Intratumoral Morphological Heterogeneity of Invasive Ductal Breast Carcinoma Not Otherwise Specified
MV Zavyalova, EV Denisov, LA Tashireva, TS Gerashchenko, NV Litviakov, NA Skryabin, SV Vtorushin, NS Telegina, EM Slonimskaya, NV Cherdyntseva, VM Perelmuter |
BioResearch Open Access | 2013 |
Next generation sequencing in cancer research and clinical application
D Shyr, Q Liu |
Biological Procedures Online | 2013 |
Collagen Triple Helix Repeat Containing-1 (CTHRC1) Expression in Invasive Ductal Carcinoma of the Breast: The Impact on Prognosis and Correlation to Clinicopathologic Features
JH Kim, TH Baek, HS Yim, KH Kim, SH Jeong, HB Kang, S Oh, HG Lee, JW Kim, KD Kim |
Pathology & Oncology Research | 2013 |
Cancer heterogeneity: implications for targeted therapeutics
R Fisher, L Pusztai, C Swanton |
British Journal of Cancer | 2013 |
A multi-site feasibility study for personalized medicine in canines with Osteosarcoma
NR Monks, DM Cherba, SG Kamerling, H Simpson, AW Rusk, D Carter, E Eugster, M Mooney, R Sigler, M Steensma, T Grabinski, KR Marotti, CP Webb |
Journal of Translational Medicine | 2013 |
STX140, but not paclitaxel, inhibits mammary tumour initiation and progression in C3(1)/SV40 T/t-antigen transgenic mice
F Meyer-Losic, SP Newman, JM Day, MJ Reed, PG Kasprzyk, A Purohit, PA Foster |
PloS one | 2013 |
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
SA Eccles, EO Aboagye, S Ali, AS Anderson, J Armes, F Berditchevski, JP Blaydes, K Brennan, NJ Brown, HE Bryant, NJ Bundred, JM Burchell, AM Campbell, JS Carroll, RB Clarke, CE Coles, GJ Cook, A Cox, NJ Curtin, LV Dekker, IS Silva, SW Duffy, DF Easton, DM Eccles, DR Edwards, J Edwards, D Evans, DF Fenlon, JM Flanagan, C Foster, WM Gallagher, M Garcia-Closas, JM Gee, AJ Gescher, V Goh, AM Groves, AJ Harvey, M Harvie, BT Hennessy, S Hiscox, I Holen, SJ Howell, A Howell, G Hubbard, N Hulbert-Williams, MS Hunter, B Jasani, LJ Jones, TJ Key, CC Kirwan, A Kong, IH Kunkler, SP Langdon, MO Leach, DJ Mann, JF Marshall, L Martin, SG Martin, JE Macdougall, DW Miles, WR Miller, JR Morris, SM Moss, P Mullan, R Natrajan, JP O'Connor, R O'Connor, C Palmieri, PD Pharoah, EA Rakha, E Reed, SP Robinson, E Sahai, JM Saxton, P Schmid, MJ Smalley, V Speirs, R Stein, J Stingl, CH Streuli, AN Tutt, G Velikova, RA Walker, CJ Watson, KJ Williams, LS Young, AM Thompson |
Breast Cancer Research | 2013 |
Inhibition of BRCA2 and Thymidylate Synthase Creates Multidrug Sensitive Tumor Cells via the Induction of Combined "Complementary Lethality"
M Rytelewski, PJ Ferguson, SM Vareki, R Figueredo, M Vincent, J Koropatnick |
Molecular Therapy — Nucleic Acids | 2013 |
Elite model for the generation of induced pluripotent cancer cells (iPCs)
J Lai, CM Kong, D Mahalingam, X Xie, X Wang |
PloS one | 2013 |
The optimal approach to early breast cancer
Wyld L |
EJC Supplements | 2013 |
Ovarian Cancer Biomarker Discovery Based on Genomic Approaches
Lee JY, Kim HS, Suh DH, Kim MK, Chung HH, Song YS |
Journal of Cancer Prevention | 2013 |
Intra-tumour heterogeneity: a looking glass for cancer?
A Marusyk, V Almendro, K Polyak |
Nature Reviews Cancer | 2012 |
Whole genome sequencing for lung cancer
M Daniels, F Goh, CM Wright, KB Sriram, V Relan, BE Clarke, EE Duhig, RV Bowman, IA Yang, KM Fong |
Journal of Thoracic Disease | 2012 |
Progress in breast cancer research
K Polyak, PK Vogt |
Proceedings of the National Academy of Sciences | 2012 |
PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells
J Węsierska-Gądek, N Zulehner, F Ferk, A Składanowski, O Komina, M Maurer |
Biochemical Pharmacology | 2012 |
What is personalized medicine and what should it replace?
DC Whitcomb |
Nature Reviews Gastroenterology & Hepatology | 2012 |
Epigenetics advancing personalized nanomedicine in cancer therapy
S Liu |
Advanced Drug Delivery Reviews | 2012 |
Next-generation sequencing: application in liver cancer-past, present and future?
JU Marquardt, JB Andersen |
Biology : open access journal | 2012 |
Effective normalization for copy number variation detection from whole genome sequencing
A Janevski, V Varadan, S Kamalakaran, N Banerjee, N Dimitrova |
BMC Genomics | 2012 |
Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells
JW Ruan, YC Liao, I Lua, MH Li, CY Hsu, JH Chen |
Breast Cancer Research | 2012 |
Biomarkers in Breast Cancer – An Update
M Schmidt, P Fasching, M Beckmann, H Kölbl |
Geburtshilfe und Frauenheilkunde | 2012 |
Germline copy number variants are not associated with globally acquired copy number changes in familial breast tumours
Walker LC, Krause L, Spurdle AB, Waddell N |
Breast Cancer Research and Treatment | 2012 |
Heterogeneity in breast cancer
Kornelia Polyak |
Journal of Clinical Investigation | 2011 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
The potential for liquid biopsies in the precision medical treatment of breast cancer
Victoria A. Forte, Dany K. Barrak, Mostafa Elhodaky, Lily Tung, Anson Snow, Julie E. Lang |
Cancer biology & medicine |