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Citations to this article

Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice
Qing Ding, … , Nader Najafian, David M. Rothstein
Qing Ding, … , Nader Najafian, David M. Rothstein
Published August 8, 2011
Citation Information: J Clin Invest. 2011;121(9):3645-3656. https://doi.org/10.1172/JCI46274.
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Research Article Immunology Article has an altmetric score of 7

Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice

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Abstract

T cell Ig domain and mucin domain protein 1 (TIM-1) is a costimulatory molecule that regulates immune responses by modulating CD4+ T cell effector differentiation. However, the function of TIM-1 on other immune cell populations is unknown. Here, we show that in vivo in mice, TIM-1 is predominantly expressed on B rather than T cells. Importantly, TIM-1 was expressed by a large majority of IL-10–expressing regulatory B cells in all major B cell subpopulations, including transitional, marginal zone, and follicular B cells, as well as the B cell population characterized as CD1dhiCD5+. A low-affinity TIM-1–specific antibody that normally promotes tolerance in mice, actually accelerated (T cell–mediated) immune responsiveness in the absence of B cells. TIM-1+ B cells were highly enriched for IL-4 and IL-10 expression, promoted Th2 responses, and could directly transfer allograft tolerance. Both cytokine expression and number of TIM-1+ regulatory B cells (Bregs) were induced by TIM-1–specific antibody, and this was dependent on IL-4 signaling. Thus, TIM-1 is an inclusive marker for IL-10+ Bregs that can be induced by TIM-1 ligation. These findings suggest that TIM-1 may be a novel therapeutic target for modulating the immune response and provide insight into the signals involved in the generation and induction of Bregs.

Authors

Qing Ding, Melissa Yeung, Geoffrey Camirand, Qiang Zeng, Hisaya Akiba, Hideo Yagita, Geetha Chalasani, Mohamed H. Sayegh, Nader Najafian, David M. Rothstein

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009 Total
Citations: 9 14 10 16 21 20 18 16 20 25 18 23 17 14 4 1 246
Citation information
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Citations to this article in year 2018 (16)

Title and authors Publication Year
Equal Expansion of Endogenous Transplant-Specific Regulatory T Cell and Recruitment Into the Allograft During Rejection and Tolerance
JS Young, D Yin, AG Vannier, ML Alegre, AS Chong
Frontiers in immunology 2018
Anti‐TIM‐1 Monoclonal Antibody (RMT1‐10) Attenuates Atherosclerosis By Expanding IgM‐producing B1a Cells
H Hosseini, L Yi, P Kanellakis, A Cao, C Tay, K Peter, A Bobik, BH Toh, T Kyaw
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2018
Immune Tolerance to Apoptotic Self Is Mediated Primarily by Regulatory B1a Cells
K Miles, J Simpson, S Brown, G Cowan, D Gray, M Gray
Frontiers in immunology 2018
Natural regulatory plasma cells
S Fillatreau
Current Opinion in Immunology 2018
Maintaining T cell tolerance of alloantigens: Lessons from animal studies
KA Robinson, W Orent, JC Madsen, G Benichou
American Journal of Transplantation 2018
Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1+ regulatory B cell expansion
L Ye, Q Zhang, Y Cheng, X Chen, G Wang, M Shi, T Zhang, Y Cao, H Pan, L Zhang, G Wang, Y Deng, Y Yang, G Chen
Journal for ImmunoTherapy of Cancer 2018
Galectin-1 is required for the regulatory function of B cells
R Alhabbab, P Blair, LA Smyth, K Ratnasothy, Q Peng, A Moreau, R Lechler, R Elgueta, G Lombardi
Scientific Reports 2018
Regulatory B cells: the cutting edge of immune tolerance in kidney transplantation
B Peng, Y Ming, C Yang
Cell Death and Disease 2018
Frequency and immunophenotype of IL10-producing regulatory B cells in optic neuritis
S Lundqvist, S Modvig, EA Fischer, JL Frederiksen, M Degn
Immunology 2018
CD27+TIM-1+ memory B cells promoted the development of Foxp3+ Tregs and were associated with better survival in acute respiratory distress syndrome
G Zhu, Y Liu, W Zhang, Y Huang, K Li
Immunologic Research 2018
Regulatory B cells and transplantation: almost prime time?
K Mohib, A Cherukuri, DM Rothstein
Current Opinion in Organ Transplantation 2018
Determinants in the Ig Variable Domain of Human HAVCR1 (TIM-1) Are Required To Enhance Hepatitis C Virus Entry
A Kachko, MI Costafreda, I Zubkova, J Jacques, K Takeda, F Wells, G Kaplan, ME Major, MS Diamond
Journal of virology 2018
Plasma Cell Alloantigen 1 and IL-10 Secretion Define Two Distinct Peritoneal B1a B Cell Subsets With Opposite Functions, PC1high Cells Being Protective and PC1low Cells Harmful for the Growing Fetus
A Schumacher, S Ehrentraut, M Scharm, H Wang, R Hartig, HC Morse, AC Zenclussen
Frontiers in immunology 2018
Downregulated Tim‑3 expression is responsible for the incidence and development of colorectal cancer
P Zhang, Y Wang, XR Liu, SR Hong, J Yao
Oncology Letters 2018
MiR-15a/16-1 deficiency induces IL-10-producing CD19 + TIM-1 + cells in tumor microenvironment
X Jia, H Liu, C Xu, S Han, Y Shen, X Miao, X Hu, Z Lin, L Qian, Z Wang, W Gong
Journal of Cellular and Molecular Medicine 2018
Preconception immunization can modulate intracellular Th2 cytokine profile in offspring: in vivo influence of interleukin 10 and B/T cell collaboration
MG de Oliveira, AA de Lima Lira, F da Ressureição Sgnotto, AH Inoue, AJ da Silva Duarte, JR Victor
CENT EUR J IMMUNOL 2018

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