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N Barzilai, … , W Chen, L Rossetti
Published April 1, 1998
Citation Information: J Clin Invest. 1998;101(7):1353-1361. https://doi.org/10.1172/JCI485.
Citation Information: J Clin Invest. 1998;101(7):1353-1361. https://doi.org/10.1172/JCI485.
Abstract
Hyperinsulinemia and increased visceral/abdominal fat (VF) are common features of human aging. To examine the relationships among VF, peripheral, and hepatic insulin sensitivity, we studied 4- and 18-mo-old male Sprague-Dawley rats (n = 42) fed ad libitum (4 AL and 18 AL) or moderately calorie restricted (18 CR) up to 18 mo of age. Total fat mass (FM) and VF were decreased in 18 CR to approximately one-third of that of 18 AL (P < 0.001), while lean body mass (LBM) was unchanged. Most important, 18 CR had more FM (65+/-6 vs. 45+/-6 g) but less VF (7.8+/-0.6 vs. 12.3+/-3.3 g) compared with 4 AL (P < 0.01 for both). Thus, the effects of variable VF on HIS could be assessed, independent of FM and age. Marked hepatic insulin resistance ensued with aging (18 AL) and CR restored hepatic insulin sensitivity to the levels of young rats, while peripheral insulin sensitivity remained unchanged (by insulin clamp of 18 mU/kg/min). In fact, the rates of insulin infusion required to maintain basal hepatic glucose production in the presence of pancreatic clamp were 0.75+/-0.10, 1.41+/-0.13, and 0.51+/-0.12 mU/kg . min, in 4 AL, 18 AL, and 18 CR, respectively (P < 0.01 between all groups), and in 18 CR rats infused with insulin at similar rates as in the 18 AL (1.4 mU/kg/min) hepatic glucose production was decreased by 32% (P < 0. 005). Furthermore, when 18 CR rats were fed AL for 14 d, VF rapidly and selectively increased and severe hepatic insulin resistance was induced. We propose that in this animal model the age-associated decrease in hepatic (rather than peripheral) insulin action is the major determinant of fasting hyperinsulinemia and that increased visceral adiposity plays the major role in inducing hepatic insulin resistance. Thus, interventions designed to prevent the accumulation of VF are likely to represent an effective mean to improve carbohydrate metabolism in aging.
Authors
N Barzilai, S Banerjee, M Hawkins, W Chen, L Rossetti
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Sirtuins in Aging and Age-Related Diseases
MC Haigis, DA Sinclair |
Handbook of the Biology of Aging | 2011 |
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Hypothalamic lipophagy and energetic balance
R Singh |
Aging | 2011 |
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Caloric restriction: powerful protection for the aging heart and vasculature
EP Weiss, L Fontana |
American journal of physiology. Heart and circulatory physiology | 2011 |
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Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?
AF Bokov, N Garg, Y Ikeno, S Thakur, N Musi, RA DeFronzo, N Zhang, RC Erickson, J Gelfond, GB Hubbard, ML Adamo, A Richardson, AC Lo |
PloS one | 2011 |
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Caloric restriction: powerful protection for the aging heart and vasculature
EP Weiss, L Fontana |
American journal of physiology. Heart and circulatory physiology | 2011 |
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Adipokines and Aging
Y Arai, M Takayama, Y Abe, N Hirose |
Journal of Atherosclerosis and Thrombosis | 2011 |
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Adiponectin Lowers Glucose Production by Increasing SOGA
RB Cowherd, RB Cowerd, MM Asmar, JM Alderman, EA Alderman, AL Garland, WH Busby, WM Bodnar, I Rusyn, BD Medoff, R Tisch, E Mayer-Davis, JA Swenberg, SH Zeisel, TP Combs |
The American Journal of Pathology | 2010 |
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Adipokines as novel biomarkers and regulators of the metabolic syndrome
Y Deng, PE Scherer |
Annals of the New York Academy of Sciences | 2010 |
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Intrinsic Depot-Specific Differences in the Secretome of Adipose Tissue, Preadipocytes, and Adipose Tissue-Derived Microvascular Endothelial Cells
SL Hocking, LE Wu, M Guilhaus, DJ Chisholm, DE James |
Diabetes | 2010 |
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Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?
AB Salmon, A Richardson, VI Pérez |
Free radical biology & medicine | 2010 |
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Tissue-specific dysregulation of DNA methylation in aging
RF Thompson, G Atzmon, C Gheorghe, HQ Liang, C Lowes, JM Greally, N Barzilai |
Aging Cell | 2010 |
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"Control" laboratory rodents are metabolically morbid: why it matters
B Martin, S Ji, S Maudsley, MP Mattson |
Proceedings of the National Academy of Sciences | 2010 |
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Regulation of energy metabolism by inflammation: a feedback response in obesity and calorie restriction
J Ye, JN Keller |
Aging | 2010 |
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Impaired quality control of mitochondria: Aging from a new perspective
TA Weber, AS Reichert |
Experimental Gerontology | 2010 |
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Prenatal Androgen Treatment Alters Body Composition and Glucose Homeostasis in Male Rats
M Lazic, F Aird, JE Levine, A Dunaif |
The Journal of endocrinology | 2010 |
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SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
M Pacholec, JE Bleasdale, B Chrunyk, D Cunningham, D Flynn, RS Garofalo, D Griffith, M Griffor, P Loulakis, B Pabst, X Qiu, B Stockman, V Thanabal, A Varghese, J Ward, J Withka, K Ahn |
2010 | |
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The Future of Aging
GM Fahy, MD West, LS Coles, SB Harris |
2010 | |
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Physical Activity, Dietary Calorie Restriction, and Cancer
A McTiernan |
2010 | |
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Hormonal control of aging in rodents: The somatotropic axis
HM Brown-Borg |
Molecular and Cellular Endocrinology | 2009 |
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Role of visceral adipose tissue in aging
DM Huffman, N Barzilai |
Biochimica et Biophysica Acta | 2009 |
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Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production
L Fontana, S Klein, JO Holloszy |
AGE | 2009 |
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Effect of long- and short-term treatments with pravastatin on diabetes mellitus and pancreatic fibrosis in the Otsuka-Long-Evans-Tokushima Fatty rat
M Otani, M Yamamoto, M Harada, M Otsuki |
British Journal of Pharmacology | 2009 |
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Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats
Y Zheng, W Zhang, E Pendleton, S Leng, J Wu, R Chen, XJ Sun |
The Journal of endocrinology | 2009 |
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Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction
X Liu, M Liu, J Zhang, X Bai, F Ramos, HV Remmen, A Richardson, FY Liu, LQ Dong, F Liu |
American journal of physiology. Endocrinology and metabolism | 2009 |
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The scientific basis of caloric restriction leading to longer life
L Fontana |
Current Opinion in Gastroenterology | 2009 |
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The expression of rat resistin isoforms is differentially regulated in visceral adipose tissues: effects of aging and food restriction
CM Fernández, E Moltó, N Gallardo, A Arco, C Martínez, A Andrés, M Ros, JM Carrascosa, C Arribas |
Metabolism | 2009 |
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Effects of High-Fat High-Sucrose Feeding, Energy Restriction, and trans -10, cis -12 Conjugated Linoleic Acid on Visfatin and Apelin in Hamsters
A Lasa, I Churruca, E Simón, MT Macarulla, A Fernández-Quintela, VM Rodríguez, MP Portillo |
Journal of the American College of Nutrition | 2009 |
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Effect of Food Restriction on Adipose Tissue in Spontaneously Diabetic Torii Fatty Rats
H Morinaga, T Ohta, K Matsui, T Sasase, S Fukuda, M Ito, M Ueda, Y Ishii, K Miyajima, M Matsushita |
Experimental Diabetes Research | 2009 |
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Sirtuin inhibitors
FJ Alcaín, JM Villalba |
Expert Opinion on Therapeutic Patents | 2009 |
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Sirtuin activators
FJ Alcaín, JM Villalba |
Expert Opinion on Therapeutic Patents | 2009 |
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Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction
X Liu, M Liu, J Zhang, X Bai, F Ramos, HV Remmen, A Richardson, FY Liu, LQ Dong, F Liu |
American journal of physiology. Endocrinology and metabolism | 2009 |
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Life-Span Extension
C Sell, A Lorenzini, HM Brown-Borg |
2009 | |
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Iron accumulation with age, oxidative stress and functional decline
J Xu, MD Knutson, CS Carter, C Leeuwenburgh |
PloS one | 2008 |
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Modern Nutrition
K LaPoint, M McIntosh |
Handbook of Nutrition in the Aged, Fourth Edition | 2008 |
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Adaptations in pulsatile insulin secretion, hepatic insulin clearance, and beta-cell mass to age-related insulin resistance in rats
AV Matveyenko, JD Veldhuis, PC Butler |
American journal of physiology. Endocrinology and metabolism | 2008 |
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Reduction of mitochondrial H2O2by overexpressing peroxiredoxin 3 improves glucose tolerance in mice
L Chen, R Na, M Gu, AB Salmon, Y Liu, H Liang, W Qi, HV Remmen, A Richardson, Q Ran |
Aging Cell | 2008 |
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Calorie restriction minimizes activation of insulin signaling in response to glucose: Potential involvement of the growth hormone-insulin-like growth factor 1 axis
H Hayashi, H Yamaza, T Komatsu, S Park, T Chiba, Y Higami, T Nagayasu, I Shimokawa |
Experimental Gerontology | 2008 |
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Abdominal Obesity and the Endocannabinoid System: From Basic Aspects to Clinical Management of Related Cardiometabolic Risk
D Huffman, N Barzilai |
Abdominal Obesity and the Endocannabinoid System: From Basic Aspects to Clinical Management of Related Cardiometabolic Risk | 2008 |
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Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48 −/− Lep ob/ob mice devoid of ApoE or Ldlr
DJ Lloyd, J McCormick, J Helmering, KW Kim, M Wang, P Fordstrom, SA Kaufman, RA Lindberg, MM Véniant |
American journal of physiology. Endocrinology and metabolism | 2008 |
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Adaptations in pulsatile insulin secretion, hepatic insulin clearance, and β-cell mass to age-related insulin resistance in rats
AV Matveyenko, JD Veldhuis, PC Butler |
American journal of physiology. Endocrinology and metabolism | 2008 |
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3T3-L1 Adipocytes and Rat Adipose Tissue Have a High Capacity for Taurine Synthesis by the Cysteine Dioxygenase/Cysteinesulfinate Decarboxylase and Cysteamine Dioxygenase Pathways
I Ueki, MH Stipanuk |
The Journal of nutrition | 2008 |
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Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice: Role of adipose mitochondria in longevity, M. Katic et al
M Katic, AR Kennedy, I Leykin, A Norris, A McGettrick, S Gesta, SJ Russell, M Bluher, E Maratos-Flier, CR Kahn |
Aging Cell | 2007 |
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Metabolic Reprogramming in Dietary Restriction
Anderson RM, Weindruch R |
Interdisciplinary topics in gerontology | 2007 |
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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
JC Milne, PD Lambert, S Schenk, DP Carney, JJ Smith, DJ Gagne, L Jin, O Boss, RB Perni, CB Vu, JE Bemis, R Xie, JS Disch, PY Ng, JJ Nunes, AV Lynch, H Yang, H Galonek, K Israelian, W Choy, A Iffland, S Lavu, O Medvedik, DA Sinclair, JM Olefsky, MR Jirousek, PJ Elliott, CH Westphal |
Nature | 2007 |
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Hormonal regulation of longevity in mammals
HM Brown-Borg |
Ageing Research Reviews | 2007 |
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Transcriptional response to aging and caloric restriction in heart and adipose tissue
NJ Linford, RP Beyer, K Gollahon, RA Krajcik, VL Malloy, V Demas, GC Burmer, PS Rabinovitch |
Aging Cell | 2007 |
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Sirtuins, nuclear hormone receptor acetylation and transcriptional regulation
JR Whittle, MJ Powell, VM Popov, LA Shirley, C Wang, RG Pestell |
Trends in Endocrinology & Metabolism | 2007 |
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Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice
M Katic, AR Kennedy, I Leykin, A Norris, A McGettrick, S Gesta, SJ Russell, M Bluher, E Maratos-Flier, CR Kahn |
Aging Cell | 2007 |
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SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B
C Sun, F Zhang, X Ge, T Yan, X Chen, X Shi, Q Zhai |
Cell Metabolism | 2007 |
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Glucose Toxicity Is Responsible for the Development of Impaired Regulation of Endogenous Glucose Production and Hepatic Glucokinase in Zucker Diabetic Fatty Rats
Y Fujimoto, TP Torres, EP Donahue, M Shiota |
2006 | |
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Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction
VL Malloy, RA Krajcik, SJ Bailey, G Hristopoulos, JD Plummer, N Orentreich |
Aging Cell | 2006 |
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Effect of inhibition of α-glucosidase on age-related glucose intolerance and pancreatic atrophy in rats
M Yamamoto, M Otsuki |
Metabolism | 2006 |
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MCH-/- Mice Are Resistant to Aging-Associated Increases in Body Weight and Insulin Resistance
JY Jeon, RL Bradley, EG Kokkotou, FE Marino, X Wang, P Pissios, E Maratos-Flier |
Diabetes | 2006 |
|
Energy Restriction Lowers the Expression of Genes Linked to Inflammation, the Cytoskeleton, the Extracellular Matrix, and Angiogenesis in Mouse Adipose Tissue
Y Higami, JL Barger, GP Page, DB Allison, SR Smith, TA Prolla, R Weindruch |
The Journal of nutrition | 2006 |
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Synthetic protease inhibitor camostat prevents and reverses dyslipidemia, insulin secretory defects, and histological abnormalities of the pancreas in genetically obese and diabetic rats
D Jia, M Taguchi, M Otsuki |
Metabolism | 2005 |
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The Growth Hormone/Insulin-Like Growth Factor Axis During Development
I Varela-Nieto, JA Chowen |
The Growth Hormone/Insulin-Like Growth Factor Axis During Development | 2005 |
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The Growth Hormone/Insulin-Like Growth Factor Axis During Development
I Varela-Nieto, JA Chowen |
The Growth Hormone/Insulin-Like Growth Factor Axis During Development | 2005 |
|
The Growth Hormone/Insulin-Like Growth Factor Axis During Development
I Varela-Nieto, JA Chowen |
The Growth Hormone/Insulin-Like Growth Factor Axis During Development | 2005 |
|
The Growth Hormone/Insulin-Like Growth Factor Axis During Development
I Varela-Nieto, JA Chowen |
The Growth Hormone/Insulin-Like Growth Factor Axis During Development | 2005 |
|
The Growth Hormone/Insulin-Like Growth Factor Axis During Development
I Varela-Nieto, JA Chowen |
The Growth Hormone/Insulin-Like Growth Factor Axis During Development | 2005 |
|
The Growth Hormone/Insulin-Like Growth Factor Axis During Development
I Varela-Nieto, JA Chowen |
The Growth Hormone/Insulin-Like Growth Factor Axis During Development | 2005 |
|
The Growth Hormone/Insulin-Like Growth Factor Axis During Development
I Varela-Nieto, JA Chowen |
The Growth Hormone/Insulin-Like Growth Factor Axis During Development | 2005 |
|
The Growth Hormone/Insulin-Like Growth Factor Axis During Development
I Varela-Nieto, JA Chowen |
The Growth Hormone/Insulin-Like Growth Factor Axis During Development | 2005 |
|
The Growth Hormone/Insulin-Like Growth Factor Axis During Development
I Varela-Nieto, JA Chowen |
The Growth Hormone/Insulin-Like Growth Factor Axis During Development | 2005 |
|
The Growth Hormone/Insulin-Like Growth Factor Axis During Development
I Varela-Nieto, JA Chowen |
The Growth Hormone/Insulin-Like Growth Factor Axis During Development | 2005 |
|
The Growth Hormone/Insulin-Like Growth Factor Axis During Development
I Varela-Nieto, JA Chowen |
The Growth Hormone/Insulin-Like Growth Factor Axis During Development | 2005 |
|
Calorie restriction, SIRT1 and metabolism: understanding longevity
L Bordone, L Guarente |
Nature Reviews Molecular Cell Biology | 2005 |
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The insulin/IGF-1 signaling in mammals and its relevance to human longevity
M Rincon, E Rudin, N Barzilai |
Experimental Gerontology | 2005 |
|
Extended longevity and insulin signaling in adipose tissue
N Klöting, M Blüher |
Experimental Gerontology | 2005 |
|
Lessons learned from gene expression profile studies of aging and caloric restriction
SK Park, TA Prolla |
Ageing Research Reviews | 2005 |
|
Central resistance to the inhibitory effects of leptin on stimulated insulin secretion with aging
RH Muzumdar, X Ma, X Yang, G Atzmon, N Barzilai |
Neurobiology of Aging | 2005 |
|
Handbook of the Biology of Aging
PM Wise |
Handbook of the Biology of Aging | 2005 |
|
Increased Susceptibility to Insulin Resistance Associated with Abdominal Obesity in Aging Rats **
KJ Catalano, RN Bergman, M Ader |
Obesity research | 2005 |
|
Caloric restriction, body fat and ageing in experimental models
M Das, I Gabriely, N Barzilai |
Obesity Reviews | 2004 |
|
The role of insulin and insulin-like growth factor-I in mammalian ageing
A Richardson, F Liu, ML Adamo, HV Remmen, JF Nelson |
Best Practice & Research Clinical Endocrinology & Metabolism | 2004 |
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Effects of life-long exercise on circulating free fatty acids and muscle triglyceride content in ageing rats
M Novelli, A Pocai, M Skalicky, A Viidik, E Bergamini, P Masiello |
Experimental Gerontology | 2004 |
|
Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action
Radhika Muzumdar, Xiaohui Ma, Gil Atzmon, Patricia Vuguin, Xiaoman Yang, Nir Barzilai |
Diabetes | 2004 |
|
Leptin impairs insulin signaling in rat adipocytes
Coralia Pérez, Carmen Fernández-Galaz, Teresa Fernández-Agulló, Carmen Arribas, Antonio Andrés, Manuel Ros, José M Carrascosa |
Diabetes | 2004 |
|
Sexual Differentiation, Pregnancy, Calorie Restriction, and Aging Affect the Adipocyte-Specific Secretory Protein Adiponectin
TP Combs, AH Berg, MW Rajala, S Klebanov, P Iyengar, JC Jimenez-Chillaron, ME Patti, SL Klein, RS Weinstein, PE Scherer |
Diabetes | 2003 |
|
Activation of the retinoid X receptor suppresses appetite in the rat
KM Ogilvie, R Saladin, TR Nagy, MS Urcan, RA Heyman, MD Leibowitz |
Endocrinology | 2003 |
|
Surgical removal of visceral adipose tissue: Effects on insulin action
I Gabriely, N Barzilai |
Current Diabetes Reports | 2003 |
|
Aging accelerates dietary lard-induced increase in blood pressure in rats
N Tamaya-Mori, K Uemura, S Tanaka, A Iguchi |
Experimental Gerontology | 2003 |
|
High fat feeding is associated with increased blood pressure, sympathetic nerve activity and hypothalamic mu opioid receptors
MJ Barnes, K Lapanowski, A Conley, JA Rafols, KL Jen, JC Dunbar |
Brain Research Bulletin | 2003 |
|
Does the brain lead the metabolic decline in aging?
X Ma, R Muzumdar, I Gabriely, G Atzmon, N Barzilai |
Clinical Neuroscience Research | 2003 |
|
How does prolonged caloric restriction ameliorate age-related impairment of long-term potentiation in the hippocampus?
M Okada, H Nakanishi, T Amamoto, R Urae, S Ando, K Yazawa, M Fujiwara |
Molecular Brain Research | 2003 |
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CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice
JR Goudriaan, VE Dahlmans, B Teusink, DM Ouwens, M Febbraio, JA Maassen, JA Romijn, LM Havekes, PJ Voshol |
Journal of lipid research | 2003 |
|
Visceral Fat: Higher Responsiveness of Fat Mass and Gene Expression to Calorie Restriction than Subcutaneous Fat
Y Li, H Bujo, K Takahashi, M Shibasaki, Y Zhu, Y Yoshida, Y Otsuka, N Hashimoto, Y Saito |
Experimental biology and medicine (Maywood, N.J.) | 2003 |
|
Calorie restriction and aging: review of the literature and implications for studies in humans
LK Heilbronn, E Ravussin |
The American journal of clinical nutrition | 2003 |
|
Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long‐term caloric restriction
Y Higami, TD Pugh, GP Page, DB Allison, TA Prolla, R Weindruch |
The FASEB Journal | 2003 |
|
Resistance to obesity in Lou/C rats prevents ageing-associated metabolic alterations
D Perrin, C Soulage, JM Pequignot, A Glon |
Diabetologia | 2003 |
|
Aging Is Associated With Resistance to Effects of Leptin on Fat Distribution and Insulin Action
XH Ma, R Muzumdar, XM Yang, I Gabriely, R Berger, N Barzilai |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2002 |
|
Anti-aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling
T Chiba, H Yamaza, Y Higami, I Shimokawa |
Microscopy Research and Technique | 2002 |
|
Steatohepatitis in obese individuals
WI Youssef, AJ McCullough |
Best Practice & Research Clinical Gastroenterology | 2002 |
|
Metabolic Characteristics and Body Composition in a Model of Anti-Obese Rats (Lou/C)
K Couturier, S Servais, H Koubi, B Sempore, MH Sornay-Mayet, JM Cottet-Emard, JM Lavoie, R Favier |
Obesity research | 2002 |
|
The Concurrent Accumulation of Intra-Abdominal and Subcutaneous Fat Explains the Association Between Insulin Resistance and Plasma Leptin Concentrations : Distinct Metabolic Effects of Two Fat Compartments
M Cnop, MJ Landchild, J Vidal, PJ Havel, NG Knowles, DR Carr, F Wang, RL Hull, EJ Boyko, BM Retzlaff, CE Walden, RH Knopp, SE Kahn |
Diabetes | 2002 |
|
Removal of Visceral Fat Prevents Insulin Resistance and Glucose Intolerance of Aging: An Adipokine-Mediated Process?
I Gabriely, XH Ma, XM Yang, G Atzmon, MW Rajala, AH Berg, P Scherer, L Rossetti, N Barzilai |
Diabetes | 2002 |
|
Leptin Resistance During Aging Is Independent of Fat Mass
I Gabriely, XH Ma, XM Yang, L Rossetti, N Barzilai |
Diabetes | 2002 |
|
Unique effect of visceral fat on insulin sensitivity in obese Hispanic children with a family history of type 2 diabetes
Martha L Cruz, Richard N Bergman, Michael I Goran |
Diabetes care | 2002 |
|
Middle-aged C57BL/6 mice have impaired responses to leptin that are not improved by calorie restriction
L Jacobson |
American journal of physiology. Endocrinology and metabolism | 2002 |
|
Abdominal adiposity and insulin resistance in obese men
R Ross, J Aru, J Freeman, R Hudson, I Janssen |
American journal of physiology. Endocrinology and metabolism | 2002 |
|
Energy Restriction Reduces Long-Chain Saturated Fatty Acids Associated with Plasma Lipids in Aging Male Rats
RW Hardy, KA Meckling-Gill, J Williford, RA Desmond, H Wei |
The Journal of nutrition | 2002 |
|
Age-related insulin resistance: is it an obligatory finding? The lesson from healthy centenarians
M Barbieri, MR Rizzo, D Manzella, G Paolisso |
Diabetes/Metabolism Research and Reviews | 2001 |
|
Mechanisms of Prolonged Longevity: Mutants, Knock-Outs, and Caloric Restriction
A Bartke, D Turyn |
Journal of Anti-Aging Medicine | 2001 |
|
Food Deprivation Limits Insulin Secretory Capacity in Postpubertal Rats
P Vuguin, X Ma, X Yang, M Surana, B Liu, N Barzilai |
Pediatric Research | 2001 |
|
Overfeeding rapidly induces leptin and insulin resistance
J Wang, S Obici, K Morgan, N Barzilai, Z Feng, L Rossetti |
Diabetes | 2001 |
|
High-fat hypocaloric diet modifies carbohydrate utilization of obese rats during weight loss
MC Cha, JA Johnson, CY Hsu, CN Boozer |
American journal of physiology. Endocrinology and metabolism | 2001 |
|
Nicotine infusion alters leptin and uncoupling protein 1 mRNA expression in adipose tissues of rats
K Arai, K Kim, K Kaneko, M Iketani, A Otagiri, N Yamauchi, T Shibasaki |
American journal of physiology. Endocrinology and metabolism | 2001 |
|
Functional Expression of MT2 (Mel1b) Melatonin Receptors in Human PAZ6 Adipocytes
L Brydon, L Petit, P Delagrange, AD Strosberg, R Jockers |
Endocrinology | 2001 |
|
Changes in Protein, Carbohydrate, and Fat Metabolism with Aging: Possible Role of Insulin
P Tessari |
Nutrition Reviews | 2000 |
|
The effect of alcohol on body composition
Y Falck-Ytter, AJ McCullough |
The American Journal of Gastroenterology | 2000 |
|
METABOLIC COMPLICATIONS OF OBESITY
MT Sheehan, MD Jensen |
Medical Clinics of North America | 2000 |
|
Aging does not contribute to the decline in insulin action on storage of muscle glycogen in rats
G Gupta, L She, XH Ma, XM Yang, M Hu, JA Cases, P Vuguin, L Rossetti, N Barzilai |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2000 |
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Defense of body weight against chronic caloric restriction in obesity-prone and -resistant rats
BE Levin, AA Dunn-Meynell |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2000 |
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Ability of insulin to modulate hepatic glucose production in aging rats is impaired by fat accumulation
G Gupta, JA Cases, L She, XH Ma, XM Yang, M Hu, J Wu, L Rossetti, N Barzilai |
American journal of physiology. Endocrinology and metabolism | 2000 |
|
Interaction between Aging and Syndrome X: New Insights on the Pathophysiology of Fat Distribution
N Barzilai, G Gupta |
Annals of the New York Academy of Sciences | 1999 |
|
Changing pattern of prevalence of insulin resistance in Psammomys obesus, a model of nutritionally induced type 2 diabetes
E Ziv, E Shafrir, R Kalman, S Galer, H Bar-On |
Metabolism | 1999 |
|
Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: Evidence for a preconditioning mechanism
ZF Yu, MP Mattson |
Journal of Neuroscience Research | 1999 |
|
Dietary fat type alters glucose metabolism in isolated rat hepatocytes
ME Bizeau, JR Hazel |
The Journal of Nutritional Biochemistry | 1999 |
|
Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action
N Barzilai, L She, L Liu, J Wang, M Hu, P Vuguin, L Rossetti |
American journal of physiology. Endocrinology and metabolism | 1999 |
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Body composition and hepatic steatosis as precursors for fibrotic liver disease
AJ McCullough, Y Falck-Ytter |
Hepatology | 1999 |
|
Special considerations in the therapy of diabetic hypertension
CB Guzmán, JR Sowers |
Progress in Cardiovascular Diseases | 1999 |
|
Reviews of the Geriatric Literature
PR Katz |
Journal of the American Geriatrics Society | 1998 |
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