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Citations to this article

β3-integrin–deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
Kairbaan M. Hodivala-Dilke, … , Steven Teitelbaum, Richard O. Hynes
Kairbaan M. Hodivala-Dilke, … , Steven Teitelbaum, Richard O. Hynes
Published January 15, 1999
Citation Information: J Clin Invest. 1999;103(2):229-238. https://doi.org/10.1172/JCI5487.
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β3-integrin–deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival

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Abstract

β3 integrins have been implicated in a wide variety of functions, including platelet aggregation and thrombosis (αIIbβ3) and implantation, placentation, angiogenesis, bone remodeling, and tumor progression (αvβ3). The human bleeding disorder Glanzmann thrombasthenia (GT) can result from defects in the genes for either the αIIb or the β3 subunit. In order to develop a mouse model of this disease and to further studies of hemostasis, thrombosis, and other suggested roles of β3 integrins, we have generated a strain of β3-null mice. The mice are viable and fertile, and show all the cardinal features of GT (defects in platelet aggregation and clot retraction, prolonged bleeding times, and cutaneous and gastrointestinal bleeding). Implantation appears to be unaffected, but placental defects do occur and lead to fetal mortality. Postnatal hemorrhage leads to anemia and reduced survival. These mice will allow analyses of the other suggested functions of β3 integrins and we report that postnatal neovascularization of the retina appears to be β3-integrin–independent, contrary to expectations from inhibition experiments.

Authors

Kairbaan M. Hodivala-Dilke, Kevin P. McHugh, Dimitrios A. Tsakiris, Helen Rayburn, Denise Crowley, Mollie Ullman-Culleré, F. Patrick Ross, Barry S. Coller, Steven Teitelbaum, Richard O. Hynes

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1986 1949 Total
Citations: 4 3 8 5 13 14 12 11 9 17 20 24 29 43 158 37 30 41 34 21 21 24 32 31 31 26 11 2 1 712
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Citations to this article in year 2022 (5)

Title and authors Publication Year
Pathobiology of Airway Remodeling in Asthma: The Emerging Role of Integrins
C Joseph, A Tatler
Journal of asthma and allergy 2022
State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions
Lavin KM, Coen PM, Baptista LC, Bell MB, Drummer D, Harper SA, Lixandrão ME, McAdam JS, O\u2019Bryan SM, Ramos S, Roberts LM, Vega RB, Goodpaster BH, Bamman MM, Buford TW
Comprehensive Physiology 2022
Examining the lineage autonomous role of β3-integrin in muscle regeneration.
Gerassimov N, Crain C, Bilyeu C, Jacob A, Fan CM
The FASEB Journal 2022
Integrin β3 in forebrain Emx1-expressing cells regulates repetitive self-grooming and sociability in mice.
Lopuch AJ, Swinehart BD, Widener EL, Holley ZL, Bland KM, Handwerk CJ, Brett CA, Cook HN, Kalinowski AR, Rodriguez HV, Song MI, Vidal GS
BMC neuroscience 2022
The NOGO receptor NgR2, a novel αVβ3 integrin effector, induces neuroendocrine differentiation in prostate cancer.
Quaglia F, Krishn SR, Sossey-Alaoui K, Rana PS, Pluskota E, Park PH, Shields CD, Lin S, McCue P, Kossenkov AV, Wang Y, Goodrich DW, Ku SY, Beltran H, Kelly WK, Corey E, Klose M, Bandtlow C, Liu Q, Altieri DC, Plow EF, Languino LR
Scientific Reports 2022

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