Food allergies affect up to 6% of young children and 3%–4% of adults. They encompass a range of disorders that may be IgE and/or non-IgE mediated, including anaphylaxis, pollen food syndrome, food-protein–induced enterocolitis syndrome, food-induced proctocolitis, eosinophilic gastroenteropathies, and atopic dermatitis. Many complex host factors and properties of foods are involved in the development of food allergy. With recent advances in the understanding of how these factors interact, the development of several novel diagnostic and therapeutic strategies is underway and showing promise.
Julie Wang, Hugh A. Sampson
Title and authors | Publication | Year |
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Maternal supplementation with α-tocopherol inhibits the development of offspring food allergy, H1R signaling and ultimately anaphylaxis early in life
Kosins AE, Gao H, Blankenship RL, Emmerson LN, Ochoa JA, Cook-Mills JM |
The Journal of Immunology Author Choice | 2025 |
Depletion of eosinophils during sensitization but not challenge phase in mice blocks the development of food allergy early in life
Gao H, Kosins AE, Ochoa JA, Jacobsen EA, Cook-Mills JM |
The Journal of Immunology Author Choice | 2025 |
Contribution of the Microbiome, Environment, and Genetics to Mucosal Type 2 Immunity and Anaphylaxis in a Murine Food Allergy Model
Stark KG, Falkowski NR, Brown CA, McDonald RA, Huffnagle GB |
2022 | |
Potential Allergenicity Response to Moringa oleifera Leaf Proteins in BALB/c Mice
Zhang J, Liu X, Wang Z, Zhang H, Gao J, Wu Y, Meng X, Zhong Y, Chen H |
Nutrients | 2022 |
Cut-Off Values of Specific IgE and Skin Prick Test to Predict Oral Food Challenge Positivity in Children with Cow’s Milk Allergy
Ciğerci Günaydın N, Eren Akarcan S, Gülen F, Bal CM, Tanaç R, Atasever M, Demir E |
2022 | |
Mucosal Immunoregulatory Properties of Tsukamurella inchonensis to Reverse Experimental Food Allergy
PL Smaldini, FM Trejo, GP Rizzo, DJ Comerci, J Kampinga, GH Docena |
Frontiers in immunology | 2021 |
New Perspectives in Food Allergy
MD Martinis, MM Sirufo, M Suppa, L Ginaldi |
International journal of molecular sciences | 2020 |
Oral Immunotherapy with Cow's Milk Allergy: Five Years' Experience from a Single Center in Turkey
E Demir, NC Günaydın, F Gülen, R Tanaç |
BALK MED J | 2020 |
IL-13–induced intestinal secretory epithelial cell antigen passages are required for IgE-mediated food-induced anaphylaxis
TK Noah, KA Knoop, KG McDonald, JK Gustafsson, L Waggoner, S Vanoni, M Batie, K Arora, AP Naren, YH Wang, NW Lukacs, A Munitz, MA Helmrath, MM Mahe, RD Newberry, SP Hogan |
Journal of Allergy and Clinical Immunology | 2019 |
Mouse Models for Food Allergies: Where Do We Stand?
S Schülke, M Albrecht |
Cells | 2019 |
Mouse strain differences in response to oral immunotherapy for peanut allergy
L Wagenaar, MW Bol-Schoenmakers, G Giustarini, J Garssen, JJ Smit, RH Pieters |
Immunity, Inflammation and Disease | 2019 |
Epidemiology of Cow’s Milk Allergy
JD Flom, SH Sicherer |
Nutrients | 2019 |
Mechanisms by which gut microorganisms influence food sensitivities
A Caminero, M Meisel, B Jabri, EF Verdu |
Nature Reviews Gastroenterology & Hepatology | 2018 |
Early Infant Feeding Practices as Possible Risk Factors for Immunoglobulin E-Mediated Food Allergies in Kuwait
D Alkazemi, M Albeajan, S Kubow |
International journal of pediatrics | 2018 |
Mechanism for initiation of food allergy: Dependence on skin barrier mutations and environmental allergen costimulation
MT Walker, JE Green, RP Ferrie, AM Queener, MH Kaplan, JM Cook-Mills |
Journal of Allergy and Clinical Immunology | 2018 |
Diagnosis of fish and shellfish allergies
WS Tong, AW Yuen, CY Wai, NY Leung, KH Chu, PS Leung |
Journal of asthma and allergy | 2018 |
Dietary Intervention with β-Lactoglobulin-Derived Peptides and a Specific Mixture of Fructo-Oligosaccharides and Bifidobacterium breve M-16V Facilitates the Prevention of Whey-Induced Allergy in Mice by Supporting a Tolerance-Prone Immune Environment
AI Kostadinova, A Pablos-Tanarro, MA Diks, BC van Esch, J Garssen, LM Knippels, LE Willemsen |
Frontiers in immunology | 2017 |
A Comprehensive Review on Mustard-Induced Allergy and Implications for Human Health
A Sharma, AK Verma, RK Gupta, Neelabh, PD Dwivedi |
Clinical Reviews in Allergy & Immunology | 2017 |
Foxp3+ Tregs require WASP to restrain Th2-mediated food allergy
Willem Lexmond, Jeremy Goettel, Jonathan Lyons, Justin Jacobse, Marion Deken, Monica Lawrence, Thomas DiMaggio, daniel kotlarz, Elizabeth Garabedian, Paul Sackstein, Celeste Nelson, Nina Jones, Kelly Stone, Fabio Candotti, Edmond Rings, Adrian Thrasher, Joshua D. Milner, Scott Snapper, Edda Fiebiger |
Journal of Clinical Investigation | 2016 |
Mesenteric IL-10-producing CD5+ regulatory B cells suppress cow’s milk casein-induced allergic responses in mice
AR Kim, HS Kim, DK Kim, ST Nam, HW Kim, YH Park, D Lee, MB Lee, JH Lee, B Kim, MA Beaven, HS Kim, YM Kim, WS Choi |
Scientific Reports | 2016 |
Food Allergy and Helicobacter pylori Infection: A Systematic Review
ZF Ma, NA Majid, Y Yamaoka, YY Lee |
Frontiers in microbiology | 2016 |
The future of biologics: Applications for food allergy
RN Bauer, M Manohar, AM Singh, DC Jay, KC Nadeau |
Journal of Allergy and Clinical Immunology | 2015 |
The role of the commensal microbiota in the regulation of tolerance to dietary allergens:
RB Canani, JA Gilbert, CR Nagler |
Current Opinion in Allergy and Clinical Immunology | 2015 |
Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants
RB Canani, N Sangwan, AT Stefka, R Nocerino, L Paparo, R Aitoro, A Calignano, AA Khan, JA Gilbert, CR Nagler |
The ISME Journal | 2015 |
Orally-Induced Intestinal CD4+ CD25+ FoxP3+ Treg Controlled Undesired Responses towards Oral Antigens and Effectively Dampened Food Allergic Reactions
PL Smaldini, ML Delgado, CA Fossati, GH Docena, HM Ashour |
PloS one | 2015 |
Food allergy: Insights into etiology, prevention, and treatment provided by murine models
MK Oyoshi, HC Oettgen, TA Chatila, RS Geha, PJ Bryce |
Journal of Allergy and Clinical Immunology | 2014 |
The role of commensal bacteria in the regulation of sensitization to food allergens
S Cao, TJ Feehley, CR Nagler |
FEBS Letters | 2014 |
Two single group, prospective, baseline-controlled feeding studies in infants and children with chronic diarrhea fed a hypoallergenic free amino acid-based formula
MW Borschel, DL Antonson, ND Murray, M Oliva-Hemker, LE Mattis, B Kerzner, V Tolia, G Baggs |
BMC Pediatrics | 2014 |
Eosinophilic gastroenteritis with refractory ulcer disease and gastrointestinal bleeding as a rare manifestation of seronegative gastrointestinal food allergy
M Raithel, M Hahn, K Donhuijsen, AF Hagel, A Nägel, RJ Rieker, MF Neurath, M Reinshagen |
Nutrition Journal | 2014 |
Peyer’s Patches and Mesenteric Lymph Nodes Cooperatively Promote Enteropathy in a Mouse Model of Food Allergy
H Nakajima-Adachi, A Kikuchi, Y Fujimura, K Shibahara, T Makino, M Goseki-Sone, M Kihara-Fujioka, T Nochi, Y Kurashima, O Igarashi, M Yamamoto, J Kunisawa, M Toda, S Kaminogawa, R Sato, H Kiyono, S Hachimura, S Grivennikov |
PloS one | 2014 |
Food allergy: an enigmatic epidemic
MC Berin, HA Sampson |
Trends in Immunology | 2013 |
Food components and the immune system: from tonic agents to allergens
AM Faria, AC Gomes-Santos, JL Gonçalves, TG Moreira, SR Medeiros, LP Dourado, DC Cara |
Frontiers in immunology | 2013 |
The management of food allergy in Indonesia
Z Munasir, D Muktiarti |
Asia Pacific Allergy | 2013 |
Novel Approaches to Food Allergy
YH Yang, BL Chiang |
Clinical Reviews in Allergy & Immunology | 2013 |
Fructose and lactose intolerance and malabsorption testing: the relationship with symptoms in functional gastrointestinal disorders
CH Wilder-Smith, A Materna, C Wermelinger, J Schuler |
Alimentary Pharmacology & Therapeutics | 2013 |
Purification, crystallization and preliminary X-ray analysis of the strawberry allergens Fra a 1E and Fra a 3 in the presence of catechin
A Casañal, U Zander, F Dupeux, V Valpuesta, JA Marquez |
Acta Crystallographica Section F Structural Biology and Crystallization Communications | 2013 |
Food Allergy and Increased Asthma Morbidity in a School-Based Inner-City Asthma Study
JL Friedlander, WJ Sheehan, SN Baxi, LS Kopel, JM Gaffin, A Ozonoff, C Fu, DR Gold, W Phipatanakul |
The Journal of Allergy and Clinical Immunology: In Practice | 2013 |
Use of animal models to investigate major allergens associated with food allergy
JL van Gramberg, MJ de Veer, RE O'Hehir, EN Meeusen, RJ Bischof |
Journal of allergy | 2013 |
Erkrankungen und Therapieformen des unteren Gastrointestinaltrakts
Fuchs J, Ellerkamp V, Zimmer KP, Steiß JO, Hauer AC, Buderus S, Keller KM, von Schweinitz D, Lacaille F, Rümmele FM, Goulet O, Müller H, Waag KL, Petersen C |
2013 | |
Food-induced anaphylaxis: mast cells as modulators of anaphylactic severity
SP Hogan, YH Wang, R Strait, FD Finkelman |
Seminars in Immunopathology | 2012 |
Induction and suppression of allergic diarrhea and systemic anaphylaxis in a mouse model of food allergy
ZY Kucuk, R Strait, MV Khodoun, A Mahler, S Hogan, FD Finkelman |
Journal of Allergy and Clinical Immunology | 2012 |
Microbial regulation of allergic responses to food
T Feehley, AT Stefka, S Cao, CR Nagler |
Seminars in Immunopathology | 2012 |
A Comprehensive Review of Legume Allergy
AK Verma, S Kumar, M Das, PD Dwivedi |
Clinical Reviews in Allergy & Immunology | 2012 |
Dietary Resveratrol Prevents the Development of Food Allergy in Mice
Y Okada, K Oh-Oka, Y Nakamura, K Ishimaru, S Matsuoka, K Okumura, H Ogawa, M Hisamoto, T Okuda, A Nakao |
PloS one | 2012 |
Introduction to Special Issue on Food Allergy
CR Nagler |
Seminars in Immunopathology | 2012 |
Single nucleotide polymorphisms (SNPs) in key cytokines may modulate food allergy phenotypes
P Brown, B Nair, SD Mahajan, DE Sykes, G Rich, JL Reynolds, R Aalinkeel, J Wheeler, SA Schwartz |
European Food Research and Technology | 2012 |
The Role of Retinoic Acid in Tolerance and Immunity
JA Hall, JR Grainger, SP Spencer, Y Belkaid |
Immunity | 2011 |
The genetics of asthma and allergic disease: a 21st century perspective
C Ober, TC Yao |
Immunological Reviews | 2011 |
Treatment of Asthma and Food Allergy With Herbal Interventions From Traditional Chinese Medicine
XM Li |
Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine | 2011 |