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Citations to this article

The LRF transcription factor regulates mature B cell development and the germinal center response in mice
Nagisa Sakurai, … , Ravi Bhatia, Takahiro Maeda
Nagisa Sakurai, … , Ravi Bhatia, Takahiro Maeda
Published June 6, 2011
Citation Information: J Clin Invest. 2011;121(7):2583-2598. https://doi.org/10.1172/JCI45682.
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Research Article Immunology Article has an altmetric score of 5

The LRF transcription factor regulates mature B cell development and the germinal center response in mice

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Abstract

B cells play a central role in immune system function. Deregulation of normal B cell maturation can lead to the development of autoimmune syndromes as well as B cell malignancies. Elucidation of the molecular features of normal B cell development is important for the development of new target therapies for autoimmune diseases and B cell malignancies. Employing B cell–specific conditional knockout mice, we have demonstrated here that the transcription factor leukemia/lymphoma-related factor (LRF) forms an obligate dimer in B cells and regulates mature B cell lineage fate and humoral immune responses via distinctive mechanisms. Moreover, LRF inactivation in transformed B cells attenuated their growth rate. These studies identify what we believe to be a new key factor for mature B cell development and provide a rationale for targeting LRF dimers for the treatment of autoimmune diseases and B cell malignancies.

Authors

Nagisa Sakurai, Manami Maeda, Sung-Uk Lee, Yuichi Ishikawa, Min Li, John C. Williams, Lisheng Wang, Leila Su, Mai Suzuki, Toshiki I. Saito, Shigeru Chiba, Stefano Casola, Hideo Yagita, Julie Teruya-Feldstein, Shinobu Tsuzuki, Ravi Bhatia, Takahiro Maeda

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Total citations by year

Year: 2023 2022 2019 2018 2017 2016 2015 2014 2013 2012 2011 Total
Citations: 1 3 2 1 2 5 1 2 2 6 1 26
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2012 (6)

Title and authors Publication Year
ADAM10 Regulates Transcription Factor Expression Required for Plasma Cell Function
NS Chaimowitz, DJ Kang, LM Dean, DH Conrad
PloS one 2012
Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development
K Tsuji-Takechi, T Negishi-Koga, E Sumiya, A Kukita, S Kato, T Maeda, PP Pandolfi, K Moriyama, H Takayanagi
Proceedings of the National Academy of Sciences 2012
LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance
SU Lee, M Maeda, Y Ishikawa, SM Li, A Wilson, AM Jubb, N Sakurai, L Weng, E Fiorini, F Radtke, M Yan, HR MacDonald, CC Chen, T Maeda
Blood 2012
The BTB-ZF transcription factors
OM Siggs, B Beutler
Cell cycle (Georgetown, Tex.) 2012
The Transcription Factors Thpok and LRF Are Necessary and Partly Redundant for T Helper Cell Differentiation
AC Carpenter, JR Grainger, Y Xiong, Y Kanno, HH Chu, L Wang, S Naik, L dos Santos, L Wei, MK Jenkins, JJ O’Shea, Y Belkaid, R Bosselut
Immunity 2012
POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function
SU Lee, T Maeda
Immunological Reviews 2012

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