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Usage Information

Genetic approaches to understanding human obesity
Shwetha Ramachandrappa, I. Sadaf Farooqi
Shwetha Ramachandrappa, I. Sadaf Farooqi
Published June 1, 2011
Citation Information: J Clin Invest. 2011;121(6):2080-2086. https://doi.org/10.1172/JCI46044.
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Genetic approaches to understanding human obesity

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Abstract

Obesity and its associated comorbidities represent one of the biggest public health challenges facing the world today. The heritability of body weight is high, and genetic variation plays a major role in determining the interindividual differences in susceptibility or resistance to the obesogenic environment. Here we discuss how genetic studies in humans have contributed to our understanding of the central pathways that govern energy homeostasis. We discuss how the arrival of technological advances such as next-generation sequencing will result in a major acceleration in the pace of gene discovery. The study of patients harboring these genetic variants has informed our understanding of the molecular and physiological pathways involved in energy homeostasis. We anticipate that future studies will provide the framework for the development of a more rational targeted approach to the prevention and treatment of genetically susceptible individuals.

Authors

Shwetha Ramachandrappa, I. Sadaf Farooqi

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 1,115 72
PDF 90 31
Table 56 0
Citation downloads 67 0
Totals 1,328 103
Total Views 1,431
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