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Xudong Liao, … , Karine Clément, Mukesh K. Jain
Published June 13, 2011
Citation Information: J Clin Invest. 2011;121(7):2736-2749. https://doi.org/10.1172/JCI45444.
Citation Information: J Clin Invest. 2011;121(7):2736-2749. https://doi.org/10.1172/JCI45444.
Abstract
Current paradigms suggest that two macrophage subsets, termed M1 and M2, are involved in inflammation and host defense. While the distinct functions of M1 and M2 macrophages have been intensively studied — the former are considered proinflammatory and the latter antiinflammatory — the determinants of their speciation are incompletely understood. Here we report our studies that identify Krüppel-like factor 4 (KLF4) as a critical regulator of macrophage polarization. Macrophage KLF4 expression was robustly induced in M2 macrophages and strongly reduced in M1 macrophages, observations that were recapitulated in human inflammatory paradigms in vivo. Mechanistically, KLF4 was found to cooperate with Stat6 to induce an M2 genetic program and inhibit M1 targets via sequestration of coactivators required for NF-κB activation. KLF4-deficient macrophages demonstrated increased proinflammatory gene expression, enhanced bactericidal activity, and altered metabolism. Furthermore, mice bearing myeloid-specific deletion of KLF4 exhibited delayed wound healing and were predisposed to developing diet-induced obesity, glucose intolerance, and insulin resistance. Collectively, these data identify KLF4 as what we believe to be a novel regulator of macrophage polarization.
Authors
Xudong Liao, Nikunj Sharma, Fehmida Kapadia, Guangjin Zhou, Yuan Lu, Hong Hong, Kaavya Paruchuri, Ganapati H. Mahabeleshwar, Elise Dalmas, Nicolas Venteclef, Chris A. Flask, Julian Kim, Bryan W. Doreian, Kurt Q. Lu, Klaus H. Kaestner, Anne Hamik, Karine Clément, Mukesh K. Jain
Total citations by year
Citation information
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MEF2C promotes M1 macrophage polarization and Th1 responses
X Zhao, Q Di, H Liu, J Quan, J Ling, Z Zhao, Y Xiao, H Wu, Z Wu, W Song, H An, W Chen |
Cellular and Molecular Immunology | 2022 |
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Inhibition of STAT6 Activation by AS1517499 Inhibits Expression and Activity of PPARγ in Macrophages to Resolve Acute Inflammation in Mice
Y Lee, K Kim, M Kim, Y Ahn, J Kang |
Biomolecules | 2022 |
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Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity
K Hezaveh, R Shinde, A Klötgen, M Halaby, S Lamorte, M Ciudad, R Quevedo, L Neufeld, Z Liu, R Jin, B Grünwald, E Foerster, D Chaharlangi, M Guo, P Makhijani, X Zhang, T Pugh, D Pinto, I Co, A McGuigan, G Jang, R Khokha, P Ohashi, G OKane, S Gallinger, W Navarre, H Maughan, D Philpott, D Brooks, T McGaha |
Immunity | 2022 |
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CD146 Associates with Gp130 to Control a Macrophage Pro‐inflammatory Program That Regulates the Metabolic Response to Obesity
Duan H, Jing L, Xiang J, Ju C, Wu Z, Liu J, Ma X, Chen X, Liu Z, Feng J, Yan X |
Advanced Science | 2022 |
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miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages
Nguyen MA, Hoang HD, Rasheed A, Duchez AC, Wyatt H, Cottee ML, Graber TE, Susser L, Robichaud S, Berber İ, Geoffrion M, Ouimet M, Kazan H, Maegdefessel L, Mulvihill EE, Alain T, Rayner KJ |
Circulation research | 2022 |
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Immune Cell Plasticity in Inflammation: Insights into Description and Regulation of Immune Cell Phenotypes
Margraf A, Perretti M |
Cells | 2022 |
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The Roles of Adipose Tissue Macrophages in Human Disease
Liang W, Qi Y, Yi H, Mao C, Meng Q, Wang H, Zheng C |
Frontiers in immunology | 2022 |
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Inhibition of Anti-Inflammatory Macrophage Phenotype Reduces Tumour Growth in Mouse Models of Brain Metastasis.
Economopoulos V, Pannell M, Johanssen VA, Scott H, Andreou KE, Larkin JR, Sibson NR |
Frontiers in Oncology | 2022 |
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Iguratimod Attenuates Macrophage Polarization and Antibody-Mediated Rejection After Renal Transplant by Regulating KLF4
Hang Z, Wei J, Zheng M, Gui Z, Chen H, Sun L, Fei S, Han Z, Tao J, Wang Z, Tan R, Gu M |
Frontiers in pharmacology | 2022 |
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Macrophage polarization in hypoxia and ischemia/reperfusion: Insights into the role of energetic metabolism
Yakupova EI, Maleev GV, Krivtsov AV, Plotnikov EY |
Experimental Biology and Medicine | 2022 |
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Effect of Thrombin on the Metabolism and Function of Murine Macrophages
Ukan Ü, Delgado Lagos F, Kempf S, Günther S, Siragusa M, Fisslthaler B, Fleming I |
Cells | 2022 |
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In vivo single cell transcriptomics reveals Klebsiella pneumoniae rewiring of lung macrophages to promote infection
Amy Dumigan, Oisin Cappa, Brenda Morris, Joana Sa-Pessoa, Ricardo Calderon-Gonzalez, Grant Mills, Rebecca Lancaster, David Simpson, Adrien Kissenpfennig, Jose A. Bengoechea |
EMBO Molecular Medicine | 2022 |
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25-Hydroxycholesterol as a Signaling Molecule of the Nervous System
Odnoshivkina UG, Kuznetsova EA, Petrov AM |
Biochemistry (Moscow) | 2022 |
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Manipulation of the tumor immuno-microenvironment via TAM-targeted expression of transcription factors.
Musick M, Yu X |
Immunologic research | 2022 |
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MSC-Derived Small Extracellular Vesicles Attenuate Autoimmune Dacryoadenitis by Promoting M2 Macrophage Polarization and Inducing Tregs via miR-100-5p.
Li N, Gao Z, Zhao L, Du B, Ma B, Nian H, Wei R |
Frontiers in immunology | 2022 |
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Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis
Sebastian A, Hum NR, McCool JL, Wilson SP, Murugesh DK, Martin KA, Rios-Arce ND, Amiri B, Christiansen BA, Loots GG |
Frontiers in immunology | 2022 |
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Engineered endosymbionts that alter mammalian cell surface marker, cytokine and chemokine expression
Madsen CS, Makela AV, Greeson EM, Hardy JW, Contag CH |
2022 | |
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Immune Function of Endothelial Cells: Evolutionary Aspects, Molecular Biology and Role in Atherogenesis.
Kotlyarov S |
International journal of molecular sciences | 2022 |
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Adipose tissue macrophage in obesity-associated metabolic diseases
Yao J, Wu D, Qiu Y |
Frontiers in immunology | 2022 |
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The Roles of Tumor-Associated Macrophages in Prostate Cancer.
Han C, Deng Y, Xu W, Liu Z, Wang T, Wang S, Liu J, Liu X |
Journal of Oncology | 2022 |
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Physiological Convergence and Antagonism Between GR and PPARγ in Inflammation and Metabolism.
Dacic M, Shibu G, Rogatsky I |
Advances in experimental medicine and biology | 2022 |
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Reprogramming alternative macrophage polarization by GATM-mediated endogenous creatine synthesis: A potential target for HDM-induced asthma treatment
Yu L, Wang L, Hu G, Ren L, Qiu C, Li S, Zhou X, Chen S, Chen R |
Frontiers in immunology | 2022 |
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Identification of five genetic variants with differential effects on obesity-related traits based on age.
Chung JY, Jung HU, Kim DJ, Baek EJ, Kim HK, Kang JO, Lim JE, Oh B |
Frontiers in Genetics | 2022 |
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Immune regulation and emerging roles of noncoding RNAs in Mycobacterium tuberculosis infection.
Liang S, Ma J, Gong H, Shao J, Li J, Zhan Y, Wang Z, Wang C, Li W |
Frontiers in immunology | 2022 |
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Macrophages in periodontitis: A dynamic shift between tissue destruction and repair.
Yin L, Li X, Hou J |
The Japanese dental science review | 2022 |
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Genetic deletion of Krüppel-like factor 11 aggravates traumatic brain injury
Zhou C, Sun P, Hamblin MH, Yin KJ |
Journal of Neuroinflammation | 2022 |
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Differential regulation of Type 1 and Type 2 mouse eosinophil activation by apoptotic cells
Dolitzky A, Hazut I, Avlas S, Grisaru-Tal S, Itan M, Zaffran I, Levi-Schaffer F, Gerlic M, Munitz A |
Frontiers in immunology | 2022 |
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Identification of biomarkers in nonalcoholic fatty liver disease: A machine learning method and experimental study
Han N, He J, Shi L, Zhang M, Zheng J, Fan Y |
Frontiers in Genetics | 2022 |
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Old macrophages lose their (circadian) rhythm
McRae HM, Hargreaves DC |
Trends in Immunology | 2022 |
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The PI3K/Akt Pathway in Meta-Inflammation
Acosta-Martinez M, Cabail MZ |
International journal of molecular sciences | 2022 |
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LncRNA MEG3: Potential stock for precision treatment of cardiovascular diseases.
Li Z, Gao J, Sun D, Jiao Q, Ma J, Cui W, Lou Y, Xu F, Li S, Li H |
Frontiers in pharmacology | 2022 |
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Boolean modeling reveals that cyclic attractors in macrophage polarization serve as reservoirs of states to balance external perturbations from the tumor microenvironment
de León UA, Vázquez-Jiménez A, Matadamas-Guzmán M, Resendis-Antonio O |
Frontiers in immunology | 2022 |
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Lipedema: Insights into Morphology, Pathophysiology, and Challenges
Poojari A, Dev K, Rabiee A |
Biomedicines | 2022 |
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Tumor Growth Remains Refractory to Myc Ablation in Host Macrophages.
Morrow RJ, Allam AH, Konecnik J, Baloyan D, Dijkstra C, Eissmann MF, Jacob SP, O'Brien M, Poh AR, Ernst M |
Cells | 2022 |
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Steroid receptor coactivators – their role in immunity
Gilad Y, Lonard DM, O\u2019Malley BW |
Frontiers in immunology | 2022 |
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Chicken CSF2 and IL-4-, and CSF2-dependent bone marrow cultures differentiate into macrophages over time
Borowska D, Sives S, Vervelde L, Sutton KM |
Frontiers in immunology | 2022 |
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Biomaterial mediated simultaneous delivery of spermine and alpha ketoglutarate modulate metabolism and innate immune cell phenotype in sepsis mouse models
Inamdar S, Tylek T, Thumsi A, Suresh AP, Jaggarapu MM, Halim M, Mantri S, Esrafili A, Ng ND, Schmitzer E, Lintecum K, de Ávila C, Fryer JD, Xu Y, Spiller KL, Acharya AP |
Biomaterials | 2022 |
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Tumour-associated macrophages heterogeneity drives resistance to clinical therapy
Guo S, Chen X, Guo C, Wang W |
Expert Reviews in Molecular Medicine | 2022 |
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Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma
Koh KD, Bonser LR, Eckalbar WL, Yizhar-Barnea O, Shen J, Zeng X, Hargett KL, Sun DI, Zlock LT, Finkbeiner WE, Ahituv N, Erle DJ |
2022 | |
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Inference of age-associated transcription factor regulatory activity changes in single cells.
Maity AK, Hu X, Zhu T, Teschendorff AE |
2022 | |
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LncRNA DRAIR is downregulated in diabetic monocytes and modulates inflammatory phenotype via epigenetic mechanisms
Marpadga A Reddy, Vishnu Amaram, Sadhan Das, Vinay Tanwar, Rituparna Ganguly, Mei Wang, Linda Lanting, Linxiao Zhang, Maryam Abdollahi, Zhuo Chen, Xiwei Wu, Sridevi Devaraj, Rama Natarajan |
JCI Insight | 2021 |
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Single-cell RNA-sequencing reveals distinct immune cell subsets and signaling pathways in IgA nephropathy
H Zeng, L Wang, J Li, S Luo, Q Han, F Su, J Wei, X Wei, J Wu, B Li, J Huang, P Tang, C Cao, Y Zhou, Q Yang |
Cell & Bioscience | 2021 |
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Nuclear Receptors as Multiple Regulators of NLRP3 Inflammasome Function
A Alatshan, S Benkő |
Frontiers in immunology | 2021 |
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Attenuated macrophage activation mediated by microRNA‑183 knockdown through targeting NR4A2
FH Gong, L Long, YS Yang, DH Shen, YS Zhang, XS Wang, XP Zhang, XQ Xiao |
Experimental and therapeutic medicine | 2021 |
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The Cholinergic Anti-Inflammatory Pathway Attenuates the Development of Atherosclerosis in Apoe-/- Mice through Modulating Macrophage Functions
Z Qian, H Yang, H Li, C Liu, L Yang, Z Qu, X Li |
Biomedicines | 2021 |
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MicroRNAs and Circular RNAs in Lipoprotein Metabolism
P Fernández-Tussy, I Ruz-Maldonado, C Fernández-Hernando |
Current Atherosclerosis Reports | 2021 |
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A narrative review of tumor-associated macrophages in lung cancer: regulation of macrophage polarization and therapeutic implications
SS Sedighzadeh, AP Khoshbin, S Razi, M Keshavarz-Fathi, N Rezaei |
Translational Lung Cancer Research | 2021 |
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Signal transduction and molecular regulation in fatty liver disease
XC Dong, K Chowdhury, M Huang, HG Kim |
Antioxidants & Redox Signaling | 2021 |
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PP2Acα promotes macrophage accumulation and activation to exacerbate tubular cell death and kidney fibrosis through activating Rap1 and TNFα production
Y Liang, X Sun, M Wang, Q Lu, M Gu, L Zhou, Q Hou, M Tan, S Wang, X Xue, C Dai |
Cell Death and Differentiation | 2021 |
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STAT6 Signaling Mediates PPARγ Activation and Resolution of Acute Sterile Inflammation in Mice
YJ Lee, BM Kim, YH Ahn, JH Choi, YH Choi, JL Kang |
Cells | 2021 |
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Critical Role of Synovial Tissue–Resident Macrophage and Fibroblast Subsets in the Persistence of Joint Inflammation
S Kemble, AP Croft |
Frontiers in immunology | 2021 |
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Safeguarding the Vasculature: Redundant Transcriptional Machinery Ensures Endothelial Protection
DR Sweet, MK Jain |
Arteriosclerosis, thrombosis, and vascular biology | 2021 |
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Evolutionary Protection of Krüppel-Like Factors 2 and 4 in the Development of the Mature Hemovascular System
DR Sweet, C Lam, MK Jain |
Frontiers in Cardiovascular Medicine | 2021 |
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Phenotypic Modulation of Macrophages and Vascular Smooth Muscle Cells in Atherosclerosis—Nitro-Redox Interconnections
J Bonetti, A Corti, L Lerouge, A Pompella, C Gaucher |
Antioxidants | 2021 |
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Palmitic acid up regulates Gal‑3 and induces insulin resistance in macrophages by mediating the balance between KLF4 and NF‑κB
J Li, YS Mao, F Chen, DX Xia, TQ Zhao |
Experimental and therapeutic medicine | 2021 |
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RNA-Seq Transcriptome Analysis of Peripheral Blood From Cattle Infected With Mycobacterium bovis Across an Experimental Time Course
KE McLoughlin, CN Correia, JA Browne, DA Magee, NC Nalpas, K Rue-Albrecht, AO Whelan, B Villarreal-Ramos, HM Vordermeier, E Gormley, SV Gordon, DE MacHugh |
Frontiers in Veterinary Science | 2021 |
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Two ST11 Klebsiella pneumoniae strains exacerbate colorectal tumorigenesis in a colitis-associated mouse model
MK Chiang, PY Hsiao, YY Liu, HL Tang, CS Chiou, MC Lu, YC Lai |
Gut microbes | 2021 |
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Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages
DL Ou, CW Chen, CL Hsu, CH Chung, ZR Feng, BS Lee, AL Cheng, MH Yang, C Hsu |
Journal for ImmunoTherapy of Cancer | 2021 |
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Transcriptome-targeted analysis of human peripheral blood-derived macrophages when cultured on biomaterial meshes
C Mora-Navarro, EW Ozpinar, D Sze, DP Martin, DO Freytes |
Biomedical Materials | 2021 |
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Acetyl oxygen benzoate engeletin ester promotes KLF4 degradation leading to the attenuation of pulmonary fibrosis via inhibiting TGFβ1–smad/p38MAPK–lnc865/lnc556–miR-29b-2-5p–STAT3 signal pathway
K Shen, R Li, X Zhang, G Qu, R Li, Y Wang, B Liu, C Lv, M Li, X Song |
Aging | 2021 |
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The Paired Siglecs in Brain Tumours Therapy: The Immunomodulatory Effect of Dexamethasone and Temozolomide in Human Glioma In Vitro Model
P Wielgat, N Wawrusiewicz-Kurylonek, R Czarnomysy, K Rogowski, K Bielawski, H Car |
International journal of molecular sciences | 2021 |
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Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells
AR Muñoz-Rojas, I Kelsey, JL Pappalardo, M Chen, K Miller-Jensen |
Nature Communications | 2021 |
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Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
H Atcha, A Jairaman, JR Holt, VS Meli, RR Nagalla, PK Veerasubramanian, KT Brumm, HE Lim, S Othy, MD Cahalan, MM Pathak, WF Liu |
Nature Communications | 2021 |
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Comprehensive Integrative Analysis Reveals the Association of KLF4 with Macrophage Infiltration and Polarization in Lung Cancer Microenvironment
S Arora, P Singh, S Ahmad, T Ahmad, R Dohare, SA Almatroodi, F Alrumaihi, AH Rahmani, MA Syed |
Cells | 2021 |
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Single-cell RNA sequencing identifies macrophage transcriptional heterogeneities in granulomatous diseases
SY Liao, SM Atif, K Mould, IR Konigsberg, R Fu, E Davidson, L Li, AP Fontenot, LA Maier, IV Yang |
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology | 2021 |
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Prostaglandin E 3 attenuates macrophage‐associated inflammation and prostate tumour growth by modulating polarization
J Cui, K Shan, Q Yang, Y Qi, H Qu, J Li, R Wang, L Jia, W Chen, N Feng, YQ Chen |
Journal of Cellular and Molecular Medicine | 2021 |
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Co-Administration of Gagam-Sipjeondaebo-Tang and Ibuprofen Alleviates the Inflammatory Response in MPTP-Induced Parkinson’s Disease Mouse Model and RAW264.7 Macrophages
S Won, JH Ko, H Jeon, SS Park, SN Kim |
Pathogens | 2021 |
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Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level
M Rao, X Wang, G Guo, L Wang, S Chen, P Yin, K Chen, L Chen, Z Zhang, X Chen, X Hu, S Hu, J Song |
Basic Research in Cardiology | 2021 |
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Mechanisms underlying divergent responses of genetically distinct macrophages to IL-4
MA Hoeksema, Z Shen, IR Holtman, A Zheng, NJ Spann, I Cobo, M Gymrek, CK Glass |
Science Advances | 2021 |
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Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia
D Hirani, C Alvira, S Danopoulos, C Milla, M Donato, L Tian, J Mohr, K Dinger, C Vohlen, J Selle, S v. Koningsbruggen-Rietschel, V Barbarino, C Pallasch, S Rose-John, M Odenthal, G Pryhuber, S Mansouri, R Savai, W Seeger, P Khatri, D Alam, J Dötsch, M Alcazar |
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology | 2021 |
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Recent Developments in Extracellular Matrix Remodeling for Fat Grafting
X Bi, Y Li, Z Dong, J Zhao, W Wu, J Zou, L Guo, F Lu, J Gao |
Frontiers in Cell and Developmental Biology | 2021 |
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Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease
Z Michailidou, M Gomez-Salazar, V Alexaki |
Journal of Innate Immunity | 2021 |
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Extracellular Vesicles in Musculoskeletal Regeneration: Modulating the Therapy of the Future
H Abreu, E Canciani, D Raineri, G Cappellano, L Rimondini, A Chiocchetti |
Cells | 2021 |
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Resident and migratory adipose immune cells control systemic metabolism and thermogenesis
K Man, A Kallies, A Vasanthakumar |
Cellular and Molecular Immunology | 2021 |
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Nobiletin Alleviates Non-alcoholic Steatohepatitis in MCD-Induced Mice by Regulating Macrophage Polarization
S Wang, T Lan, H Sheng, F Zheng, M Lei, L Wang, H Chen, C Xu, F Zhang |
Frontiers in physiology | 2021 |
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Establishment of tumor inflammasome clusters with distinct immunogenomic landscape aids immunotherapy
Q Liang, J Wu, X Zhao, S Shen, C Zhu, T Liu, X Cui, L Chen, C Wei, P Cheng, W Cheng, A Wu |
Theranostics | 2021 |
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Single-Cell Transcriptome Profiles Reveal Fibrocytes as Potential Targets of Cell Therapies for Abdominal Aortic Aneurysm.
Li B, Song X, Guo W, Hou Y, Hu H, Ge W, Fan T, Han Z, Li Z, Yang P, Gao R, Zhao H, Wang J |
Frontiers in Cardiovascular Medicine | 2021 |
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Aging disrupts circadian gene regulation and function in macrophages.
Blacher E, Tsai C, Litichevskiy L, Shipony Z, Iweka CA, Schneider KM, Chuluun B, Heller HC, Menon V, Thaiss CA, Andreasson KI |
Nature Immunology | 2021 |
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Six Shades of Vascular Smooth Muscle Cells Illuminated by KLF4 (Krüppel-Like Factor 4)
Yap C, Mieremet A, de Vries CJ, Micha D, de Waard V |
Arteriosclerosis, thrombosis, and vascular biology | 2021 |
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Exposure of Microglia to Interleukin-4 Represses NF-κB-Dependent Transcription of Toll-Like Receptor-Induced Cytokines
Zuiderwijk-Sick EA, van der Putten C, Timmerman R, Veth J, Pasini EM, van Straalen L, van der Valk P, Amor S, Bajramovic JJ |
Frontiers in immunology | 2021 |
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Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases
He X, Tan S, Shao Z, Wang X |
Genes & Diseases | 2021 |
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MicroRNA-206 promotes the recruitment of CD8+ T cells by driving M1 polarisation of Kupffer cells
Liu N, Wang X, Steer CJ, Song G |
Gut | 2021 |
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Myxomavirus serpin alters macrophage function and prevents diffuse alveolar hemorrhage in pristane-induced lupus
Zhuang H, Han S, Lu L, Reeves WH |
Clinical Immunology | 2021 |
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Hematoma Resolution In Vivo Is Directed by Activating Transcription Factor 1 (ATF1)
AN Seneviratne, Y Han, E Wong, ER Walter, L Jiang, L Cave, NJ Long, D Carling, JC Mason, DO Haskard, JJ Boyle |
Circulation research | 2020 |
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Macrophages in Atherosclerosis Regression
TJ Barrett |
Arteriosclerosis, thrombosis, and vascular biology | 2020 |
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TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation
RA Irizarry-Caro, MM McDaniel, GR Overcast, VG Jain, TD Troutman, C Pasare |
Proceedings of the National Academy of Sciences | 2020 |
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Converging Relationships of Obesity and Hyperuricemia with Special Reference to Metabolic Disorders and Plausible Therapeutic Implications M Gong, S Wen, T Nguyen, C Wang, J Jin, L Zhou |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy | 2020 |
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Alternatively activated macrophages; a double-edged sword in allergic asthma
MH Abdelaziz, SF Abdelwahab, J Wan, W Cai, W Huixuan, C Jianjun, KD Kumar, A Vasudevan, A Sadek, Z Su, S Wang, H Xu |
Journal of Translational Medicine | 2020 |
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Transcriptome Profiling of Bovine Macrophages Infected by Mycobacterium avium spp. paratuberculosis Depicts Foam Cell and Innate Immune Tolerance Phenotypes
O Ariel, D Gendron, PL Dudemaine, N Gévry, EM Ibeagha-Awemu, N Bissonnette |
Frontiers in immunology | 2020 |
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Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome
X Chen, J Tang, W Shuai, J Meng, J Feng, Z Han |
Inflammation Research | 2020 |
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Hacking the host: exploitation of macrophage polarization by intracellular bacterial pathogens
JD Thiriot, YB Martinez-Martinez, JJ Endsley, AG Torres |
Pathogens and Disease | 2020 |
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Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages
I Larionova, E Kazakova, M Patysheva, J Kzhyshkowska |
Cancers | 2020 |
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Immune checkpoint inhibitor induces cardiac injury through polarizing macrophages via modulating microRNA-34a/Kruppel-like factor 4 signaling
W Xia, C Zou, H Chen, C Xie, M Hou |
Cell Death and Disease | 2020 |
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Recent Discoveries on the Involvement of Krüppel-Like Factor 4 in the Most Common Cancer Types
A Taracha-Wisniewska, G Kotarba, S Dworkin, T Wilanowski |
International journal of molecular sciences | 2020 |
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Anti-Inflammatory Activity of Extracts and Pure Compounds Derived from Plants via Modulation of Signaling Pathways, Especially PI3K/AKT in Macrophages
A Merecz-Sadowska, P Sitarek, T Śliwiński, R Zajdel |
International journal of molecular sciences | 2020 |
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DNA methylation in promoter regions of genes involved in the reproductive and metabolic function of children born to women with PCOS
B Echiburú, F Milagro, N Crisosto, F Pérez-Bravo, C Flores, A Arpón, F Salas-Pérez, SE Recabarren, T Sir-Petermann, M Maliqueo |
Epigenetics : official journal of the DNA Methylation Society | 2020 |
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Tumour-derived CSF2/granulocyte macrophage colony stimulating factor controls myeloid cell accumulation and progression of gliomas
M Sielska, P Przanowski, M Pasierbińska, K Wojnicki, K Poleszak, B Wojtas, D Grzeganek, A Ellert-Miklaszewska, MC Ku, H Kettenmann, B Kaminska |
British Journal of Cancer | 2020 |
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Secoiridoid Glucosides and Anti-Inflammatory Constituents from the Stem Bark of Fraxinus chinensis
HC Chang, SW Wang, CY Chen, TL Hwang, MJ Cheng, PJ Sung, KW Liao, JJ Chen |
Molecules (Basel, Switzerland) | 2020 |
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Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization
J Wang, J Xia, R Huang, Y Hu, J Fan, Q Shu, J Xu |
Stem Cell Research & Therapy | 2020 |
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The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization
B Daniel, Z Czimmerer, L Halasz, P Boto, Z Kolostyak, S Poliska, WK Berger, P Tzerpos, G Nagy, A Horvath, G Hajas, T Cseh, A Nagy, S Sauer, J Francois-Deleuze, I Szatmari, A Bacsi, L Nagy |
Genes & development | 2020 |
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Benzophenone and Benzoylphloroglucinol Derivatives from Hypericum sampsonii with Anti-Inflammatory Mechanism of Otogirinin A
CY Huang, TC Chang, YJ Wu, Y Chen, JJ Chen |
Molecules (Basel, Switzerland) | 2020 |
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Epigallocatechin-3-Gallate (EGCG), an Active Compound of Green Tea Attenuates Acute Lung Injury Regulating Macrophage Polarization and Krüpple-Like-Factor 4 (KLF4) Expression
SA Almatroodi, A Almatroudi, MA Alsahli, MA Aljasir, MA Syed, AH Rahmani |
Molecules (Basel, Switzerland) | 2020 |
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ALK5 deficiency inhibits macrophage inflammation and lipid loading by targeting KLF4
W Li, J Wang, Z Li |
Bioscience Reports | 2020 |
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USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy
T Liu, L Wang, P Liang, X Wang, Y Liu, J Cai, Y She, D Wang, Z Wang, Z Guo, S Bates, X Xia, J Huang, J Cui |
Cellular and Molecular Immunology | 2020 |
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Inhibition of miRNA-34a Promotes M2 Macrophage Polarization and Improves LPS-Induced Lung Injury by Targeting Klf4
MJ Khan, P Singh, R Dohare, R Jha, AH Rahmani, SA Almatroodi, S Ali, MA Syed |
Genes & development | 2020 |
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Targeted Krüppel-Like Factor 4 Gene Knock-Out in Retinal Ganglion Cells Improves Visual Function in Multiple Sclerosis Mouse Model
V Talla, R Koilkonda |
eNeuro | 2020 |
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Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE -/- mice
C Ma, R Xia, S Yang, L Liu, J Zhang, K Feng, Y Shang, J Qu, L Li, N Chen, S Xu, W Zhang, J Mao, J Han, Y Chen, X Yang, Y Duan, G Fan |
Theranostics | 2020 |
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PACAP neuropeptide promotes Hepatocellular Protection via CREB-KLF4 dependent autophagy in mouse liver Ischemia Reperfusion Injury.
Xue Z, Zhang Y, Liu Y, Zhang C, Shen XD, Gao F, Busuttil RW, Zheng S, Kupiec-Weglinski JW, Ji H |
Theranostics | 2020 |
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miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism.
Sun L, Lin P, Chen Y, Yu H, Ren S, Wang J, Zhao L, Du G |
Theranostics | 2020 |
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Elevated circulating Krüppel-like factor 4 level as a novel independent marker of the proatherogenic risk in patients with psoriasis: a preliminary study.
Baran A, Krahel JA, Kaminski TW, Krawiel M, Maciaszek M, Flisiak I |
2020 | |
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Sirtuin 2 enhances allergic asthmatic inflammation
Yong Gyu Lee, Brenda F. Reader, Derrick Herman, Adam Streicher, Joshua A. Englert, Mathias Ziegler, Sangwoon Chung, Manjula Karpurapu, Gye Young Park, John W. Christman, Megan N. Ballinger |
JCI Insight | 2019 |
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Adipocyte-secreted exosomal miR-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation
Yong Pan, Xiaoyan Hui, Ruby LC Hoo, Dewei Ye, Cyrus Yuk Cheung Chan, Tianshi Feng, Yu Wang, Karen SL Lam, Aimin Xu |
Journal of Clinical Investigation | 2019 |
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The role of macrophages in the resolution of inflammation
Satoshi Watanabe, Michael Jason Alexander, Alexander Misharin, G.R. Scott Budinger |
Journal of Clinical Investigation | 2019 |
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Increased flux through the mevalonate pathway mediates fibrotic repair without injury
Jennifer L. Larson-Casey, Mudit Vaid, Linlin Gu, Chao He, Guoqiang Cai, Qiang Ding, Dana Davis, Taylor F Berryhill, Landon Wilson, Stephen Barnes, Jeffrey D Neighbors, Raymond Hohl, Kurt A. Zimmerman, Bradley Yoder, Ana Leda Longhini, Vidya Sagar Hanumanthu, Ranu Surolia, Veena B. Antony, A. Brent Carter |
Journal of Clinical Investigation | 2019 |
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Hedgehog signaling promotes tumor-associated macrophages polarization to suppress intratumoral CD8+ T cell recruitment
Amy J Petty, Ang Li, Xinyi Wang, Rui Dai, Benjamin Heyman, David Hsu, Xiaopei Huang, Yiping Yang |
Journal of Clinical Investigation | 2019 |
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M2 Macrophages as a Potential Target for Antiatherosclerosis Treatment
Y Bi, J Chen, F Hu, J Liu, M Li, L Zhao |
Neural plasticity | 2019 |
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LPA receptor 4 deficiency attenuates experimental atherosclerosis
L Yang, M Kraemer, XF Fang, PM Angel, RR Drake, AJ Morris, SS Smyth |
Journal of lipid research | 2019 |
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Platelet regulation of myeloid suppressor of cytokine signaling 3 accelerates atherosclerosis
TJ Barrett, M Schlegel, F Zhou, M Gorenchtein, J Bolstorff, KJ Moore, EA Fisher, JS Berger |
Science Translational Medicine | 2019 |
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MicroRNA Extracellular Vesicle Stowaways in Cell-Cell Communication and Organ Crosstalk
MA Rogers, E Aikawa |
Arteriosclerosis, thrombosis, and vascular biology | 2019 |
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HDL and Reverse Cholesterol Transport: Basic Mechanisms and Their Roles in Vascular Health and Disease
M Ouimet, TJ Barrett, EA Fisher |
Circulation research | 2019 |
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Influence of Resveratrol on the Immune Response
Malaguarnera |
Nutrients | 2019 |
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Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor
L Escoter-Torres, G Caratti, A Mechtidou, J Tuckermann, NH Uhlenhaut, S Vettorazzi |
Frontiers in immunology | 2019 |
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Role of innate immune cells in metabolism: from physiology to type 2 diabetes
E Dalmas |
Seminars in Immunopathology | 2019 |
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KLF4 in Macrophages Attenuates TNF α -Mediated Kidney Injury and Fibrosis
Y Wen, X Lu, J Ren, JR Privratsky, B Yang, NP Rudemiller, J Zhang, R Griffiths, MK Jain, SA Nedospasov, BC Liu, SD Crowley |
Journal of the American Society of Nephrology : JASN | 2019 |
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Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis
Y Xu, Y Xu, Y Zhu, H Sun, C Juguilon, F Li, D Fan, L Yin, Y Zhang |
Molecular Therapy | 2019 |
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Commensal microbiota drive the functional diversification of colon macrophages
B Kang, LJ Alvarado, T Kim, ML Lehmann, H Cho, J He, P Li, BH Kim, A Larochelle, BL Kelsall |
Mucosal Immunology | 2019 |
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Role of microRNA in CB1 antagonist–mediated regulation of adipose tissue macrophage polarization and chemotaxis during diet-induced obesity
P Mehrpouya-Bahrami, K Miranda, NP Singh, EE Zumbrun, M Nagarkatti, PS Nagarkatti |
The Journal of biological chemistry | 2019 |
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Regulation of Systemic Glucose Homeostasis by T Helper Type 2 Cytokines
YE Kang, HJ Kim, M Shong |
Diabetes & Metabolism Journal | 2019 |
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Underlying Genes Involved in Atherosclerotic Macrophages: Insights from Microarray Data Mining
W Wang, K Zhang, H Zhang, M Li, Y Zhao, B Wang, W Xin, W Yang, J Zhang, S Yue, X Yang |
Medical science monitor : international medical journal of experimental and clinical research | 2019 |
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SHP2 deficiency promotes Staphylococcus aureus pneumonia following influenza infection
W Ouyang, C Liu, Y Pan, Y Han, L Yang, J Xia, F Xu |
Cell Proliferation | 2019 |
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Human Embryonic Stem Cell-Derived Cardiovascular Progenitors Repair Infarcted Hearts through Modulation of Macrophages via Activation of STAT6
HT Yang, J Wang, M Liu, Q Wu, Q Li, L Gao, Y Jiang, B Deng, W Huang, W Bi, Z Chen, YE Chin, C Paul, Y Wang |
Antioxidants & Redox Signaling | 2019 |
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Vitamin D improves sunburns by increasing autophagy in M2 macrophages
LM Das, AM Binko, ZP Traylor, H Peng, KQ Lu |
Autophagy | 2019 |
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Concise Review: Regulation of Self-Renewal in Normal and Malignant Hematopoietic Stem Cells by Krüppel-Like Factor 4: KLF4 regulation of Self-Renewal
CS Park, A Lewis, T Chen, D Lacorazza |
Stem Cells Translational Medicine | 2019 |
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Differential Targeting of c-Maf, Bach-1, and Elmo-1 by microRNA-143 and microRNA-365 Promotes the Intracellular Growth of Mycobacterium tuberculosis in Alternatively IL-4/IL-13 Activated Macrophages
O Tamgue, L Gcanga, M Ozturk, L Whitehead, S Pillay, R Jacobs, S Roy, S Schmeier, M Davids, YA Medvedeva, K Dheda, H Suzuki, F Brombacher, R Guler |
Frontiers in immunology | 2019 |
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Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39
MC Takenaka, G Gabriely, V Rothhammer, ID Mascanfroni, MA Wheeler, CC Chao, C Gutiérrez-Vázquez, J Kenison, EC Tjon, A Barroso, T Vandeventer, KA de Lima, S Rothweiler, L Mayo, S Ghannam, S Zandee, L Healy, D Sherr, MF Farez, A Pratt, J Antel, DA Reardon, H Zhang, SC Robson, G Getz, HL Weiner, FJ Quintana |
Nature Neuroscience | 2019 |
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SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity
N Keiran, V Ceperuelo-Mallafré, E Calvo, MI Hernández-Alvarez, M Ejarque, C Núñez-Roa, D Horrillo, E Maymó-Masip, MM Rodríguez, R Fradera, JV de la Rosa, R Jorba, A Megia, A Zorzano, G Medina-Gómez, C Serena, A Castrillo, J Vendrell, S Fernández-Veledo |
Nature Immunology | 2019 |
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KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF
K Shaverdashvili, J Padlo, D Weinblatt, Y Jia, W Jiang, D Rao, D Laczkó, KA Whelan, JP Lynch, AB Muir, JP Katz, CD Andl |
PloS one | 2019 |
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Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer
AH Tan, WJ Tu, R McCuaig, K Hardy, T Donovan, S Tsimbalyuk, JK Forwood, S Rao |
Frontiers in immunology | 2019 |
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The Intra-nuclear SphK2-S1P Axis Facilitates M1-to-M2 Shift of Microglia via Suppressing HDAC1-Mediated KLF4 Deacetylation
J Ji, J Wang, J Yang, , JJ Huang, TF Xue, XL Sun |
Frontiers in immunology | 2019 |
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Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages
Y Tian, C Yang, Q Yao, L Qian, J Liu, X Xie, W Ma, X Nie, B Lai, L Xiao, N Wang |
Frontiers in immunology | 2019 |
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A Dynamic Transcriptional Analysis Reveals IL-6 Axis as a Prominent Mediator of Surgical Acute Response in Non-ischemic Mouse Heart
S Badawi, A Paccalet, Z Harhous, B Pillot, L Augeul, FV Coppenolle, J Lachuer, M Kurdi, CC Silva, M Ovize, G Bidaux |
Frontiers in physiology | 2019 |
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Adipose-Derived Mesenchymal Stem Cells Promote M2 Macrophage Phenotype through Exosomes
JS Heo, Y Choi, HO Kim |
Stem Cells International | 2019 |
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Extracellular MicroRNA-92a Mediates Endothelial Cell–Macrophage Communication
YJ Chang, YS Li, CC Wu, KC Wang, TC Huang, Z Chen, S Chien |
Arteriosclerosis, thrombosis, and vascular biology | 2019 |
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Biological approaches for hypertrophic scars
Z Lingzhi, L Meirong, F Xiaobing |
International Wound Journal | 2019 |
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C/EBP Homologous Protein (CHOP) Activates Macrophages and Promotes Liver Fibrosis in Schistosoma japonicum -Infected Mice
M Duan, Y Yang, S Peng, X Liu, J Zhong, Y Guo, M Lu, H Nie, B Ren, X Zhang, L Liu |
Journal of Immunology Research | 2019 |
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A Porcine Ex Vivo Lung Perfusion Model To Investigate Bacterial Pathogenesis
A Dumigan, M Fitzgerald, JS Santos, U Hamid, CM OKane, DF McAuley, JA Bengoechea, IC Allen, JB Goldberg |
mBio | 2019 |
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Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types
J Vijay, MF Gauthier, RL Biswell, DA Louiselle, JJ Johnston, WA Cheung, B Belden, A Pramatarova, L Biertho, M Gibson, MM Simon, H Djambazian, A Staffa, G Bourque, A Laitinen, J Nystedt, MC Vohl, JD Fraser, T Pastinen, A Tchernof, E Grundberg |
2019 | |
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CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets
HJ Jürgensen, LM Silva, O Krigslund, S van Putten, DH Madsen, N Behrendt, LH Engelholm, TH Bugge |
2019 | |
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Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models
Fumiyuki Sasaki, Tomoaki Koga, Mai Ohba, Kazuko Saeki, Toshiaki Okuno, Keijiro Ishikawa, Takahito Nakama, Shintaro Nakao, Shigeo Yoshida, Tatsuro Ishibashi, Hamid Ahmadieh, Mozhgan Rezaei Kanavi, Ali Hafezi-Moghadam, Josef Penninger, Koh-Hei Sonoda, Takehiko Yokomizo |
JCI Insight | 2018 |
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Insights From Pre-Clinical and Clinical Studies on the Role of Innate Inflammation in Atherosclerosis Regression
K Rahman, EA Fisher |
Frontiers in Cardiovascular Medicine | 2018 |
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Krüppel-Like Factors in Metabolic Homeostasis and Cardiometabolic Disease
Y Oishi, I Manabe |
Frontiers in Cardiovascular Medicine | 2018 |
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Targeting Macrophages in Cancer: From Bench to Bedside
AR Poh, M Ernst |
Frontiers in Oncology | 2018 |
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Immune cell subset differentiation and tissue inflammation
P Fang, X Li, J Dai, L Cole, JA Camacho, Y Zhang, Y Ji, J Wang, XF Yang, H Wang |
Journal of Hematology & Oncology | 2018 |
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Krüppel-Like Factors in Vascular Inflammation: Mechanistic Insights and Therapeutic Potential
DR Sweet, L Fan, PN Hsieh, MK Jain |
Frontiers in Cardiovascular Medicine | 2018 |
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Innate immune cells in the adipose tissue
KJ Chung, M Nati, T Chavakis, A Chatzigeorgiou |
Reviews in Endocrine and Metabolic Disorders | 2018 |
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MicroRNA-30 modulates metabolic inflammation by regulating Notch signaling in adipose tissue macrophages
K Miranda, X Yang, M Bam, EA Murphy, PS Nagarkatti, M Nagarkatti |
International Journal of Obesity | 2018 |
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TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in mice
Z Wang, Y Xu, M Wang, J Ye, J Liu, H Jiang, D Ye, J Wan |
EBioMedicine | 2018 |
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TACI Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis
L Liu, KE Inouye, WR Allman, AS Coleman, S Siddiqui, GS Hotamisligil, M Akkoyunlu |
Diabetes | 2018 |
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Implications of macrophage polarization in autoimmunity
SC Funes, M Rios, J Escobar-Vera, AM Kalergis |
Immunology | 2018 |
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Alternative splicing analysis in human monocytes and macrophages reveals MBNL1 as major regulator
H Liu, PA Lorenzini, F Zhang, S Xu, MS Wong, J Zheng, X Roca |
Nucleic Acids Research | 2018 |
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Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy
X Liao, Y Shen, R Zhang, K Sugi, NT Vasudevan, MA Alaiti, DR Sweet, L Zhou, Y Qing, SL Gerson, C Fu, A Wynshaw-Boris, R Hu, MA Schwartz, H Fujioka, B Richardson, MJ Cameron, H Hayashi, JS Stamler, MK Jain |
Proceedings of the National Academy of Sciences | 2018 |
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Macrophage polarization and allergic asthma
A Saradna, DC Do, S Kumar, QL Fu, P Gao |
Translational research : the journal of laboratory and clinical medicine | 2018 |
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Dynamic Macrophages: Understanding Mechanisms of Activation as Guide to Therapy for Atherosclerotic Vascular Disease
JL Decano, M Aikawa |
Frontiers in Cardiovascular Medicine | 2018 |
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Absence of myeloid Klf4 reduces prostate cancer growth with pro-atherosclerotic activation of tumor myeloid cells and infiltration of CD8 T cells
DJ Barakat, R Suresh, T Barberi, KJ Pienta, BW Simons, AD Friedman, A Ahmad |
PloS one | 2018 |
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DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages
T Herta, A Bhattacharyya, C Bollensdorf, C Kabus, P García, N Suttorp, S Hippenstiel, J Zahlten |
Scientific Reports | 2018 |
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Macrophages: friend or foe in idiopathic pulmonary fibrosis?
L Zhang, Y Wang, G Wu, W Xiong, W Gu, CY Wang |
Respiratory Research | 2018 |
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Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo
F Nakazeki, M Nishiga, T Horie, H Nishi, Y Nakashima, O Baba, Y Kuwabara, T Nishino, T Nakao, Y Ide, S Koyama, M Kimura, S Tsuji, N Sowa, S Yoshida, SJ Conway, M Yanagita, T Kimura, K Ono |
Scientific Reports | 2018 |
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Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages
J Yan, G Tie, S Wang, A Tutto, N DeMarco, L Khair, TG Fazzio, LM Messina |
Nature Communications | 2018 |
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Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
Q Wang, Z He, M Huang, T Liu, Y Wang, H Xu, H Duan, P Ma, L Zhang, SS Zamvil, J Hidalgo, Z Zhang, DM ORourke, N Dahmane, S Brem, Y Mou, Y Gong, Y Fan |
Nature Communications | 2018 |
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IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages
H Cui, S Banerjee, S Guo, N Xie, G Liu |
Journal of immunology (Baltimore, Md. : 1950) | 2018 |
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miRNAs reshape immunity and inflammatory responses in bacterial infection
X Zhou, X Li, M Wu |
Signal Transduction and Targeted Therapy | 2018 |
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Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition
E Giurisato, Q Xu, S Lonardi, B Telfer, I Russo, A Pearson, KG Finegan, W Wang, J Wang, NS Gray, W Vermi, Z Xia, C Tournier |
Proceedings of the National Academy of Sciences | 2018 |
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Beneficial or Harmful Role of Macrophages in Guillain-Barré Syndrome and Experimental Autoimmune Neuritis
D Shen, F Chu, Y Lang, Y Geng, X Zheng, J Zhu, K Liu |
Mediators of Inflammation | 2018 |
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Transcriptional Regulation of Macrophages Polarization by MicroRNAs
H Li, T Jiang, MQ Li, , GJ Zhao |
Frontiers in immunology | 2018 |
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Histone deacetylase 2 is essential for LPS-induced inflammatory responses in macrophages
C Wu, A Li, J Hu, J Kang |
Immunology and Cell Biology | 2018 |
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The Effect and Mechanism of TLR9/KLF4 in FFA-Induced Adipocyte Inflammation
C Wang, M Zhang, J Wu, W Li, X Ha, Y Gu, B Han, J Xie, J Zhang |
Mediators of Inflammation | 2018 |
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Efferocytosis of Erythrocytes Modulates Macrophages towards Recovery after Intracerebral Hemorrhage
Che-Feng Chang, Brittany Goods, Michael H. Askenase, Matthew Hammond, Stephen Renfroe, Arthur Steinschneider, Margaret Landreneau, Youxi Ai, Hannah Beatty, Luís Angenendt da Costa, Matthias Mack, Kevin N. Sheth, David M. Greer, Anita Huttner, Daniel Coman, Fahmeed Hyder, Sourav Ghosh, Carla V. Rothlin, J. Christopher Love, Lauren Sansing |
Journal of Clinical Investigation | 2017 |
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The transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophages
H Kim |
Scientific Reports | 2017 |
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Promising landscape for regulating macrophage polarization: epigenetic viewpoint
D Zhou, K Yang, L Chen, W Zhang, Z Xu, J Zuo, H Jiang, J Luan |
Oncotarget | 2017 |
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Sex-based differences in myocardial gene expression in recently deceased organ donors with no prior cardiovascular disease
K InanlooRahatloo, G Liang, D Vo, A Ebert, I Nguyen, PK Nguyen, X Xu |
PloS one | 2017 |
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RegulatorTrail: a web service for the identification of key transcriptional regulators
T Kehl, L Schneider, F Schmidt, D Stöckel, N Gerstner, C Backes, E Meese, A Keller, MH Schulz, HP Lenhof |
Nucleic Acids Research | 2017 |
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Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo
K Zieger, J Weiner, A Kunath, M Gericke, K Krause, M Kern, M Stumvoll, N Klöting, M Blüher, JT Heiker |
Cellular and Molecular Life Sciences | 2017 |
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Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells
AW Roberts, BL Lee, J Deguine, S John, MJ Shlomchik, GM Barton |
Immunity | 2017 |
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Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility
Z Li, M Martin, J Zhang, HY Huang, L Bai, J Zhang, J Kang, M He, J Li, MR Maurya, S Gupta, G Zhou, P Sangwung, YJ Xu, T Lei, HD Huang, M Jain, MK Jain, S Subramaniam, JY Shyy |
Circulation | 2017 |
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Perturbed microRNA Expression by Mycobacterium tuberculosis Promotes Macrophage Polarization Leading to Pro-survival Foam Cell
PK Ahluwalia, RK Pandey, PK Sehajpal, VK Prajapati |
Frontiers in immunology | 2017 |
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Krüppel-like factor 4 (KLF4): What we currently know
AM Ghaleb, VW Yang |
Gene | 2017 |
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Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease
JK Baillie, E Arner, C Daub, MD Hoon, M Itoh, H Kawaji, T Lassmann, P Carninci, AR Forrest, Y Hayashizaki, GJ Faulkner, CA Wells, M Rehli, P Pavli, KM Summers, DA Hume, JH Cho |
PLoS genetics | 2017 |
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Kruppel-like factor 4 regulates neutrophil activation
Y Shen, H Hong, P Sangwung, S Lapping, L Nayak, L Zhang, MK Jain, X Liao |
Blood Advances | 2017 |
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MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBPβ regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection
SK Sahu, M Kumar, S Chakraborty, SK Banerjee, R Kumar, P Gupta, K Jana, UD Gupta, Z Ghosh, M Kundu, J Basu, P Salgame |
PLoS pathogens | 2017 |
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BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases
AE Papathanassiu, JH Ko, M Imprialou, M Bagnati, PK Srivastava, HA Vu, D Cucchi, SP McAdoo, EA Ananieva, C Mauro, J Behmoaras |
Nature Communications | 2017 |
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Krüppel-like factor 4 regulates the expression of inducible nitric oxide synthase induced by TNF-α in human fibroblast-like synoviocyte MH7A cells
X Mo, J Chen, X Wang, Z Pan, Y Ke, Z Zhou, J Xie, G Lv, X Luo |
Molecular and Cellular Biochemistry | 2017 |
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Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis)
M Shao, GZ Ge, WJ Liu, J Xiao, HJ Xia, Y Fan, F Zhao, BL He, C Chen |
Oncotarget | 2017 |
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Macrophages under pressure: the role of macrophage polarization in hypertension
SC Harwani |
Translational Research | 2017 |
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Microarray and bioinformatics analyses of gene expression profiles in BALB/c murine macrophage polarization
L Jiang, X Li, Y Zhang, M Zhang, Z Tang, K Lv |
Molecular medicine reports | 2017 |
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The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity.
Shan B, Wang X, Wu Y, Xu C, Xia Z, Dai J, Shao M, Zhao F, He S, Yang L, Zhang M, Nan F, Li J, Liu J, Liu J, Jia W, Qiu Y, Song B, Han JJ, Rui L, Duan SZ, Liu Y |
Nature Immunology | 2017 |
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Arctic berry extracts target the gut-liver axis to alleviate metabolic endotoxaemia, insulin resistance and hepatic steatosis in diet-induced obese mice.
Anhê FF, Varin TV, Le Barz M, Pilon G, Dudonné S, Trottier J, St-Pierre P, Harris CS, Lucas M, Lemire M, Dewailly É, Barbier O, Desjardins Y, Roy D, Marette A |
Diabetologia | 2017 |
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The critical role of Krüppel-like factors in kidney disease
SK Mallipattu, CC Estrada, JC He |
American journal of physiology. Renal physiology | 2016 |
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MicroRNA regulation of macrophages in human pathologies
Y Wei, A Schober |
Cellular and Molecular Life Sciences | 2016 |
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Macrophages in Vascular Inflammation: Origins and Functions
JL Decano, PC Mattson, M Aikawa |
Current Atherosclerosis Reports | 2016 |
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Pleiotropic effects of statins on acute kidney injury: involvement of Krüppel-like factor 4
T Yoshida, M Hayashi |
Clinical and Experimental Nephrology | 2016 |
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Macrophages as Effectors of Acute and Chronic Allograft Injury
Y Liu, M Kloc, XC Li |
Current Transplantation Reports | 2016 |
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The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis
M Coppo, Y Chinenov, MA Sacta, I Rogatsky |
Nature Communications | 2016 |
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CD301b+ Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha
Y Kumamoto, JP Camporez, MJ Jurczak, M Shanabrough, T Horvath, GI Shulman, A Iwasaki |
Immunity | 2016 |
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Novel Action of Carotenoids on Non-Alcoholic Fatty Liver Disease: Macrophage Polarization and Liver Homeostasis
Y Ni, F Zhuge, M Nagashimada, T Ota |
Nutrients | 2016 |
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MiR-16 regulates mouse peritoneal macrophage polarization and affects T-cell activation
X Jia, X Li, Y Shen, J Miao, H Liu, G Li, Z Wang |
Journal of Cellular and Molecular Medicine | 2016 |
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FoxO1 regulates allergic asthmatic inflammation through regulating polarization of the macrophage inflammatory phenotype
S Chung, TJ Lee, BF Reader, JY Kim, YG Lee, GY Park, M Karpurapu, MN Ballinger, F Qian, L Rusu, HY Chung, TG Unterman, CM Croce, JW Christman |
Oncotarget | 2016 |
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KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis
D Wei, L Wang, Y Yan, Z Jia, M Gagea, Z Li, X Zuo, X Kong, S Huang, K Xie |
Cancer Cell | 2016 |
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Epigenetic dynamics of monocyte-to-macrophage differentiation
S Wallner, C Schröder, E Leitão, T Berulava, C Haak, D Beißer, S Rahmann, AS Richter, T Manke, U Bönisch, L Arrigoni, S Fröhler, F Klironomos, W Chen, N Rajewsky, F Müller, P Ebert, T Lengauer, M Barann, P Rosenstiel, G Gasparoni, K Nordström, J Walter, B Brors, G Zipprich, B Felder, L Klein-Hitpass, C Attenberger, G Schmitz, B Horsthemke |
Epigenetics & chromatin | 2016 |
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Correlation of A2bAR and KLF4/KLF15 with Obesity-Dyslipidemia Induced Inflammation in Uygur Population
C Wang, X Ha, W Li, P Xu, Y Gu, T Wang, Y Wang, J Xie, J Zhang |
Mediators of Inflammation | 2016 |
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Telomerase reverse transcriptase acts in a feedback loop with NF-κB pathway to regulate macrophage polarization in alcoholic liver disease
X Wu, Y Yang, W Li, Y Cheng, X Li, C Huang, X Meng, B Wu, X Liu, L Zhang, X Lv, J Li |
Scientific Reports | 2016 |
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Krüppel-like Factor 4 modulates interleukin-6 release in human dendritic cells after in vitro stimulation with Aspergillus fumigatus and Candida albicans
K Czakai, I Leonhardt, A Dix, M Bonin, J Linde, H Einsele, O Kurzai, J Loeffler |
Scientific Reports | 2016 |
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Identification of Caspase-6 as a New Regulator of Alternatively Activated Macrophages
Y Yao, Q Shi, B Chen, Q Wang, X Li, L Li, Y Huang, J Ji, P Shen |
The Journal of biological chemistry | 2016 |
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Statistical ensemble of gene regulatory networks of macrophage differentiation
F Castiglione, P Tieri, A Palma, AS Jarrah |
BMC bioinformatics | 2016 |
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SUMOylation of KLF4 promotes IL-4 induced macrophage M2 polarization
K Wang, W Zhou, Q Cai, J Cheng, R Cai, R Xing |
Cell cycle (Georgetown, Tex.) | 2016 |
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Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6Clow Monocytes while Preserving Macrophage Gene Function
GD Thomas, RN Hanna, NT Vasudevan, AA Hamers, CE Romanoski, S McArdle, KD Ross, A Blatchley, D Yoakum, BA Hamilton, Z Mikulski, MK Jain, CK Glass, CC Hedrick |
Immunity | 2016 |
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MFHAS1 promotes colorectal cancer progress by regulating polarization of tumor-associated macrophages via STAT6 signaling pathway
W Chen, Y Xu, J Zhong, H Wang, M Weng, Q Cheng, Q Wu, Z Sun, H Jiang, M Zhu, Y Ren, P Xu, J Chen, C Miao |
Oncotarget | 2016 |
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High salt reduces the activation of IL-4+IL-13 stimulated macrophages
Katrina Binger, Matthias Gebhardt, Matthias Heinig, Carola Rintisch, Agnes Schröder, Wolfgang Neuhofer, Karl Hilgers, Arndt Manzel, Christian Schwartz, Markus Kleinewietfeld, Jakob Voelkl, Valentin Schatz, Ralf Linker, Florian Lang, David Voehringer, Mark Wright, Norbert Hubner, Ralf Dechend, Jonathan Jantsch, Jens Titze, Dominik N. Müller |
Journal of Clinical Investigation | 2015 |
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miR-33 regulation of macrophage metabolism directs immune cell polarization in atherosclerosis
Mireille Ouimet, Hasini Ediriweera, Uma Mahesh Gundra, Frederick Sheedy, Bhama Ramkhelawon, Susan Hutchison, Kaitlyn Rinehold, Coen van Solingen, Morgan Fullerton, Katharine Cecchini, Katey Rayner, Gregory Steinberg, Phillip Zamore, Edward A. Fisher, P'ng Loke, Kathryn Moore |
Journal of Clinical Investigation | 2015 |
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Transcriptional Control of Cardiac Mitochondrial Homeostasis by KLF4
Xudong Liao, Rongli Zhang, Yuan Lu, Domenick A. Prosdocimo, Panjamaporn Sangwung, lilei zhang, guangjin zhou, Puneet Anand, Ling Lai, Teresa C. Leone, Hisashi Fujioka, Fang Ye, Mariana Rosca, Charles Hoppel, P. Christian Schulze, E. Dale Abel, Jonathan S. Stamler, Daniel P. Kelly, Mukesh Jain |
Journal of Clinical Investigation | 2015 |
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M2 Macrophage Polarization Mediates Anti-inflammatory Effects of Endothelial Nitric Oxide Signaling
WJ Lee, S Tateya, AM Cheng, N Rizzo-DeLeon, NF Wang, P Handa, CL Wilson, AW Clowes, IR Sweet, K Bomsztyk, MW Schwartz, F Kim |
Diabetes | 2015 |
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KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis
LS Shankman, D Gomez, OA Cherepanova, M Salmon, GF Alencar, RM Haskins, P Swiatlowska, AA Newman, ES Greene, AC Straub, B Isakson, GJ Randolph, GK Owens |
Nature Medicine | 2015 |
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Ontogeny and Polarization of Macrophages in Inflammation: Blood Monocytes Versus Tissue Macrophages
A Dey, J Allen, PA Hankey-Giblin |
Frontiers in immunology | 2015 |
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Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages
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Inflammatory Cytokines in General and Central Obesity and Modulating Effects of Physical Activity
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Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans
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International Journal of Obesity | 2015 |
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Macrophages in vascular inflammation – From atherosclerosis to vasculitis
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Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity
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Nature Medicine | 2015 |
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HIV vasculopathy: role of mononuclear cell-associated Krüppel-like factors 2 and 4
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AIDS | 2015 |
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Circadian control of bile acid synthesis by a KLF15-Fgf15 axis
SS Han, R Zhang, R Jain, H Shi, L Zhang, G Zhou, P Sangwung, D Tugal, GB Atkins, DA Prosdocimo, Y Lu, X Han, P Tso, X Liao, JA Epstein, MK Jain |
Nature Communications | 2015 |
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Autophagy: an emerging therapeutic target in vascular diseases: Autophagy in vascular diseases
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British Journal of Pharmacology | 2015 |
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Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl glycoanthraquinone-decorated graphene electrodes
XP He, BW Zhu, Y Zang, J Li, GR Chen, H Tian, YT Long |
Chemical Science | 2015 |
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Kruppel-Like Factor KLF4 Facilitates Cutaneous Wound Healing by Promoting Fibrocyte Generation from Myeloid-Derived Suppressor Cells
L Ou, Y Shi, W Dong, C Liu, TJ Schmidt, P Nagarkatti, M Nagarkatti, D Fan, W Ai |
Journal of Investigative Dermatology | 2015 |
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Nuclear Receptor Nr4a2 Promotes Alternative Polarization of Macrophages and Confers Protection in Sepsis
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The Journal of biological chemistry | 2015 |
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Transcription Factors STAT6 and KLF4 Implement Macrophage Polarization via the Dual Catalytic Powers of MCPIP
N Kapoor, J Niu, Y Saad, S Kumar, T Sirakova, E Becerra, X Li, PE Kolattukudy |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
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Kruppel-like factor 4 is a transcriptional regulator of M1/M2 macrophage polarization in alcoholic liver disease
B Saha, S Bala, N Hosseini, K Kodys, G Szabo |
Journal of leukocyte biology | 2015 |
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Endothelial Kru ppel-Like Factor 4 Mediates the Protective Effect of Statins against Ischemic AKI
T Yoshida, M Yamashita, M Iwai, M Hayashi |
Journal of the American Society of Nephrology : JASN | 2015 |
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Chronic Ethanol Exposure: Pathogenesis of Pulmonary Disease and Dysfunction
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Biomolecules | 2015 |
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The Role of Krüppel-like Factor 4 in Renal Fibrosis
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Frontiers in physiology | 2015 |
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Novel Markers to Delineate Murine M1 and M2 Macrophages
KA Jablonski, SA Amici, LM Webb, JD Ruiz-Rosado, PG Popovich, S Partida-Sanchez, M Guerau-de-Arellano, MA Olszewski |
PloS one | 2015 |
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CREB pathway links PGE2 signaling with macrophage polarization
B Luan, YS Yoon, JL Lay, KH Kaestner, S Hedrick, M Montminy |
Proceedings of the National Academy of Sciences | 2015 |
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Receptor-Interacting Protein 140 Orchestrates the Dynamics of Macrophage M1/M2 Polarization
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Deletion of Krüppel‐Like Factor 4 in Endothelial and Hematopoietic Cells Enhances Neointimal Formation Following Vascular Injury
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2014 |
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Macrophage heterogeneity, phenotypes, and roles in renal fibrosis
Q Cao, Y Wang, DC Harris |
Kidney International Supplements | 2014 |
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Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance
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Frontiers in immunology | 2014 |
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Mechanisms Driving Macrophage Diversity and Specialization in Distinct Tumor Microenvironments and Parallelisms with Other Tissues
EV Overmeire, D Laoui, J Keirsse, JA van Ginderachter, A Sarukhan |
Frontiers in immunology | 2014 |
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The Role of Macrophage Polarization in Infectious and Inflammatory Diseases
AC Labonte, AC Tosello-Trampont, YS Hahn |
Molecules and Cells | 2014 |
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Monocyte to macrophage differentiation goes along with modulation of the plasmalogen pattern through transcriptional regulation
S Wallner, M Grandl, T Konovalova, A Sigrüner, T Kopf, M Peer, E Orsó, G Liebisch, G Schmitz |
PloS one | 2014 |
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I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis
J Moltke, RM Locksley |
Current Opinion in Immunology | 2014 |
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Macrophage-mediated injury and repair after ischemic kidney injury
SC Huen, LG Cantley |
Pediatric Nephrology | 2014 |
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The dynamic lives of macrophage and dendritic cell subsets in atherosclerosis: Dendritic cells, macrophages, and atherosclerosis
PL Taghavie-Moghadam, MJ Butcher, EV Galkina |
Annals of the New York Academy of Sciences | 2014 |
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Regulation of an Inflammatory Disease: Kruppel-Like Factors and Atherosclerosis
MK Jain, P Sangwung, A Hamik |
Arteriosclerosis, thrombosis, and vascular biology | 2014 |
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Regulation of Inflammatory Phenotype in Macrophages by a Diabetes-Induced Long Noncoding RNA
MA Reddy, Z Chen, JT Park, M Wang, L Lanting, Q Zhang, K Bhatt, A Leung, X Wu, S Putta, P Saetrom, S Devaraj, R Natarajan |
Diabetes | 2014 |
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Leptin-Mediated Increases in Catecholamine Signaling Reduce Adipose Tissue Inflammation via Activation of Macrophage HDAC4
B Luan, MO Goodarzi, NG Phillips, X Guo, YD Chen, J Yao, M Allison, JI Rotter, R Shaw, M Montminy |
Cell Metabolism | 2014 |
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Colony-Stimulating Factor-1 Signaling Suppresses Renal Crystal Formation
K Taguchi, A Okada, H Kitamura, T Yasui, T Naiki, S Hamamoto, R Ando, K Mizuno, N Kawai, K Tozawa, K Asano, M Tanaka, I Miyoshi, K Kohri |
Journal of the American Society of Nephrology : JASN | 2014 |
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Protective role of 5-azacytidine on myocardial infarction is associated with modulation of macrophage phenotype and inhibition of fibrosis
YS Kim, WS Kang, JS Kwon, MH Hong, H Jeong, HC Jeong, MH Jeong, Y Ahn |
Journal of Cellular and Molecular Medicine | 2014 |
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Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct
UM Gundra, NM Girgis, D Ruckerl, S Jenkins, LN Ward, ZD Kurtz, KE Wiens, MS Tang, U Basu-Roy, A Mansukhani, JE Allen, P Loke |
Blood | 2014 |
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Transcriptomic profiling of the development of the inflammatory response in human monocytes in vitro
P Italiani, EM Mazza, D Lucchesi, I Cifola, C Gemelli, A Grande, C Battaglia, S Bicciato, D Boraschi |
PloS one | 2014 |
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Btk regulates macrophage polarization in response to lipopolysaccharide
JN Gabhann, E Hams, S Smith, C Wynne, JC Byrne, K Brennan, S Spence, A Kissenpfennig, JA Johnston, PG Fallon, CA Jefferies |
PloS one | 2014 |
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Myeloid Kruppel-like factor 2 deficiency exacerbates neurological dysfunction and neuroinflammation in a murine model of multiple sclerosis
H Shi, B Sheng, C Zhang, L Nayak, Z Lin, MK Jain, GB Atkins |
Journal of Neuroimmunology | 2014 |
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PI3K/Akt Signaling Pathway Modulates Influenza Virus Induced Mouse Alveolar Macrophage Polarization to M1/M2b
X Zhao, J Dai, X Xiao, L Wu, J Zeng, J Sheng, J Su, X Chen, G Wang, K Li |
PloS one | 2014 |
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Glucocorticoid receptor coordinates transcription factor-dominated regulatory network in macrophages
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BMC Genomics | 2014 |
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Shared signaling systems in myeloid cell-mediated muscle regeneration
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Development (Cambridge, England) | 2014 |
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Myeloid Colony-Stimulating Factors as Regulators of Macrophage Polarization
TA Hamilton, C Zhao, PG Pavicic, S Datta |
Frontiers in immunology | 2014 |
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Genetic Susceptibility and Loss of Nr4a1 Enhances Macrophage-Mediated Renal Injury in CKD
L Westbrook, AC Johnson, KR Regner, JM Williams, DL Mattson, PB Kyle, JR Henegar, MR Garrett |
Journal of the American Society of Nephrology : JASN | 2014 |
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Kruppel-like Transcription Factor 6 Regulates Inflammatory Macrophage Polarization
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The Journal of biological chemistry | 2014 |
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Monoamine oxidase A (MAO-A): a signature marker of alternatively activated monocytes/macrophages.
Cathcart MK, Bhattacharjee A |
Inflammation and Cell Signaling | 2014 |
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Kruppel Like Factor 15 is critical for vascular inflammation
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Journal of Clinical Investigation | 2013 |
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Comprehensive Physiology
LJ Dixon, M Barnes, H Tang, MT Pritchard, LE Nagy |
Comprehensive Physiology | 2013 |
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Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology
PS Eisele, C Handschin |
Seminars in Immunopathology | 2013 |
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Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance
BC Lee, J Lee |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 |
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Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 Diabetes
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Archives of Pharmacal Research | 2013 |
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Recent advances in obesity-induced inflammation and insulin resistance
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Frontiers in Endocrinology | 2013 |
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miR-125a-5p Regulates Differential Activation of Macrophages and Inflammation
S Banerjee, H Cui, N Xie, Z Tan, S Yang, M Icyuz, VJ Thannickal, E Abraham, G Liu |
The Journal of biological chemistry | 2013 |
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Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis
JI Odegaard, A Chawla |
Science | 2013 |
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Blood spotlight on leukocytes and obesity
JB Carvalheira, Y Qiu, A Chawla |
Blood | 2013 |
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Origins and Hallmarks of Macrophages: Development, Homeostasis, and Disease
TA Wynn, A Chawla, JW Pollard |
Nature | 2013 |
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The Adventitia: Essential Regulator of Vascular Wall Structure and Function
KR Stenmark, ME Yeager, KC el Kasmi, E Nozik-Grayck, EV Gerasimovskaya, M Li, SR Riddle, MG Frid |
Annual Review of Physiology | 2013 |
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Anti-tumour strategies aiming to target tumour-associated macrophages
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Immunology | 2013 |
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Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension
RM Tuder, SL Archer, P Dorfmüller, SC Erzurum, C Guignabert, E Michelakis, M Rabinovitch, R Schermuly, KR Stenmark, NW Morrell |
Journal of the American College of Cardiology | 2013 |
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Macrophages in atherosclerosis: a dynamic balance
KJ Moore, FJ Sheedy, EA Fisher |
Nature Reviews Immunology | 2013 |
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Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease
SJ van Dyken, RM Locksley |
Annual Review of Immunology | 2013 |
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Alternatively Activated Macrophages Revisited: New Insights into the Regulation of Immunity, Inflammation and Metabolic Function following Parasite Infection
JC Jang, MG Nair |
Current immunology reviews | 2013 |
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Shaping the murine macrophage phenotype: IL-4 and cyclic AMP synergistically activate the arginase I promoter
KE Sheldon, H Shandilya, D Kepka-Lenhart, M Poljakovic, A Ghosh, SM Morris |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
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Interferon Regulatory Factor 4 Regulates Obesity-Induced Inflammation Through Regulation of Adipose Tissue Macrophage Polarization
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Diabetes | 2013 |
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Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation
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Krüppel-like factors in cancer
MP Tetreault, Y Yang, JP Katz |
Nature Reviews Cancer | 2013 |
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Phenotypic Polarization of Macrophages in Atherosclerosis
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Arteriosclerosis, thrombosis, and vascular biology | 2013 |
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Deficiency of Kruppel-like factor KLF4 in mammary tumor cells inhibits tumor growth and pulmonary metastasis and is accompanied by compromised recruitment of myeloid-derived suppressor cells: KLF4 Deficiency Results in Less MDSC Recruitment
F Yu, Y Shi, J Wang, J Li, D Fan, W Ai |
International Journal of Cancer | 2013 |
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Regulation of inflammation by adenosine
G Haskó, B Cronstein |
Frontiers in immunology | 2013 |
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Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks
M Chopin, C Seillet, S Chevrier, L Wu, H Wang, HC Morse, GT Belz, SL Nutt |
Journal of Experimental Medicine | 2013 |
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IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1
SJ Jenkins, D Ruckerl, GD Thomas, JP Hewitson, S Duncan, F Brombacher, RM Maizels, DA Hume, JE Allen |
Journal of Experimental Medicine | 2013 |
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Hyperoxia exacerbates postnatal inflammation-induced lung injury in neonatal BRP-39 null mutant mice promoting the M1 macrophage phenotype
MA Syed, V Bhandari |
Mediators of Inflammation | 2013 |
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Lipopolysaccharide-induced M2 to M1 macrophage transformation for IL-12p70 production is blocked by Candida albicans mediated up-regulation of EBI3 expression
XF Zheng, YX Hong, GJ Feng, GF Zhang, H Rogers, MA Lewis, DW Williams, ZF Xia, B Song, XQ Wei |
PloS one | 2013 |
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Platelet factor 4 mediates vascular smooth muscle cell injury responses
G Shi, DJ Field, X Long, D Mickelsen, K Ko, S Ture, VA Korshunov, JM Miano, CN Morrell |
Blood | 2013 |
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Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro
V Chhor, TL Charpentier, S Lebon, MV Oré, IL Celador, J Josserand, V Degos, E Jacotot, H Hagberg, K Sävman, C Mallard, P Gressens, B Fleiss |
Brain, Behavior, and Immunity | 2013 |
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Pathophysiology of NASH: perspectives for a targeted treatment.
Marra F, Lotersztajn S |
Current pharmaceutical design | 2013 |
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Macrophage plasticity and polarization: in vivo veritas
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Journal of Clinical Investigation | 2012 |
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Endothelial Kruppel-like Factor 4 Protects against Atherothrombosis
Guangjin Zhou, Anne Hamik, Lalitha Nayak, Hongmei Tian, Hong Shi, Yuan Lu, Nikunj Sharma, Xudong Liao, Andrew Hale, Lauren Boerboom, Ryan Feaver, Huiyun Gao, Amar Desai, Alvin Schmaier, Stanton Gerson, Yunmei Wang, Brandon Atkins, Brett Blackman, Daniel Simon, Mukesh Jain |
Journal of Clinical Investigation | 2012 |
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Cooperative Binding of KLF4, pELK-1, and HDAC2 to a G/C Repressor Element in the SM22α Promoter Mediates Transcriptional Silencing During SMC Phenotypic Switching In Vivo
M Salmon, D Gomez, E Greene, L Shankman, GK Owens |
Circulation research | 2012 |
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SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation
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The cellular and signaling networks linking the immune system and metabolism in disease
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Nature Medicine | 2012 |
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Molecular Pathways Regulating Macrophage Polarization: Implications for Atherosclerosis
MA Hoeksema, JL Stöger, MP de Winther |
Current Atherosclerosis Reports | 2012 |
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Leukocyte set points in metabolic disease
JI Odegaard, A Chawla |
F1000 biology reports | 2012 |
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Connecting Type 1 and Type 2 Diabetes through Innate Immunity
JI Odegaard, A Chawla |
Cold Spring Harbor Perspectives in Medicine | 2012 |
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The immune system's involvement in obesity-driven type 2 diabetes
CJ Shu, C Benoist, D Mathis |
Seminars in Immunology | 2012 |
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Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation
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The Journal of biological chemistry | 2012 |
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Kruppel-Like Factors and Vascular Inflammation: Implications for Atherosclerosis
MA Alaiti, G Orasanu, D Tugal, Y Lu, MK Jain |
Current Atherosclerosis Reports | 2012 |
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Macrophage polarization and plasticity in health and disease
SK Biswas, M Chittezhath, IN Shalova, JY Lim |
Immunologic Research | 2012 |
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p53 is renoprotective after ischemic kidney injury by reducing inflammation
TA Sutton, T Hato, E Mai, M Yoshimoto, S Kuehl, M Anderson, H Mang, Z Plotkin, RJ Chan, PC Dagher |
Journal of the American Society of Nephrology : JASN | 2012 |
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Phenotypic and Functional Heterogeneity of Macrophages and Dendritic Cell Subsets in the Healthy and Atherosclerosis-Prone Aorta
MJ Butcher, EV Galkina |
Frontiers in physiology | 2012 |
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Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 Macrophages
H Tomioka, Y Tatano, WW Maw, C Sano, Y Kanehiro, T Shimizu |
Clinical and Developmental Immunology | 2012 |
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Merck Ad5/HIV induces broad innate immune activation that predicts CD8⁺ T-cell responses but is attenuated by preexisting Ad5 immunity
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Proceedings of the National Academy of Sciences | 2012 |
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Klf10 inhibits IL-12p40 production in macrophage colony-stimulating factor-induced mouse bone marrow-derived macrophages
W Zhang, X Wang, X Xia, X Liu, S Suo, J Guo, M Li, W Cao, Z Cai, Z Hui, M Subramaniam, TC Spelsberg, J Wang, L Wang |
European Journal of Immunology | 2012 |
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Myeloid Krüppel-Like Factor 4 Deficiency Augments Atherogenesis in ApoE −/− Mice—Brief Report
N Sharma, Y Lu, G Zhou, X Liao, P Kapil, P Anand, GH Mahabeleshwar, JS Stamler, MK Jain |
Arteriosclerosis, thrombosis, and vascular biology | 2012 |
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PJ Murray, TA Wynn |
Nature reviews. Immunology | 2011 |
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Macrophage-mediated inflammation in metabolic disease
A Chawla, KD Nguyen, YP Goh |
Nature reviews. Immunology | 2011 |
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Acute Lung Injury: How Macrophages Orchestrate Resolution of Inflammation and Tissue Repair
S Herold, K Mayer, J Lohmeyer |
Frontiers in immunology | 2011 |
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Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth
SP Tu, H Jin, JD Shi, LM Zhu, Y Suo, G Lu, A Liu, TC Wang, CS Yang |
Cancer prevention research (Philadelphia, Pa.) | 2011 |
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Macrophage Polarization: Convergence Point Targeted by Mycobacterium Tuberculosis and HIV
G Lugo-Villarino, C Vérollet, I Maridonneau-Parini, O Neyrolles |
Frontiers in immunology | 2011 |
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TGF-β1 signaling and Krüppel-like factor 10 regulate bone marrow–derived proangiogenic cell differentiation, function, and neovascularization
AK Wara, SY Foo, K Croce, X Sun, B Icli, Y Tesmenitsky, F Esen, JS Lee, M Subramaniam, TC Spelsberg, EI Lev, D Leshem-Lev, RL Pande, MA Creager, A Rosenzweig, MW Feinberg |
Blood | 2011 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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