Go to
JCI Insight
Citations to this article
Nagisa Sakurai, … , Ravi Bhatia, Takahiro Maeda
Published June 6, 2011
Citation Information: J Clin Invest. 2011;121(7):2583-2598. https://doi.org/10.1172/JCI45682.
Citation Information: J Clin Invest. 2011;121(7):2583-2598. https://doi.org/10.1172/JCI45682.
Abstract
B cells play a central role in immune system function. Deregulation of normal B cell maturation can lead to the development of autoimmune syndromes as well as B cell malignancies. Elucidation of the molecular features of normal B cell development is important for the development of new target therapies for autoimmune diseases and B cell malignancies. Employing B cell–specific conditional knockout mice, we have demonstrated here that the transcription factor leukemia/lymphoma-related factor (LRF) forms an obligate dimer in B cells and regulates mature B cell lineage fate and humoral immune responses via distinctive mechanisms. Moreover, LRF inactivation in transformed B cells attenuated their growth rate. These studies identify what we believe to be a new key factor for mature B cell development and provide a rationale for targeting LRF dimers for the treatment of autoimmune diseases and B cell malignancies.
Authors
Nagisa Sakurai, Manami Maeda, Sung-Uk Lee, Yuichi Ishikawa, Min Li, John C. Williams, Lisheng Wang, Leila Su, Mai Suzuki, Toshiki I. Saito, Shigeru Chiba, Stefano Casola, Hideo Yagita, Julie Teruya-Feldstein, Shinobu Tsuzuki, Ravi Bhatia, Takahiro Maeda
Total citations by year
Citation information
Citations to this article (26)
| Title and authors | Publication | Year |
|---|---|---|
|
Late fetal hematopoietic failure results from ZBTB11 deficiency despite abundant HSC specification.
Cao H, Naik SH, Amann-Zalcenstein D, Hickey P, Salim A, Cao B, Nilsson SK, Keightley MC, Lieschke GJ |
Blood Advances | 2023 |
|
Altered Phenotype and Enhanced Antibody-Producing Ability of Peripheral B Cells in Mice with Cd19-Driven Cre Expression
Zhao Y, Zhao S, Qin XY, He TT, Hu MM, Gong Z, Wang HM, Gong FY, Gao XM, Wang J |
Cells | 2022 |
|
Identification of methylation signatures associated with CAR T cell in B-cell acute lymphoblastic leukemia and non-hodgkin’s lymphoma
Song J, Huang F, Chen L, Feng K, Jian F, Huang T, Cai YD |
Frontiers in Oncology | 2022 |
|
Increased slow dynamics defines ligandability of BTB domains.
Kharchenko V, Linhares BM, Borregard M, Czaban I, Grembecka J, Jaremko M, Cierpicki T, Jaremko Ł |
Nature Communications | 2022 |
|
The multi-faceted functioning portrait of LRF/ZBTB7A
C Constantinou, M Spella, V Chondrou, GP Patrinos, A Papachatzopoulou, A Sgourou |
Human genomics | 2019 |
|
What a Difference a Gene Makes: Identification of Virulence Factors of Cowpox Virus
A Tamošiūnaitė, S Weber, T Schippers, A Franke, Z Xu, M Jenckel, F Pfaff, D Hoffmann, M Newell, BK Tischer, M Beer, N Osterrieder, RM Sandri-Goldin |
Journal of virology | 2019 |
|
Regulation of the Development and Function of B Cells by ZBTB Transcription Factors
C Zhu, G Chen, Y Zhao, XM Gao, J Wang |
Frontiers in immunology | 2018 |
|
Zbtb7a induction in alveolar macrophages is implicated in anti-HLA–mediated lung allograft rejection
DK Nayak, F Zhou, M Xu, J Huang, M Tsuji, J Yu, R Hachem, AE Gelman, RM Bremner, MA Smith, T Mohanakumar |
Science Translational Medicine | 2017 |
|
Vertebrate GAF/ThPOK: emerging functions in chromatin architecture and transcriptional regulation
A Srivastava, AS Kumar, RK Mishra |
Cellular and Molecular Life Sciences | 2017 |
|
Emerging cellular and gene therapies for congenital anemias: Emerging Cellular and Gene Therapies for Congenital
LS Ludwig, RK Khajuria, VG Sankaran |
American Journal of Medical Genetics Part C Seminars in Medical Genetics | 2016 |
|
Zfp521 promotes B-cell viability and cyclin D1 gene expression in a B cell culture system
SA Dallal, K Wolton, KE Hentges |
Leukemia Research | 2016 |
|
PIAS1 Promotes Lymphomagenesis through MYC Upregulation
A Rabellino, M Melegari, VS Tompkins, W Chen, BG Van Ness, J Teruya-Feldstein, M Conacci-Sorrell, S Janz, PP Scaglioni |
Cell Reports | 2016 |
|
Regulation of hematopoietic development by ZBTB transcription factors
T Maeda |
International Journal of Hematology | 2016 |
|
Downregulation of ZBTB24 hampers the G0/1- to S-phase cell-cycle transition via upregulating the expression of IRF-4 in human B cells
J Liang, R Yan, G Chen, J Feng, WW Wu, W Ren, C Zhu, Y Zhao, XM Gao, J Wang |
Genes and Immunity | 2016 |
|
Somatic human ZBTB7A zinc finger mutations promote cancer progression
XS Liu, Z Liu, C Gerarduzzi, DE Choi, S Ganapathy, PP Pandolfi, ZM Yuan |
Oncogene | 2015 |
|
The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection
AM Beaulieu, CL Zawislak, T Nakayama, JC Sun |
Nature Immunology | 2014 |
|
The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity
S Chevrier, D Emslie, W Shi, T Kratina, C Wellard, A Karnowski, E Erikci, GK Smyth, K Chowdhury, D Tarlinton, LM Corcoran |
Journal of Experimental Medicine | 2014 |
|
Role of LRF/Pokemon in lineage fate decisions
A Lunardi, J Guarnerio, G Wang, T Maeda, PP Pandolfi |
Blood | 2013 |
|
Utility of LRF/Pokemon and NOTCH1 Protein Expression in the Distinction Between Nodular Lymphocyte-Predominant Hodgkin Lymphoma and Classical Hodgkin Lymphoma
O Bohn, T Maeda, A Filatov, A Lunardi, PP Pandolfi, J Teruya-Feldstein |
International Journal of Surgical Pathology | 2013 |
|
ADAM10 Regulates Transcription Factor Expression Required for Plasma Cell Function
NS Chaimowitz, DJ Kang, LM Dean, DH Conrad |
PloS one | 2012 |
|
Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development
K Tsuji-Takechi, T Negishi-Koga, E Sumiya, A Kukita, S Kato, T Maeda, PP Pandolfi, K Moriyama, H Takayanagi |
Proceedings of the National Academy of Sciences | 2012 |
|
LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance
SU Lee, M Maeda, Y Ishikawa, SM Li, A Wilson, AM Jubb, N Sakurai, L Weng, E Fiorini, F Radtke, M Yan, HR MacDonald, CC Chen, T Maeda |
Blood | 2012 |
|
The BTB-ZF transcription factors
OM Siggs, B Beutler |
Cell cycle (Georgetown, Tex.) | 2012 |
|
The Transcription Factors Thpok and LRF Are Necessary and Partly Redundant for T Helper Cell Differentiation
AC Carpenter, JR Grainger, Y Xiong, Y Kanno, HH Chu, L Wang, S Naik, L dos Santos, L Wei, MK Jenkins, JJ O’Shea, Y Belkaid, R Bosselut |
Immunity | 2012 |
|
POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function
SU Lee, T Maeda |
Immunological Reviews | 2012 |
|
A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture
NS Chaimowitz, RK Martin, J Cichy, DR Gibb, P Patil, DJ Kang, J Farnsworth, EC Butcher, B McCright, DH Conrad |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)