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Citations to this article

Insight into the heterogeneity of breast cancer through next-generation sequencing
Hege G. Russnes, … , James Hicks, Anne-Lise Borresen-Dale
Hege G. Russnes, … , James Hicks, Anne-Lise Borresen-Dale
Published October 3, 2011
Citation Information: J Clin Invest. 2011;121(10):3810-3818. https://doi.org/10.1172/JCI57088.
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Insight into the heterogeneity of breast cancer through next-generation sequencing

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Abstract

Rapid and sophisticated improvements in molecular analysis have allowed us to sequence whole human genomes as well as cancer genomes, and the findings suggest that we may be approaching the ability to individualize the diagnosis and treatment of cancer. This paradigmatic shift in approach will require clinicians and researchers to overcome several challenges including the huge spectrum of tumor types within a given cancer, as well as the cell-to-cell variations observed within tumors. This review discusses how next-generation sequencing of breast cancer genomes already reveals insight into tumor heterogeneity and how it can contribute to future breast cancer classification and management.

Authors

Hege G. Russnes, Nicholas Navin, James Hicks, Anne-Lise Borresen-Dale

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009 Total
Citations: 3 7 3 8 6 9 5 6 6 5 16 18 17 11 1 1 122
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Biology : open access journal 2012
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Germline copy number variants are not associated with globally acquired copy number changes in familial breast tumours
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Pulmonary surfactant: an immunological perspective
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