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Citations to this article

Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein
Fayez F. Safadi, … , Stephen A. Liebhaber, Nancy E. Cooke
Fayez F. Safadi, … , Stephen A. Liebhaber, Nancy E. Cooke
Published January 15, 1999
Citation Information: J Clin Invest. 1999;103(2):239-251. https://doi.org/10.1172/JCI5244.
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Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein

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Abstract

A line of mice deficient in vitamin D binding protein (DBP) was generated by targeted mutagenesis to establish a model for analysis of DBP's biological functions in vitamin D metabolism and action. On vitamin D–replete diets, DBP–/– mice had low levels of total serum vitamin D metabolites but were otherwise normal. When maintained on vitamin D–deficient diets for a brief period, the DBP–/–, but not DBP+/+, mice developed secondary hyperparathyroidism and the accompanying bone changes associated with vitamin D deficiency. DBP markedly prolonged the serum half-life of 25(OH)D and less dramatically prolonged the half-life of vitamin D by slowing its hepatic uptake and increasing the efficiency of its conversion to 25(OH)D in the liver. After an overload of vitamin D, DBP–/– mice were unexpectedly less susceptible to hypercalcemia and its toxic effects. Peak steady-state mRNA levels of the vitamin D–dependent calbindin-D9K gene were induced by 1,25(OH)2D more rapidly in the DBP–/– mice. Thus, the role of DBP is to maintain stable serum stores of vitamin D metabolites and modulate the rates of its bioavailability, activation, and end-organ responsiveness. These properties may have evolved to stabilize and maintain serum levels of vitamin D in environments with variable vitamin D availability.

Authors

Fayez F. Safadi, Paul Thornton, Holly Magiera, Bruce W. Hollis, Michael Gentile, John G. Haddad, Stephen A. Liebhaber, Nancy E. Cooke

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1997 1988 Total
Citations: 2 7 3 6 18 16 18 12 23 17 16 22 26 14 15 8 5 9 4 8 1 5 6 6 3 4 3 1 1 279
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Citations to this article in year 2020 (16)

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Osteoporosis: Pathophysiology and Clinical Management
BZ Leder, MN Wein
2020
An Overview of Rickets in Children
R Chanchlani, P Nemer, R Sinha, L Nemer, V Krishnappa, E Sochett, F Safadi, R Raina
Kidney International Reports 2020
Vitamin D Metabolism and Profiling in Veterinary Species
EA Hurst, NZ Homer, RJ Mellanby
Metabolites 2020
New aspects of vitamin D metabolism and action — addressing the skin as source and target
D Bikle, S Christakos
Nature Reviews Endocrinology 2020
High Fidelity of Mouse Models Mimicking Human Genetic Skeletal Disorders
R Brommage, C Ohlsson
Frontiers in Endocrinology 2020
Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion.
Viloria K, Nasteska D, Briant LJB, Heising S, Larner DP, Fine NHF, Ashford FB, da Silva Xavier G, Ramos MJ, Hasib A, Cuozzo F, Manning Fox JE, MacDonald PE, Akerman I, Lavery GG, Flaxman C, Morgan NG, Richardson SJ, Hewison M, Hodson DJ
Cell Reports 2020
Vitamin D Binding Protein: A Historic Overview
R Bouillon, F Schuit, L Antonio, F Rastinejad
Frontiers in Endocrinology 2020
Association of prediagnostic vitamin D status with mortality among colorectal cancer patients differs by common, inherited vitamin D‐binding protein isoforms
DC Gibbs, RM Bostick, ML McCullough, CY Um, WD Flanders, M Jenab, E Weiderpass, B Gylling, IT Gram, AK Heath, S ColoradoYohar, CC Dahm, B BuenodeMesquita, A PerezCornago, A Trichopoulou, R Tumino, T Kühn, V Fedirko
International Journal of Cancer 2020
The Free Hormone Hypothesis: When, Why, and How to Measure the Free Hormone Levels to Assess Vitamin D, Thyroid, Sex Hormone, and Cortisol Status
DD Bikle
JBMR Plus 2020
No association between the vitamin D-binding protein (DBP) gene polymorphisms (rs7041 and rs4588) and multiple sclerosis and type 1 diabetes mellitus: A meta-analysis
X Zhang, B Gao, B Xu, J Devaney
PloS one 2020
Comparison of Serum Free and Bioavailable 25-Hydroxyvitamin D Levels in Alzheimer’s Disease and Healthy Control Patients
E Ertilav, NE Barcin, S Ozdem
Laboratory Medicine 2020
The Vitamin D Metabolite Ratio Is Independent of Vitamin D Binding Protein Concentration
C Ginsberg, AN Hoofnagle, R Katz, JO Becker, SB Kritchevsky, MG Shlipak, MJ Sarnak, J H
Clinical chemistry 2020
COVID-19 and vitamin D supplementation: Is there any evidence based to reduce the risk?
A Chentouf
2020
Review of proteomics approach to eye diseases affecting the anterior segment
H Aghamollaei, S Parvin, A Shahriary
Journal of Proteomics 2020
In Reply: The Causal Relationship of Total and Free 25-Hydroxyvitamin D and Vitamin D Binding Protein with Risk of Osteoporotic Fractures
Y Çolak, S Afzal, BG Nordestgaard
Clinical chemistry 2020
Total, Bioavailable, and Free Vitamin D Levels and Their Prognostic Value in Pulmonary Arterial Hypertension
M Callejo, G Mondejar-Parreño, S Esquivel-Ruiz, MA Olivencia, L Moreno, I Blanco, P Escribano-Subias, A Cogolludo, JA Barbera, F Perez-Vizcaino
Journal of Clinical Medicine 2020

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